Details for: DUSP9

Gene ID: 1852

Symbol: DUSP9

Ensembl ID: ENSG00000130829

Description: dual specificity phosphatase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell (CL0000510)
    Fold Change: 13.9128
    Cell Significance Index: 143.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.7707
    Cell Significance Index: 80.2400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.8390
    Cell Significance Index: 24.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8705
    Cell Significance Index: 371.2000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.2875
    Cell Significance Index: 4.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1848
    Cell Significance Index: 28.7000
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.1795
    Cell Significance Index: 4.0500
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1045
    Cell Significance Index: 5.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.9639
    Cell Significance Index: 76.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9034
    Cell Significance Index: 11.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6978
    Cell Significance Index: 24.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.6508
    Cell Significance Index: 12.7300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.5839
    Cell Significance Index: 8.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5830
    Cell Significance Index: 4.6600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.5618
    Cell Significance Index: 6.6400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5172
    Cell Significance Index: 3.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4355
    Cell Significance Index: 10.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3789
    Cell Significance Index: 277.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2805
    Cell Significance Index: 7.4900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.2525
    Cell Significance Index: 2.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2283
    Cell Significance Index: 11.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1822
    Cell Significance Index: 4.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1639
    Cell Significance Index: 2.3800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.1306
    Cell Significance Index: 0.6400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1078
    Cell Significance Index: 0.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0620
    Cell Significance Index: 11.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0581
    Cell Significance Index: 6.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0568
    Cell Significance Index: 3.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0522
    Cell Significance Index: 6.4200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0353
    Cell Significance Index: 0.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0213
    Cell Significance Index: 0.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0142
    Cell Significance Index: 0.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0128
    Cell Significance Index: 2.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0021
    Cell Significance Index: 0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0016
    Cell Significance Index: 0.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0008
    Cell Significance Index: 0.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0015
    Cell Significance Index: -0.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0028
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0058
    Cell Significance Index: -3.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0061
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0091
    Cell Significance Index: -4.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0136
    Cell Significance Index: -0.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0139
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0159
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0164
    Cell Significance Index: -3.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0167
    Cell Significance Index: -2.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0174
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0187
    Cell Significance Index: -2.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0220
    Cell Significance Index: -2.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0242
    Cell Significance Index: -0.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0281
    Cell Significance Index: -1.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0282
    Cell Significance Index: -2.8800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0347
    Cell Significance Index: -0.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0356
    Cell Significance Index: -2.1900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0389
    Cell Significance Index: -0.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0423
    Cell Significance Index: -2.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0447
    Cell Significance Index: -0.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0467
    Cell Significance Index: -3.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0513
    Cell Significance Index: -3.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0531
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0535
    Cell Significance Index: -1.1200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0551
    Cell Significance Index: -0.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0577
    Cell Significance Index: -1.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0588
    Cell Significance Index: -2.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0599
    Cell Significance Index: -1.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0745
    Cell Significance Index: -4.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0748
    Cell Significance Index: -2.4500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0757
    Cell Significance Index: -0.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0777
    Cell Significance Index: -3.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0828
    Cell Significance Index: -2.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0829
    Cell Significance Index: -2.6400
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.0838
    Cell Significance Index: -0.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0852
    Cell Significance Index: -3.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0892
    Cell Significance Index: -2.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0932
    Cell Significance Index: -3.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0986
    Cell Significance Index: -2.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0990
    Cell Significance Index: -1.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1001
    Cell Significance Index: -2.5000
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1066
    Cell Significance Index: -1.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1078
    Cell Significance Index: -2.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1111
    Cell Significance Index: -1.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1147
    Cell Significance Index: -2.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1168
    Cell Significance Index: -2.9200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1215
    Cell Significance Index: -2.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1231
    Cell Significance Index: -2.5100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1269
    Cell Significance Index: -1.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1270
    Cell Significance Index: -3.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1272
    Cell Significance Index: -3.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1315
    Cell Significance Index: -2.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1359
    Cell Significance Index: -3.2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1405
    Cell Significance Index: -2.0000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1422
    Cell Significance Index: -0.6800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1423
    Cell Significance Index: -1.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1433
    Cell Significance Index: -3.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1454
    Cell Significance Index: -3.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DUSP9 is a dual specificity phosphatase, meaning it possesses the ability to remove phosphate groups from both tyrosine and threonine/serine residues. This dual specificity allows DUSP9 to regulate a wide range of signaling pathways, including those mediated by MAPK kinases and other kinases. DUSP9 is also known for its ability to interact with various proteins, including other phosphatases, kinases, and transcription factors, further highlighting its role as a key regulator of signal transduction pathways. **Pathways and Functions:** DUSP9 is involved in the regulation of several key signaling pathways, including: 1. **MAPK pathway:** DUSP9 has been shown to dephosphorylate and inactivate MAPK kinases, such as JNK (c-Jun N-terminal kinase) and p38, thereby regulating cell proliferation, differentiation, and survival. 2. **ERK1/2 cascade:** DUSP9 has been implicated in the regulation of the ERK1/2 (extracellular signal-regulated kinase 1/2) cascade, which is involved in cell proliferation, differentiation, and survival. 3. **Raf-independent MAPK1/3 activation:** DUSP9 has been shown to regulate the activation of MAPK1/3 in a Raf-independent manner, suggesting a novel mechanism of regulation of the MAPK pathway. 4. **Negative regulation of MAPK cascade:** DUSP9 has been shown to negatively regulate the MAPK cascade, thereby preventing excessive activation of MAPK kinases and subsequent downstream effects. **Clinical Significance:** DUSP9 has been implicated in various diseases, including: 1. **Cancer:** DUSP9 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, suggesting a potential role in tumorigenesis. 2. **Neurological disorders:** DUSP9 has been implicated in the regulation of neuronal signaling pathways, and dysregulation of DUSP9 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Inflammatory disorders:** DUSP9 has been shown to regulate inflammatory signaling pathways, and dysregulation of DUSP9 has been linked to inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. In conclusion, DUSP9 is a key regulator of signal transduction pathways, including the MAPK pathway, and has been implicated in various diseases. Further research is needed to fully elucidate the role of DUSP9 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3862108505

Symbol: DUS9_HUMAN

Name: Dual specificity protein phosphatase 9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9030581

Title: Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4.

PubMed ID: 9030581

DOI: 10.1074/jbc.272.8.5141

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18058037

Title: Structural genomics of protein phosphatases.

PubMed ID: 18058037

DOI: 10.1007/s10969-007-9036-1

Sequence Information:

  • Length: 384
  • Mass: 41868
  • Checksum: F8598CA95AB379B7
  • Sequence:
  • MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS 
    VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA 
    YYLQGGFSRF QAECPHLCET SLAGRAGSSM APVPGPVPVV GLGSLCLGSD CSDAESEADR 
    DSMSCGLDSE GATPPPVGLR ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL 
    PNFFEKNGDF HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNCGVLVHC LAGVSRSVTV 
    TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH SQEQGSGGQA 
    SAASNPPSFF TTPTSDGAFE LAPT

Genular Protein ID: 79328219

Symbol: Q6P9C2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 384
  • Mass: 41935
  • Checksum: 506C1BACC3BAF22A
  • Sequence:
  • MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS 
    VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA 
    YYLQGGFSRF QAECPHLCET SLAGRAGSSM APLPGPVPVV GLGSLCLGSD CSDAESEADR 
    DSMSCGLDSE GATPPPVGLR ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL 
    PNFFEKNGDF HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNRGVLVHC LAGVSRSVTV 
    TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH SQEQGSGGQA 
    SAASNPPSFF TTPTSDGAFE LAPT

Genular Protein ID: 2006767270

Symbol: B2RAL9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 384
  • Mass: 41810
  • Checksum: DE80A83AAA8F8A78
  • Sequence:
  • MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS 
    VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA 
    YYLQGGFSRF QAECPHLCET SLAGRAGSSM APVPGPVPVV GLGSLCLGSD CSDAESEADR 
    DSMSCGLDSE GATPPPVGLR ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL 
    PNFFEKNGDF HYKQIPISDH WSQNLSRFFP EAIEFIGEAL SQNCGVLVHC LAGVSRSVTV 
    TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH SQEQGSGGQA 
    SAASNPPSFF TTPTSDGAFE LAPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.