Details for: HIBADH
Gene ID: 11112
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: HIBADH
Ensembl ID: ENSG00000106049
Description: 3-hydroxyisobutyrate dehydrogenase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 19.87rCSI 35.57%PRS 39.39
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CSI 16.31rCSI 22.23%PRS 34.98
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CSI 15.25rCSI 27.03%PRS 25.8
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CSI 15.06rCSI 39.13%PRS 46.29
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CSI 13.4rCSI 16.23%PRS 37.96
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CSI 12.71rCSI 43.55%PRS 33.72
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CSI 12.33rCSI 18.04%PRS 43.61
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CSI 12.29rCSI 21.71%PRS 25.73
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CSI 11.89rCSI 11.45%PRS 41.44
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CSI 11.83rCSI 19.31%PRS 21.98
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CSI 11.04rCSI 28%PRS 32.31
-
CSI 10.31rCSI 22.77%PRS 30.36
-
CSI 9.92rCSI 35.71%PRS 25.6
-
CSI 9.91rCSI 10.38%PRS 38.39
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CSI 9.87rCSI 15.08%PRS 45.27
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CSI 9.82rCSI 25.91%PRS 47.98
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CSI 9.76rCSI 48.55%PRS 41.01
-
CSI 9.66rCSI 38.26%PRS 44.03
-
CSI 9.64rCSI 16.98%PRS 39.63
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CSI 9.61rCSI 11.96%PRS 25.25
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CSI 9.5rCSI 24.13%PRS 37.52
-
CSI 9.42rCSI 6.98%PRS 35.2
-
CSI 9.12rCSI 22.17%PRS 25.87
-
CSI 9.04rCSI 13.78%PRS 37.75
-
CSI 8.98rCSI 20.05%PRS 46.89
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CSI 8.87rCSI 12.09%PRS 21.51
-
CSI 8.41rCSI 11.92%PRS 38.14
-
CSI 8.27rCSI 13.16%PRS 34.72
-
CSI 8.04rCSI 20.66%PRS 44.24
-
CSI 7.82rCSI 22.53%PRS 58.73
-
CSI 7.67rCSI 19.99%PRS 40.81
-
CSI 7.35rCSI 10.53%PRS 48.3
-
CSI 7.3rCSI 11.64%PRS 35.27
-
CSI 7.21rCSI 42.46%PRS 27.9
-
CSI 7.13rCSI 14.46%PRS 25
-
CSI 6.91rCSI 10.68%PRS 38.93
-
CSI 6.85rCSI 21.42%PRS 29.82
-
CSI 6.82rCSI 6.58%PRS 32.21
-
CSI 6.64rCSI 9.82%PRS 45.42
-
CSI 6.41rCSI 10.77%PRS 26.65
-
CSI 6.35rCSI 6.63%PRS 41.42
-
CSI 6.24rCSI 10.1%PRS 39.6
-
CSI 5.83rCSI 15.2%PRS 39.94
-
CSI 5.82rCSI 7.51%PRS 27.54
-
CSI 5.75rCSI 17.98%PRS 27.76
-
CSI 5.59rCSI 12.78%PRS 40.29
-
CSI 5.32rCSI 7.07%PRS 45.21
-
CSI 5.17rCSI 29.65%PRS 52.87
-
CSI 5.16rCSI 19.35%PRS 34.82
-
CSI 5.16rCSI 7.05%PRS 43.48
-
CSI 5.15rCSI 19.47%PRS 27.53
-
CSI 5.08rCSI 11.6%PRS 35.07
-
CSI 5.01rCSI 8.05%PRS 28.67
-
CSI 4.98rCSI 6.66%PRS 48.92
-
CSI 4.95rCSI 6.3%PRS 45.81
-
CSI 4.79rCSI 6.63%PRS 46.45
-
CSI 4.7rCSI 10.84%PRS 33.57
-
CSI 4.65rCSI 9.04%PRS 42.69
-
CSI 4.58rCSI 5.47%PRS 26.58
-
CSI 4.56rCSI 3.61%PRS 29.68
-
CSI 4.44rCSI 7.97%PRS 34.83
-
CSI 4.42rCSI 23.25%PRS 39.44
-
CSI 4.42rCSI 6.14%PRS 40.46
-
CSI 4.37rCSI 3.84%PRS 45.5
-
CSI 4.3rCSI 5.52%PRS 38.89
-
CSI 4.19rCSI 3.59%PRS 50.11
-
CSI 4.1rCSI 12.17%PRS 52.34
-
CSI 4.04rCSI 4.22%PRS 40.59
-
CSI 4.03rCSI 4.02%PRS 35.53
-
CSI 3.97rCSI 9.7%PRS 37.48
-
CSI 3.93rCSI 8.93%PRS 46.45
-
CSI 3.92rCSI 6.03%PRS 43.96
-
CSI 3.85rCSI 4.76%PRS 37
-
CSI 3.71rCSI 8.72%PRS 50.32
-
CSI 3.65rCSI 9.44%PRS 37.38
-
CSI 3.65rCSI 10.05%PRS 38.03
-
CSI 3.62rCSI 15.21%PRS 64.32
-
CSI 3.57rCSI 6.68%PRS 31.6
-
CSI 3.51rCSI 3.09%PRS 31.01
-
CSI 3.44rCSI 3.97%PRS 35.75
-
CSI 3.43rCSI 3.19%PRS 40.78
-
CSI 3.42rCSI 4.39%PRS 37.21
-
CSI 3.4rCSI 24.25%PRS 47.61
-
CSI 3.36rCSI 5.82%PRS 32.4
-
CSI 3.31rCSI 22.52%PRS 39.21
-
CSI 3.24rCSI 2.68%PRS 41.68
-
CSI 3.21rCSI 2.85%PRS 40.11
-
CSI 3.13rCSI 2.59%PRS 39.41
-
CSI 3.13rCSI 6.85%PRS 50.76
-
CSI 3.12rCSI 12.14%PRS 50.09
-
CSI 3.05rCSI 12.3%PRS 39.54
-
CSI 3.02rCSI 6.66%PRS 44.63
-
CSI 2.93rCSI 4.65%PRS 50.81
-
CSI 2.93rCSI 6.08%PRS 39.12
-
CSI 2.89rCSI 2.84%PRS 43.05
-
CSI 2.88rCSI 21.18%PRS 29.92
-
CSI 2.85rCSI 68.19%PRS 26.07
-
CSI 2.8rCSI 2.41%PRS 50.17
-
CSI 2.79rCSI 6.36%PRS 39.76
-
CSI 2.79rCSI 67.2%PRS 26.95
-
CSI 0.1rCSI 0.6%PRS 57.8%
-
CSI 0.3rCSI 2.3%PRS 29.3%
-
CSI 0.4rCSI 5.5%PRS 44.3%
-
CSI 0.4rCSI 1.1%PRS 54.2%
-
CSI 0.4rCSI 3.3%PRS 61.1%
-
CSI 0.5rCSI 5.2%PRS 67.9%
-
CSI 0.5rCSI 2.0%PRS 38.5%
-
CSI 0.5rCSI 3.5%PRS 37.5%
-
CSI 0.5rCSI 2.4%PRS 39.5%
-
CSI 0.6rCSI 1.1%PRS 50.4%
-
CSI 0.6rCSI 3.8%PRS 34.1%
-
CSI 0.6rCSI 3.6%PRS 39.5%
-
CSI 0.7rCSI 3.0%PRS 35.3%
-
CSI 0.7rCSI 0.5%PRS 39.4%
-
CSI 0.7rCSI 5.1%PRS 75.0%
-
CSI 0.9rCSI 6.7%PRS 37.6%
-
CSI 0.9rCSI 3.2%PRS 56.6%
-
CSI 0.9rCSI 2.6%PRS 42.0%
-
CSI 0.9rCSI 1.3%PRS 53.4%
-
CSI 1.0rCSI 13.6%PRS 34.1%
-
CSI 1.0rCSI 2.8%PRS 55.6%
-
CSI 1.0rCSI 3.8%PRS 35.4%
-
CSI 1.0rCSI 2.5%PRS 31.3%
-
CSI 1.1rCSI 2.6%PRS 51.3%
-
CSI 1.1rCSI 1.3%PRS 31.8%
-
CSI 1.2rCSI 12.2%PRS 42.9%
-
CSI 1.2rCSI 9.2%PRS 39.3%
-
CSI 1.2rCSI 5.9%PRS 52.1%
-
CSI 1.2rCSI 1.7%PRS 50.9%
-
CSI 1.2rCSI 2.5%PRS 63.2%
-
CSI 1.2rCSI 17.5%PRS 74.1%
-
CSI 1.3rCSI 4.2%PRS 30.6%
-
CSI 1.3rCSI 2.8%PRS 38.1%
-
CSI 1.3rCSI 6.0%PRS 39.4%
-
CSI 1.3rCSI 2.6%PRS 40.6%
-
CSI 1.4rCSI 0.9%PRS 44.9%
-
CSI 1.4rCSI 1.7%PRS 51.9%
-
CSI 1.4rCSI 8.0%PRS 28.4%
-
CSI 1.4rCSI 3.6%PRS 48.8%
-
CSI 1.4rCSI 11.4%PRS 66.1%
-
CSI 1.5rCSI 4.5%PRS 53.1%
-
CSI 1.5rCSI 6.0%PRS 53.1%
-
CSI 1.5rCSI 1.2%PRS 41.3%
-
CSI 1.5rCSI 1.1%PRS 42.5%
-
CSI 1.5rCSI 5.0%PRS 44.2%
-
CSI 1.5rCSI 13.3%PRS 43.5%
-
CSI 1.6rCSI 4.2%PRS 49.7%
-
CSI 1.6rCSI 3.9%PRS 51.8%
-
CSI 1.6rCSI 1.3%PRS 41.1%
-
CSI 1.6rCSI 5.2%PRS 40.4%
-
CSI 1.6rCSI 10.9%PRS 40.1%
-
CSI 1.6rCSI 1.9%PRS 44.7%
-
CSI 1.7rCSI 2.5%PRS 42.5%
-
CSI 1.7rCSI 2.7%PRS 32.5%
-
CSI 1.7rCSI 1.4%PRS 45.9%
-
CSI 1.7rCSI 4.1%PRS 43.4%
-
CSI 1.8rCSI 1.9%PRS 43.3%
-
CSI 1.8rCSI 3.2%PRS 49.1%
-
CSI 1.8rCSI 3.0%PRS 32.5%
-
CSI 1.8rCSI 4.7%PRS 49.8%
-
CSI 1.9rCSI 6.0%PRS 43.6%
-
CSI 1.9rCSI 1.7%PRS 55.3%
-
CSI 1.9rCSI 1.7%PRS 37.6%
-
CSI 2.0rCSI 4.7%PRS 57.4%
-
CSI 2.0rCSI 9.4%PRS 39.4%
-
CSI 2.0rCSI 2.9%PRS 54.5%
-
CSI 2.0rCSI 3.2%PRS 41.9%
-
CSI 2.1rCSI 2.3%PRS 38.8%
-
CSI 2.1rCSI 3.3%PRS 41.4%
-
CSI 2.1rCSI 2.9%PRS 37.9%
-
CSI 2.2rCSI 3.2%PRS 43.8%
-
CSI 2.2rCSI 10.4%PRS 42.9%
-
CSI 2.2rCSI 6.4%PRS 43.4%
-
CSI 2.2rCSI 3.9%PRS 33.9%
-
CSI 2.2rCSI 3.7%PRS 46.1%
-
CSI 2.2rCSI 2.7%PRS 39.1%
-
CSI 2.2rCSI 4.1%PRS 56.8%
-
CSI 2.3rCSI 3.3%PRS 41.0%
-
CSI 2.3rCSI 6.7%PRS 33.2%
-
CSI 2.3rCSI 5.8%PRS 39.0%
-
CSI 2.3rCSI 47.6%PRS 35.5%
-
CSI 2.4rCSI 2.6%PRS 44.6%
-
CSI 2.4rCSI 4.4%PRS 35.2%
-
CSI 2.4rCSI 6.5%PRS 34.6%
-
CSI 2.5rCSI 7.9%PRS 38.1%
-
CSI 2.5rCSI 50.6%PRS 34.3%
-
CSI 2.5rCSI 5.6%PRS 27.3%
-
CSI 2.5rCSI 5.2%PRS 47.9%
-
CSI 2.6rCSI 3.2%PRS 43.5%
-
CSI 2.6rCSI 5.2%PRS 31.6%
-
CSI 2.6rCSI 3.7%PRS 33.1%
-
CSI 2.6rCSI 7.4%PRS 41.0%
-
CSI 2.6rCSI 3.8%PRS 37.5%
-
CSI 2.7rCSI 3.8%PRS 49.9%
-
CSI 2.7rCSI 3.8%PRS 43.6%
-
CSI 2.7rCSI 7.9%PRS 40.1%
-
CSI 2.8rCSI 67.2%PRS 27.0%
-
CSI 2.8rCSI 6.4%PRS 39.8%
-
CSI 2.8rCSI 2.4%PRS 50.2%
-
CSI 2.9rCSI 68.2%PRS 26.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 622721413
Symbol: 3HIDH_HUMAN
Name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8313870
PubMed ID: 16466957
Title: Clinical, biochemical, and molecular findings in three patients with 3-hydroxyisobutyric aciduria.
PubMed ID: 16466957
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 336
- Mass: 35329
- Checksum: DA3128774A91AF48
- Sequence:
MAASLRLLGA ASGLRYWSRR LRPAAGSFAA VCSRSVASKT PVGFIGLGNM GNPMAKNLMK HGYPLIIYDV FPDACKEFQD AGEQVVSSPA DVAEKADRII TMLPTSINAI EAYSGANGIL KKVKKGSLLI DSSTIDPAVS KELAKEVEKM GAVFMDAPVS GGVGAARSGN LTFMVGGVED EFAAAQELLG CMGSNVVYCG AVGTGQAAKI CNNMLLAISM IGTAEAMNLG IRLGLDPKLL AKILNMSSGR CWSSDTYNPV PGVMDGVPSA NNYQGGFGTT LMAKDLGLAQ DSATSTKSPI LLGSLAHQIY RMMCAKGYSK KDFSSVFQFL REEETF