Details for: MPC1

Gene ID: 51660

Symbol: MPC1

Ensembl ID: ENSG00000060762

Description: mitochondrial pyruvate carrier 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 278.6971
    Cell Significance Index: -43.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 184.2745
    Cell Significance Index: -46.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.5411
    Cell Significance Index: -54.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.1949
    Cell Significance Index: -47.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.8020
    Cell Significance Index: -51.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 99.9057
    Cell Significance Index: -51.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 77.3894
    Cell Significance Index: -51.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.5159
    Cell Significance Index: -47.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.4833
    Cell Significance Index: -52.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6719
    Cell Significance Index: -53.9500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3878
    Cell Significance Index: -41.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.4661
    Cell Significance Index: -33.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3975
    Cell Significance Index: -16.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.5825
    Cell Significance Index: 316.9000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.6681
    Cell Significance Index: 14.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.6055
    Cell Significance Index: 43.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.5588
    Cell Significance Index: 298.2000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.5251
    Cell Significance Index: 21.2100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.3803
    Cell Significance Index: 25.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7529
    Cell Significance Index: 81.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6541
    Cell Significance Index: 126.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4761
    Cell Significance Index: 1332.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3529
    Cell Significance Index: 243.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.3310
    Cell Significance Index: 19.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.2674
    Cell Significance Index: 100.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2274
    Cell Significance Index: 150.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2110
    Cell Significance Index: 63.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1896
    Cell Significance Index: 16.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1216
    Cell Significance Index: 224.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0423
    Cell Significance Index: 206.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8937
    Cell Significance Index: 8.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8789
    Cell Significance Index: 120.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8128
    Cell Significance Index: 359.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7606
    Cell Significance Index: 123.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7586
    Cell Significance Index: 53.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7148
    Cell Significance Index: 45.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6904
    Cell Significance Index: 32.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6861
    Cell Significance Index: 35.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6339
    Cell Significance Index: 68.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6230
    Cell Significance Index: 223.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6215
    Cell Significance Index: 339.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6181
    Cell Significance Index: 453.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5012
    Cell Significance Index: 22.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4987
    Cell Significance Index: 29.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4769
    Cell Significance Index: 61.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4624
    Cell Significance Index: 88.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3831
    Cell Significance Index: 49.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2918
    Cell Significance Index: 49.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2571
    Cell Significance Index: 16.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2072
    Cell Significance Index: 24.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2068
    Cell Significance Index: 15.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1577
    Cell Significance Index: 5.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1084
    Cell Significance Index: 2.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0706
    Cell Significance Index: 53.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0662
    Cell Significance Index: 124.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0624
    Cell Significance Index: 6.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0537
    Cell Significance Index: 1.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0381
    Cell Significance Index: 17.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0295
    Cell Significance Index: 18.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0163
    Cell Significance Index: 30.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0120
    Cell Significance Index: 18.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0085
    Cell Significance Index: -0.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0153
    Cell Significance Index: -20.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0157
    Cell Significance Index: -9.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0310
    Cell Significance Index: -4.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0423
    Cell Significance Index: -1.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0473
    Cell Significance Index: -4.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0489
    Cell Significance Index: -27.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0749
    Cell Significance Index: -1.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0775
    Cell Significance Index: -2.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0905
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1108
    Cell Significance Index: -23.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1501
    Cell Significance Index: -17.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1541
    Cell Significance Index: -5.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1575
    Cell Significance Index: -2.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1601
    Cell Significance Index: -46.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2039
    Cell Significance Index: -3.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2643
    Cell Significance Index: -4.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2778
    Cell Significance Index: -6.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3007
    Cell Significance Index: -20.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3072
    Cell Significance Index: -6.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3160
    Cell Significance Index: -6.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3366
    Cell Significance Index: -38.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3930
    Cell Significance Index: -10.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4562
    Cell Significance Index: -47.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4775
    Cell Significance Index: -12.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5551
    Cell Significance Index: -10.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6097
    Cell Significance Index: -13.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6159
    Cell Significance Index: -34.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6216
    Cell Significance Index: -17.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6295
    Cell Significance Index: -16.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7177
    Cell Significance Index: -44.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7275
    Cell Significance Index: -17.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7520
    Cell Significance Index: -15.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7548
    Cell Significance Index: -26.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7559
    Cell Significance Index: -21.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7788
    Cell Significance Index: -20.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8368
    Cell Significance Index: -43.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8504
    Cell Significance Index: -24.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: MPC1 is a mitochondrial inner membrane protein, which suggests its involvement in mitochondrial function and metabolism. 2. **Pyruvate transport**: MPC1 is responsible for the transport of pyruvate across the mitochondrial membrane, which is a critical step in the regulation of cellular metabolism. 3. **Aerobic respiration**: MPC1 is involved in the regulation of aerobic respiration, which is a key process in the production of ATP in mitochondria. 4. **Metabolic regulation**: MPC1 plays a role in the regulation of metabolic pathways, including glycolysis and the citric acid cycle. **Pathways and Functions:** 1. **Aerobic respiration and respiratory electron transport**: MPC1 is involved in the regulation of aerobic respiration and the respiratory electron transport chain, which are critical processes in the production of ATP in mitochondria. 2. **Pyruvate metabolism**: MPC1 plays a role in the regulation of pyruvate metabolism, which is a key process in the production of ATP in mitochondria. 3. **Mitochondrial inner membrane protein complex**: MPC1 is part of the mitochondrial inner membrane protein complex, which is a critical complex involved in the regulation of mitochondrial function and metabolism. 4. **Protein binding**: MPC1 has protein binding capabilities, which suggests its interaction with other proteins involved in mitochondrial function and metabolism. **Clinical Significance:** 1. **Cancer**: Dysregulation of MPC1 has been implicated in various cancers, including leukemia and lymphoma. 2. **Metabolic disorders**: MPC1 dysregulation has been linked to metabolic disorders, including type 2 diabetes and metabolic syndrome. 3. **Mitochondrial dysfunction**: MPC1 is involved in the regulation of mitochondrial function and metabolism, and its dysregulation can lead to mitochondrial dysfunction, which is a hallmark of various diseases. 4. **Stem cell regulation**: MPC1 is expressed in stem cells, and its dysregulation can affect stem cell regulation and function. In conclusion, MPC1 is a critical protein involved in mitochondrial function and metabolism. Its dysregulation has been implicated in various diseases, including cancer and metabolic disorders. Further research is needed to fully understand the role of MPC1 in human health and disease.

Genular Protein ID: 4062865124

Symbol: MPC1_HUMAN

Name: Mitochondrial pyruvate carrier 1

UniProtKB Accession Codes:

Q9Y5U8 B2R5I7 Q5TI66 Q9HB67 Q9UQN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22628558

Title: A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.

PubMed ID: 22628558

DOI: 10.1126/science.1218099

PubMed ID: 26253029

Title: Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect.

PubMed ID: 26253029

DOI: 10.1016/j.molcel.2015.06.035

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27317664

Title: MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells.

PubMed ID: 27317664

DOI: 10.1074/jbc.m116.733840

PubMed ID: 32403431

Title: Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases.

PubMed ID: 32403431

DOI: 10.3390/ijms21093403

Sequence Information:

  • Length: 109
  • Mass: 12347
  • Checksum: E33344CD1AA29124
  • Sequence:
    • MAGALVRKAA DYVRSKDFRD YLMSTHFWGP VANWGLPIAA INDMKKSPEI ISGRMTFALC 
CYSLTFMRFA YKVQPRNWLL FACHATNEVA QLIQGGRLIK HEMTKTASA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.