Gene EGF - ENSG00000138798 | NCBI Gene ID: 1950

Details for: EGF

Gene ID: 1950

Symbol: EGF

Ensembl ID: ENSG00000138798

Description: epidermal growth factor

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Constitutive signaling by egfrviii
(R-HSA-5637810)
Constitutive signaling by ligand-responsive egfr cancer variants
(R-HSA-1236382)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hemostasis
(R-HSA-109582)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Notch3 activation and transmission of signal to the nucleus
(R-HSA-9013507)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Plcg1 events in erbb2 signaling
(R-HSA-1251932)
Raf/map kinase cascade
(R-HSA-5673001)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by notch3
(R-HSA-9012852)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Angiogenesis
(GO:0001525)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Calcium ion binding
(GO:0005509)
Cerebellar granule cell precursor proliferation
(GO:0021930)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epithelial cell proliferation
(GO:0050673)
Erbb2-egfr signaling pathway
(GO:0038134)
Erk1 and erk2 cascade
(GO:0070371)
Growth factor activity
(GO:0008083)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Mammary gland alveolus development
(GO:0060749)
Negative regulation of secretion
(GO:0051048)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cerebellar granule cell precursor proliferation
(GO:0021940)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of receptor internalization
(GO:0002092)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.57
Marker Score: 6896
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.54
Marker Score: 2690
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.42
Marker Score: 2677
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.92
Marker Score: 4818
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.8
Marker Score: 950
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168945
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.43
Marker Score: 5061
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.4
Marker Score: 1699
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 871
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.26
Marker Score: 914.5
Cell Name: acinar cell (CL0000622)
Fold Change: 1.23
Marker Score: 867
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.22
Marker Score: 937
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.15
Marker Score: 1236
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.13
Marker Score: 4004
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.04
Marker Score: 2117
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.02
Marker Score: 688
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71817
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48042
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.99
Marker Score: 981
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.99
Marker Score: 410
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.99
Marker Score: 22080
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5264
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2739
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.91
Marker Score: 14177
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.91
Marker Score: 1987
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5287
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.87
Marker Score: 53227
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.86
Marker Score: 900
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.85
Marker Score: 2009
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.82
Marker Score: 544.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 629
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.81
Marker Score: 6956
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.8
Marker Score: 1077
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.78
Marker Score: 1476
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1261
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.76
Marker Score: 3196
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.76
Marker Score: 1596
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.67
Marker Score: 1533
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.67
Marker Score: 1034
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.65
Marker Score: 6222
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.65
Marker Score: 189
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.61
Marker Score: 388
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.6
Marker Score: 572
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.59
Marker Score: 940
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.58
Marker Score: 350
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.57
Marker Score: 11339
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 453
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.57
Marker Score: 182
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.56
Marker Score: 1084
Cell Name: podocyte (CL0000653)
Fold Change: 0.55
Marker Score: 205
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.55
Marker Score: 11724
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.54
Marker Score: 5075
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.53
Marker Score: 167
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.51
Marker Score: 5316
Cell Name: neuron (CL0000540)
Fold Change: 0.51
Marker Score: 2074
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.51
Marker Score: 842
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.49
Marker Score: 697
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.47
Marker Score: 148
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.47
Marker Score: 197
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.47
Marker Score: 1806
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.44
Marker Score: 338
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.44
Marker Score: 158
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.42
Marker Score: 109
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.41
Marker Score: 398
Cell Name: astrocyte (CL0000127)
Fold Change: 0.4
Marker Score: 350
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.39
Marker Score: 134
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.39
Marker Score: 104
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.39
Marker Score: 221
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.38
Marker Score: 223
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.36
Marker Score: 368
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.35
Marker Score: 166
Cell Name: interneuron (CL0000099)
Fold Change: 0.35
Marker Score: 158
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.33
Marker Score: 464
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.33
Marker Score: 328
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.33
Marker Score: 406
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.33
Marker Score: 318.5
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.32
Marker Score: 97
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.32
Marker Score: 87
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.29
Marker Score: 92.5
Cell Name: platelet (CL0000233)
Fold Change: 0.28
Marker Score: 126
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.27
Marker Score: 163
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.26
Marker Score: 174
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.26
Marker Score: 108
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.25
Marker Score: 111
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.25
Marker Score: 86.5
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.24
Marker Score: 612
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.24
Marker Score: 668
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.23
Marker Score: 392
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.23
Marker Score: 975.5
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 66

Hover over a box to see details here...

**Key characteristics:** - EGF is a glycoprotein with a molecular weight of approximately 175 kDa. - It is a secreted protein that is primarily produced by epithelial cells. - EGF is a potent mitogen that can stimulate cell growth and proliferation. - It is also a potent activator of the MAPK signaling pathway. **Pathways and functions:** - EGF signaling pathway is activated by various growth factor receptors, including EGFR, ERBB2, and ERBB4. - EGF binds to its receptors and triggers the activation of the MAPK signaling pathway. - The MAPK pathway is a major regulator of cell growth, differentiation, and proliferation. - Activation of the MAPK pathway by EGF promotes the expression of genes involved in cell cycle progression, cell growth, and survival. **Clinical significance:** - Increased EGF levels are associated with various human cancers, including breast cancer, lung cancer, and colorectal cancer. - Inhibition of EGF signaling has been shown to inhibit cancer growth and metastasis. - Therefore, EGF is a potential target for cancer therapy. **Other important points:** - EGF is also involved in wound healing, tissue development, and stem cell differentiation. - It is a key factor in maintaining the integrity and function of epithelial tissues. - Dysfunction of the EGF signaling pathway has been linked to various diseases, including cancer and cardiovascular disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Pro-epidermal growth factor

Genular Protein ID: 3083959669

Symbol: EGF_HUMAN

Name: Pro-epidermal growth factor

UniProtKB Accession Codes:

P01133 B4DRK7 E7EVD2 E9PBF0 Q52LZ6

Database IDs:

Citations:

PubMed ID: 3491360

Title: Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.

PubMed ID: 3491360

DOI: 10.1093/nar/14.21.8427

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 300079

Title: The primary structure of human urogastrone.

PubMed ID: 300079

DOI: 10.1111/j.1399-3011.1977.tb03470.x

PubMed ID: 2789514

Title: The primary structure of human EGF produced by genetic engineering, studied by high-performance tandem mass spectrometry.

PubMed ID: 2789514

DOI: 10.1016/0006-291x(89)92334-6

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 1522591

Title: Human epidermal growth factor. High resolution solution structure and comparison with human transforming growth factor alpha.

PubMed ID: 1522591

DOI: 10.1016/0022-2836(92)90697-i

PubMed ID: 10964941

Title: Neurotrophic actions of a novel molluscan epidermal growth factor.

PubMed ID: 10964941

DOI: 10.1523/jneurosci.20-17-06355.2000

PubMed ID: 17671655

Title: Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.

PubMed ID: 17671655

DOI: 10.1172/jci31680

PubMed ID: 21439629

Title: Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.

PubMed ID: 21439629

DOI: 10.1016/j.cell.2011.02.047

PubMed ID: 11438527

Title: Crystal structure of human epidermal growth factor and its dimerization.

PubMed ID: 11438527

DOI: 10.1074/jbc.m102874200

PubMed ID: 12297050

Title: Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.

PubMed ID: 12297050

DOI: 10.1016/s0092-8674(02)00963-7

PubMed ID: 12620237

Title: EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.

PubMed ID: 12620237

DOI: 10.1016/s1097-2765(03)00047-9

PubMed ID: 21029725

Title: The NMR solution structure of human epidermal growth factor (hEGF) at physiological pH and its interactions with suramin.

PubMed ID: 21029725

DOI: 10.1016/j.bbrc.2010.10.089

PubMed ID: 20837704

Title: Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor.

PubMed ID: 20837704

DOI: 10.1128/mcb.00742-10

Sequence Information:

Length: 1207
Mass: 133994
Checksum: 3C787F1D405CFAF1
Sequence:

MLLTLIILLP VVSKFSFVSL SAPQHWSCPE GTLAGNGNST CVGPAPFLIF SHGNSIFRID 
TEGTNYEQLV VDAGVSVIMD FHYNEKRIYW VDLERQLLQR VFLNGSRQER VCNIEKNVSG 
MAINWINEEV IWSNQQEGII TVTDMKGNNS HILLSALKYP ANVAVDPVER FIFWSSEVAG 
SLYRADLDGV GVKALLETSE KITAVSLDVL DKRLFWIQYN REGSNSLICS CDYDGGSVHI 
SKHPTQHNLF AMSLFGDRIF YSTWKMKTIW IANKHTGKDM VRINLHSSFV PLGELKVVHP 
LAQPKAEDDT WEPEQKLCKL RKGNCSSTVC GQDLQSHLCM CAEGYALSRD RKYCEDVNEC 
AFWNHGCTLG CKNTPGSYYC TCPVGFVLLP DGKRCHQLVS CPRNVSECSH DCVLTSEGPL 
CFCPEGSVLE RDGKTCSGCS SPDNGGCSQL CVPLSPVSWE CDCFPGYDLQ LDEKSCAASG 
PQPFLLFANS QDIRHMHFDG TDYGTLLSQQ MGMVYALDHD PVENKIYFAH TALKWIERAN 
MDGSQRERLI EEGVDVPEGL AVDWIGRRFY WTDRGKSLIG RSDLNGKRSK IITKENISQP 
RGIAVHPMAK RLFWTDTGIN PRIESSSLQG LGRLVIASSD LIWPSGITID FLTDKLYWCD 
AKQSVIEMAN LDGSKRRRLT QNDVGHPFAV AVFEDYVWFS DWAMPSVMRV NKRTGKDRVR 
LQGSMLKPSS LVVVHPLAKP GADPCLYQNG GCEHICKKRL GTAWCSCREG FMKASDGKTC 
LALDGHQLLA GGEVDLKNQV TPLDILSKTR VSEDNITESQ HMLVAEIMVS DQDDCAPVGC 
SMYARCISEG EDATCQCLKG FAGDGKLCSD IDECEMGVPV CPPASSKCIN TEGGYVCRCS 
EGYQGDGIHC LDIDECQLGE HSCGENASCT NTEGGYTCMC AGRLSEPGLI CPDSTPPPHL 
REDDHHYSVR NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW 
ELRHAGHGQQ QKVIVVAVCV VVLVMLLLLS LWGAHYYRTQ KLLSKNPKNP YEESSRDVRS 
RRPADTEDGM SSCPQPWFVV IKEHQDLKNG GQPVAGEDGQ AADGSMQPTS WRQEPQLCGM 
GTEQGCWIPV SSDKGSCPQV MERSFHMPSY GTQTLEGGVE KPHSLLSANP LWQQRALDPP 
HQMELTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EGF

Associated with

Cells (max top 100)

Other Information

Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. PubMed ID: 3491360

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The primary structure of human urogastrone. PubMed ID: 300079

The primary structure of human EGF produced by genetic engineering, studied by high-performance tandem mass spectrometry. PubMed ID: 2789514

Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. PubMed ID: 22171320

Human epidermal growth factor. High resolution solution structure and comparison with human transforming growth factor alpha. PubMed ID: 1522591

Neurotrophic actions of a novel molluscan epidermal growth factor. PubMed ID: 10964941

Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. PubMed ID: 17671655

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. PubMed ID: 21439629

Crystal structure of human epidermal growth factor and its dimerization. PubMed ID: 11438527

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. PubMed ID: 12297050

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. PubMed ID: 12620237

The NMR solution structure of human epidermal growth factor (hEGF) at physiological pH and its interactions with suramin. PubMed ID: 21029725

Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. PubMed ID: 20837704