Details for: NDUFA13

Gene ID: 51079

Symbol: NDUFA13

Ensembl ID: ENSG00000186010

Description: NADH:ubiquinone oxidoreductase subunit A13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 497.1544
    Cell Significance Index: -77.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 342.6070
    Cell Significance Index: -86.9000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 238.2220
    Cell Significance Index: -98.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 207.0966
    Cell Significance Index: -97.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 184.8031
    Cell Significance Index: -95.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 146.0384
    Cell Significance Index: -98.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 74.7391
    Cell Significance Index: -92.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.9942
    Cell Significance Index: -79.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.9287
    Cell Significance Index: -98.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7215
    Cell Significance Index: -55.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.8307
    Cell Significance Index: 204.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.5635
    Cell Significance Index: 52.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.3460
    Cell Significance Index: 49.2300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.3326
    Cell Significance Index: 37.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.2162
    Cell Significance Index: 760.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.1357
    Cell Significance Index: 121.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.6864
    Cell Significance Index: 453.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.5713
    Cell Significance Index: 95.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.4599
    Cell Significance Index: 315.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3961
    Cell Significance Index: 178.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3683
    Cell Significance Index: 67.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2345
    Cell Significance Index: 306.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.1499
    Cell Significance Index: 45.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1105
    Cell Significance Index: 99.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8527
    Cell Significance Index: 50.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7957
    Cell Significance Index: 20.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7589
    Cell Significance Index: 777.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6102
    Cell Significance Index: 84.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5531
    Cell Significance Index: 200.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5203
    Cell Significance Index: 107.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4077
    Cell Significance Index: 768.7600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3113
    Cell Significance Index: 8.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1360
    Cell Significance Index: 29.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1264
    Cell Significance Index: 52.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9595
    Cell Significance Index: 60.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8743
    Cell Significance Index: 175.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7755
    Cell Significance Index: 26.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7692
    Cell Significance Index: 39.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7023
    Cell Significance Index: 82.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6396
    Cell Significance Index: 104.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4711
    Cell Significance Index: 89.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3766
    Cell Significance Index: 135.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3142
    Cell Significance Index: 11.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2908
    Cell Significance Index: 16.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2429
    Cell Significance Index: 14.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2350
    Cell Significance Index: 23.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2129
    Cell Significance Index: 61.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1835
    Cell Significance Index: 4.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1766
    Cell Significance Index: 133.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1730
    Cell Significance Index: 2.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1500
    Cell Significance Index: 10.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1148
    Cell Significance Index: 1.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0995
    Cell Significance Index: 72.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0571
    Cell Significance Index: 0.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0482
    Cell Significance Index: -90.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0587
    Cell Significance Index: -108.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0710
    Cell Significance Index: -109.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0828
    Cell Significance Index: -112.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0957
    Cell Significance Index: -70.8700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0964
    Cell Significance Index: -0.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1324
    Cell Significance Index: -8.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1346
    Cell Significance Index: -13.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1399
    Cell Significance Index: -88.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1482
    Cell Significance Index: -83.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1904
    Cell Significance Index: -118.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2082
    Cell Significance Index: -94.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2679
    Cell Significance Index: -45.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2766
    Cell Significance Index: -7.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2783
    Cell Significance Index: -21.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3947
    Cell Significance Index: -78.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4220
    Cell Significance Index: -48.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4630
    Cell Significance Index: -14.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4791
    Cell Significance Index: -100.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5044
    Cell Significance Index: -12.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5357
    Cell Significance Index: -62.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5652
    Cell Significance Index: -3.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6187
    Cell Significance Index: -13.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6301
    Cell Significance Index: -28.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6365
    Cell Significance Index: -6.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6503
    Cell Significance Index: -94.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6629
    Cell Significance Index: -52.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8918
    Cell Significance Index: -15.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9592
    Cell Significance Index: -99.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.0480
    Cell Significance Index: -42.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.2237
    Cell Significance Index: -61.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2497
    Cell Significance Index: -33.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4994
    Cell Significance Index: -100.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5743
    Cell Significance Index: -96.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.6174
    Cell Significance Index: -45.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.6442
    Cell Significance Index: -30.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8001
    Cell Significance Index: -53.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8360
    Cell Significance Index: -81.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.2124
    Cell Significance Index: -72.4400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -2.2306
    Cell Significance Index: -13.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.2737
    Cell Significance Index: -86.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.2788
    Cell Significance Index: -79.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.2929
    Cell Significance Index: -54.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.3095
    Cell Significance Index: -84.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.3584
    Cell Significance Index: -19.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.3621
    Cell Significance Index: -75.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: NDUFA13 is exclusively localized to the mitochondrial inner membrane, where it integrates into complex I of the respiratory chain. 2. **Subunit composition**: NDUFA13 is a subunit of the NADH dehydrogenase complex, which is a crucial component of the mitochondrial respiratory chain. 3. **Expression patterns**: NDUFA13 is highly expressed in cells with high energy demands, such as erythroblasts, stem cells, and smooth muscle fibers. 4. **Protein structure**: NDUFA13 consists of a single transmembrane domain and a large cytoplasmic domain. **Pathways and Functions:** 1. **Electron transport chain**: NDUFA13 participates in the electron transport chain, facilitating the transfer of electrons from NADH to ubiquinone, resulting in the production of ATP. 2. **Apoptosis regulation**: NDUFA13 has been shown to regulate apoptosis through interactions with pro-apoptotic and anti-apoptotic proteins. 3. **Cellular differentiation**: NDUFA13 is involved in cellular differentiation, particularly in the development of hematopoietic cells and muscle fibers. 4. **Immune response**: NDUFA13 has been implicated in the regulation of immune responses, including the activation of T cells and the production of cytokines. 5. **Mitochondrial biogenesis**: NDUFA13 is required for the assembly and biogenesis of complex I in the mitochondrial respiratory chain. **Clinical Significance:** 1. **Mitochondrial disorders**: Mutations in NDUFA13 have been associated with mitochondrial disorders, such as mitochondrial myopathies and encephalopathies. 2. **Cancer**: Altered expression of NDUFA13 has been observed in various types of cancer, including leukemia and lymphoma. 3. **Inflammatory diseases**: NDUFA13 has been implicated in the regulation of inflammatory responses, particularly in the context of autoimmune diseases such as multiple sclerosis. 4. **Neurological disorders**: NDUFA13 has been associated with neurological disorders, including Parkinson's disease and Alzheimer's disease. In conclusion, NDUFA13 plays a critical role in mitochondrial function, cellular metabolism, and immune regulation. Its dysregulation has been implicated in various human diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which NDUFA13 regulates cellular processes and to develop therapeutic strategies for the treatment of NDUFA13-related disorders.

Genular Protein ID: 1816738588

Symbol: NDUAD_HUMAN

Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

UniProtKB Accession Codes:

Q9P0J0 B4DF76 K7EK58 Q6PKI0 Q9H2L3 Q9Y327

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10924506

Title: Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach.

PubMed ID: 10924506

DOI: 10.1074/jbc.m003929200

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12163600

Title: Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death.

PubMed ID: 12163600

DOI: 10.1128/jvi.76.17.8797-8807.2002

PubMed ID: 12628925

Title: GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.

PubMed ID: 12628925

DOI: 10.1093/emboj/cdg135

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 12867595

Title: The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.

PubMed ID: 12867595

DOI: 10.1073/pnas.1633516100

PubMed ID: 15367666

Title: GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I.

PubMed ID: 15367666

DOI: 10.1128/mcb.24.19.8447-8456.2004

PubMed ID: 15059901

Title: GW112, a novel antiapoptotic protein that promotes tumor growth.

PubMed ID: 15059901

DOI: 10.1158/0008-5472.can-03-3443

PubMed ID: 15753091

Title: GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells.

PubMed ID: 15753091

DOI: 10.1074/jbc.m413776200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

PubMed ID: 15841082

Title: Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid.

PubMed ID: 15841082

DOI: 10.1038/sj.bjc.6602547

PubMed ID: 25901006

Title: Mutation in NDUFA13/GRIM19 leads to early onset hypotonia, dyskinesia and sensorial deficiencies, and mitochondrial complex I instability.

PubMed ID: 25901006

DOI: 10.1093/hmg/ddv133

Sequence Information:

  • Length: 144
  • Mass: 16698
  • Checksum: 058F608B235FF856
  • Sequence:
    • MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMLAIGI GTLIYGHWSI MKWNRERRRL 
QIEDFEARIA LLPLLQAETD RRTLQMLREN LEEEAIIMKD VPDWKVGESV FHTTRWVPPL 
IGELYGLRTT EEALHASHGF MWYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.