EGF | ENSG00000138798 | NCBI 1950

Details for: EGF

Gene ID: 1950

Symbol: EGF

Ensembl ID: ENSG00000138798

Description: epidermal growth factor

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Constitutive signaling by egfrviii
(R-HSA-5637810)
Constitutive signaling by ligand-responsive egfr cancer variants
(R-HSA-1236382)
Developmental biology
(R-HSA-1266738)
Developmental cell lineages
(R-HSA-9734767)
Differentiation of keratinocytes in interfollicular epidermis in mammalian skin
(R-HSA-9725554)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hemostasis
(R-HSA-109582)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Notch3 activation and transmission of signal to the nucleus
(R-HSA-9013507)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Plcg1 events in erbb2 signaling
(R-HSA-1251932)
Raf/map kinase cascade
(R-HSA-5673001)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by notch3
(R-HSA-9012852)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Angiogenesis
(GO:0001525)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Calcium ion binding
(GO:0005509)
Cerebellar granule cell precursor proliferation
(GO:0021930)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-egfr signaling pathway
(GO:0038134)
Growth factor activity
(GO:0008083)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cerebellar granule cell precursor proliferation
(GO:0021940)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of receptor internalization
(GO:0002092)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 40.8250
Cell Significance Index: -10.3600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 6.4160
Cell Significance Index: 164.9200
Cell Name: type II muscle cell (CL0002212)
Fold Change: 6.0315
Cell Significance Index: 97.3200
Cell Name: type I muscle cell (CL0002211)
Fold Change: 4.0829
Cell Significance Index: 99.6200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.8541
Cell Significance Index: 44.9100
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.8493
Cell Significance Index: 26.3300
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 1.5392
Cell Significance Index: 1.1000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.5224
Cell Significance Index: 116.8300
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.3990
Cell Significance Index: 14.4900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2526
Cell Significance Index: 17.0900
Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 1.0433
Cell Significance Index: 10.4400
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.6686
Cell Significance Index: 0.8700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.3867
Cell Significance Index: 283.5600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2688
Cell Significance Index: 7.6700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2429
Cell Significance Index: 87.1200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2231
Cell Significance Index: 10.4000
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.2197
Cell Significance Index: 1.6900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1985
Cell Significance Index: 9.3300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.1937
Cell Significance Index: 11.8800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1417
Cell Significance Index: 26.9700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1370
Cell Significance Index: 210.9200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1080
Cell Significance Index: 18.4500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1028
Cell Significance Index: 20.6200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0740
Cell Significance Index: 47.0100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0613
Cell Significance Index: 113.1000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0535
Cell Significance Index: 1.8800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0394
Cell Significance Index: 17.9000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0371
Cell Significance Index: 4.7900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0320
Cell Significance Index: 3.1700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0306
Cell Significance Index: 27.6700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0302
Cell Significance Index: 4.9100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0241
Cell Significance Index: 3.5000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0198
Cell Significance Index: 0.5700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0167
Cell Significance Index: 1.8200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0165
Cell Significance Index: 0.9900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0130
Cell Significance Index: 24.4900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0041
Cell Significance Index: 0.0600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.0030
Cell Significance Index: 0.2400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0020
Cell Significance Index: 2.7100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0025
Cell Significance Index: -1.1200
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: -0.0052
Cell Significance Index: -0.0200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0053
Cell Significance Index: -3.7000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0099
Cell Significance Index: -2.8500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0109
Cell Significance Index: -8.0800
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.0111
Cell Significance Index: -0.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0123
Cell Significance Index: -9.2900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0152
Cell Significance Index: -8.5800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0154
Cell Significance Index: -8.4000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0162
Cell Significance Index: -10.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0221
Cell Significance Index: -2.5300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0226
Cell Significance Index: -1.0300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0267
Cell Significance Index: -0.7100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0273
Cell Significance Index: -4.9300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0299
Cell Significance Index: -0.3100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0333
Cell Significance Index: -3.4000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0370
Cell Significance Index: -7.3500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0442
Cell Significance Index: -9.3200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0494
Cell Significance Index: -1.0700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0550
Cell Significance Index: -3.8100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0622
Cell Significance Index: -1.5600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0680
Cell Significance Index: -8.3600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0686
Cell Significance Index: -9.4200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0709
Cell Significance Index: -7.3800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0726
Cell Significance Index: -1.0400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0835
Cell Significance Index: -9.7400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0858
Cell Significance Index: -10.1200
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0964
Cell Significance Index: -1.3000
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0986
Cell Significance Index: -1.9500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0992
Cell Significance Index: -6.2600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1027
Cell Significance Index: -4.2100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1058
Cell Significance Index: -2.9600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1123
Cell Significance Index: -6.3000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1183
Cell Significance Index: -8.8200
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1230
Cell Significance Index: -5.3500
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1240
Cell Significance Index: -1.5900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1286
Cell Significance Index: -4.2100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1331
Cell Significance Index: -4.2400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1333
Cell Significance Index: -4.6700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1356
Cell Significance Index: -9.1200
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: -0.1374
Cell Significance Index: -1.4500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1384
Cell Significance Index: -8.5100
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1515
Cell Significance Index: -3.7800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1516
Cell Significance Index: -7.6600
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.1532
Cell Significance Index: -1.6100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1577
Cell Significance Index: -8.1900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1622
Cell Significance Index: -10.4600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1798
Cell Significance Index: -5.7600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1808
Cell Significance Index: -9.4200
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1827
Cell Significance Index: -5.7800
Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.1852
Cell Significance Index: -2.7700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1861
Cell Significance Index: -8.2300
Cell Name: muscle cell (CL0000187)
Fold Change: -0.1861
Cell Significance Index: -1.7800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1878
Cell Significance Index: -2.8300
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.1969
Cell Significance Index: -1.5100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1988
Cell Significance Index: -10.4400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2021
Cell Significance Index: -4.3100
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: -0.2108
Cell Significance Index: -2.7000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2124
Cell Significance Index: -3.6400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2147
Cell Significance Index: -8.1300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2177
Cell Significance Index: -7.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Structure**: EGF is a small, cysteine-rich protein with a molecular weight of approximately 6 kDa. 2. **Function**: EGF is a ligand that binds to the EGFR, triggering a series of downstream signaling events that regulate cell growth, differentiation, and survival. 3. **Expression**: EGF is expressed in various tissues, including epithelial cells, muscle fibers, and immune cells. 4. **Regulation**: EGF expression is regulated by a variety of factors, including growth factors, cytokines, and transcription factors. **Pathways and Functions** 1. **Cell Proliferation**: EGF signaling regulates cell proliferation by activating the PI3K/AKT pathway, which promotes cell growth and survival. 2. **Differentiation**: EGF signaling regulates cell differentiation by activating the MAPK/ERK pathway, which controls the expression of genes involved in cell differentiation. 3. **Migration**: EGF signaling regulates cell migration by activating the PI3K/AKT pathway, which promotes cell migration and invasion. 4. **Survival**: EGF signaling regulates cell survival by activating the PI3K/AKT pathway, which promotes cell survival and apoptosis resistance. 5. **Angiogenesis**: EGF signaling regulates angiogenesis by activating the PI3K/AKT pathway, which promotes the formation of new blood vessels. **Clinical Significance** 1. **Cancer**: EGF signaling is dysregulated in various types of cancer, including breast, lung, and colon cancer. Overexpression of EGFR can lead to increased cell proliferation, migration, and invasion, contributing to cancer progression. 2. **Wound Healing**: EGF signaling plays a crucial role in wound healing by promoting cell proliferation, differentiation, and migration. 3. **Neurological Disorders**: EGF signaling is involved in the development and maintenance of the nervous system, and dysregulation of EGF signaling has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease**: EGF signaling is involved in the development and progression of cardiovascular disease, including atherosclerosis and myocardial infarction. In conclusion, the EGF gene plays a critical role in regulating various cellular processes, including proliferation, differentiation, migration, and survival. Dysregulation of EGF signaling has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular disease. Further research is needed to fully understand the mechanisms of EGF signaling and to develop effective therapeutic strategies to target EGF signaling in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Pro-epidermal growth factor

Genular Protein ID: 3083959669

Symbol: EGF_HUMAN

Name: Pro-epidermal growth factor

UniProtKB Accession Codes:

P01133 B4DRK7 E7EVD2 E9PBF0 Q52LZ6

Database IDs:

Citations:

PubMed ID: 3491360

Title: Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.

PubMed ID: 3491360

DOI: 10.1093/nar/14.21.8427

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 300079

Title: The primary structure of human urogastrone.

PubMed ID: 300079

DOI: 10.1111/j.1399-3011.1977.tb03470.x

PubMed ID: 2789514

Title: The primary structure of human EGF produced by genetic engineering, studied by high-performance tandem mass spectrometry.

PubMed ID: 2789514

DOI: 10.1016/0006-291x(89)92334-6

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 1522591

Title: Human epidermal growth factor. High resolution solution structure and comparison with human transforming growth factor alpha.

PubMed ID: 1522591

DOI: 10.1016/0022-2836(92)90697-i

PubMed ID: 10964941

Title: Neurotrophic actions of a novel molluscan epidermal growth factor.

PubMed ID: 10964941

DOI: 10.1523/jneurosci.20-17-06355.2000

PubMed ID: 17671655

Title: Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.

PubMed ID: 17671655

DOI: 10.1172/jci31680

PubMed ID: 21439629

Title: Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.

PubMed ID: 21439629

DOI: 10.1016/j.cell.2011.02.047

PubMed ID: 11438527

Title: Crystal structure of human epidermal growth factor and its dimerization.

PubMed ID: 11438527

DOI: 10.1074/jbc.m102874200

PubMed ID: 12297050

Title: Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.

PubMed ID: 12297050

DOI: 10.1016/s0092-8674(02)00963-7

PubMed ID: 12620237

Title: EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.

PubMed ID: 12620237

DOI: 10.1016/s1097-2765(03)00047-9

PubMed ID: 21029725

Title: The NMR solution structure of human epidermal growth factor (hEGF) at physiological pH and its interactions with suramin.

PubMed ID: 21029725

DOI: 10.1016/j.bbrc.2010.10.089

PubMed ID: 20837704

Title: Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor.

PubMed ID: 20837704

DOI: 10.1128/mcb.00742-10

Sequence Information:

Length: 1207
Mass: 133994
Checksum: 3C787F1D405CFAF1
Sequence:

MLLTLIILLP VVSKFSFVSL SAPQHWSCPE GTLAGNGNST CVGPAPFLIF SHGNSIFRID 
TEGTNYEQLV VDAGVSVIMD FHYNEKRIYW VDLERQLLQR VFLNGSRQER VCNIEKNVSG 
MAINWINEEV IWSNQQEGII TVTDMKGNNS HILLSALKYP ANVAVDPVER FIFWSSEVAG 
SLYRADLDGV GVKALLETSE KITAVSLDVL DKRLFWIQYN REGSNSLICS CDYDGGSVHI 
SKHPTQHNLF AMSLFGDRIF YSTWKMKTIW IANKHTGKDM VRINLHSSFV PLGELKVVHP 
LAQPKAEDDT WEPEQKLCKL RKGNCSSTVC GQDLQSHLCM CAEGYALSRD RKYCEDVNEC 
AFWNHGCTLG CKNTPGSYYC TCPVGFVLLP DGKRCHQLVS CPRNVSECSH DCVLTSEGPL 
CFCPEGSVLE RDGKTCSGCS SPDNGGCSQL CVPLSPVSWE CDCFPGYDLQ LDEKSCAASG 
PQPFLLFANS QDIRHMHFDG TDYGTLLSQQ MGMVYALDHD PVENKIYFAH TALKWIERAN 
MDGSQRERLI EEGVDVPEGL AVDWIGRRFY WTDRGKSLIG RSDLNGKRSK IITKENISQP 
RGIAVHPMAK RLFWTDTGIN PRIESSSLQG LGRLVIASSD LIWPSGITID FLTDKLYWCD 
AKQSVIEMAN LDGSKRRRLT QNDVGHPFAV AVFEDYVWFS DWAMPSVMRV NKRTGKDRVR 
LQGSMLKPSS LVVVHPLAKP GADPCLYQNG GCEHICKKRL GTAWCSCREG FMKASDGKTC 
LALDGHQLLA GGEVDLKNQV TPLDILSKTR VSEDNITESQ HMLVAEIMVS DQDDCAPVGC 
SMYARCISEG EDATCQCLKG FAGDGKLCSD IDECEMGVPV CPPASSKCIN TEGGYVCRCS 
EGYQGDGIHC LDIDECQLGE HSCGENASCT NTEGGYTCMC AGRLSEPGLI CPDSTPPPHL 
REDDHHYSVR NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW 
ELRHAGHGQQ QKVIVVAVCV VVLVMLLLLS LWGAHYYRTQ KLLSKNPKNP YEESSRDVRS 
RRPADTEDGM SSCPQPWFVV IKEHQDLKNG GQPVAGEDGQ AADGSMQPTS WRQEPQLCGM 
GTEQGCWIPV SSDKGSCPQV MERSFHMPSY GTQTLEGGVE KPHSLLSANP LWQQRALDPP 
HQMELTQ

Database document:

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Details for: EGF

Associated with

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Other Information

Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. PubMed ID: 3491360

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The primary structure of human urogastrone. PubMed ID: 300079

The primary structure of human EGF produced by genetic engineering, studied by high-performance tandem mass spectrometry. PubMed ID: 2789514

Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. PubMed ID: 22171320

Human epidermal growth factor. High resolution solution structure and comparison with human transforming growth factor alpha. PubMed ID: 1522591

Neurotrophic actions of a novel molluscan epidermal growth factor. PubMed ID: 10964941

Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. PubMed ID: 17671655

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. PubMed ID: 21439629

Crystal structure of human epidermal growth factor and its dimerization. PubMed ID: 11438527

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. PubMed ID: 12297050

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. PubMed ID: 12620237

The NMR solution structure of human epidermal growth factor (hEGF) at physiological pH and its interactions with suramin. PubMed ID: 21029725

Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. PubMed ID: 20837704