Details for: DUSP9

Gene ID: 1852

Symbol: DUSP9

Ensembl ID: ENSG00000130829

Description: dual specificity phosphatase 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.84
    Marker Score: 7609
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.56
    Marker Score: 1346
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.29
    Marker Score: 9017
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.18
    Marker Score: 3707
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.96
    Marker Score: 1750
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.76
    Marker Score: 1862
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.59
    Marker Score: 1099
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.4
    Marker Score: 2639
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.34
    Marker Score: 1326.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.33
    Marker Score: 2331.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7686
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.09
    Marker Score: 897
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.01
    Marker Score: 1074
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.99
    Marker Score: 655
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.97
    Marker Score: 5763
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.95
    Marker Score: 1028
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.94
    Marker Score: 1345.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.87
    Marker Score: 205
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 494
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 650
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.85
    Marker Score: 1215
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.83
    Marker Score: 786
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.79
    Marker Score: 209
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.77
    Marker Score: 782
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.73
    Marker Score: 404
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.71
    Marker Score: 1092
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.69
    Marker Score: 1303
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.65
    Marker Score: 1049
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9852
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.63
    Marker Score: 181
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.62
    Marker Score: 425
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 483
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6
    Marker Score: 250
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.58
    Marker Score: 5864
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.57
    Marker Score: 1160
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.55
    Marker Score: 3582
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.54
    Marker Score: 770
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.53
    Marker Score: 301
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.52
    Marker Score: 522
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.43
    Marker Score: 162
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.43
    Marker Score: 477
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 254
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.38
    Marker Score: 414
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.37
    Marker Score: 250
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.37
    Marker Score: 1010
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.35
    Marker Score: 483
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.35
    Marker Score: 2086
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.34
    Marker Score: 198.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.32
    Marker Score: 191
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.31
    Marker Score: 301
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 148
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.31
    Marker Score: 274
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.29
    Marker Score: 1384
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.29
    Marker Score: 599
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.29
    Marker Score: 473
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.27
    Marker Score: 673
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.26
    Marker Score: 120
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.26
    Marker Score: 142
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.26
    Marker Score: 320.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.25
    Marker Score: 436
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.24
    Marker Score: 228
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.22
    Marker Score: 1856
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.21
    Marker Score: 151
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 112
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 467
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.2
    Marker Score: 122
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 399
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.18
    Marker Score: 189
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.17
    Marker Score: 318
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.16
    Marker Score: 3483
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.16
    Marker Score: 106
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.16
    Marker Score: 32
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.16
    Marker Score: 102
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.15
    Marker Score: 93.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.15
    Marker Score: 147
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.14
    Marker Score: 225
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.14
    Marker Score: 61

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Other Information

**Key characteristics:** * DUSP9 is a serine/threonine phosphatase that can be activated by both upstream and downstream signaling pathways. * It is a key regulator of the Jnk cascade, a major signaling pathway involved in cell growth, differentiation, and survival. * It is also involved in the regulation of inflammation, cell cycle regulation, and apoptosis. **Pathways and functions:** * DUSP9 is a negative regulator of the Jnk cascade. * It inhibits the phosphorylation of Jnk1 and Jnk2, thereby blocking the activation of the Jnk cascade. * This leads to the inhibition of cell growth, proliferation, and survival. * In cancer cells, DUSP9 overexpression can promote the activation of the Jnk cascade, leading to cell proliferation and tumor growth. **Clinical significance:** * Dysregulation of DUSP9 has been implicated in various human diseases, including cancer, cardiovascular disease, and metabolic disorders. * Inhibition of DUSP9 has been shown to inhibit cancer cell growth and metastasis. * Therefore, DUSP9 is a potential therapeutic target for cancer treatment. **Additional notes:** * DUSP9 is a highly conserved protein with homologs in other species. * It is a member of the dual-specificity phosphatase family of proteins, which also includes DUSP1, DUSP3, and DUSP5. * DUSP9 is a promising target for cancer therapy due to its critical role in tumor growth and metastasis.

Genular Protein ID: 3862108505

Symbol: DUS9_HUMAN

Name: Dual specificity protein phosphatase 9

UniProtKB Accession Codes:

Q99956 D3DWU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 5 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 9 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9030581

Title: Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4.

PubMed ID: 9030581

DOI: 10.1074/jbc.272.8.5141

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18058037

Title: Structural genomics of protein phosphatases.

PubMed ID: 18058037

DOI: 10.1007/s10969-007-9036-1

Sequence Information:

  • Length: 384
  • Mass: 41868
  • Checksum: F8598CA95AB379B7
  • Sequence:
    • MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS 
VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA 
YYLQGGFSRF QAECPHLCET SLAGRAGSSM APVPGPVPVV GLGSLCLGSD CSDAESEADR 
DSMSCGLDSE GATPPPVGLR ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL 
PNFFEKNGDF HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNCGVLVHC LAGVSRSVTV 
TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH SQEQGSGGQA 
SAASNPPSFF TTPTSDGAFE LAPT

Genular Protein ID: 2006767270

Symbol: B2RAL9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RAL9

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 DNASU 1 EC 2 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 6 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 384
  • Mass: 41810
  • Checksum: DE80A83AAA8F8A78
  • Sequence:
    • MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS 
VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA 
YYLQGGFSRF QAECPHLCET SLAGRAGSSM APVPGPVPVV GLGSLCLGSD CSDAESEADR 
DSMSCGLDSE GATPPPVGLR ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL 
PNFFEKNGDF HYKQIPISDH WSQNLSRFFP EAIEFIGEAL SQNCGVLVHC LAGVSRSVTV 
TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH SQEQGSGGQA 
SAASNPPSFF TTPTSDGAFE LAPT

Genular Protein ID: 79328219

Symbol: Q6P9C2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P9C2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 EC 2 EMBL 2 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 6 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 384
  • Mass: 41935
  • Checksum: 506C1BACC3BAF22A
  • Sequence:
    • MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS 
VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA 
YYLQGGFSRF QAECPHLCET SLAGRAGSSM APLPGPVPVV GLGSLCLGSD CSDAESEADR 
DSMSCGLDSE GATPPPVGLR ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL 
PNFFEKNGDF HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNRGVLVHC LAGVSRSVTV 
TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH SQEQGSGGQA 
SAASNPPSFF TTPTSDGAFE LAPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.