IER3 | ENSG00000137331 | NCBI 8870

Details for: IER3

Gene ID: 8870

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: IER3

Ensembl ID: ENSG00000137331

Description: immediate early response 3

Cell Significance Landscape

Display Count:

Associated with

Intracellular signaling by second messengers
(R-HSA-9006925)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Signal transduction
(R-HSA-162582)
Anatomical structure morphogenesis
(GO:0009653)
Apoptotic process
(GO:0006915)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Glycolytic process
(GO:0006096)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of glycolytic process
(GO:0045820)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Nucleus
(GO:0005634)
Positive regulation of protein catabolic process
(GO:0045732)
Protein binding
(GO:0005515)
Regulation of dna repair
(GO:0006282)
Regulation of nucleocytoplasmic transport
(GO:0046822)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Response to protozoan
(GO:0001562)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

activated CD4-positive, alpha-beta T cell CL0000896

CSI 45.98

rCSI 42.51%

PRS 85.14
keratinocyte CL0000312

CSI 41.32

rCSI 34.64%

PRS 70.55
luminal epithelial cell of mammary gland CL0002326

CSI 37.85

rCSI 68.77%

PRS 80.73
activated CD8-positive, alpha-beta T cell CL0000906

CSI 35.16

rCSI 34.56%

PRS 85.76
cerebral cortex endothelial cell CL1001602

CSI 34.87

rCSI 60.31%

PRS 57.11
mucous neck cell CL0000651

CSI 34.41

rCSI 49.59%

PRS 76.47
skin fibroblast CL0002620

CSI 33

rCSI 28.45%

PRS 71.04
perivascular cell CL4033054

CSI 32.88

rCSI 44.95%

PRS 72.54
Hofbauer cell CL3000001

CSI 32.5

rCSI 61.36%

PRS 76.96
respiratory basal cell CL0002633

CSI 30.45

rCSI 31.55%

PRS 72.59
pancreatic ductal cell CL0002079

CSI 29.74

rCSI 57.83%

PRS 69.83
fallopian tube secretory epithelial cell CL4030006

CSI 28.87

rCSI 27.79%

PRS 66.45
respiratory suprabasal cell CL4033048

CSI 24.54

rCSI 31.48%

PRS 71.21
stem cell CL0000034

CSI 24.18

rCSI 23.31%

PRS 58.01
colon epithelial cell CL0011108

CSI 23.91

rCSI 25.05%

PRS 63.42
goblet cell CL0000160

CSI 23.79

rCSI 22.48%

PRS 65.85
basal cell of prostate epithelium CL0002341

CSI 23.17

rCSI 67.04%

PRS 77.27
pancreatic acinar cell CL0002064

CSI 22.36

rCSI 29.73%

PRS 73.12
glandular epithelial cell CL0000150

CSI 22.28

rCSI 58.65%

PRS 83.25
conjunctival epithelial cell CL1000432

CSI 20.39

rCSI 31.15%

PRS 67.59
secretory cell CL0000151

CSI 19.54

rCSI 20.39%

PRS 66.81
intermediate monocyte CL0002393

CSI 19.39

rCSI 29.26%

PRS 71.65
macrophage CL0000235

CSI 18.63

rCSI 33.9%

PRS 81.05
mammary gland epithelial cell CL0002327

CSI 17.64

rCSI 61.9%

PRS 78.22
bronchus fibroblast of lung CL2000093

CSI 17.58

rCSI 14.29%

PRS 67.16
myeloid leukocyte CL0000766

CSI 17.17

rCSI 15.84%

PRS 68.54
hepatic stellate cell CL0000632

CSI 17.01

rCSI 63.72%

PRS 58.69
chondrocyte CL0000138

CSI 16.46

rCSI 26.18%

PRS 59.43
intrahepatic cholangiocyte CL0002538

CSI 16.46

rCSI 39.5%

PRS 75.32
enteric smooth muscle cell CL0002504

CSI 16.08

rCSI 22.95%

PRS 68.73
myeloid dendritic cell CL0000782

CSI 15.25

rCSI 22.09%

PRS 82.13
double negative thymocyte CL0002489

CSI 15.17

rCSI 10.55%

PRS 78.24
foveolar cell of stomach CL0002179

CSI 15.02

rCSI 31.96%

PRS 76.44
tissue-resident macrophage CL0000864

CSI 14.55

rCSI 68.09%

PRS 81.67
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 13.95

rCSI 16.91%

PRS 51.8
mature T cell CL0002419

CSI 13.91

rCSI 10.82%

PRS 83.74
keratocyte CL0002363

CSI 13.8

rCSI 33.19%

PRS 73.54
type B pancreatic cell CL0000169

CSI 13.62

rCSI 30.15%

PRS 65.09
dendritic cell CL0000451

CSI 13.6

rCSI 16.76%

PRS 77.78
basal-myoepithelial cell of mammary gland CL0002324

CSI 13.52

rCSI 25.56%

PRS 83.21
epithelial cell CL0000066

CSI 13

rCSI 19.97%

PRS 60.55
fibroblast of lung CL0002553

CSI 12.54

rCSI 11.67%

PRS 67.51
dendritic cell, human CL0001056

CSI 12.53

rCSI 19.25%

PRS 76.05
syncytiotrophoblast cell CL0000525

CSI 12.49

rCSI 35.97%

PRS 78.38
CD8-positive, alpha-beta memory T cell CL0000909

CSI 12.35

rCSI 12.9%

PRS 86.2
melanocyte CL0000148

CSI 12.22

rCSI 9.05%

PRS 59.65
colon macrophage CL0009038

CSI 12.21

rCSI 56.4%

PRS 83.77
intestine goblet cell CL0019031

CSI 12.2

rCSI 10.83%

PRS 64.48
precursor B cell CL0000817

CSI 12.15

rCSI 10.64%

PRS 75.77
retinal pigment epithelial cell CL0002586

CSI 12.11

rCSI 24.04%

PRS 63.81
adventitial cell CL0002503

CSI 11.98

rCSI 28.61%

PRS 74.59
midzonal region hepatocyte CL0019028

CSI 11.82

rCSI 27.74%

PRS 70.11
monocyte CL0000576

CSI 11.71

rCSI 21.17%

PRS 78.46
myofibroblast cell CL0000186

CSI 11.61

rCSI 16.07%

PRS 66.78
CD14-positive monocyte CL0001054

CSI 11.53

rCSI 14.36%

PRS 77.41
CD14-positive, CD16-positive monocyte CL0002397

CSI 11.39

rCSI 14.93%

PRS 79.81
epithelial cell of proximal tubule CL0002306

CSI 11.37

rCSI 27.78%

PRS 59.77
ciliated epithelial cell CL0000067

CSI 11.3

rCSI 9.94%

PRS 54.7
brush cell CL0002204

CSI 11.24

rCSI 22.26%

PRS 80.88
placental villous trophoblast CL2000060

CSI 11.14

rCSI 17.22%

PRS 65.29
alternatively activated macrophage CL0000890

CSI 10.91

rCSI 13.71%

PRS 78.24
Langerhans cell CL0000453

CSI 10.77

rCSI 16.44%

PRS 81.45
endothelial cell of artery CL1000413

CSI 10.67

rCSI 15.63%

PRS 81.27
renal alpha-intercalated cell CL0005011

CSI 10.64

rCSI 14.23%

PRS 75.29
retinal blood vessel endothelial cell CL0002585

CSI 10.31

rCSI 16.47%

PRS 71.06
mesenchymal cell CL0008019

CSI 10.15

rCSI 25.77%

PRS 60.63
cardiac muscle cell CL0000746

CSI 9.92

rCSI 14.23%

PRS 56.37
Kupffer cell CL0000091

CSI 9.87

rCSI 22.57%

PRS 67.08
blood vessel endothelial cell CL0000071

CSI 9.85

rCSI 20.44%

PRS 63.8
inflammatory macrophage CL0000863

CSI 9.76

rCSI 16.68%

PRS 87.4
periportal region hepatocyte CL0019026

CSI 9.73

rCSI 37.85%

PRS 70.03
endothelial cell of lymphatic vessel CL0002138

CSI 9.31

rCSI 18.46%

PRS 78.51
basal cell CL0000646

CSI 8.99

rCSI 12.02%

PRS 66.72
M cell of gut CL0000682

CSI 8.91

rCSI 9.46%

PRS 75.29
multi-ciliated epithelial cell CL0005012

CSI 8.75

rCSI 8.73%

PRS 60.3
microglial cell CL0000129

CSI 8.69

rCSI 34.98%

PRS 70.15
fibroblast of breast CL4006000

CSI 8.61

rCSI 36.2%

PRS 77.58
group 3 innate lymphoid cell CL0001071

CSI 8.48

rCSI 6.37%

PRS 72.6
conventional dendritic cell CL0000990

CSI 8.4

rCSI 7.01%

PRS 74.5
enteroglial cell CL4040002

CSI 8.35

rCSI 43.9%

PRS 71.32
pancreatic A cell CL0000171

CSI 8.29

rCSI 8.69%

PRS 70.41
renal principal cell CL0005009

CSI 8.19

rCSI 21.27%

PRS 69.76
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 8.14

rCSI 49.26%

PRS 83.54
deuterosomal cell CL4033044

CSI 8.13

rCSI 27.5%

PRS 68.97
mononuclear phagocyte CL0000113

CSI 8.09

rCSI 17.81%

PRS 70.84
lung interstitial macrophage CL4033043

CSI 8.09

rCSI 18.15%

PRS 82.69
granulocyte CL0000094

CSI 8.01

rCSI 12.23%

PRS 75.88
pro-B cell CL0000826

CSI 8

rCSI 6.62%

PRS 69.32
lung endothelial cell CL1001567

CSI 7.89

rCSI 18.39%

PRS 83.23
pulmonary capillary endothelial cell CL4028001

CSI 7.87

rCSI 15.02%

PRS 80.51
vein endothelial cell of respiratory system CL4033008

CSI 7.83

rCSI 53.73%

PRS 78.4
mast cell CL0000097

CSI 7.78

rCSI 16.79%

PRS 81.14
megakaryocyte-erythroid progenitor cell CL0000050

CSI 7.66

rCSI 6.91%

PRS 63.98
nasal mucosa goblet cell CL0002480

CSI 7.6

rCSI 8.81%

PRS 73.66
double-positive, alpha-beta thymocyte CL0000809

CSI 7.52

rCSI 7.67%

PRS 78.71
squamous epithelial cell CL0000076

CSI 7.5

rCSI 17.8%

PRS 69.75
pancreatic stellate cell CL0002410

CSI 7.46

rCSI 43.41%

PRS 74.5
CD14-low, CD16-positive monocyte CL0002396

CSI 7.33

rCSI 5.65%

PRS 68.02
kidney collecting duct principal cell CL1001431

CSI 7.19

rCSI 36.17%

PRS 66.27
early lymphoid progenitor CL0000936

CSI 6.96

rCSI 6.11%

PRS 72.3

mesenchymal stem cell CL0000134

CSI 0.2

rCSI 2.2%

PRS 77.6%
epithelial cell of esophagus CL0002252

CSI 0.5

rCSI 4.5%

PRS 80.9%
macula densa epithelial cell CL1000850

CSI 0.5

rCSI 6.6%

PRS 78.7%
endothelial cell of venule CL1000414

CSI 0.5

rCSI 4.5%

PRS 81.1%
type EC enteroendocrine cell CL0000577

CSI 0.5

rCSI 1.9%

PRS 74.1%
transit amplifying cell of small intestine CL0009012

CSI 0.6

rCSI 2.4%

PRS 79.6%
myelocyte CL0002193

CSI 0.6

rCSI 3.8%

PRS 89.2%
respiratory epithelial cell CL0002368

CSI 0.6

rCSI 3.7%

PRS 90.2%
skeletal muscle satellite stem cell CL0008011

CSI 0.6

rCSI 2.7%

PRS 81.3%
kidney interstitial cell CL1000500

CSI 0.7

rCSI 10.6%

PRS 76.2%
intestinal crypt stem cell of colon CL0009043

CSI 0.8

rCSI 5.8%

PRS 80.9%
eosinophil CL0000771

CSI 0.8

rCSI 5.2%

PRS 90.5%
basal cell of epidermis CL0002187

CSI 0.8

rCSI 1.4%

PRS 39.1%
acinar cell of salivary gland CL0002623

CSI 0.9

rCSI 22.0%

PRS 83.5%
intestinal epithelial cell CL0002563

CSI 1.0

rCSI 1.0%

PRS 64.6%
enteroendocrine cell of colon CL0009042

CSI 1.1

rCSI 5.0%

PRS 81.6%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 1.2

rCSI 5.3%

PRS 90.3%
promyelocyte CL0000836

CSI 1.4

rCSI 2.0%

PRS 75.4%
endothelial cell of uterus CL0009095

CSI 1.4

rCSI 10.1%

PRS 81.3%
uterine smooth muscle cell CL0002601

CSI 1.5

rCSI 9.9%

PRS 82.2%
basal cell of epithelium of trachea CL1000348

CSI 1.5

rCSI 10.7%

PRS 78.6%
myeloid lineage restricted progenitor cell CL0000839

CSI 1.6

rCSI 8.1%

PRS 86.7%
BEST4+ enteroycte CL4030026

CSI 1.6

rCSI 2.0%

PRS 68.4%
kidney connecting tubule epithelial cell CL1000768

CSI 1.7

rCSI 4.3%

PRS 56.3%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.7

rCSI 17.8%

PRS 64.6%
smooth muscle cell of the pulmonary artery CL0002591

CSI 1.7

rCSI 13.1%

PRS 71.8%
enterocyte of epithelium of large intestine CL0002071

CSI 1.7

rCSI 9.0%

PRS 75.0%
cytotoxic T cell CL0000910

CSI 1.7

rCSI 9.8%

PRS 75.0%
pulmonary ionocyte CL0017000

CSI 1.8

rCSI 2.2%

PRS 74.3%
mucus secreting cell CL0000319

CSI 1.9

rCSI 3.0%

PRS 77.2%
paneth cell of colon CL0009009

CSI 2.0

rCSI 19.2%

PRS 81.3%
myeloid dendritic cell, human CL0001057

CSI 2.0

rCSI 11.3%

PRS 86.7%
endothelial cell of placenta CL0009092

CSI 2.0

rCSI 10.0%

PRS 77.4%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 2.0

rCSI 17.6%

PRS 63.3%
enteroendocrine cell of small intestine CL0009006

CSI 2.1

rCSI 4.5%

PRS 78.3%
metallothionein-positive alveolar macrophage CL4033042

CSI 2.2

rCSI 23.8%

PRS 84.0%
muscle cell CL0000187

CSI 2.2

rCSI 4.5%

PRS 82.9%
colonocyte CL1000347

CSI 2.2

rCSI 3.2%

PRS 69.5%
vasa recta ascending limb cell CL1001131

CSI 2.3

rCSI 10.3%

PRS 80.9%
airway submucosal gland duct basal cell CL4033024

CSI 2.3

rCSI 14.6%

PRS 75.6%
kidney epithelial cell CL0002518

CSI 2.3

rCSI 4.5%

PRS 84.8%
duct epithelial cell CL0000068

CSI 2.4

rCSI 3.4%

PRS 71.7%
odontoblast CL0000060

CSI 2.4

rCSI 53.7%

PRS 84.3%
paneth cell CL0000510

CSI 2.4

rCSI 3.6%

PRS 81.2%
corneal epithelial cell CL0000575

CSI 2.5

rCSI 7.0%

PRS 77.4%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 2.5

rCSI 3.0%

PRS 85.1%
IgG plasma cell CL0000985

CSI 2.5

rCSI 3.0%

PRS 82.0%
intestinal crypt stem cell of small intestine CL0009017

CSI 2.5

rCSI 6.8%

PRS 73.3%
myoepithelial cell CL0000185

CSI 2.6

rCSI 6.5%

PRS 74.2%
pancreatic epsilon cell CL0005019

CSI 2.6

rCSI 12.1%

PRS 81.2%
epithelial cell of urethra CL1000296

CSI 2.7

rCSI 67.9%

PRS 80.8%
lung pericyte CL0009089

CSI 2.7

rCSI 7.1%

PRS 75.4%
pulmonary alveolar type 1 cell CL0002062

CSI 2.9

rCSI 16.5%

PRS 64.8%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.9

rCSI 4.1%

PRS 63.1%
podocyte CL0000653

CSI 3.1

rCSI 13.6%

PRS 66.8%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 3.1

rCSI 17.5%

PRS 83.7%
T-helper 17 cell CL0000899

CSI 3.1

rCSI 2.5%

PRS 86.8%
interstitial cell of Cajal CL0002088

CSI 3.2

rCSI 4.0%

PRS 72.9%
prostate gland microvascular endothelial cell CL2000059

CSI 3.2

rCSI 75.7%

PRS 82.1%
colon goblet cell CL0009039

CSI 3.3

rCSI 7.7%

PRS 74.6%
paneth cell of epithelium of small intestine CL1000343

CSI 3.4

rCSI 9.5%

PRS 76.9%
centrilobular region hepatocyte CL0019029

CSI 3.5

rCSI 9.2%

PRS 69.0%
tracheal goblet cell CL1000329

CSI 3.6

rCSI 7.9%

PRS 78.4%
common myeloid progenitor CL0000049

CSI 3.8

rCSI 3.1%

PRS 68.7%
mesodermal cell CL0000222

CSI 3.9

rCSI 4.7%

PRS 64.9%
blood vessel smooth muscle cell CL0019018

CSI 3.9

rCSI 31.7%

PRS 60.2%
lung microvascular endothelial cell CL2000016

CSI 3.9

rCSI 75.5%

PRS 80.4%
microcirculation associated smooth muscle cell CL0008035

CSI 3.9

rCSI 11.3%

PRS 67.7%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 4.0

rCSI 11.4%

PRS 85.9%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 4.0

rCSI 10.3%

PRS 61.7%
hair follicular keratinocyte CL2000092

CSI 4.0

rCSI 69.3%

PRS 84.8%
transit amplifying cell CL0009010

CSI 4.1

rCSI 6.3%

PRS 78.9%
T-helper 1 cell CL0000545

CSI 4.2

rCSI 7.6%

PRS 86.7%
stromal cell of ovary CL0002132

CSI 4.4

rCSI 12.1%

PRS 78.2%
neutrophil CL0000775

CSI 4.5

rCSI 25.3%

PRS 72.1%
activated type II NK T cell CL0000931

CSI 4.5

rCSI 5.1%

PRS 82.8%
regular atrial cardiac myocyte CL0002129

CSI 4.6

rCSI 14.7%

PRS 64.5%
large pre-B-II cell CL0000957

CSI 4.6

rCSI 13.1%

PRS 76.9%
peptic cell CL0000155

CSI 4.6

rCSI 45.2%

PRS 82.9%
luminal cell of prostate epithelium CL0002340

CSI 4.7

rCSI 25.1%

PRS 77.4%
choroid plexus epithelial cell CL0000706

CSI 4.7

rCSI 7.6%

PRS 55.9%
kidney collecting duct intercalated cell CL1001432

CSI 4.7

rCSI 33.3%

PRS 66.4%
small intestine goblet cell CL1000495

CSI 4.7

rCSI 10.2%

PRS 74.1%
bronchiolar smooth muscle cell CL4033017

CSI 4.7

rCSI 70.3%

PRS 81.2%
lung ciliated cell CL1000271

CSI 4.8

rCSI 5.5%

PRS 57.4%
endothelial cell of arteriole CL1000412

CSI 4.9

rCSI 27.0%

PRS 80.7%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 4.9

rCSI 11.1%

PRS 62.6%
tendon cell CL0000388

CSI 4.9

rCSI 12.7%

PRS 79.8%
promonocyte CL0000559

CSI 5.0

rCSI 8.5%

PRS 75.0%
ionocyte CL0005006

CSI 5.0

rCSI 5.4%

PRS 66.9%
alveolar macrophage CL0000583

CSI 5.1

rCSI 8.4%

PRS 72.1%
pulmonary artery endothelial cell CL1001568

CSI 5.2

rCSI 7.0%

PRS 78.1%
lung secretory cell CL1000272

CSI 5.3

rCSI 13.1%

PRS 65.5%
smooth muscle cell of prostate CL1000487

CSI 5.4

rCSI 31.9%

PRS 78.9%
endothelial cell of vascular tree CL0002139

CSI 5.4

rCSI 29.7%

PRS 64.8%
peripheral nervous system neuron CL2000032

CSI 5.5

rCSI 7.4%

PRS 58.3%
lung neuroendocrine cell CL1000223

CSI 5.6

rCSI 8.3%

PRS 72.0%
club cell CL0000158

CSI 5.7

rCSI 8.3%

PRS 62.0%
intestinal tuft cell CL0019032

CSI 5.7

rCSI 8.8%

PRS 71.0%
neural crest cell CL0011012

CSI 5.8

rCSI 4.6%

PRS 53.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Immediate early response 3 ([IER3](/details-gene/8870)) is a protein-coding gene located on chromosome 6p21.33, known to be rapidly induced by various cellular stressors, including radiation [Link](https://pubmed.ncbi.nlm.nih.gov/8603392/). Functionally, it is a multifaceted signaling modulator involved in critical cellular processes such as the [DNA damage response](/details-go/GO:0006974), regulation of [apoptosis](/details-go/GO:0006915), and control of inflammatory pathways. **Overall**, expression data reveals its significance across diverse cell types, with particularly high relevance in activated immune cells, such as [activated CD4-positive, alpha-beta T cells](/details-cell/CL0000896), and a wide range of epithelial and stromal cells, including [keratinocytes](/details-cell/CL0000312) and [luminal epithelial cells of the mammary gland](/details-cell/CL0002326), underscoring its broad role in tissue homeostasis and stress response. ## Cellular Roles and Expression Landscape The expression profile of [IER3](/details-gene/8870) highlights its importance in several distinct cellular compartments. **1. Immune System:** The gene shows prominent significance in activated lymphocyte populations, including both [activated CD4-positive, alpha-beta T cells](/details-cell/CL0000896) and [activated CD8-positive, alpha-beta T cells](/details-cell/CL0000906). This pattern is consistent with its classification as an immediate-early gene, suggesting it is rapidly transcribed following T-cell receptor stimulation to modulate the ensuing immune response. Its expression in [Hofbauer cells](/details-cell/CL3000001), which are placental macrophages, further points to a role in regulating immune function at the maternal-fetal interface. **2. Epithelial Tissues:** [IER3](/details-gene/8870) is a significant gene in a broad array of epithelial cells, indicating a conserved function in barrier tissues and glands. It is highly ranked in [keratinocytes](/details-cell/CL0000312) of the skin, [luminal epithelial cells of the mammary gland](/details-cell/CL0002326), [mucous neck cells](/details-cell/CL0000651) of the stomach, [respiratory basal](/details-cell/CL0002633) and [suprabasal cells](/details-cell/CL4033048), [pancreatic ductal cells](/details-cell/CL0002079), [fallopian tube secretory epithelial cells](/details-cell/CL4030006), and [colon epithelial cells](/details-cell/CL0011108). This widespread epithelial expression suggests a role in maintaining tissue integrity, managing cellular turnover, and responding to environmental stressors. **3. Stromal and Endothelial Compartments:** The gene is also significantly expressed in structural and vascular cells. Its high CSI in [cerebral cortex endothelial cells](/details-cell/CL1001602), [skin fibroblasts](/details-cell/CL0002620), and [perivascular cells](/details-cell/CL4033054) suggests involvement in vascular function, wound healing, and tissue remodeling. ## Pathways and Molecular Function The functional annotations for [IER3](/details-gene/8870) position it as a critical regulator of cell fate and signaling. It is strongly associated with the [apoptotic process](/details-go/GO:0006915), where it predominantly functions as an inhibitor, as indicated by its role in the [negative regulation of apoptotic process](/details-go/GO:0043066) and [negative regulation of mitochondrial outer membrane permeabilization](/details-go/GO:1901029). This pro-survival function is tightly linked to its involvement in the [DNA damage response](/details-go/GO:0006974), where it likely acts to pause cell death to allow for DNA repair. At the molecular level, [IER3](/details-gene/8870) is a key component of major intracellular signaling pathways. Reactome data places it within the [PI5P, PP2A and IER3 regulate PI3K/AKT signaling](/details-reactome/R-HSA-6811558) pathway, highlighting its role in the [negative regulation of the PI3K/AKT network](/details-reactome/R-HSA-199418). This is supported by research demonstrating that IER3 is a substrate for ERK and controls the activity of the phosphatase PP2A, forming a feedback loop that modulates MAPK/ERK signaling [Link](https://doi.org/10.1093/emboj/cdf488) [Link](https://doi.org/10.1038/sj.emboj.7600980). Furthermore, its annotation for [negative regulation of inflammatory response](/details-go/GO:0050728) aligns with its high expression in activated immune cells, suggesting it functions to dampen signaling and prevent excessive inflammation. ## Research Directions The dual role of [IER3](/details-gene/8870) in promoting cell survival while negatively regulating key signaling and inflammatory pathways presents several avenues for future investigation. **Testable Hypotheses:** 1. Given its high expression in diverse epithelial tissues and its function in the DNA damage response, [IER3](/details-gene/8870) may function as a master regulator of epithelial homeostasis, transiently inhibiting apoptosis in response to low-level genotoxic stress to allow for repair, thereby preventing premature cell loss and maintaining barrier integrity. 2. In the context of the immune system, the high significance of [IER3](/details-gene/8870) in activated T cells, coupled with its role in negatively regulating inflammatory responses, suggests it acts as a critical feedback inhibitor. Its induction following T-cell activation may serve to establish an activation threshold, preventing hyper-responsiveness and subsequent immunopathology. **Proposed Experimental Approach:** To test the hypothesis that [IER3](/details-gene/8870) is a feedback inhibitor of T-cell activation, one could perform a targeted knockout of the gene in primary human CD4+ T cells using CRISPR-Cas9 technology. Control (wild-type) and IER3-knockout T cells could then be stimulated *in vitro* with anti-CD3/CD28 antibodies. The functional consequences would be assessed by measuring T-cell proliferation via CFSE dilution, quantifying cytokine secretion (e.g., IFN-γ, TNF-α, IL-2) using a multiplex immunoassay, and analyzing the expression of key transcription factors (e.g., T-bet, GATA3) by intracellular flow cytometry or RT-qPCR. A significant increase in proliferation, cytokine production, and lineage-defining transcription factor expression in the knockout cells compared to controls would support its role as a negative regulator. **Therapeutic Potential:** The context-dependent functions of [IER3](/details-gene/8870) make it a nuanced therapeutic target. Its anti-apoptotic role and association with pancreatic cancer progression suggest that **inhibition** of [IER3](/details-gene/8870) could be a viable strategy in oncology, potentially sensitizing cancer cells to chemotherapy or other stressors [Link](https://doi.org/10.1172/jci60144). Conversely, its anti-inflammatory properties suggest that **activation** or delivery of [IER3](/details-gene/8870) might be beneficial in autoimmune or inflammatory disorders characterized by excessive T-cell activity. Therefore, the therapeutic approach would be highly dependent on the specific pathology.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Radiation-inducible immediate-early gene IEX-1

Genular Protein ID: 4117920558

Symbol: IEX1_HUMAN

Name: Radiation-inducible immediate-early gene IEX-1

UniProtKB Accession Codes:

P46695 Q5SU30 Q92691 Q93044

Database IDs:

Citations:

PubMed ID: 8603392

Title: Identification and characterization of a radiation-inducible glycosylated human early-response gene.

PubMed ID: 8603392

PubMed ID: 8653710

Title: PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line.

PubMed ID: 8653710

PubMed ID: 9196025

Title: Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine.

PubMed ID: 9196025

DOI: 10.1006/bbrc.1997.6715

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12356731

Title: IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.

PubMed ID: 12356731

DOI: 10.1093/emboj/cdf488

PubMed ID: 16456541

Title: B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.

PubMed ID: 16456541

DOI: 10.1038/sj.emboj.7600980

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22565310

Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

PubMed ID: 22565310

DOI: 10.1172/jci60144

Sequence Information:

Length: 156
Mass: 16903
Checksum: 83C06116C81B8341
Sequence:

MCHSRSCHPT MTILQAPTPA PSTIPGPRRG SGPEIFTFDP LPEPAAAPAG RPSASRGHRK 
RSRRVLYPRV VRRQLPVEEP NPAKRLLFLL LTIVFCQILM AEEGVPAPLP PEDAPNAASL 
APTPVSAVLE PFNLTSEPSD YALDLSTFLQ QHPAAF

Details for: IER3

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification and characterization of a radiation-inducible glycosylated human early-response gene. PubMed ID: 8603392

PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. PubMed ID: 8653710

Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. PubMed ID: 9196025

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. PubMed ID: 12356731

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. PubMed ID: 16456541

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. PubMed ID: 22565310