Details for: ATP6V0A4

Gene ID: 50617

Symbol: ATP6V0A4

Ensembl ID: ENSG00000105929

Description: ATPase H+ transporting V0 subunit a4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.1427
    Cell Significance Index: -5.8700
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 20.2613
    Cell Significance Index: 14.4800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 10.0718
    Cell Significance Index: 38.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.9076
    Cell Significance Index: -6.6000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6241
    Cell Significance Index: 39.3400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.9107
    Cell Significance Index: 6.0500
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.7168
    Cell Significance Index: 3.9900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.4480
    Cell Significance Index: 1.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3873
    Cell Significance Index: 8.4800
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.3292
    Cell Significance Index: 3.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3221
    Cell Significance Index: 5.5200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.2798
    Cell Significance Index: 2.8000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2356
    Cell Significance Index: 2.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1580
    Cell Significance Index: 4.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1551
    Cell Significance Index: 2.4000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1376
    Cell Significance Index: 1.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0885
    Cell Significance Index: 64.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0841
    Cell Significance Index: 16.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0358
    Cell Significance Index: 2.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0347
    Cell Significance Index: 4.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0324
    Cell Significance Index: 20.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0273
    Cell Significance Index: 18.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0264
    Cell Significance Index: 1.2300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0218
    Cell Significance Index: 0.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0181
    Cell Significance Index: 6.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0122
    Cell Significance Index: 2.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.8000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0003
    Cell Significance Index: 0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0052
    Cell Significance Index: -0.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0056
    Cell Significance Index: -3.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0072
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0075
    Cell Significance Index: -0.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0079
    Cell Significance Index: -1.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0086
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0092
    Cell Significance Index: -0.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0094
    Cell Significance Index: -5.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0103
    Cell Significance Index: -6.4500
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.0113
    Cell Significance Index: -0.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0122
    Cell Significance Index: -0.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0126
    Cell Significance Index: -3.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0129
    Cell Significance Index: -0.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0141
    Cell Significance Index: -6.4200
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0165
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0167
    Cell Significance Index: -2.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0287
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0294
    Cell Significance Index: -6.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0324
    Cell Significance Index: -2.5700
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0363
    Cell Significance Index: -0.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0388
    Cell Significance Index: -0.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0398
    Cell Significance Index: -2.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0406
    Cell Significance Index: -1.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0407
    Cell Significance Index: -1.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0458
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0510
    Cell Significance Index: -5.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0513
    Cell Significance Index: -5.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0531
    Cell Significance Index: -2.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0566
    Cell Significance Index: -5.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0624
    Cell Significance Index: -1.7800
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0694
    Cell Significance Index: -0.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0732
    Cell Significance Index: -5.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0809
    Cell Significance Index: -6.2100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0956
    Cell Significance Index: -1.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1054
    Cell Significance Index: -6.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1132
    Cell Significance Index: -6.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1139
    Cell Significance Index: -5.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1176
    Cell Significance Index: -4.1200
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1209
    Cell Significance Index: -1.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1273
    Cell Significance Index: -3.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1274
    Cell Significance Index: -3.2800
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.1284
    Cell Significance Index: -1.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1311
    Cell Significance Index: -3.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1319
    Cell Significance Index: -5.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1335
    Cell Significance Index: -4.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1350
    Cell Significance Index: -4.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1418
    Cell Significance Index: -3.8000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1424
    Cell Significance Index: -4.5100
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: -0.1449
    Cell Significance Index: -0.5000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1521
    Cell Significance Index: -2.1100
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: -0.1643
    Cell Significance Index: -1.5200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1773
    Cell Significance Index: -3.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1776
    Cell Significance Index: -3.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1819
    Cell Significance Index: -4.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1822
    Cell Significance Index: -6.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1936
    Cell Significance Index: -2.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1967
    Cell Significance Index: -4.2500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2034
    Cell Significance Index: -1.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2045
    Cell Significance Index: -5.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2135
    Cell Significance Index: -6.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2183
    Cell Significance Index: -5.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2200
    Cell Significance Index: -4.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2268
    Cell Significance Index: -7.9700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2285
    Cell Significance Index: -3.1600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2301
    Cell Significance Index: -2.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2309
    Cell Significance Index: -4.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Summary of ATP6V0A4: The ATPase H+ Transporting V0 Subunit A4** The ATP6V0A4 gene encodes the V-type proton ATPase 116 kDa subunit a4, a crucial component of the V-type ATPase complex, which plays a pivotal role in maintaining cellular pH homeostasis. This gene has been identified as significantly expressed in various cell types, including hematopoietic oligopotent progenitor cells, epithelial cells, and immune cells, suggesting its involvement in multiple physiological processes. **Key Characteristics of ATP6V0A4** 1. **Subunit a4 of the V-type ATPase complex**: The ATP6V0A4 gene encodes a subunit a4 of the V-type ATPase complex, which is responsible for transporting protons across the membrane. 2. **Proton-transporting activity**: The V-type ATPase complex, composed of ATP6V0A4, exhibits proton-transporting activity, which is essential for maintaining cellular pH homeostasis. 3. **Regulation of pH**: The ATP6V0A4 gene is involved in regulating pH levels within cells, which is critical for various cellular processes, including protein folding, enzyme activity, and membrane transport. **Pathways and Functions of ATP6V0A4** 1. **Endosomal acidification**: The V-type ATPase complex, including ATP6V0A4, plays a crucial role in acidifying endosomes, which is essential for protein degradation and trafficking. 2. **Lysosomal acidification**: ATP6V0A4 is also involved in acidifying lysosomes, which is necessary for protein degradation, autophagy, and immune responses. 3. **Proton transport**: The V-type ATPase complex, composed of ATP6V0A4, transports protons across the membrane, which is essential for maintaining cellular pH homeostasis. 4. **Iron uptake and transport**: ATP6V0A4 has been shown to be involved in iron uptake and transport, which is critical for maintaining iron homeostasis within cells. 5. **Immune responses**: The ATP6V0A4 gene is expressed in immune cells, suggesting its involvement in immune responses, including phagocytosis and antigen presentation. **Clinical Significance of ATP6V0A4** 1. **Neurological disorders**: Mutations in the ATP6V0A4 gene have been associated with neurological disorders, including epilepsy and ataxia. 2. **Immunodeficiency**: The ATP6V0A4 gene is expressed in immune cells, and alterations in its expression may contribute to immunodeficiency disorders. 3. **Cancer**: The V-type ATPase complex, including ATP6V0A4, has been implicated in cancer progression, including cell growth, migration, and invasion. 4. **Infectious diseases**: The ATP6V0A4 gene is expressed in epithelial cells, and alterations in its expression may contribute to infectious diseases, including respiratory and gastrointestinal infections. In conclusion, the ATP6V0A4 gene plays a crucial role in maintaining cellular pH homeostasis, regulating endosomal and lysosomal acidification, and transporting protons across the membrane. Its dysregulation has been implicated in various diseases, including neurological disorders, immunodeficiency, cancer, and infectious diseases. Further research is necessary to fully understand the functional significance of ATP6V0A4 and its role in human disease.

Genular Protein ID: 1821438971

Symbol: VPP4_HUMAN

Name: V-type proton ATPase 116 kDa subunit a 4

UniProtKB Accession Codes:

Q9HBG4 A4D1R4 A8KA80 Q32M47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 24 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 5 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10973252

Title: Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing.

PubMed ID: 10973252

DOI: 10.1038/79208

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12414817

Title: Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss.

PubMed ID: 12414817

DOI: 10.1136/jmg.39.11.796

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 840
  • Mass: 96386
  • Checksum: 449964EBC01D4649
  • Sequence:
    • MVSVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NMNVNSFQRK FVNEVRRCES 
LERILRFLED EMQNEIVVQL LEKSPLTPLP REMITLETVL EKLEGELQEA NQNQQALKQS 
FLELTELKYL LKKTQDFFET ETNLADDFFT EDTSGLLELK AVPAYMTGKL GFIAGVINRE 
RMASFERLLW RICRGNVYLK FSEMDAPLED PVTKEEIQKN IFIIFYQGEQ LRQKIKKICD 
GFRATVYPCP EPAVERREML ESVNVRLEDL ITVITQTESH RQRLLQEAAA NWHSWLIKVQ 
KMKAVYHILN MCNIDVTQQC VIAEIWFPVA DATRIKRALE QGMELSGSSM APIMTTVQSK 
TAPPTFNRTN KFTAGFQNIV DAYGVGSYRE INPAPYTIIT FPFLFAVMFG DCGHGTVMLL 
AALWMILNER RLLSQKTDNE IWNTFFHGRY LILLMGIFSI YTGLIYNDCF SKSLNIFGSS 
WSVQPMFRNG TWNTHVMEES LYLQLDPAIP GVYFGNPYPF GIDPIWNLAS NKLTFLNSYK 
MKMSVILGIV QMVFGVILSL FNHIYFRRTL NIILQFIPEM IFILCLFGYL VFMIIFKWCC 
FDVHVSQHAP SILIHFINMF LFNYSDSSNA PLYKHQQEVQ SFFVVMALIS VPWMLLIKPF 
ILRASHRKSQ LQASRIQEDA TENIEGDSSS PSSRSGQRTS ADTHGALDDH GEEFNFGDVF 
VHQAIHTIEY CLGCISNTAS YLRLWALSLA HAQLSEVLWT MVMNSGLQTR GWGGIVGVFI 
IFAVFAVLTV AILLIMEGLS AFLHALRLHW VEFQNKFYVG DGYKFSPFSF KHILDGTAEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.