Details for: ABLIM1

Gene ID: 3983

Symbol: ABLIM1

Ensembl ID: ENSG00000099204

Description: actin binding LIM protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.4
    Marker Score: 120714
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.91
    Marker Score: 4734.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.8
    Marker Score: 2150
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.75
    Marker Score: 20144
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.73
    Marker Score: 28133
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.6
    Marker Score: 2372
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.55
    Marker Score: 4778
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.54
    Marker Score: 12593
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.54
    Marker Score: 18568
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.49
    Marker Score: 3722
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.41
    Marker Score: 7481.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.39
    Marker Score: 4222
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.3
    Marker Score: 2172
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.29
    Marker Score: 7555
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.25
    Marker Score: 69332
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.17
    Marker Score: 13252.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.14
    Marker Score: 2421
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.11
    Marker Score: 1623
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.06
    Marker Score: 4443
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.93
    Marker Score: 931
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.87
    Marker Score: 1672
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.75
    Marker Score: 21070
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.75
    Marker Score: 54613
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.72
    Marker Score: 2861.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.71
    Marker Score: 7265
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.71
    Marker Score: 1583
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.7
    Marker Score: 40307
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.68
    Marker Score: 2324.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.64
    Marker Score: 1576
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.63
    Marker Score: 99925
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.55
    Marker Score: 16270
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.5
    Marker Score: 11550
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.43
    Marker Score: 10072
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.43
    Marker Score: 1622
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.4
    Marker Score: 88705
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.39
    Marker Score: 1629
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.38
    Marker Score: 2871
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.31
    Marker Score: 18071
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.3
    Marker Score: 726
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.28
    Marker Score: 8799
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.23
    Marker Score: 19219
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.21
    Marker Score: 2508
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.2
    Marker Score: 7827
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.2
    Marker Score: 799
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.18
    Marker Score: 638
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.17
    Marker Score: 626.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.17
    Marker Score: 20433
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.1
    Marker Score: 5258
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.06
    Marker Score: 865
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.06
    Marker Score: 1782
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.06
    Marker Score: 2893
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.05
    Marker Score: 6888
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.02
    Marker Score: 464
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.02
    Marker Score: 2226
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.01
    Marker Score: 1168
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2
    Marker Score: 105896
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.99
    Marker Score: 2146
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.96
    Marker Score: 7991
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119550
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.94
    Marker Score: 2856
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.94
    Marker Score: 780
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.92
    Marker Score: 4371
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17930
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.88
    Marker Score: 2169
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.88
    Marker Score: 19432
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.87
    Marker Score: 1899
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.85
    Marker Score: 2311
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.82
    Marker Score: 849
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.79
    Marker Score: 669
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.77
    Marker Score: 5063
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.75
    Marker Score: 555
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.75
    Marker Score: 3195
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.75
    Marker Score: 1855
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15004
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7
    Marker Score: 27346
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.7
    Marker Score: 577
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.68
    Marker Score: 58328
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.68
    Marker Score: 3804
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.68
    Marker Score: 5763
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.67
    Marker Score: 2162
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.67
    Marker Score: 3938
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.67
    Marker Score: 1316
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.62
    Marker Score: 10385
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.61
    Marker Score: 2280
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.61
    Marker Score: 54399
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.6
    Marker Score: 3913
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.58
    Marker Score: 1298
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.58
    Marker Score: 882
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2436
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.57
    Marker Score: 5148
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.56
    Marker Score: 493
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.55
    Marker Score: 1133
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.55
    Marker Score: 6652
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.54
    Marker Score: 489
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.52
    Marker Score: 20206
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.51
    Marker Score: 1264
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.51
    Marker Score: 413
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.5
    Marker Score: 371
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.49
    Marker Score: 1742
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.49
    Marker Score: 714

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Other Information

## Summary ABLIM1 is a protein that plays a crucial role in the development and function of various tissues and organs in the human body. It is expressed in a wide range of cell types, including cardiac, neural, and epithelial cells. ## Key characteristics * ABLIM1 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the Actin-binding LIM protein (ABLIM) family of proteins. * ABLIM1 is highly expressed in cardiac, neural, and epithelial tissues. * It is involved in the regulation of various cellular processes, including cell migration, proliferation, and differentiation. ## Pathways and functions * ABLIM1 is involved in the regulation of cardiac morphogenesis and function. * It is expressed in the heart, where it is required for the development and maintenance of cardiac valves, the heart chamber, and the conduction system. * ABLIM1 also plays a role in the development of the nervous system, where it is expressed in neurons and glial cells. * It is involved in the regulation of epithelial cell migration and tissue morphogenesis. * ABLIM1 has also been implicated in the regulation of cell migration, proliferation, and differentiation in various other tissues, including the lens, skin, and bone. ## Clinical significance Mutations in ABLIM1 have been linked to several human diseases, including cardiovascular disease, cancer, and developmental disorders. These mutations can disrupt the normal function of ABLIM1, leading to cellular abnormalities and disease. **Clinical significance:** * ABLIM1 is a promising target for the treatment of cardiovascular disease and other disorders that are characterized by abnormal cell migration and proliferation. * Inhibition of ABLIM1 has been shown to be effective in preventing the development and progression of these diseases. * Further research is needed to develop effective therapeutic strategies that target ABLIM1 and improve patient outcomes.

Genular Protein ID: 2967548982

Symbol: ABLM1_HUMAN

Name: Actin-binding LIM protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9245787

Title: Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein.

PubMed ID: 9245787

DOI: 10.1083/jcb.138.3.575

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17194709

Title: Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin.

PubMed ID: 17194709

DOI: 10.1074/jbc.m607549200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 778
  • Mass: 87688
  • Checksum: EBC2F14BE558752B
  • Sequence:
  • MPAFLGLKCL GKLCSSEKSK VTSSERTSAR GSNRKRLIVE DRRVSGTSFT AHRRATITHL 
    LYLCPKDYCP RGRVCNSVDP FVAHPQDPHH PSEKPVIHCH KCGEPCKGEV LRVQTKHFHI 
    KCFTCKVCGC DLAQGGFFIK NGEYLCTLDY QRMYGTRCHG CGEFVEGEVV TALGKTYHPN 
    CFACTICKRP FPPGDRVTFN GRDCLCQLCA QPMSSSPKET TFSSNCAGCG RDIKNGQALL 
    ALDKQWHLGC FKCKSCGKVL TGEYISKDGA PYCEKDYQGL FGVKCEACHQ FITGKVLEAG 
    DKHYHPSCAR CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRPTR TSSESIYSRP 
    GSSIPGSPGH TIYAKVDNEI LDYKDLAAIP KVKAIYDIER PDLITYEPFY TSGYDDKQER 
    QSLGESPRTL SPTPSAEGYQ DVRDRMIHRS TSQGSINSPV YSRHSYTPTT SRSPQHFHRP 
    GNEPSSGRNS PLPYRPDSRP LTPTYAQAPK HFHVPDQGIN IYRKPPIYKQ HAALAAQSKS 
    SEDIIKFSKF PAAQAPDPSE TPKIETDHWP GPPSFAVVGP DMKRRSSGRE EDDEELLRRR 
    QLQEEQLMKL NSGLGQLILK EEMEKESRER SSLLASRYDS PINSASHIPS SKTASLPGYG 
    RNGLHRPVST DFAQYNSYGD VSGGVRDYQT LPDGHMPAMR MDRGVSMPNM LEPKIFPYEM 
    LMVTNRGRNK ILREVDRTRL ERHLAPEVFR EIFGMSIQEF DRLPLWRRND MKKKAKLF

Genular Protein ID: 2505618305

Symbol: B3KSG3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 531
  • Mass: 60190
  • Checksum: 1233E00E29196C2E
  • Sequence:
  • MSSSPKETTF SSNCAGCGRD IKNGQALLAL DKQWHLGCFK CKSCGKVLTG EYISKDGAPY 
    CEKDYQGLFG VKCEACHQFI TGKVLEAGDK HYHPSCARCS RCNQMFTEGE EMYLQGSTVW 
    HPDCKQSTKT EERLRPTRTS SESIYSRPGS SIPGSPGHTI YAKVDNEILD YKDLAAIPKV 
    KAIYDIERPD LITYEPFYTS GYDDKQERQS LGESPRTLSP TPSAEGYQDV RDRMIHRSTS 
    QGSINSPVYS RHSYTPTTSR SPQHFHRPDQ GINIYRKPPI YKQHAALAAQ SKSSEDIIKF 
    SKFPAAQAPD PSETPKIETD HWPGPPSFAV VGPDMKRRSS GREEDDEELL RRRQLQEEQL 
    MKLNSGLGQL ILKEEMEKES RERSSLLASR YDSPINSASH IPSSKTASLP GYGRNGLHRP 
    VSTDFAQYNS YGDVSGGVRD YQTLPDGHMP AMRMDRGVSM PNMLEPKIFP YEMLMVTNRG 
    RNKILREVDR TRLERHLAPE VFREIFGMSI QEFDRLPLWR RNDMKKKAKL F

Genular Protein ID: 1567689244

Symbol: B4DQA3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 380
  • Mass: 43856
  • Checksum: 8D49DD5C5458E510
  • Sequence:
  • MFTEGEEMYL QGSTVWHPDC KQSTKTEEKL RPTRTSSESI YSRPGSSIPG SPGHTIYAKV 
    DNEILDYKDL AAIPKVKAIY DIERPDLITY EPFYTSGYDD KQERQSLGES PRTLSPTPSA 
    EGYQDVRDRM IHRSTSQGSI NSPVYSRHSY TPTTSRSPQH FHRPDQGINI YRKPPIYKQH 
    GPDMKRRSSG REEDDEELLR RRQLQEEQLM KLNSGLGQLI LKEEMEKESR ERSSLLASRY 
    DSPINSASHI PSSKTASLPG YGRNGLHRPV STDFAQYNSY GDVSGGVRDY QTLPDGHMPA 
    MRMDRGVSMP NMLEPKIFPY EMLMVTNRGR NKILREVDRT RLERHLAPEV FREIFGMSIQ 
    EFDRLPLWRR NDMKKKAKLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.