Details for: ATP5IF1

Gene ID: 93974

Symbol: ATP5IF1

Ensembl ID: ENSG00000130770

Description: ATP synthase inhibitory factor subunit 1

Associated with

  • Angiogenesis
    (GO:0001525)
  • Angiostatin binding
    (GO:0043532)
  • Atpase binding
    (GO:0051117)
  • Atpase inhibitor activity
    (GO:0042030)
  • Calmodulin binding
    (GO:0005516)
  • Cell surface
    (GO:0009986)
  • Enzyme binding
    (GO:0019899)
  • Enzyme inhibitor activity
    (GO:0004857)
  • Erythrocyte differentiation
    (GO:0030218)
  • Generation of precursor metabolites and energy
    (GO:0006091)
  • Heme biosynthetic process
    (GO:0006783)
  • Identical protein binding
    (GO:0042802)
  • Mitochondrial depolarization
    (GO:0051882)
  • Mitochondrial proton-transporting atp synthase complex binding
    (GO:0140260)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of atp-dependent activity
    (GO:0032780)
  • Negative regulation of endothelial cell proliferation
    (GO:0001937)
  • Negative regulation of hydrolase activity
    (GO:0051346)
  • Positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
    (GO:1904925)
  • Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901030)
  • Positive regulation of proteolysis involved in protein catabolic process
    (GO:1903052)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Reactive oxygen species metabolic process
    (GO:0072593)
  • Regulation of atp metabolic process
    (GO:1903578)
  • Regulation of protein targeting to mitochondrion
    (GO:1903214)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 4.57
    Marker Score: 3055
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.51
    Marker Score: 3612
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.42
    Marker Score: 9324
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.78
    Marker Score: 50333
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 3.63
    Marker Score: 3930.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.62
    Marker Score: 31468
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.58
    Marker Score: 12700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.57
    Marker Score: 9009
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.48
    Marker Score: 2114
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.41
    Marker Score: 9137
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.41
    Marker Score: 3041
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.3
    Marker Score: 2325.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.29
    Marker Score: 963
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.27
    Marker Score: 113284
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.25
    Marker Score: 2545
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.24
    Marker Score: 32106
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.22
    Marker Score: 3883
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.17
    Marker Score: 2689
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.17
    Marker Score: 1688
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.12
    Marker Score: 9810
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.09
    Marker Score: 1725
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.08
    Marker Score: 5114
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.05
    Marker Score: 14658
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.03
    Marker Score: 2854.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3
    Marker Score: 19116
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.93
    Marker Score: 39377
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.92
    Marker Score: 17340
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.85
    Marker Score: 33177
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.82
    Marker Score: 18363
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.81
    Marker Score: 7776
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.81
    Marker Score: 3980
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.8
    Marker Score: 5685
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.8
    Marker Score: 4585
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.76
    Marker Score: 14512
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.75
    Marker Score: 20498.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.72
    Marker Score: 2055
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.71
    Marker Score: 7745
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.7
    Marker Score: 2736
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.69
    Marker Score: 2581
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.68
    Marker Score: 6086
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.68
    Marker Score: 857
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.67
    Marker Score: 2827
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.66
    Marker Score: 7877.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.65
    Marker Score: 4267
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.65
    Marker Score: 4214
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.63
    Marker Score: 4999
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.62
    Marker Score: 8276
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.6
    Marker Score: 897
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.6
    Marker Score: 7285
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.58
    Marker Score: 1069
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.57
    Marker Score: 3645
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.56
    Marker Score: 641
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.55
    Marker Score: 1275
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.55
    Marker Score: 3925
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.53
    Marker Score: 1201
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.53
    Marker Score: 3507
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.53
    Marker Score: 5274
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.52
    Marker Score: 1819
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.5
    Marker Score: 33018
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.5
    Marker Score: 3852
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.5
    Marker Score: 1231.5
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.49
    Marker Score: 2072
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.49
    Marker Score: 1284
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.49
    Marker Score: 1773
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.49
    Marker Score: 2584
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.46
    Marker Score: 587
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.46
    Marker Score: 808
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.45
    Marker Score: 19159
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.45
    Marker Score: 27615
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.45
    Marker Score: 21088.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.45
    Marker Score: 15913
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.44
    Marker Score: 2178.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.43
    Marker Score: 128415
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.43
    Marker Score: 15525
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.42
    Marker Score: 1896
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.41
    Marker Score: 1283
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.41
    Marker Score: 10334
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.41
    Marker Score: 1411.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.39
    Marker Score: 1002
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.39
    Marker Score: 4482
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.38
    Marker Score: 1030
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.38
    Marker Score: 1351
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.38
    Marker Score: 1732
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.38
    Marker Score: 1586
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.37
    Marker Score: 1170
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.37
    Marker Score: 2293
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.37
    Marker Score: 8758
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.34
    Marker Score: 9596
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.34
    Marker Score: 2624
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.33
    Marker Score: 2591
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.33
    Marker Score: 5531
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.33
    Marker Score: 866.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.31
    Marker Score: 1944
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.31
    Marker Score: 716
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.31
    Marker Score: 8896
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.3
    Marker Score: 1962
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.29
    Marker Score: 5221
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.29
    Marker Score: 658
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.29
    Marker Score: 1520
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.28
    Marker Score: 22972

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Other Information

**Key Characteristics** ATP5IF1 is a subunit of the ATP synthase inhibitory factor complex, which plays a crucial role in regulating mitochondrial energy metabolism. The protein is composed of two subunits, ATIF1 and ATIF2, which interact with the ATP synthase complex to inhibit its activity. ATP5IF1 is highly expressed in cells that require high energy demands, such as skeletal muscle and cardiac muscle cells. The protein exhibits a unique ability to bind to calmodulin, a calcium-binding protein, which regulates its activity. **Pathways and Functions** ATP5IF1 is involved in several key pathways that regulate mitochondrial function and energy metabolism. These include: 1. **Angiogenesis**: ATP5IF1 inhibits endothelial cell proliferation, which is essential for angiogenesis, the process of new blood vessel formation. 2. **Mitochondrial regulation**: ATP5IF1 regulates the activity of ATP synthase, the primary enzyme responsible for generating ATP in mitochondria. 3. **Autophagy**: ATP5IF1 promotes the autophagy of mitochondria in response to mitochondrial depolarization, which is essential for maintaining mitochondrial function and preventing cell death. 4. **Proteolysis**: ATP5IF1 regulates proteolysis involved in protein catabolic processes, which is essential for maintaining protein homeostasis in cells. **Clinical Significance** Dysregulation of ATP5IF1 has been implicated in various diseases, including: 1. **Cardiovascular disease**: Altered expression of ATP5IF1 has been linked to cardiovascular disease, including hypertension and atherosclerosis. 2. **Cancer**: ATP5IF1 has been shown to regulate angiogenesis and tumor growth, making it a potential target for cancer therapy. 3. **Neurodegenerative diseases**: ATP5IF1 has been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, where mitochondrial dysfunction is a key feature. In conclusion, ATP5IF1 plays a critical role in regulating mitochondrial function and energy metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms by which ATP5IF1 regulates mitochondrial function and to explore its therapeutic potential. **References** [Insert references here] Note: This article discussion is a hypothetical example and not meant to be a real publication. The information provided is based on the given gene description and may not reflect the actual research findings or clinical significance of the gene.

Genular Protein ID: 3890755385

Symbol: ATIF1_HUMAN

Name: Inhibitor of F(1)F(o)-ATPase

UniProtKB Accession Codes:

Q9UII2 Q5JXL8 Q6IAQ7 Q9BSL9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 4 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10664857

Title: Nucleotide sequence of cDNA coding the mitochondrial precursor protein of the ATPase inhibitor from humans.

PubMed ID: 10664857

DOI: 10.1271/bbb.63.2225

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 12110673

Title: A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies.

PubMed ID: 12110673

DOI: 10.1074/jbc.m204538200

PubMed ID: 15528193

Title: An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface.

PubMed ID: 15528193

DOI: 10.1074/jbc.m405947200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19559621

Title: IF(1): setting the pace of the F(1)F(o)-ATP synthase.

PubMed ID: 19559621

DOI: 10.1016/j.tibs.2009.03.006

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23135403

Title: Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.

PubMed ID: 23135403

DOI: 10.1038/nature11536

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 106
  • Mass: 12249
  • Checksum: A6144431125D5A86
  • Sequence:
    • MAVTALAART WLGVWGVRTM QARGFGSDQS ENVDRGAGSI REAGGAFGKR EQAEEERYFR 
AQSREQLAAL KKHHEEEIVH HKKEIERLQK EIERHKQKIK MLKHDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.