Details for: DEFB1

Gene ID: 1672

Symbol: DEFB1

Ensembl ID: ENSG00000164825

Description: defensin beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 8.34
    Marker Score: 11971.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.44
    Marker Score: 11902.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.43
    Marker Score: 11183
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 4.25
    Marker Score: 4507
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.36
    Marker Score: 5564
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 3.31
    Marker Score: 4685
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 3.18
    Marker Score: 1009
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.17
    Marker Score: 1693
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.99
    Marker Score: 1683
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.47
    Marker Score: 596
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.45
    Marker Score: 872
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.35
    Marker Score: 5749
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.21
    Marker Score: 2381
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.11
    Marker Score: 16452.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.04
    Marker Score: 2120
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.02
    Marker Score: 1588
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.86
    Marker Score: 15993
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.81
    Marker Score: 3818
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.68
    Marker Score: 866
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.59
    Marker Score: 5631
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.51
    Marker Score: 1161
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.5
    Marker Score: 919
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.46
    Marker Score: 4597
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.44
    Marker Score: 673.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.39
    Marker Score: 35608
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.38
    Marker Score: 2439
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.37
    Marker Score: 321
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.36
    Marker Score: 1297
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.23
    Marker Score: 2242
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.2
    Marker Score: 279
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.19
    Marker Score: 849
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.16
    Marker Score: 966
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.15
    Marker Score: 1089
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.14
    Marker Score: 1684
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.14
    Marker Score: 2596
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.14
    Marker Score: 7246
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.13
    Marker Score: 1144
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.09
    Marker Score: 1142
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 682
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.04
    Marker Score: 595
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.01
    Marker Score: 905
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5316
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9
    Marker Score: 1089
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.9
    Marker Score: 1048
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.89
    Marker Score: 10032
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.89
    Marker Score: 467
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.87
    Marker Score: 30308
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.87
    Marker Score: 175
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.85
    Marker Score: 1632
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.83
    Marker Score: 3495.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.83
    Marker Score: 280
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1338
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 326
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.79
    Marker Score: 3804
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.76
    Marker Score: 241
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.75
    Marker Score: 2905
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.74
    Marker Score: 9945
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.73
    Marker Score: 358
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.69
    Marker Score: 250
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.68
    Marker Score: 341.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.67
    Marker Score: 594
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 424
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.63
    Marker Score: 124
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.63
    Marker Score: 145
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.62
    Marker Score: 993
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.62
    Marker Score: 797
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.59
    Marker Score: 581
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.58
    Marker Score: 338
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.57
    Marker Score: 3471
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.55
    Marker Score: 285
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.54
    Marker Score: 4055
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.54
    Marker Score: 1345
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.54
    Marker Score: 201.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.53
    Marker Score: 335
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.53
    Marker Score: 134
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.52
    Marker Score: 151
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.52
    Marker Score: 795
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.51
    Marker Score: 373
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.49
    Marker Score: 1161
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.46
    Marker Score: 105
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.44
    Marker Score: 117
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 203

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Other Information

**Key characteristics:** - DEFB1 is a transmembrane protein with a molecular weight of approximately 35 kDa. - It is expressed in a variety of cell types, including respiratory epithelial cells, kidney cells, and pancreatic cells. - DEFB1 is a key component of the innate immune response to bacteria, and its overexpression can lead to resistance to antibiotics. **Pathways and functions:** - DEFB1 is a key component of the innate immune response to bacteria. - It is produced by epithelial cells in mucosal tissues and is released into the extracellular environment. - DEFB1 binds to bacterial components, such as lipopolysaccharide (LPS) and peptidoglycan, and activates the immune response. - It also inhibits the activity of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), which can help bacteria to evade the immune response. - DEFB1 is also involved in the regulation of epithelial cell migration and differentiation. **Clinical significance:** - Mutations in the DEFB1 gene have been linked to the development of antibiotic-resistant bacteria. - DEFB1 is a potential target for the development of new antibiotics that are effective against antibiotic-resistant bacteria. **Additional information:** - DEFB1 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. - It is a member of the defensin superfamily, which also includes defensins A, B, and C. - DEFB1 is a potent antibacterial peptide that can inhibit the growth of a wide range of bacterial pathogens.

Genular Protein ID: 2217761765

Symbol: DEFB1_HUMAN

Name: Beta-defensin 1

UniProtKB Accession Codes:

P60022 Q09753

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 15 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9268634

Title: The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry.

PubMed ID: 9268634

DOI: 10.1006/geno.1997.4801

PubMed ID: 9070620

Title: Human airway epithelia express a beta-defensin.

PubMed ID: 9070620

DOI: 10.1165/ajrcmb.16.3.9070620

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7628632

Title: hBD-1: a novel beta-defensin from human plasma.

PubMed ID: 7628632

DOI: 10.1016/0014-5793(95)00687-5

PubMed ID: 12010514

Title: Chemical synthesis of beta-defensins and LEAP-1/hepcidin.

PubMed ID: 12010514

DOI: 10.1034/j.1399-3011.2002.00980.x

PubMed ID: 25122636

Title: Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.

PubMed ID: 25122636

DOI: 10.1126/scitranslmed.3009071

PubMed ID: 23938203

Title: Structural basis for the interaction of human beta-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles.

PubMed ID: 23938203

DOI: 10.1016/j.jmb.2013.08.001

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11486002

Title: The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.

PubMed ID: 11486002

DOI: 10.1074/jbc.m103830200

PubMed ID: 11714914

Title: Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.

PubMed ID: 11714914

DOI: 10.1110/ps.24401

Sequence Information:

  • Length: 68
  • Mass: 7420
  • Checksum: B0AB76DEC3B14F94
  • Sequence:
    • MRTSYLLLFT LCLLLSEMAS GGNFLTGLGH RSDHYNCVSS GGQCLYSACP IFTKIQGTCY 
RGKAKCCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.