Details for: MECOM

Gene ID: 2122

Symbol: MECOM

Ensembl ID: ENSG00000085276

Description: MDS1 and EVI1 complex locus

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 7.91
    Marker Score: 32,979
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 7.69
    Marker Score: 6,646
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 6.06
    Marker Score: 5,373
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.47
    Marker Score: 16,225
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 5.44
    Marker Score: 3,778
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.95
    Marker Score: 3,041
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.92
    Marker Score: 4,446
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.56
    Marker Score: 30,140
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.52
    Marker Score: 1,856
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 3.44
    Marker Score: 990
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.29
    Marker Score: 961
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.22
    Marker Score: 51,655
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 3.08
    Marker Score: 1,839
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.94
    Marker Score: 2,983
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.89
    Marker Score: 7,733
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.82
    Marker Score: 2,688
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.79
    Marker Score: 1,557
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.69
    Marker Score: 5,171
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.58
    Marker Score: 6,508
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.54
    Marker Score: 1,433
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.44
    Marker Score: 15,890
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.4
    Marker Score: 3,492
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.35
    Marker Score: 2,497
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.35
    Marker Score: 622
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.32
    Marker Score: 9,697
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.24
    Marker Score: 707
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 2.02
    Marker Score: 641
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.99
    Marker Score: 2,938
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.93
    Marker Score: 1,292
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.89
    Marker Score: 2,038
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.87
    Marker Score: 4,251
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.86
    Marker Score: 1,026
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.83
    Marker Score: 6,498
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.81
    Marker Score: 1,702
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.79
    Marker Score: 361
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.77
    Marker Score: 415
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.74
    Marker Score: 3,183
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.73
    Marker Score: 2,442
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.66
    Marker Score: 1,174
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.66
    Marker Score: 1,942
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.64
    Marker Score: 685
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.63
    Marker Score: 592
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.63
    Marker Score: 1,302
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.6
    Marker Score: 502
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.58
    Marker Score: 3,206
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.58
    Marker Score: 54,595
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.51
    Marker Score: 1,298
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.46
    Marker Score: 711
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.46
    Marker Score: 5,020
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.46
    Marker Score: 1,757
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,749
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.41
    Marker Score: 2,341
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.41
    Marker Score: 8,990
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.41
    Marker Score: 7,397
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.38
    Marker Score: 10,247
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.34
    Marker Score: 386
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.32
    Marker Score: 794
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.28
    Marker Score: 3,042
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.28
    Marker Score: 1,143
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.27
    Marker Score: 867
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.25
    Marker Score: 397
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.24
    Marker Score: 1,972
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.24
    Marker Score: 10,734
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.21
    Marker Score: 596
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.2
    Marker Score: 2,276
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.19
    Marker Score: 2,522
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.17
    Marker Score: 1,166
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.15
    Marker Score: 535
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.14
    Marker Score: 540
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.14
    Marker Score: 223
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.14
    Marker Score: 420
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.13
    Marker Score: 298
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17,596
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.12
    Marker Score: 2,244
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.12
    Marker Score: 269
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.12
    Marker Score: 1,391
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1
    Marker Score: 9,676
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.1
    Marker Score: 1,769
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.09
    Marker Score: 6,571
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.06
    Marker Score: 485
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,730
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.03
    Marker Score: 933
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.03
    Marker Score: 388
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.02
    Marker Score: 423
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.01
    Marker Score: 1,310
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.01
    Marker Score: 2,379
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1
    Marker Score: 555
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1
    Marker Score: 1,202
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,752
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,975
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.97
    Marker Score: 248
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1,543
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.94
    Marker Score: 245
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,305
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.93
    Marker Score: 977
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,732

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MECOM is a member of the ETS family of transcription factors, which are characterized by their DNA-binding capabilities and ability to regulate gene expression through the recruitment of co-factors and chromatin-modifying enzymes. The MECOM protein exhibits a unique structure, comprising an N-terminal domain with a basic helix-loop-helix (bHLH) motif, a central domain with a transcriptional repressor activity, and a C-terminal domain with a proline-rich sequence. This complex structure allows MECOM to interact with various proteins and regulate gene expression through multiple mechanisms. **Pathways and Functions** MECOM is involved in several key cellular pathways, including: 1. **Apoptotic Process**: MECOM regulates the expression of anti-apoptotic genes, promoting cell survival and preventing premature apoptosis. 2. **Chromatin Organization**: MECOM interacts with chromatin-modifying enzymes, such as histone deacetylases and histone methyltransferases, to regulate chromatin structure and gene expression. 3. **Developmental Biology**: MECOM is essential for the development of epithelial tissues, including the kidney, lung, and prostate, where it regulates the expression of developmental genes. 4. **Hematopoietic Stem Cell Proliferation**: MECOM promotes the proliferation of hematopoietic stem cells by regulating the expression of genes involved in cell cycle progression and differentiation. 5. **Intracellular Signaling**: MECOM interacts with signaling pathways, such as the PI3K/AKT pathway, to regulate cellular responses to external stimuli. **Clinical Significance** Dysregulation of MECOM has been implicated in various diseases, including: 1. **Acute Myeloid Leukemia (AML)**: Mutations in MECOM have been identified in AML patients, suggesting its role in leukemogenesis. 2. **Chronic Myeloid Leukemia (CML)**: MECOM has been shown to be a target of the BCR-ABL oncogene, leading to its dysregulation in CML. 3. **Prostate Cancer**: MECOM has been identified as a tumor suppressor gene in prostate cancer, with its expression being reduced in prostate cancer cells. 4. **Kidney Disease**: MECOM has been implicated in the pathogenesis of kidney disease, including diabetic nephropathy and chronic kidney disease. In conclusion, MECOM is a critical regulator of hematopoiesis, development, and cell cycle progression, with its dysregulation contributing to various diseases. Further studies are needed to fully elucidate the mechanisms by which MECOM regulates gene expression and to explore its therapeutic potential in the treatment of diseases associated with its dysregulation.

Genular Protein ID: 1097495277

Symbol: MECOM_HUMAN

Name: Ecotropic virus integration site 1 protein homolog

UniProtKB Accession Codes:

Q03112 A1L4F3 A8KA00 B7Z8W7 B7ZLQ3 B7ZLQ4 C9JAK0 D3DNP7 E7EQ57 Q13465 Q13466 Q16122 Q5HYI1 Q6FH90 Q6MZS6 Q8NEI5 Q99917

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 26 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 Reactome 2 RefSeq 15 Rhea 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2115646

Title: Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts.

PubMed ID: 2115646

PubMed ID: 8643684

Title: Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.

PubMed ID: 8643684

DOI: 10.1073/pnas.93.4.1642

PubMed ID: 11050005

Title: A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells.

PubMed ID: 11050005

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8313895

Title: Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

PubMed ID: 8313895

DOI: 10.1002/j.1460-2075.1994.tb06288.x

PubMed ID: 8700545

Title: Structurally altered Evi-1 protein generated in the 3q21q26 syndrome.

PubMed ID: 8700545

PubMed ID: 9665135

Title: The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3.

PubMed ID: 9665135

DOI: 10.1038/27945

PubMed ID: 10856240

Title: The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death.

PubMed ID: 10856240

DOI: 10.1093/emboj/19.12.2958

PubMed ID: 11568182

Title: Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.

PubMed ID: 11568182

DOI: 10.1074/jbc.m106733200

PubMed ID: 15897867

Title: Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP.

PubMed ID: 15897867

DOI: 10.1038/sj.onc.1208754

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16462766

Title: Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT.

PubMed ID: 16462766

DOI: 10.1038/sj.onc.1209403

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19767769

Title: Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells.

PubMed ID: 19767769

DOI: 10.1038/onc.2009.288

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22939622

Title: Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

PubMed ID: 22939622

DOI: 10.1016/j.cell.2012.06.048

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26581901

Title: Mutations in MECOM, encoding oncoprotein EVI1, cause radioulnar synostosis with amegakaryocytic thrombocytopenia.

PubMed ID: 26581901

DOI: 10.1016/j.ajhg.2015.10.010

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1230
  • Mass: 138136
  • Checksum: 49E9B7CBCD422042
  • Sequence:
    • MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE 
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP 
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA 
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS 
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF 
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS 
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL 
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT 
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD 
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD 
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND 
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL 
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR 
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL 
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL 
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR 
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED 
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE 
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH 
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL 
HSTSHSSSNV WHSMARAAAE SSAIQSISHV

Genular Protein ID: 2796166744

Symbol: A0A0C3SFZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C3SFZ7

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 3 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 2 Proteomes 2 RefSeq 3 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1052
  • Mass: 118404
  • Checksum: EBD71A48C4BE480F
  • Sequence:
    • MKSEDYPHET MAPDIHEERQ YRCEDCDQLF ESKAELADHQ KFPCSTPHSA FSMVEEDFQQ 
KLESENDLQE IHTIQECKEC DQVFPDLQSL EKHMLSHTEE REYKCDQCPK AFNWKSNLIR 
HQMSHDSGKH YECENCAKQV FTDPSNLQRH IRSQHVGARA HACPECGKTF ATSSGLKQHK 
HIHSSVKPFI CEVCHKSYTQ FSNLCRHKRM HADCRTQIKC KDCGQMFSTT SSLNKHRRFC 
EGKNHFAAGG FFGQGISLPG TPAMDKTSMV NMSHANPGLA DYFGANRHPA GLTFPTAPGF 
SFSFPGLFPS GLYHRPPLIP ASSPVKGLSS TEQTNKSQSP LMTHPQILPA TQDILKALSK 
HPSVGDNKPV ELQPERSSEE RPFEKISDQS ESSDLDDVST PSGSDLETTS GSDLESDIES 
DKEKFKENGK MFKDKVSPLQ NLASINNKKE YSNHSIFSPS LEEQTAVSGA VNDSIKAIAS 
IAEKYFGSTG LVGLQDKKVG ALPYPSMFPL PFFPAFSQSM YPFPDRDLRS LPLKMEPQSP 
GEVKKLQKGS SESPFDLTTK RKDEKPLTPV PSKPPVTPAT SQDQPLDLSM GSRSRASGTK 
LTEPRKNHVF GGKKGSNVES RPASDGSLQH ARPTPFFMDP IYRVEKRKLT DPLEALKEKY 
LRPSPGFLFH PQFQLPDQRT WMSAIENMAE KLESFSALKP EASELLQSVP SMFNFRAPPN 
ALPENLLRKG KERYTCRYCG KIFPRSANLT RHLRTHTGEQ PYRCKYCDRS FSISSNLQRH 
VRNIHNKEKP FKCHLCDRCF GQQTNLDRHL KKHENGNMSG TATSSPHSEL ESTGAILDDK 
EDAYFTEIRN FIGNSNHGSQ SPRNVEERMN GSHFKDEKAL VTSQNSDLLD DEEVEDEVLL 
DEEDEDNDIT GKTGKEPVTS NLHEGNPEDD YEETSALEMS CKTSPVRYKE EEYKSGLSAL 
DHIRHFTDSL KMRKMEDNQY SEAELSSFST SHVPEELKQP LHRKSKSQAY AMMLSLSDKE 
SLHSTSHSSS NVWHSMARAA AESSAIQSIS HV

Genular Protein ID: 3115095008

Symbol: C7FEN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

C7FEN9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 1051
  • Mass: 118335
  • Checksum: 3270955E25D99D51
  • Sequence:
    • MKSEDYPHET MAPDIHEERQ YRCEDCDQLF ESKAELADHQ KFPCSTPHSA FSMVEEDFQQ 
KLESENDLQE IHTIQECKEC DQVFPDLQSL EKHMLSHTEE REYKCDQCPK AFNWKSNLIR 
HQMSHDSGKH YECENCAKVF TDPSNLQRHI RSQHVGARAH ACPECGKTFA TSSGLKQHKH 
IHSSVKPFIC EVCHKSYTQF SNLCRHKRMH ADCRTQIKCK DCGQMFSTTS SLNKHRRFCE 
GKNHFAAGGF FGQGISLPGT PAMDKTSMVN MSHANPGLAD YFGANRHPAG LTFPTAPGFS 
FSVPGLFPSG LYHRPPLIPA SSPVKGLSST EQTNKSQSPL MTHPQILPAT QDILKALSKH 
PSVGDNKPVE LQPERSSEER PFEKISDQSE SSDLDDVSTP SGSDLETTSG SDLESDIESD 
KEKFKENGKM FKDKVSPLQN LASINNKKEY SNHSIFSPSL EEQTAVSGAV NDSIKAIASI 
AEKYFGSTGL VGLQDKKVGA LPYPSMFPLP FFPAFSQSMY PFPDRDLRSL PLKMEPQSPG 
EVKKLQKGSS ESPFDLTTKR KDEKPLTPVP SKPPVTPATS QDQPLDLSMG SRSRASGTKL 
TEPRKNHVFG GKKGSNVESR PASDGSLQHA RPTPFFMDPI YRVEKRKLTD PLEALKEKYL 
RPSPGFLFHP QFQLPDQRTW MSAIENMAEK LESFSALKPE ASELLQSVPS MFNFRAPPNA 
LPENLLRKGK ERYTCRYCGK IFPRSANLTR HLRTHTGEQP YRCKYCDRSF SISSNLQRHV 
RNIHNKEKPF KCHLCYRCFG QQTNLDRHLK KHENGNMSGT ATSSPHSELE STGAILDDKE 
DAYFTEIRNF IGNSNHGSQS PRNVEERMNG SHFKEEKALV PSQNSDLLDD EEVEDEVLLD 
EEDEDYDITG KTGKEPVTSN LHEGNPEDDY EETSALEMSC KTSPVRYKEE EYKSGLSALD 
HIRHFTDSLK MRKMEDNQYS EAELSSFSTS HVPEELKQPL HRKSKSQAYA MMLSLSDKES 
LHSTSHSSSN VWHSMARAAA ESSAIQSISH V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.