Details for: XRCC5

Gene ID: 7520

Symbol: XRCC5

Ensembl ID: ENSG00000079246

Description: X-ray repair cross complementing 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 604.5830
    Cell Significance Index: -94.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 361.2552
    Cell Significance Index: -91.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 274.5009
    Cell Significance Index: -113.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 246.9062
    Cell Significance Index: -116.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 240.2912
    Cell Significance Index: -97.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 216.2581
    Cell Significance Index: -111.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 174.3758
    Cell Significance Index: -117.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 103.1377
    Cell Significance Index: -98.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 89.0218
    Cell Significance Index: -109.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 36.0377
    Cell Significance Index: -96.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.7275
    Cell Significance Index: -113.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.4402
    Cell Significance Index: -81.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.9287
    Cell Significance Index: -52.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.9625
    Cell Significance Index: 166.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.8255
    Cell Significance Index: 347.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7349
    Cell Significance Index: 542.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.6692
    Cell Significance Index: 481.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3560
    Cell Significance Index: 62.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3115
    Cell Significance Index: 317.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0893
    Cell Significance Index: 419.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0444
    Cell Significance Index: 1116.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.0075
    Cell Significance Index: 69.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7713
    Cell Significance Index: 783.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6617
    Cell Significance Index: 107.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5981
    Cell Significance Index: 83.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5750
    Cell Significance Index: 96.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4465
    Cell Significance Index: 518.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3294
    Cell Significance Index: 156.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2792
    Cell Significance Index: 34.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2650
    Cell Significance Index: 59.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2310
    Cell Significance Index: 87.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0690
    Cell Significance Index: 137.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9484
    Cell Significance Index: 44.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9248
    Cell Significance Index: 639.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8850
    Cell Significance Index: 18.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8695
    Cell Significance Index: 45.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8441
    Cell Significance Index: 43.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8099
    Cell Significance Index: 88.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7800
    Cell Significance Index: 18.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7589
    Cell Significance Index: 56.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6497
    Cell Significance Index: 5.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5290
    Cell Significance Index: 68.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4909
    Cell Significance Index: 14.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4906
    Cell Significance Index: 12.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4387
    Cell Significance Index: 12.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3926
    Cell Significance Index: 63.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3102
    Cell Significance Index: 9.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2491
    Cell Significance Index: 42.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2117
    Cell Significance Index: 398.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1658
    Cell Significance Index: 12.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1647
    Cell Significance Index: 303.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1397
    Cell Significance Index: 215.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0723
    Cell Significance Index: 2.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0722
    Cell Significance Index: 45.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0630
    Cell Significance Index: 3.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0590
    Cell Significance Index: 26.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0228
    Cell Significance Index: 16.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0135
    Cell Significance Index: 18.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0198
    Cell Significance Index: -0.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0249
    Cell Significance Index: -1.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0486
    Cell Significance Index: -36.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0533
    Cell Significance Index: -10.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0598
    Cell Significance Index: -44.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0688
    Cell Significance Index: -42.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0959
    Cell Significance Index: -6.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1264
    Cell Significance Index: -71.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1317
    Cell Significance Index: -1.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1361
    Cell Significance Index: -1.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1362
    Cell Significance Index: -2.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1595
    Cell Significance Index: -16.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2603
    Cell Significance Index: -54.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3479
    Cell Significance Index: -100.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3774
    Cell Significance Index: -54.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3806
    Cell Significance Index: -37.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5708
    Cell Significance Index: -13.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6262
    Cell Significance Index: -27.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6405
    Cell Significance Index: -73.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6426
    Cell Significance Index: -74.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8381
    Cell Significance Index: -21.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8446
    Cell Significance Index: -24.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8625
    Cell Significance Index: -32.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8932
    Cell Significance Index: -22.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9117
    Cell Significance Index: -104.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9290
    Cell Significance Index: -96.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9401
    Cell Significance Index: -30.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9939
    Cell Significance Index: -78.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0364
    Cell Significance Index: -14.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.2025
    Cell Significance Index: -14.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.2942
    Cell Significance Index: -25.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3889
    Cell Significance Index: -30.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.5438
    Cell Significance Index: -92.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.6037
    Cell Significance Index: -29.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.6210
    Cell Significance Index: -43.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.7112
    Cell Significance Index: -19.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.7560
    Cell Significance Index: -14.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8624
    Cell Significance Index: -114.1800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.8740
    Cell Significance Index: -11.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -2.0611
    Cell Significance Index: -34.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2920
    Cell Significance Index: -67.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.3238
    Cell Significance Index: -76.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** XRCC5 is a phosphoprotein that belongs to the XRCC family of DNA repair proteins. It is a 35-kDa protein that is highly expressed in hematopoietic cells, including myeloid leukocytes, T cells, and natural killer T cells. XRCC5 is also expressed in other cell types, including neurons, muscle cells, and epithelial cells. The gene is located on chromosome 11q22.1 and is highly conserved across species, suggesting its essential role in maintaining genome integrity. **Pathways and Functions:** XRCC5 is a critical component of the NHEJ pathway, which is responsible for repairing DNA DSBs by joining the broken ends together. XRCC5 interacts with other proteins, including Ku70 and Ku80, to form the Ku70-Ku80-XRCC5 complex, which is responsible for recognizing and binding to DNA DSBs. This complex then recruits other proteins, such as DNA ligase IV, to facilitate the repair process. XRCC5 also plays a role in the repair of telomeric DNA, which is essential for maintaining telomere length and preventing telomere fusions. In addition to its role in DNA repair, XRCC5 also plays a role in regulating cell growth and differentiation. For example, XRCC5 is involved in the regulation of hematopoietic stem cell proliferation and differentiation, and it also plays a role in regulating the early phase of HIV life cycle. **Clinical Significance:** Dysregulation of XRCC5 has been implicated in various diseases, including cancer, immunodeficiency disorders, and genetic disorders. For example, mutations in the XRCC5 gene have been associated with X-linked lymphoproliferative disease (XLP), a rare genetic disorder characterized by impaired immune function and an increased risk of developing lymphoma. Additionally, XRCC5 has been shown to play a role in the development of certain types of cancer, including leukemia and lymphoma. Furthermore, XRCC5 has been used as a biomarker for radiation exposure, as it is highly expressed in cells that have been exposed to ionizing radiation. This has implications for the diagnosis and treatment of radiation exposure-related diseases. **Conclusion:** XRCC5 is a critical gene involved in maintaining genome integrity and regulating cell growth and differentiation. Its dysregulation has been implicated in various diseases, including cancer, immunodeficiency disorders, and genetic disorders. Further research is needed to fully understand the role of XRCC5 in human health and disease, and to develop effective therapeutic strategies for diseases associated with XRCC5 dysfunction. **Recommendations:** 1. Further research is needed to fully understand the role of XRCC5 in human health and disease. 2. XRCC5 should be considered as a biomarker for radiation exposure and as a potential therapeutic target for diseases associated with XRCC5 dysfunction. 3. The development of effective therapeutic strategies for diseases associated with XRCC5 dysfunction, such as XLP and certain types of cancer, should be explored. 4. XRCC5 should be considered as a potential target for gene therapy approaches aimed at treating genetic disorders. **Limitations:** 1. The current understanding of XRCC5 is based on in vitro and in vivo studies, and further research is needed to fully understand the role of XRCC5 in human health and disease. 2. The development of effective therapeutic strategies for diseases associated with XRCC5 dysfunction is limited by the current understanding of XRCC5 biology. 3. The use of XRCC5 as a biomarker for radiation exposure is limited by the availability of sensitive and specific assays for detecting XRCC5 expression. **Future Directions:** 1. Further research is needed to fully understand the role of XRCC5 in human health and disease. 2. The development of effective therapeutic strategies for diseases associated with XRCC5 dysfunction should be explored. 3. XRCC5 should be considered as a potential target for gene therapy approaches aimed at treating genetic disorders. 4. The use of XRCC5 as a biomarker for radiation exposure should be explored further.

Genular Protein ID: 595504917

Symbol: XRCC5_HUMAN

Name: X-ray repair cross-complementing protein 5

UniProtKB Accession Codes:

P13010 A8K3X5 Q0Z7V0 Q4VBQ5 Q53HH7 Q7M4N0 Q9UCQ0 Q9UCQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 ELM 1 EMBL 9 EMDB 24 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 41 PDBsum 41 PIR 3 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2760028

Title: cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen.

PubMed ID: 2760028

DOI: 10.1016/s0021-9258(18)80011-4

PubMed ID: 2308937

Title: Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome.

PubMed ID: 2308937

DOI: 10.1073/pnas.87.5.1777

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2211668

Title: Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter.

PubMed ID: 2211668

DOI: 10.1016/s0021-9258(18)38250-4

PubMed ID: 7957065

Title: Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.

PubMed ID: 7957065

DOI: 10.1002/j.1460-2075.1994.tb06826.x

PubMed ID: 8605992

Title: Non-histone protein 1 (NHP1) is a member of the Ku protein family which is upregulated in differentiating mouse myoblasts and human promyelocytes.

PubMed ID: 8605992

DOI: 10.1016/0014-5793(96)00189-5

PubMed ID: 2212941

Title: The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes.

PubMed ID: 2212941

DOI: 10.1084/jem.172.4.1049

PubMed ID: 8031790

Title: DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen.

PubMed ID: 8031790

DOI: 10.1021/bi00194a021

PubMed ID: 8621488

Title: The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.

PubMed ID: 8621488

DOI: 10.1074/jbc.271.15.8593

PubMed ID: 1537839

Title: Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells.

PubMed ID: 1537839

DOI: 10.1016/s0021-9258(18)42866-9

PubMed ID: 7882982

Title: Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.

PubMed ID: 7882982

DOI: 10.1002/j.1460-2075.1995.tb07057.x

PubMed ID: 10026262

Title: DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer.

PubMed ID: 10026262

DOI: 10.1021/bi982584b

PubMed ID: 12145306

Title: Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.

PubMed ID: 12145306

DOI: 10.1074/jbc.m206482200

PubMed ID: 15075319

Title: Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.

PubMed ID: 15075319

DOI: 10.1074/jbc.m401356200

PubMed ID: 14704337

Title: DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner.

PubMed ID: 14704337

DOI: 10.1093/nar/gkg933

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 15758953

Title: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.

PubMed ID: 15758953

DOI: 10.1038/nature03442

PubMed ID: 17396150

Title: A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.

PubMed ID: 17396150

DOI: 10.1038/sj.emboj.7601663

PubMed ID: 17353262

Title: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks.

PubMed ID: 17353262

DOI: 10.1128/mcb.02269-06

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23213405

Title: Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1alpha) docking protein.

PubMed ID: 23213405

DOI: 10.1242/bio.2011049

PubMed ID: 23972994

Title: ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair.

PubMed ID: 23972994

DOI: 10.1016/j.celrep.2013.07.027

PubMed ID: 23689425

Title: Identification and functional characterization of a Ku-binding motif in aprataxin polynucleotide kinase/phosphatase-like factor (APLF).

PubMed ID: 23689425

DOI: 10.1074/jbc.m112.440388

PubMed ID: 27063109

Title: The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.

PubMed ID: 27063109

DOI: 10.1038/ncomms11242

PubMed ID: 20383123

Title: Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.

PubMed ID: 20383123

DOI: 10.1038/nature08926

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 22442688

Title: Deformed epidermal autoregulatory factor-1 (DEAF1) interacts with the Ku70 subunit of the DNA-dependent protein kinase complex.

PubMed ID: 22442688

DOI: 10.1371/journal.pone.0033404

PubMed ID: 22266820

Title: The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.

PubMed ID: 22266820

DOI: 10.1038/nsmb.2211

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24610814

Title: A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.

PubMed ID: 24610814

DOI: 10.1074/jbc.c113.533968

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24598253

Title: PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.

PubMed ID: 24598253

DOI: 10.1093/nar/gku174

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25852083

Title: DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1.

PubMed ID: 25852083

DOI: 10.1093/cvr/cvv126

PubMed ID: 25941166

Title: XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.

PubMed ID: 25941166

DOI: 10.1038/cdd.2015.22

PubMed ID: 25670504

Title: Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.

PubMed ID: 25670504

DOI: 10.1038/ncomms7233

PubMed ID: 26359349

Title: Heat shock factor 1, an inhibitor of non-homologous end joining repair.

PubMed ID: 26359349

DOI: 10.18632/oncotarget.5073

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25574025

Title: DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.

PubMed ID: 25574025

DOI: 10.1126/science.1261971

PubMed ID: 26502055

Title: The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.

PubMed ID: 26502055

DOI: 10.1038/ncb3259

PubMed ID: 27601299

Title: Specific roles of XRCC4 paralogs PAXX and XLF during V(D)J recombination.

PubMed ID: 27601299

DOI: 10.1016/j.celrep.2016.08.069

PubMed ID: 28712728

Title: HEXIM1 and NEAT1 Long non-coding RNA form a multi-subunit complex that regulates DNA-mediated innate immune response.

PubMed ID: 28712728

DOI: 10.1016/j.molcel.2017.06.020

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28959974

Title: Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.

PubMed ID: 28959974

DOI: 10.1038/nature24023

PubMed ID: 29769340

Title: non-homologous end joining (NHEJ).

PubMed ID: 29769340

DOI: 10.1128/jvi.00672-18

PubMed ID: 29490055

Title: ATF7 mediates TNF-alpha-induced telomere shortening.

PubMed ID: 29490055

DOI: 10.1093/nar/gky155

PubMed ID: 31733588

Title: Ligand binding characteristics of the Ku80 von Willebrand domain.

PubMed ID: 31733588

DOI: 10.1016/j.dnarep.2019.102739

PubMed ID: 32103174

Title: DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.

PubMed ID: 32103174

DOI: 10.1038/s41586-020-2041-2

PubMed ID: 11493912

Title: Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.

PubMed ID: 11493912

DOI: 10.1038/35088000

PubMed ID: 34352203

Title: Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.

PubMed ID: 34352203

DOI: 10.1016/j.molcel.2021.07.005

PubMed ID: 33854234

Title: Structural basis of long-range to short-range synaptic transition in NHEJ.

PubMed ID: 33854234

DOI: 10.1038/s41586-021-03458-7

Sequence Information:

  • Length: 732
  • Mass: 82705
  • Checksum: 2363CA84834E74A3
  • Sequence:
    • MVRSGNKAAV VLCMDVGFTM SNSIPGIESP FEQAKKVITM FVQRQVFAEN KDEIALVLFG 
TDGTDNPLSG GDQYQNITVH RHLMLPDFDL LEDIESKIQP GSQQADFLDA LIVSMDVIQH 
ETIGKKFEKR HIEIFTDLSS RFSKSQLDII IHSLKKCDIS LQFFLPFSLG KEDGSGDRGD 
GPFRLGGHGP SFPLKGITEQ QKEGLEIVKM VMISLEGEDG LDEIYSFSES LRKLCVFKKI 
ERHSIHWPCR LTIGSNLSIR IAAYKSILQE RVKKTWTVVD AKTLKKEDIQ KETVYCLNDD 
DETEVLKEDI IQGFRYGSDI VPFSKVDEEQ MKYKSEGKCF SVLGFCKSSQ VQRRFFMGNQ 
VLKVFAARDD EAAAVALSSL IHALDDLDMV AIVRYAYDKR ANPQVGVAFP HIKHNYECLV 
YVQLPFMEDL RQYMFSSLKN SKKYAPTEAQ LNAVDALIDS MSLAKKDEKT DTLEDLFPTT 
KIPNPRFQRL FQCLLHRALH PREPLPPIQQ HIWNMLNPPA EVTTKSQIPL SKIKTLFPLI 
EAKKKDQVTA QEIFQDNHED GPTAKKLKTE QGGAHFSVSS LAEGSVTSVG SVNPAENFRV 
LVKQKKASFE EASNQLINHI EQFLDTNETP YFMKSIDCIR AFREEAIKFS EEQRFNNFLK 
ALQEKVEIKQ LNHFWEIVVQ DGITLITKEE ASGSSVTAEE AKKFLAPKDK PSGDTAAVFE 
EGGDVDDLLD MI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.