Details for: SEC62

Gene ID: 7095

Symbol: SEC62

Ensembl ID: ENSG00000008952

Description: SEC62 homolog, preprotein translocation factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 688.1600
    Cell Significance Index: -107.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 465.5749
    Cell Significance Index: -118.0900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 345.6750
    Cell Significance Index: -142.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 288.3888
    Cell Significance Index: -117.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 260.8356
    Cell Significance Index: -134.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 214.8960
    Cell Significance Index: -144.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 123.3631
    Cell Significance Index: -117.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 88.0810
    Cell Significance Index: -108.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 44.2539
    Cell Significance Index: -118.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 34.7892
    Cell Significance Index: -137.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 31.9458
    Cell Significance Index: -98.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 22.8047
    Cell Significance Index: -49.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.8751
    Cell Significance Index: 360.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 5.5553
    Cell Significance Index: 384.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.6746
    Cell Significance Index: 217.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.4905
    Cell Significance Index: 616.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.8179
    Cell Significance Index: 103.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.4032
    Cell Significance Index: 436.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.1524
    Cell Significance Index: 568.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.8272
    Cell Significance Index: 347.6300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.8270
    Cell Significance Index: 21.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2305
    Cell Significance Index: 63.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1960
    Cell Significance Index: 1199.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1041
    Cell Significance Index: 156.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9570
    Cell Significance Index: 392.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8381
    Cell Significance Index: 115.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7810
    Cell Significance Index: 787.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6887
    Cell Significance Index: 79.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6108
    Cell Significance Index: 189.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4934
    Cell Significance Index: 39.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4631
    Cell Significance Index: 189.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.3405
    Cell Significance Index: 228.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3003
    Cell Significance Index: 67.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2433
    Cell Significance Index: 445.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1847
    Cell Significance Index: 83.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1452
    Cell Significance Index: 13.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0956
    Cell Significance Index: 108.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0056
    Cell Significance Index: 61.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9660
    Cell Significance Index: 17.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8656
    Cell Significance Index: 171.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7798
    Cell Significance Index: 18.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7577
    Cell Significance Index: 15.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7106
    Cell Significance Index: 20.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5837
    Cell Significance Index: 403.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5221
    Cell Significance Index: 23.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4401
    Cell Significance Index: 28.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3946
    Cell Significance Index: 64.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3688
    Cell Significance Index: 40.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3362
    Cell Significance Index: 8.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3040
    Cell Significance Index: 17.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2607
    Cell Significance Index: 191.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2107
    Cell Significance Index: 190.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2028
    Cell Significance Index: 153.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1695
    Cell Significance Index: 5.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1593
    Cell Significance Index: 300.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0792
    Cell Significance Index: 15.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0072
    Cell Significance Index: 0.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0033
    Cell Significance Index: 0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0242
    Cell Significance Index: -15.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0330
    Cell Significance Index: -60.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0468
    Cell Significance Index: -1.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0471
    Cell Significance Index: -72.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0515
    Cell Significance Index: -38.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0553
    Cell Significance Index: -75.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0756
    Cell Significance Index: -47.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0881
    Cell Significance Index: -1.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1422
    Cell Significance Index: -64.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1433
    Cell Significance Index: -14.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1583
    Cell Significance Index: -89.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2588
    Cell Significance Index: -54.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3908
    Cell Significance Index: -112.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4303
    Cell Significance Index: -49.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4517
    Cell Significance Index: -4.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4906
    Cell Significance Index: -71.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5230
    Cell Significance Index: -40.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6358
    Cell Significance Index: -74.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7119
    Cell Significance Index: -47.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7651
    Cell Significance Index: -87.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7860
    Cell Significance Index: -9.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9136
    Cell Significance Index: -17.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2258
    Cell Significance Index: -127.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2458
    Cell Significance Index: -98.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.3182
    Cell Significance Index: -36.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.4154
    Cell Significance Index: -26.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6791
    Cell Significance Index: -53.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.6812
    Cell Significance Index: -40.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7288
    Cell Significance Index: -76.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.7329
    Cell Significance Index: -10.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7493
    Cell Significance Index: -107.2500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.8173
    Cell Significance Index: -14.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.1747
    Cell Significance Index: -82.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.2073
    Cell Significance Index: -47.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -2.4536
    Cell Significance Index: -72.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.5752
    Cell Significance Index: -55.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.6270
    Cell Significance Index: -67.1100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -2.7319
    Cell Significance Index: -16.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.7660
    Cell Significance Index: -71.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.7676
    Cell Significance Index: -37.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.8901
    Cell Significance Index: -77.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.9843
    Cell Significance Index: -87.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** SEC62 is predominantly expressed in cells with high protein synthesis rates, such as thyroid follicular cells, secretory cells, and immune cells. 2. **Protein translocation:** SEC62 is a key component of the COPII complex, responsible for the cotranslational translocation of proteins to the ER. 3. **ER membrane targeting:** SEC62 also plays a role in targeting proteins to the ER membrane, ensuring proper protein folding and secretion. 4. **Signaling receptor activity:** SEC62 has been implicated in signaling receptor activity, suggesting its involvement in cellular signaling pathways. **Pathways and Functions:** 1. **Cotranslational protein targeting to membrane:** SEC62 is involved in the targeting of proteins to the ER membrane, ensuring proper protein folding and secretion. 2. **Endoplasmic reticulum:** SEC62 plays a crucial role in the translocation of proteins to the ER, where they undergo proper folding, modification, and secretion. 3. **Post-translational protein targeting to endoplasmic reticulum membrane:** SEC62 is also involved in targeting proteins to the ER membrane, ensuring proper protein folding and secretion. 4. **Translocation:** SEC62 is a key component of the COPII complex, responsible for the cotranslational translocation of proteins to the ER. 5. **Signaling receptor activity:** SEC62 has been implicated in signaling receptor activity, suggesting its involvement in cellular signaling pathways. **Clinical Significance:** Dysregulation of SEC62 has been implicated in various diseases, including: 1. **Thyroid disorders:** Mutations in SEC62 have been associated with thyroid disorders, such as hypothyroidism and hyperthyroidism. 2. **Immune system disorders:** SEC62 has been implicated in immune system disorders, such as autoimmune diseases and cancer. 3. **Neurological disorders:** SEC62 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SEC62 plays a crucial role in protein translocation, cellular homeostasis, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of SEC62 in maintaining human health. Further research is necessary to fully understand the mechanisms of SEC62 and its role in disease pathogenesis.

Genular Protein ID: 988584829

Symbol: SEC62_HUMAN

Name: Translocation protein SEC62

UniProtKB Accession Codes:

Q99442 D3DNQ0 O00682 O00729

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9020021

Title: Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp-1).

PubMed ID: 9020021

DOI: 10.1006/bbrc.1996.5892

PubMed ID: 10683767

Title: Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene.

PubMed ID: 10683767

DOI: 10.1080/713803565

PubMed ID: 10799540

Title: Mammalian Sec61 is associated with Sec62 and Sec63.

PubMed ID: 10799540

DOI: 10.1074/jbc.275.19.14550

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22375059

Title: Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.

PubMed ID: 22375059

DOI: 10.1242/jcs.096727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29719251

Title: Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

PubMed ID: 29719251

DOI: 10.1016/j.celrep.2018.03.122

PubMed ID: 32620754

Title: Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes.

PubMed ID: 32620754

DOI: 10.1038/s41467-020-17163-y

Sequence Information:

  • Length: 399
  • Mass: 45862
  • Checksum: CACBF4F02E2D0AE5
  • Sequence:
    • MAERRRHKKR IQEVGEPSKE EKAVAKYLRF NCPTKSTNMM GHRVDYFIAS KAVDCLLDSK 
WAKAKKGEEA LFTTRESVVD YCNRLLKKQF FHRALKVMKM KYDKDIKKEK DKGKAESGKE 
EDKKSKKENI KDEKTKKEKE KKKDGEKEES KKEETPGTPK KKETKKKFKL EPHDDQVFLD 
GNEVYVWIYD PVHFKTFVMG LILVIAVIAA TLFPLWPAEM RVGVYYLSVG AGCFVASILL 
LAVARCILFL IIWLITGGRH HFWFLPNLTA DVGFIDSFRP LYTHEYKGPK ADLKKDEKSE 
TKKQQKSDSE EKSDSEKKED EEGKVGPGNH GTEGSGGERH SDTDSDRRED DRSQHSSGNG 
NDFEMITKEE LEQQTDGDCE EDEEEENDGE TPKSSHEKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.