IER3 | ENSG00000137331 | NCBI 8870

Details for: IER3

Gene ID: 8870

Symbol: IER3

Ensembl ID: ENSG00000137331

Description: immediate early response 3

Associated with

Intracellular signaling by second messengers
(R-HSA-9006925)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Signal transduction
(R-HSA-162582)
Anatomical structure morphogenesis
(GO:0009653)
Apoptotic process
(GO:0006915)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Glycolytic process
(GO:0006096)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of glycolytic process
(GO:0045820)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Nucleus
(GO:0005634)
Positive regulation of protein catabolic process
(GO:0045732)
Protein binding
(GO:0005515)
Regulation of dna repair
(GO:0006282)
Regulation of nucleocytoplasmic transport
(GO:0046822)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Response to protozoan
(GO:0001562)

Other Information

Proteins

Radiation-inducible immediate-early gene IEX-1

Genular Protein ID: 4117920558

Symbol: IEX1_HUMAN

Name: Radiation-inducible immediate-early gene IEX-1

UniProtKB Accession Codes:

P46695 Q5SU30 Q92691 Q93044

Database IDs:

Citations:

PubMed ID: 8603392

Title: Identification and characterization of a radiation-inducible glycosylated human early-response gene.

PubMed ID: 8603392

PubMed ID: 8653710

Title: PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line.

PubMed ID: 8653710

PubMed ID: 9196025

Title: Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine.

PubMed ID: 9196025

DOI: 10.1006/bbrc.1997.6715

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12356731

Title: IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.

PubMed ID: 12356731

DOI: 10.1093/emboj/cdf488

PubMed ID: 16456541

Title: B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.

PubMed ID: 16456541

DOI: 10.1038/sj.emboj.7600980

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22565310

Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

PubMed ID: 22565310

DOI: 10.1172/jci60144

Sequence Information:

Length: 156
Mass: 16903
Checksum: 83C06116C81B8341
Sequence:

MCHSRSCHPT MTILQAPTPA PSTIPGPRRG SGPEIFTFDP LPEPAAAPAG RPSASRGHRK 
RSRRVLYPRV VRRQLPVEEP NPAKRLLFLL LTIVFCQILM AEEGVPAPLP PEDAPNAASL 
APTPVSAVLE PFNLTSEPSD YALDLSTFLQ QHPAAF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IER3

Associated with

Other Information

Identification and characterization of a radiation-inducible glycosylated human early-response gene. PubMed ID: 8603392

PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. PubMed ID: 8653710

Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. PubMed ID: 9196025

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. PubMed ID: 12356731

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. PubMed ID: 16456541

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. PubMed ID: 22565310