Details for: ATP8

Gene ID: 4509

Symbol: ATP8

Ensembl ID: ENSG00000228253

Description: ATP synthase F0 subunit 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 176.3173
    Cell Significance Index: -90.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 155.5740
    Cell Significance Index: -73.4500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 45.2495
    Cell Significance Index: 634.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.6880
    Cell Significance Index: -79.5300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 29.1913
    Cell Significance Index: 78.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 14.3425
    Cell Significance Index: 183.6800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 14.2638
    Cell Significance Index: 113.4900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 13.0256
    Cell Significance Index: 100.4000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 12.3283
    Cell Significance Index: 78.7000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 11.6353
    Cell Significance Index: 77.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 10.7205
    Cell Significance Index: 314.8500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 9.4399
    Cell Significance Index: 139.3300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 7.9015
    Cell Significance Index: 79.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 7.1082
    Cell Significance Index: 322.1900
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 6.5807
    Cell Significance Index: 32.8300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 5.7770
    Cell Significance Index: 43.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.6334
    Cell Significance Index: 140.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 5.2862
    Cell Significance Index: 79.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.4856
    Cell Significance Index: 129.2400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 3.7925
    Cell Significance Index: 18.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 3.3261
    Cell Significance Index: 957.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2784
    Cell Significance Index: 42.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9807
    Cell Significance Index: 102.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9197
    Cell Significance Index: 41.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.7999
    Cell Significance Index: 51.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7493
    Cell Significance Index: 105.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6284
    Cell Significance Index: 177.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5217
    Cell Significance Index: 1374.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5159
    Cell Significance Index: 827.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5111
    Cell Significance Index: 13.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3674
    Cell Significance Index: 222.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2332
    Cell Significance Index: 57.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8529
    Cell Significance Index: 58.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7409
    Cell Significance Index: 101.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6477
    Cell Significance Index: 10.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6198
    Cell Significance Index: 28.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5871
    Cell Significance Index: 20.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.5814
    Cell Significance Index: 426.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5736
    Cell Significance Index: 70.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.4393
    Cell Significance Index: 44.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4370
    Cell Significance Index: 156.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4233
    Cell Significance Index: 76.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4011
    Cell Significance Index: 39.6800
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.2003
    Cell Significance Index: 1.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1629
    Cell Significance Index: 3.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1495
    Cell Significance Index: 4.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0956
    Cell Significance Index: 2.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0886
    Cell Significance Index: 1.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0637
    Cell Significance Index: 12.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0172
    Cell Significance Index: 0.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0027
    Cell Significance Index: 0.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0049
    Cell Significance Index: -0.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0360
    Cell Significance Index: -67.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0362
    Cell Significance Index: -7.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0371
    Cell Significance Index: -2.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0477
    Cell Significance Index: -36.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0487
    Cell Significance Index: -89.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0584
    Cell Significance Index: -89.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0666
    Cell Significance Index: -90.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0939
    Cell Significance Index: -69.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1165
    Cell Significance Index: -65.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1414
    Cell Significance Index: -24.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1416
    Cell Significance Index: -89.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1461
    Cell Significance Index: -91.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1633
    Cell Significance Index: -20.9300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1886
    Cell Significance Index: -3.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1915
    Cell Significance Index: -86.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2264
    Cell Significance Index: -14.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2302
    Cell Significance Index: -12.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2814
    Cell Significance Index: -14.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3234
    Cell Significance Index: -37.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3537
    Cell Significance Index: -14.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3804
    Cell Significance Index: -80.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3883
    Cell Significance Index: -50.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4675
    Cell Significance Index: -4.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5101
    Cell Significance Index: -6.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5686
    Cell Significance Index: -35.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6066
    Cell Significance Index: -88.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6109
    Cell Significance Index: -41.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6550
    Cell Significance Index: -20.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6590
    Cell Significance Index: -68.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8095
    Cell Significance Index: -60.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8976
    Cell Significance Index: -68.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9406
    Cell Significance Index: -57.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9824
    Cell Significance Index: -51.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9907
    Cell Significance Index: -43.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0311
    Cell Significance Index: -6.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1031
    Cell Significance Index: -67.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1050
    Cell Significance Index: -40.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2747
    Cell Significance Index: -48.2700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -1.3024
    Cell Significance Index: -8.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.5212
    Cell Significance Index: -43.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.6941
    Cell Significance Index: -35.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.7332
    Cell Significance Index: -25.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.8121
    Cell Significance Index: -63.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.8441
    Cell Significance Index: -20.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.8818
    Cell Significance Index: -51.2200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.9716
    Cell Significance Index: -41.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ATP8 gene is a critical component of the mitochondrial ATP synthase complex, which is responsible for generating energy for cells through the process of chemiosmotic coupling. The F0 subunit 8 (ATP8) protein is a key component of this complex, facilitating the rotation of the stalk subunits and the generation of proton motive force, which drives ATP synthesis. The ATP8 gene is also involved in the regulation of mitochondrial biogenesis and maintenance, and its dysregulation has been implicated in various diseases, including metabolic disorders and cancer. **Pathways and Functions:** The ATP8 gene is involved in several key pathways, including: 1. **Cristae formation:** The ATP8 gene plays a critical role in the formation of cristae, the infoldings of the mitochondrial inner membrane that increase the surface area for ATP production. 2. **Formation of ATP by chemiosmotic coupling:** The ATP8 gene is essential for the generation of ATP through the process of chemiosmotic coupling, where the proton motive force drives the synthesis of ATP. 3. **Mitochondrial biogenesis:** The ATP8 gene is involved in the regulation of mitochondrial biogenesis, ensuring that mitochondria are properly formed and functionally active. 4. **Proton-transporting ATP synthase activity:** The ATP8 gene is involved in the regulation of proton-transporting ATP synthase activity, which is critical for energy production in cells. 5. **Rotational mechanism:** The ATP8 gene plays a role in the rotational mechanism of the stalk subunits, which is essential for the generation of proton motive force. **Clinical Significance:** The ATP8 gene has significant implications for various diseases, including: 1. **Metabolic disorders:** Dysregulation of the ATP8 gene has been implicated in metabolic disorders such as diabetes and metabolic syndrome. 2. **Cancer:** The ATP8 gene has been shown to be overexpressed in certain types of cancer, including breast and ovarian cancer. 3. **Neurodegenerative diseases:** The ATP8 gene has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. 4. **Immune responses:** The ATP8 gene is involved in the regulation of immune responses, particularly in the context of T cell function and activation. In conclusion, the ATP8 gene is a critical component of mitochondrial function and energy production, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the role of the ATP8 gene in human health and disease.

Genular Protein ID: 2419147663

Symbol: ATP8_HUMAN

Name: ATP synthase protein 8

UniProtKB Accession Codes:

P03928 Q34771

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 100 EMDB 10 Ensembl 1 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7219534

Title: Sequence and organization of the human mitochondrial genome.

PubMed ID: 7219534

DOI: 10.1038/290457a0

PubMed ID: 7530363

Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.

PubMed ID: 7530363

DOI: 10.1073/pnas.92.2.532

PubMed ID: 12949126

Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.

PubMed ID: 12949126

DOI: 10.1093/molbev/msg230

PubMed ID: 11130070

Title: Mitochondrial genome variation and the origin of modern humans.

PubMed ID: 11130070

DOI: 10.1038/35047064

PubMed ID: 12840039

Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.

PubMed ID: 12840039

DOI: 10.1101/gr.686603

PubMed ID: 14760490

Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.

PubMed ID: 14760490

DOI: 10.1007/s00414-004-0427-6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32516135

Title: PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.

PubMed ID: 32516135

DOI: 10.1172/jci134965

PubMed ID: 1757091

Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.

PubMed ID: 1757091

DOI: 10.1007/bf00206061

PubMed ID: 9461455

Title: Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome.

PubMed ID: 9461455

DOI: 10.1093/nar/26.4.967

PubMed ID: 19188198

Title: Infantile cardiomyopathy caused by a mutation in the overlapping region of mitochondrial ATPase 6 and 8 genes.

PubMed ID: 19188198

DOI: 10.1136/jmg.2008.063149

Sequence Information:

  • Length: 68
  • Mass: 7992
  • Checksum: 7D307E513AD76936
  • Sequence:
    • MPQLNTTVWP TMITPMLLTL FLITQLKMLN TNYHLPPSPK PMKMKNYNKP WEPKWTKICS 
LHSLPPQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.