Details for: TACC1

Gene ID: 6867

Symbol: TACC1

Ensembl ID: ENSG00000147526

Description: transforming acidic coiled-coil containing protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 515.0913
    Cell Significance Index: -80.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 317.3944
    Cell Significance Index: -80.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 190.1455
    Cell Significance Index: -78.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 179.9003
    Cell Significance Index: -84.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 176.1938
    Cell Significance Index: -71.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 156.1087
    Cell Significance Index: -80.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 127.0971
    Cell Significance Index: -85.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 75.2663
    Cell Significance Index: -71.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 34.6182
    Cell Significance Index: -75.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.5350
    Cell Significance Index: -79.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.2216
    Cell Significance Index: -83.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.0132
    Cell Significance Index: -86.8700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 8.8545
    Cell Significance Index: 127.3500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 7.0563
    Cell Significance Index: 47.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 5.3798
    Cell Significance Index: 3416.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.2272
    Cell Significance Index: 102.0200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 3.9339
    Cell Significance Index: 40.7500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.5951
    Cell Significance Index: 45.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4566
    Cell Significance Index: 492.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.3209
    Cell Significance Index: 4369.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2473
    Cell Significance Index: 445.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.0387
    Cell Significance Index: 47.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6943
    Cell Significance Index: 45.2400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2830
    Cell Significance Index: 27.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2658
    Cell Significance Index: 454.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1815
    Cell Significance Index: 76.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1536
    Cell Significance Index: 77.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9027
    Cell Significance Index: 98.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8443
    Cell Significance Index: 99.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7954
    Cell Significance Index: 14.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7623
    Cell Significance Index: 93.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7123
    Cell Significance Index: 97.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6571
    Cell Significance Index: 84.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6297
    Cell Significance Index: 435.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5830
    Cell Significance Index: 264.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5612
    Cell Significance Index: 29.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5483
    Cell Significance Index: 28.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4521
    Cell Significance Index: 86.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4281
    Cell Significance Index: 77.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3431
    Cell Significance Index: 15.5500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3036
    Cell Significance Index: 4.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2650
    Cell Significance Index: 18.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2477
    Cell Significance Index: 223.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1821
    Cell Significance Index: 5.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1651
    Cell Significance Index: 1.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1523
    Cell Significance Index: 111.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1137
    Cell Significance Index: 62.1000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1108
    Cell Significance Index: 0.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0766
    Cell Significance Index: 33.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0416
    Cell Significance Index: 1.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0356
    Cell Significance Index: 65.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0317
    Cell Significance Index: 5.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0217
    Cell Significance Index: 33.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0083
    Cell Significance Index: 0.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0173
    Cell Significance Index: -1.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0231
    Cell Significance Index: -17.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0390
    Cell Significance Index: -53.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0420
    Cell Significance Index: -31.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0437
    Cell Significance Index: -7.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0604
    Cell Significance Index: -37.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0910
    Cell Significance Index: -0.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0937
    Cell Significance Index: -52.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1115
    Cell Significance Index: -5.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1122
    Cell Significance Index: -5.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1233
    Cell Significance Index: -12.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1683
    Cell Significance Index: -17.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2101
    Cell Significance Index: -44.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2236
    Cell Significance Index: -9.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2243
    Cell Significance Index: -32.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2575
    Cell Significance Index: -74.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3335
    Cell Significance Index: -38.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3598
    Cell Significance Index: -41.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3611
    Cell Significance Index: -9.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4164
    Cell Significance Index: -48.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5019
    Cell Significance Index: -64.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5203
    Cell Significance Index: -14.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5577
    Cell Significance Index: -44.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5723
    Cell Significance Index: -21.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5808
    Cell Significance Index: -35.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6118
    Cell Significance Index: -45.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7015
    Cell Significance Index: -20.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7441
    Cell Significance Index: -34.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7683
    Cell Significance Index: -14.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8983
    Cell Significance Index: -50.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0156
    Cell Significance Index: -26.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0856
    Cell Significance Index: -66.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1154
    Cell Significance Index: -70.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1628
    Cell Significance Index: -31.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1973
    Cell Significance Index: -84.6800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.2843
    Cell Significance Index: -15.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.3763
    Cell Significance Index: -40.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.4064
    Cell Significance Index: -23.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4359
    Cell Significance Index: -45.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4501
    Cell Significance Index: -38.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.5996
    Cell Significance Index: -26.7700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.6262
    Cell Significance Index: -13.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6462
    Cell Significance Index: -52.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.7078
    Cell Significance Index: -23.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.7602
    Cell Significance Index: -57.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TACC1 is a member of the transforming acidic coiled-coil containing protein family, which is characterized by its unique acidic coiled-coil motif. This motif is essential for the protein's ability to interact with microtubules and regulate the dynamics of the cytoskeleton. TACC1 is primarily expressed in cells involved in muscle, nervous system, and epithelial functions, including skeletal muscle fibroblasts, cardiac neurons, and ciliary muscle cells. **Pathways and Functions:** TACC1 is involved in several cellular pathways, including: 1. **Cell Division:** TACC1 regulates the organization of the mitotic spindle and the dynamics of microtubules during cell division, ensuring proper chromosome segregation and cytokinesis. 2. **Cytoskeleton Organization:** TACC1 interacts with microtubules and regulates the organization of the cytoskeleton, which is essential for cell shape, movement, and division. 3. **Nuclear Receptor Binding:** TACC1 binds to nuclear receptors, such as estrogen receptors, glucocorticoid receptors, and thyroid hormone receptors, regulating their activity and transcriptional programs. 4. **Microtubule Cytoskeleton Organization:** TACC1 regulates the organization of microtubules and the dynamics of the cytoskeleton, ensuring proper cell function and morphology. **Clinical Significance:** Dysregulation of TACC1 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of TACC1 has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role as an oncogene. 2. **Neurological Disorders:** Mutations in TACC1 have been associated with neurological disorders, such as progressive supranuclear palsy, highlighting its importance in maintaining neuronal function and integrity. 3. **Muscular Disorders:** TACC1 mutations have been linked to muscular dystrophy, emphasizing its role in muscle function and integrity. In conclusion, TACC1 is a multifunctional protein that plays a critical role in various cellular processes, including cell division, cytoskeleton organization, and nuclear receptor binding. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the molecular mechanisms underlying TACC1's functions and its potential therapeutic applications. **References:** * [Insert references to studies that have investigated the role of TACC1 in different diseases and cellular processes] **Future Directions:** Further research is needed to fully elucidate the mechanisms by which TACC1 regulates cellular processes and its role in disease. Potential avenues for investigation include: * **Structural Biology:** Determining the three-dimensional structure of TACC1 and its interactions with microtubules and nuclear receptors. * **Cellular Biology:** Investigating the role of TACC1 in cellular processes, including cell division, cytoskeleton organization, and nuclear receptor binding. * **Clinical Applications:** Developing therapeutic strategies targeting TACC1 dysregulation in various diseases. By exploring the complexities of TACC1's functions and its role in disease, we can gain a deeper understanding of the molecular mechanisms underlying cellular processes and develop novel therapeutic strategies to address the complex challenges posed by human disease.

Genular Protein ID: 4246145

Symbol: TACC1_HUMAN

Name: Transforming acidic coiled-coil-containing protein 1

UniProtKB Accession Codes:

O75410 B2RBD9 B4E302 D3DSX6 Q6Y687 Q86YG7 Q8IUJ2 Q8IUJ3 Q8IUJ4 Q8IZG2 Q8NEY7 Q9UPP9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 4 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 RefSeq 12 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10435627

Title: Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon.

PubMed ID: 10435627

DOI: 10.1038/sj.onc.1202801

PubMed ID: 15207008

Title: Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms.

PubMed ID: 15207008

DOI: 10.1186/1471-2148-4-16

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 12087473

Title: Serological identification and expression analysis of gastric cancer-associated genes.

PubMed ID: 12087473

DOI: 10.1038/sj.bjc.6600321

PubMed ID: 12547166

Title: Altered splicing pattern of TACC1 mRNA in gastric cancer.

PubMed ID: 12547166

DOI: 10.1016/s0165-4608(02)00607-6

PubMed ID: 11121038

Title: The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.

PubMed ID: 11121038

DOI: 10.1073/pnas.97.26.14352

PubMed ID: 11903063

Title: Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells.

PubMed ID: 11903063

DOI: 10.1042/0264-6021:3630195

PubMed ID: 12165861

Title: Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators.

PubMed ID: 12165861

DOI: 10.1038/sj.onc.1205658

PubMed ID: 14603251

Title: TACC1-chTOG-Aurora A protein complex in breast cancer.

PubMed ID: 14603251

DOI: 10.1038/sj.onc.1206972

PubMed ID: 14767476

Title: The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.

PubMed ID: 14767476

DOI: 10.1038/sj.onc.1207424

PubMed ID: 15064709

Title: Aurora B -TACC1 protein complex in cytokinesis.

PubMed ID: 15064709

DOI: 10.1038/sj.onc.1207593

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20078863

Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

PubMed ID: 20078863

DOI: 10.1186/1471-2199-11-3

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21531210

Title: Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein.

PubMed ID: 21531210

DOI: 10.1016/j.bbrc.2011.04.078

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

Sequence Information:

  • Length: 805
  • Mass: 87794
  • Checksum: 3A261EF58C165107
  • Sequence:
    • MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS LSFSSDSEGN 
FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ LVAEVVEKCS SKTCSKPSEN 
EVPQQAIDSH SVKNFREEPE HDFSKISIVR PFSIETKDST DISAVLGTKA AHGCVTAVSG 
KALPSSPPDA LQDEAMTEGS MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK 
KAIGGEFSDT NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS 
DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT PKIQKDGISK 
SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH SVLQNSPPLS SEGSYHFDPD 
NFDESMDPFK PTTTLTSSDF CSPTGNHVNE ILESPKKAKS RLITSGCKVK KHETQSLALD 
ACSRDEGAVI SQISDISNRD GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP 
VSTINHAFSS SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE 
SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA QMIEDEQRTS 
MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG VLEGFKKNEE ALKKCAQDYL 
ARVKQEEQRY QALKIHAEEK LDKANEEIAQ VRTKAKAESA ALHAGLRKEQ MKVESLERAL 
QQKNQEIEEL TKICDELIAK LGKTD

Genular Protein ID: 1974584380

Symbol: E7EVI4_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EVI4

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 4 SAM 2 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 581
  • Mass: 63902
  • Checksum: 64C0D70A67D87F7A
  • Sequence:
    • MTEGSMGVTL EASAEADLKA GNSCPELVPS RRSKLRKPKP VPLRKKAIGG EFSDTNAAVE 
GTPLPKASYH FSPEELDENT SPLLGDARFQ KSPPDLKETP GTLSSDTNDS GVELGEESRS 
SPLKLEFDFT EDTGNIEARK ALPRKLGRKL GSTLTPKIQK DGISKSAGLE QPTDPVARDG 
PLSQTSSKPD PSQWESPSFN PFGSHSVLQN SPPLSSEGSY HFDPDNFDES MDPFKPTTTL 
TSSDFCSPTG NHVNEILESP KKAKSRLITS GCKVKKHETQ SLALDACSRD EGAVISQISD 
ISNRDGHATD EEKLASTSCG QKSAGAEVKG IEKETCQKME EDGSTVLGLL ESSAEKAPVS 
VSCGGESPLD GICLSESDKT AVLTLIREEI ITKEIEANEW KKKYEETRQE VLEMRKIVAE 
YEKTIAQMIE DEQRTSMTSQ KSFQQLTMEK EQALADLNSV ERSLSDLFRR YENLKGVLEG 
FKKNEEALKK CAQDYLARVK QEEQRYQALK IHAEEKLDKA NEEIAQVRTK AKAESAALHA 
GLRKEQMKVE SLERALQQKN QEIEELTKIC DELIAKLGKT D

Genular Protein ID: 1584708789

Symbol: Q5HYH0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5HYH0

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SAM 2

Sequence Information:

  • Length: 609
  • Mass: 66914
  • Checksum: 50CE96C1D2585333
  • Sequence:
    • MTEGSMGVTL EASAEADLKA GNSCPELVPS RRSKLRKPKP VPLRKKAIGG EFSDTNAAVE 
GTPLPKASYH FSPEELDENT SPLLGDARFQ KSPPDLKETP GTLSSDTNDS GVELGEESRS 
SPLKLEFDFT EDTGNIEARK ALPRKLGRKL GSTLTPKIQK DGISKSAGLE QPTDPVARDG 
PLSQTSSKPD PSQWESPSFN PFGSHSVLQN SPPLSSEGSY HFDPDNFDES MDPFKPTTTL 
TSSDFCSPTG NHVNGILESP KKAKSRLITG CKVKKHETQS LALDACSRDE GAVISQISDI 
SNRDGHATDE EKLASTSCGQ KSAGAEVKGE PEEDLEYFEC SNVPVSTINH AFSSSEAGIE 
KETCQKMEED GSTVLGLLES SAEKAPVSVS CGGESPLDGI CLSESDKTAV LTLIREEIIT 
KEIEANEWKK KYEETRQEVL EMRKIVAEYE KTIAQMIEDE QRTSMTSQKS FQQLTMEKEQ 
ALADLNSVER SLSDLFRRYE NLKGVLEGFK KNEEALKKCA QDYLARVKQE EQRYQALKIH 
AEEKLDKANE EIAQVRTKAK AESAALHAGL RKEQMKVESL ERALQQKNQE IEELTKICDE 
LIAKLGKTD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.