Details for: SERPINA5

Gene ID: 5104

Symbol: SERPINA5

Ensembl ID: ENSG00000188488

Description: serpin family A member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 6.5135
    Cell Significance Index: 24.9400
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 6.0868
    Cell Significance Index: 20.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.6978
    Cell Significance Index: 152.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 5.3570
    Cell Significance Index: 75.1400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 5.1946
    Cell Significance Index: 87.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.6517
    Cell Significance Index: 116.0000
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 3.1971
    Cell Significance Index: 15.9500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 3.1687
    Cell Significance Index: 46.0100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.6830
    Cell Significance Index: 10.1100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.4487
    Cell Significance Index: 26.3300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.3150
    Cell Significance Index: 27.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.0179
    Cell Significance Index: 46.6200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.9181
    Cell Significance Index: 24.8200
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.7522
    Cell Significance Index: 0.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.4277
    Cell Significance Index: 24.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.0148
    Cell Significance Index: 6.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.9954
    Cell Significance Index: 15.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5471
    Cell Significance Index: 40.7800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5053
    Cell Significance Index: 5.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4546
    Cell Significance Index: 90.2100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.3846
    Cell Significance Index: 2.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3609
    Cell Significance Index: 197.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3602
    Cell Significance Index: 46.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3454
    Cell Significance Index: 253.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2575
    Cell Significance Index: 3.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1568
    Cell Significance Index: 4.2000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1389
    Cell Significance Index: 1.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0675
    Cell Significance Index: 42.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0575
    Cell Significance Index: 7.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0279
    Cell Significance Index: 2.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0242
    Cell Significance Index: 4.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0026
    Cell Significance Index: -1.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0038
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0060
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0071
    Cell Significance Index: -0.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0082
    Cell Significance Index: -0.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0103
    Cell Significance Index: -14.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0136
    Cell Significance Index: -1.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0146
    Cell Significance Index: -3.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0220
    Cell Significance Index: -9.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0234
    Cell Significance Index: -0.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0283
    Cell Significance Index: -8.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0357
    Cell Significance Index: -7.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0383
    Cell Significance Index: -6.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0422
    Cell Significance Index: -4.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0495
    Cell Significance Index: -6.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0562
    Cell Significance Index: -8.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0599
    Cell Significance Index: -7.3600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0712
    Cell Significance Index: -1.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0715
    Cell Significance Index: -7.3000
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0718
    Cell Significance Index: -0.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0740
    Cell Significance Index: -8.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0824
    Cell Significance Index: -3.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0917
    Cell Significance Index: -1.9200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1002
    Cell Significance Index: -1.2900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1082
    Cell Significance Index: -1.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1132
    Cell Significance Index: -2.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1146
    Cell Significance Index: -3.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1206
    Cell Significance Index: -1.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1210
    Cell Significance Index: -5.6400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1238
    Cell Significance Index: -2.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1298
    Cell Significance Index: -9.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1360
    Cell Significance Index: -9.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1385
    Cell Significance Index: -8.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1404
    Cell Significance Index: -7.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1660
    Cell Significance Index: -3.2400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1704
    Cell Significance Index: -1.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1786
    Cell Significance Index: -10.0200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1842
    Cell Significance Index: -1.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1895
    Cell Significance Index: -9.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1905
    Cell Significance Index: -5.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1917
    Cell Significance Index: -5.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1943
    Cell Significance Index: -1.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1969
    Cell Significance Index: -2.8200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2021
    Cell Significance Index: -2.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2135
    Cell Significance Index: -7.4800
  • Cell Name: lung perichondrial fibroblast (CL4033026)
    Fold Change: -0.2140
    Cell Significance Index: -1.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2297
    Cell Significance Index: -7.5200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2318
    Cell Significance Index: -3.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2352
    Cell Significance Index: -7.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2441
    Cell Significance Index: -7.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2449
    Cell Significance Index: -8.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2572
    Cell Significance Index: -9.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2652
    Cell Significance Index: -11.7300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2858
    Cell Significance Index: -9.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2879
    Cell Significance Index: -3.1300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2917
    Cell Significance Index: -3.2600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2950
    Cell Significance Index: -3.3400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3009
    Cell Significance Index: -6.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3106
    Cell Significance Index: -11.7600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3159
    Cell Significance Index: -7.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3203
    Cell Significance Index: -7.9900
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3217
    Cell Significance Index: -3.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3234
    Cell Significance Index: -9.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERPINA5 is a serine protease inhibitor (serpin) that belongs to the A subfamily of serpins. It is characterized by its ability to inhibit a wide range of proteolytic enzymes, including endopeptidases and hydrolases. SERPINA5 is also known to interact with various proteins, including coagulation factors, platelets, and lipoproteins, and plays a critical role in regulating proteolytic activity in different cellular contexts. **Pathways and Functions:** SERPINA5 is involved in several biological pathways, including: 1. **Fibrin Clot Formation:** SERPINA5 inhibits the activity of thrombin, a key enzyme in the coagulation cascade, thereby regulating fibrin clot formation. 2. **Hemostasis:** SERPINA5 helps to regulate platelet activation and aggregation, which are essential for hemostasis. 3. **Spermatogenesis:** SERPINA5 is expressed in Sertoli cells and plays a critical role in regulating spermatogenesis, the process by which sperm cells are produced. 4. **Glycosaminoglycan Binding:** SERPINA5 interacts with glycosaminoglycans, which are negatively charged polysaccharides found in the extracellular matrix. 5. **Protease Binding:** SERPINA5 binds to various proteases, including endopeptidases and hydrolases, thereby regulating their activity. **Clinical Significance:** Dysregulation of SERPINA5 has been implicated in various diseases, including: 1. **Cardiovascular Disorders:** SERPINA5 deficiency has been linked to an increased risk of cardiovascular disease, including atherosclerosis and thrombosis. 2. **Respiratory Disorders:** SERPINA5 deficiency has been associated with an increased risk of respiratory disorders, including chronic obstructive pulmonary disease (COPD) and emphysema. 3. **Neurological Disorders:** SERPINA5 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer:** SERPINA5 has been shown to have anti-tumor properties, and its dysregulation has been linked to an increased risk of cancer. In conclusion, SERPINA5 is a critical regulator of proteolytic activity in various cellular contexts, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of SERPINA5 in immune regulation and its clinical significance.

Genular Protein ID: 1903766174

Symbol: IPSP_HUMAN

Name: Plasma serine protease inhibitor

UniProtKB Accession Codes:

P05154 Q07616 Q9UG30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3027058

Title: Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily.

PubMed ID: 3027058

DOI: 10.1016/s0021-9258(19)75827-x

PubMed ID: 2173165

Title: Evidence for a glycine residue at position 316 in human protein C inhibitor.

PubMed ID: 2173165

DOI: 10.1016/0049-3848(90)90142-y

PubMed ID: 1714450

Title: Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14.

PubMed ID: 1714450

DOI: 10.1016/s0021-9258(18)98581-9

PubMed ID: 8148499

Title: Gene organization of human protein C inhibitor, a member of SERPIN family proteins encoded in five exons.

PubMed ID: 8148499

PubMed ID: 8713781

Title: A two-allele polymorphism in protein C inhibitor with varying frequencies in different ethnic populations.

PubMed ID: 8713781

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8471250

Title: Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor.

PubMed ID: 8471250

DOI: 10.1002/mrd.1080340308

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 2556811

Title: Protein C inhibitor from human plasma: characterization of native and cleaved inhibitor and demonstration of inhibitor complexes with plasma kallikrein.

PubMed ID: 2556811

PubMed ID: 6323392

Title: Mechanism of inhibition of activated protein C by protein C inhibitor.

PubMed ID: 6323392

DOI: 10.1093/oxfordjournals.jbchem.a134583

PubMed ID: 3501295

Title: Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for identity of PCI and plasminogen activator inhibitor 3.

PubMed ID: 3501295

DOI: 10.1515/bchm3.1987.368.2.1427

PubMed ID: 2844223

Title: Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.

PubMed ID: 2844223

DOI: 10.1021/bi00412a005

PubMed ID: 1725227

Title: Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen.

PubMed ID: 1725227

DOI: 10.1016/0049-3848(91)90002-e

PubMed ID: 1372913

Title: Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system.

PubMed ID: 1372913

DOI: 10.1172/jci115689

PubMed ID: 7521127

Title: Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa.

PubMed ID: 7521127

DOI: 10.1152/ajpcell.1994.267.2.c466

PubMed ID: 7548057

Title: Intermolecular interactions between protein C inhibitor and coagulation proteases.

PubMed ID: 7548057

DOI: 10.1021/bi00040a009

PubMed ID: 8536714

Title: Complexes of tissue kallikrein with protein C inhibitor in human semen and urine.

PubMed ID: 8536714

DOI: 10.1111/j.1432-1033.1995.641_b.x

PubMed ID: 8665956

Title: Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor.

PubMed ID: 8665956

DOI: 10.1111/j.1432-1033.1996.0088q.x

PubMed ID: 9473218

Title: Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma.

PubMed ID: 9473218

PubMed ID: 9510955

Title: Protein C inhibitor may modulate human sperm-oocyte interactions.

PubMed ID: 9510955

DOI: 10.1095/biolreprod58.3.670

PubMed ID: 9556620

Title: Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles.

PubMed ID: 9556620

DOI: 10.1074/jbc.273.18.11281

PubMed ID: 10340997

Title: Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility.

PubMed ID: 10340997

DOI: 10.1093/molehr/5.6.513

PubMed ID: 11722589

Title: Binding of retinoic acid by the inhibitory serpin protein C inhibitor.

PubMed ID: 11722589

DOI: 10.1046/j.0014-2956.2001.02560.x

PubMed ID: 14696115

Title: Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma.

PubMed ID: 14696115

DOI: 10.1002/ijc.11594

PubMed ID: 15328353

Title: Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes.

PubMed ID: 15328353

DOI: 10.1074/jbc.m403299200

PubMed ID: 15140131

Title: Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions.

PubMed ID: 15140131

DOI: 10.1111/j.1538-7836.2004.00733.x

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 15853774

Title: Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity.

PubMed ID: 15853774

DOI: 10.1042/bj20050299

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17706750

Title: Immunolocalization of protein C inhibitor in differentiation of human epidermal keratinocytes.

PubMed ID: 17706750

DOI: 10.1016/j.acthis.2007.04.007

PubMed ID: 18467335

Title: N-glycans and the N terminus of protein C inhibitor affect the cofactor-enhanced rates of thrombin inhibition.

PubMed ID: 18467335

DOI: 10.1074/jbc.m800608200

PubMed ID: 18362344

Title: Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.

PubMed ID: 18362344

DOI: 10.1073/pnas.0711055105

PubMed ID: 21056543

Title: Further insight into the roles of the glycans attached to human blood protein C inhibitor.

PubMed ID: 21056543

DOI: 10.1016/j.bbrc.2010.11.005

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 2172989

Title: Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.

PubMed ID: 2172989

DOI: 10.1073/pnas.87.21.8506

PubMed ID: 12575940

Title: Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation.

PubMed ID: 12575940

DOI: 10.1016/s0969-2126(02)00944-9

PubMed ID: 17337440

Title: Structure of native protein C inhibitor provides insight into its multiple functions.

PubMed ID: 17337440

DOI: 10.1074/jbc.m701074200

PubMed ID: 18974053

Title: The heparin binding site of protein C inhibitor is protease-dependent.

PubMed ID: 18974053

DOI: 10.1074/jbc.m805974200

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 406
  • Mass: 45675
  • Checksum: 2A8FF3DC33C77E04
  • Sequence:
    • MQLFLLLCLV LLSPQGASLH RHHPREMKKR VEDLHVGATV APSSRRDFTF DLYRALASAA 
PSQSIFFSPV SISMSLAMLS LGAGSSTKMQ ILEGLGLNLQ KSSEKELHRG FQQLLQELNQ 
PRDGFQLSLG NALFTDLVVD LQDTFVSAMK TLYLADTFPT NFRDSAGAMK QINDYVAKQT 
KGKIVDLLKN LDSNAVVIMV NYIFFKAKWE TSFNHKGTQE QDFYVTSETV VRVPMMSRED 
QYHYLLDRNL SCRVVGVPYQ GNATALFILP SEGKMQQVEN GLSEKTLRKW LKMFKKRQLE 
LYLPKFSIEG SYQLEKVLPS LGISNVFTSH ADLSGISNHS NIQVSEMVHK AVVEVDESGT 
RAAAATGTIF TFRSARLNSQ RLVFNRPFLM FIVDNNILFL GKVNRP

Genular Protein ID: 651700417

Symbol: B4DDH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DDH1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 3 InterPro 6 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 258
  • Mass: 29411
  • Checksum: 35CAAF92453C2234
  • Sequence:
    • MKTLYLADTF PTNFRDSAGA MKQINDYVAK QTKGKIVDLL KNLDSNAVVI MVNYIFFKAK 
WETSFNHKGT QEQDFYVTSE TVVRVPMMSR EDQYHYLLDR NLSCRVVGVP YQGNATALFI 
LPSEGKMQQV ENGLSEKTLR KWLKMFKKRQ LELYLPKFSI EGSYQLEKVL PSLGISNVFT 
SHADLSGISN HSNIQVSEMV HKAVVEVDES GTRAATATGT IFTFRSARLN SQRLVFNRPF 
LMFIVDNNIL FLGKVNRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.