Details for: MECOM

Gene ID: 2122

Symbol: MECOM

Ensembl ID: ENSG00000085276

Description: MDS1 and EVI1 complex locus

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 257.0314
    Cell Significance Index: -39.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 153.1678
    Cell Significance Index: -38.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.7677
    Cell Significance Index: -35.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 77.1410
    Cell Significance Index: -36.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.8476
    Cell Significance Index: -35.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.4343
    Cell Significance Index: -39.9900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 21.4356
    Cell Significance Index: 132.2500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 20.7735
    Cell Significance Index: 184.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.6226
    Cell Significance Index: -36.3800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 11.4764
    Cell Significance Index: 165.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 6.8230
    Cell Significance Index: 190.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 4.3684
    Cell Significance Index: 2774.4200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.1353
    Cell Significance Index: 48.0700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 3.6689
    Cell Significance Index: 38.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.4212
    Cell Significance Index: 177.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.0954
    Cell Significance Index: 214.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4924
    Cell Significance Index: 449.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2981
    Cell Significance Index: 456.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0419
    Cell Significance Index: 251.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.9542
    Cell Significance Index: 3679.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8863
    Cell Significance Index: 17.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5685
    Cell Significance Index: 255.1100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.5334
    Cell Significance Index: 15.3500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.4512
    Cell Significance Index: 14.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4426
    Cell Significance Index: 65.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4132
    Cell Significance Index: 153.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.3175
    Cell Significance Index: 7.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2869
    Cell Significance Index: 27.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2544
    Cell Significance Index: 28.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1177
    Cell Significance Index: 610.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0845
    Cell Significance Index: 56.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9723
    Cell Significance Index: 28.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9282
    Cell Significance Index: 838.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7366
    Cell Significance Index: 140.1700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7012
    Cell Significance Index: 10.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.5671
    Cell Significance Index: 59.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2599
    Cell Significance Index: 44.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2160
    Cell Significance Index: 4.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1928
    Cell Significance Index: 4.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1424
    Cell Significance Index: 104.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1186
    Cell Significance Index: 3.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0366
    Cell Significance Index: 1.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0294
    Cell Significance Index: 5.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0118
    Cell Significance Index: 1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0043
    Cell Significance Index: 3.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0128
    Cell Significance Index: -23.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0192
    Cell Significance Index: -29.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0208
    Cell Significance Index: -0.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0244
    Cell Significance Index: -16.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0261
    Cell Significance Index: -35.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0516
    Cell Significance Index: -38.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0625
    Cell Significance Index: -39.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0632
    Cell Significance Index: -27.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0636
    Cell Significance Index: -28.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0751
    Cell Significance Index: -26.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0765
    Cell Significance Index: -43.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0836
    Cell Significance Index: -2.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0956
    Cell Significance Index: -7.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1125
    Cell Significance Index: -32.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1573
    Cell Significance Index: -18.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1902
    Cell Significance Index: -24.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1956
    Cell Significance Index: -28.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2163
    Cell Significance Index: -45.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2169
    Cell Significance Index: -22.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2452
    Cell Significance Index: -13.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2597
    Cell Significance Index: -35.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2664
    Cell Significance Index: -21.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2792
    Cell Significance Index: -2.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2901
    Cell Significance Index: -37.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2951
    Cell Significance Index: -19.8500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.3151
    Cell Significance Index: -2.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3306
    Cell Significance Index: -9.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3350
    Cell Significance Index: -39.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3702
    Cell Significance Index: -42.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4495
    Cell Significance Index: -27.5600
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.4795
    Cell Significance Index: -4.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5137
    Cell Significance Index: -38.2900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.5229
    Cell Significance Index: -4.9800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5799
    Cell Significance Index: -4.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5963
    Cell Significance Index: -38.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6744
    Cell Significance Index: -41.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7383
    Cell Significance Index: -34.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7550
    Cell Significance Index: -23.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7800
    Cell Significance Index: -49.1600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.8372
    Cell Significance Index: -6.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8393
    Cell Significance Index: -12.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8516
    Cell Significance Index: -16.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8565
    Cell Significance Index: -22.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8575
    Cell Significance Index: -37.9300
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.8848
    Cell Significance Index: -4.2200
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.9165
    Cell Significance Index: -9.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9586
    Cell Significance Index: -35.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9604
    Cell Significance Index: -14.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0006
    Cell Significance Index: -37.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0161
    Cell Significance Index: -29.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0282
    Cell Significance Index: -51.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0302
    Cell Significance Index: -36.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0547
    Cell Significance Index: -36.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0986
    Cell Significance Index: -28.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1134
    Cell Significance Index: -35.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MECOM is a member of the ETS family of transcription factors, which are characterized by their DNA-binding capabilities and ability to regulate gene expression through the recruitment of co-factors and chromatin-modifying enzymes. The MECOM protein exhibits a unique structure, comprising an N-terminal domain with a basic helix-loop-helix (bHLH) motif, a central domain with a transcriptional repressor activity, and a C-terminal domain with a proline-rich sequence. This complex structure allows MECOM to interact with various proteins and regulate gene expression through multiple mechanisms. **Pathways and Functions** MECOM is involved in several key cellular pathways, including: 1. **Apoptotic Process**: MECOM regulates the expression of anti-apoptotic genes, promoting cell survival and preventing premature apoptosis. 2. **Chromatin Organization**: MECOM interacts with chromatin-modifying enzymes, such as histone deacetylases and histone methyltransferases, to regulate chromatin structure and gene expression. 3. **Developmental Biology**: MECOM is essential for the development of epithelial tissues, including the kidney, lung, and prostate, where it regulates the expression of developmental genes. 4. **Hematopoietic Stem Cell Proliferation**: MECOM promotes the proliferation of hematopoietic stem cells by regulating the expression of genes involved in cell cycle progression and differentiation. 5. **Intracellular Signaling**: MECOM interacts with signaling pathways, such as the PI3K/AKT pathway, to regulate cellular responses to external stimuli. **Clinical Significance** Dysregulation of MECOM has been implicated in various diseases, including: 1. **Acute Myeloid Leukemia (AML)**: Mutations in MECOM have been identified in AML patients, suggesting its role in leukemogenesis. 2. **Chronic Myeloid Leukemia (CML)**: MECOM has been shown to be a target of the BCR-ABL oncogene, leading to its dysregulation in CML. 3. **Prostate Cancer**: MECOM has been identified as a tumor suppressor gene in prostate cancer, with its expression being reduced in prostate cancer cells. 4. **Kidney Disease**: MECOM has been implicated in the pathogenesis of kidney disease, including diabetic nephropathy and chronic kidney disease. In conclusion, MECOM is a critical regulator of hematopoiesis, development, and cell cycle progression, with its dysregulation contributing to various diseases. Further studies are needed to fully elucidate the mechanisms by which MECOM regulates gene expression and to explore its therapeutic potential in the treatment of diseases associated with its dysregulation.

Genular Protein ID: 1097495277

Symbol: MECOM_HUMAN

Name: Ecotropic virus integration site 1 protein homolog

UniProtKB Accession Codes:

Q03112 A1L4F3 A8KA00 B7Z8W7 B7ZLQ3 B7ZLQ4 C9JAK0 D3DNP7 E7EQ57 Q13465 Q13466 Q16122 Q5HYI1 Q6FH90 Q6MZS6 Q8NEI5 Q99917

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 26 Ensembl 6 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 Reactome 3 RefSeq 15 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2115646

Title: Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts.

PubMed ID: 2115646

PubMed ID: 8643684

Title: Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.

PubMed ID: 8643684

DOI: 10.1073/pnas.93.4.1642

PubMed ID: 11050005

Title: A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells.

PubMed ID: 11050005

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8313895

Title: Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

PubMed ID: 8313895

DOI: 10.1002/j.1460-2075.1994.tb06288.x

PubMed ID: 8700545

Title: Structurally altered Evi-1 protein generated in the 3q21q26 syndrome.

PubMed ID: 8700545

PubMed ID: 9665135

Title: The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3.

PubMed ID: 9665135

DOI: 10.1038/27945

PubMed ID: 10856240

Title: The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death.

PubMed ID: 10856240

DOI: 10.1093/emboj/19.12.2958

PubMed ID: 11568182

Title: Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.

PubMed ID: 11568182

DOI: 10.1074/jbc.m106733200

PubMed ID: 15897867

Title: Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP.

PubMed ID: 15897867

DOI: 10.1038/sj.onc.1208754

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16462766

Title: Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT.

PubMed ID: 16462766

DOI: 10.1038/sj.onc.1209403

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19767769

Title: Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells.

PubMed ID: 19767769

DOI: 10.1038/onc.2009.288

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22939622

Title: Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

PubMed ID: 22939622

DOI: 10.1016/j.cell.2012.06.048

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26581901

Title: Mutations in MECOM, encoding oncoprotein EVI1, cause radioulnar synostosis with amegakaryocytic thrombocytopenia.

PubMed ID: 26581901

DOI: 10.1016/j.ajhg.2015.10.010

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1230
  • Mass: 138136
  • Checksum: 49E9B7CBCD422042
  • Sequence:
    • MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE 
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP 
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA 
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS 
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF 
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS 
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL 
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT 
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD 
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD 
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND 
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL 
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR 
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL 
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL 
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR 
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED 
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE 
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH 
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL 
HSTSHSSSNV WHSMARAAAE SSAIQSISHV

Genular Protein ID: 3115095008

Symbol: C7FEN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

C7FEN9

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 1051
  • Mass: 118335
  • Checksum: 3270955E25D99D51
  • Sequence:
    • MKSEDYPHET MAPDIHEERQ YRCEDCDQLF ESKAELADHQ KFPCSTPHSA FSMVEEDFQQ 
KLESENDLQE IHTIQECKEC DQVFPDLQSL EKHMLSHTEE REYKCDQCPK AFNWKSNLIR 
HQMSHDSGKH YECENCAKVF TDPSNLQRHI RSQHVGARAH ACPECGKTFA TSSGLKQHKH 
IHSSVKPFIC EVCHKSYTQF SNLCRHKRMH ADCRTQIKCK DCGQMFSTTS SLNKHRRFCE 
GKNHFAAGGF FGQGISLPGT PAMDKTSMVN MSHANPGLAD YFGANRHPAG LTFPTAPGFS 
FSVPGLFPSG LYHRPPLIPA SSPVKGLSST EQTNKSQSPL MTHPQILPAT QDILKALSKH 
PSVGDNKPVE LQPERSSEER PFEKISDQSE SSDLDDVSTP SGSDLETTSG SDLESDIESD 
KEKFKENGKM FKDKVSPLQN LASINNKKEY SNHSIFSPSL EEQTAVSGAV NDSIKAIASI 
AEKYFGSTGL VGLQDKKVGA LPYPSMFPLP FFPAFSQSMY PFPDRDLRSL PLKMEPQSPG 
EVKKLQKGSS ESPFDLTTKR KDEKPLTPVP SKPPVTPATS QDQPLDLSMG SRSRASGTKL 
TEPRKNHVFG GKKGSNVESR PASDGSLQHA RPTPFFMDPI YRVEKRKLTD PLEALKEKYL 
RPSPGFLFHP QFQLPDQRTW MSAIENMAEK LESFSALKPE ASELLQSVPS MFNFRAPPNA 
LPENLLRKGK ERYTCRYCGK IFPRSANLTR HLRTHTGEQP YRCKYCDRSF SISSNLQRHV 
RNIHNKEKPF KCHLCYRCFG QQTNLDRHLK KHENGNMSGT ATSSPHSELE STGAILDDKE 
DAYFTEIRNF IGNSNHGSQS PRNVEERMNG SHFKEEKALV PSQNSDLLDD EEVEDEVLLD 
EEDEDYDITG KTGKEPVTSN LHEGNPEDDY EETSALEMSC KTSPVRYKEE EYKSGLSALD 
HIRHFTDSLK MRKMEDNQYS EAELSSFSTS HVPEELKQPL HRKSKSQAYA MMLSLSDKES 
LHSTSHSSSN VWHSMARAAA ESSAIQSISH V

Genular Protein ID: 2796166744

Symbol: A0A0C3SFZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C3SFZ7

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1052
  • Mass: 118404
  • Checksum: EBD71A48C4BE480F
  • Sequence:
    • MKSEDYPHET MAPDIHEERQ YRCEDCDQLF ESKAELADHQ KFPCSTPHSA FSMVEEDFQQ 
KLESENDLQE IHTIQECKEC DQVFPDLQSL EKHMLSHTEE REYKCDQCPK AFNWKSNLIR 
HQMSHDSGKH YECENCAKQV FTDPSNLQRH IRSQHVGARA HACPECGKTF ATSSGLKQHK 
HIHSSVKPFI CEVCHKSYTQ FSNLCRHKRM HADCRTQIKC KDCGQMFSTT SSLNKHRRFC 
EGKNHFAAGG FFGQGISLPG TPAMDKTSMV NMSHANPGLA DYFGANRHPA GLTFPTAPGF 
SFSFPGLFPS GLYHRPPLIP ASSPVKGLSS TEQTNKSQSP LMTHPQILPA TQDILKALSK 
HPSVGDNKPV ELQPERSSEE RPFEKISDQS ESSDLDDVST PSGSDLETTS GSDLESDIES 
DKEKFKENGK MFKDKVSPLQ NLASINNKKE YSNHSIFSPS LEEQTAVSGA VNDSIKAIAS 
IAEKYFGSTG LVGLQDKKVG ALPYPSMFPL PFFPAFSQSM YPFPDRDLRS LPLKMEPQSP 
GEVKKLQKGS SESPFDLTTK RKDEKPLTPV PSKPPVTPAT SQDQPLDLSM GSRSRASGTK 
LTEPRKNHVF GGKKGSNVES RPASDGSLQH ARPTPFFMDP IYRVEKRKLT DPLEALKEKY 
LRPSPGFLFH PQFQLPDQRT WMSAIENMAE KLESFSALKP EASELLQSVP SMFNFRAPPN 
ALPENLLRKG KERYTCRYCG KIFPRSANLT RHLRTHTGEQ PYRCKYCDRS FSISSNLQRH 
VRNIHNKEKP FKCHLCDRCF GQQTNLDRHL KKHENGNMSG TATSSPHSEL ESTGAILDDK 
EDAYFTEIRN FIGNSNHGSQ SPRNVEERMN GSHFKDEKAL VTSQNSDLLD DEEVEDEVLL 
DEEDEDNDIT GKTGKEPVTS NLHEGNPEDD YEETSALEMS CKTSPVRYKE EEYKSGLSAL 
DHIRHFTDSL KMRKMEDNQY SEAELSSFST SHVPEELKQP LHRKSKSQAY AMMLSLSDKE 
SLHSTSHSSS NVWHSMARAA AESSAIQSIS HV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.