Details for: NHS
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.5108
Cell Significance Index: -37.5300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.8185
Cell Significance Index: -19.3000 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 4.4962
Cell Significance Index: 27.7400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.7374
Cell Significance Index: 100.1500 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 3.4303
Cell Significance Index: 30.4500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 3.1518
Cell Significance Index: 67.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.0833
Cell Significance Index: 173.0200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.9853
Cell Significance Index: 40.7300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.7493
Cell Significance Index: 986.1200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.2124
Cell Significance Index: 61.8300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.0818
Cell Significance Index: 127.9600 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 1.9254
Cell Significance Index: 24.9700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.7834
Cell Significance Index: 42.7700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.5911
Cell Significance Index: 1100.4800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.4893
Cell Significance Index: 2025.0300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.4034
Cell Significance Index: 72.9100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0712
Cell Significance Index: 105.9700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.0500
Cell Significance Index: 666.8500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8562
Cell Significance Index: 16.7100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.8470
Cell Significance Index: 53.3900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.7533
Cell Significance Index: 26.4700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7369
Cell Significance Index: 665.3600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.7352
Cell Significance Index: 1131.7700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6751
Cell Significance Index: 135.4300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.6430
Cell Significance Index: 1210.6100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5586
Cell Significance Index: 90.8500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.4753
Cell Significance Index: 876.6300 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.4388
Cell Significance Index: 1.9100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4284
Cell Significance Index: 85.0100 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.4070
Cell Significance Index: 4.2400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3840
Cell Significance Index: 41.7700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3512
Cell Significance Index: 8.7800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2594
Cell Significance Index: 46.7700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2125
Cell Significance Index: 26.1300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1934
Cell Significance Index: 14.8400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1779
Cell Significance Index: 80.7600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1339
Cell Significance Index: 73.1100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1264
Cell Significance Index: 24.0600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1228
Cell Significance Index: 2.6600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0944
Cell Significance Index: 2.7200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0894
Cell Significance Index: 5.3700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0760
Cell Significance Index: 3.4500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0606
Cell Significance Index: 8.3200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0598
Cell Significance Index: 7.6700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0557
Cell Significance Index: 34.7700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0429
Cell Significance Index: 2.9700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0382
Cell Significance Index: 2.5700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0316
Cell Significance Index: 13.9900 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.0144
Cell Significance Index: 0.1800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0037
Cell Significance Index: -0.1000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0158
Cell Significance Index: -2.2900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0176
Cell Significance Index: -12.9000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0254
Cell Significance Index: -18.8200 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.0270
Cell Significance Index: -0.3400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0329
Cell Significance Index: -18.5800 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0458
Cell Significance Index: -0.9200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0510
Cell Significance Index: -38.6200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1034
Cell Significance Index: -21.7700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1086
Cell Significance Index: -31.2500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1110
Cell Significance Index: -12.9300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1168
Cell Significance Index: -19.9400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1665
Cell Significance Index: -2.3900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1769
Cell Significance Index: -18.4200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2389
Cell Significance Index: -5.0700 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.2504
Cell Significance Index: -3.1600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2678
Cell Significance Index: -16.4200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2793
Cell Significance Index: -36.0800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2822
Cell Significance Index: -28.8300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3137
Cell Significance Index: -35.8100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3154
Cell Significance Index: -36.1400 - Cell Name: chandelier cell (CL4023083)
Fold Change: -0.3171
Cell Significance Index: -2.5600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3243
Cell Significance Index: -15.2400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3548
Cell Significance Index: -18.6300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3560
Cell Significance Index: -7.0400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3573
Cell Significance Index: -25.2700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3611
Cell Significance Index: -7.6900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3973
Cell Significance Index: -12.7300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4136
Cell Significance Index: -4.9300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4161
Cell Significance Index: -8.9900 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.4499
Cell Significance Index: -5.5800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4573
Cell Significance Index: -36.2200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4876
Cell Significance Index: -36.3400 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.5103
Cell Significance Index: -16.1400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5883
Cell Significance Index: -26.0200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5967
Cell Significance Index: -27.8200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.6070
Cell Significance Index: -39.1600 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.6138
Cell Significance Index: -12.8100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6197
Cell Significance Index: -10.6200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.6203
Cell Significance Index: -32.3100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6213
Cell Significance Index: -20.3400 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.6316
Cell Significance Index: -9.0700 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.6423
Cell Significance Index: -4.9100 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.6485
Cell Significance Index: -7.7600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7119
Cell Significance Index: -24.9400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.7276
Cell Significance Index: -6.7000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7636
Cell Significance Index: -21.7900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7883
Cell Significance Index: -25.1100 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.8001
Cell Significance Index: -7.2100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8078
Cell Significance Index: -30.5900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.8324
Cell Significance Index: -5.6400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3251572858
Symbol: NHS_HUMAN
Name: Congenital cataracts and dental anomalies protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14564667
Title: Mutations in a novel gene, NHS, cause the pleiotropic effects of Nance-Horan syndrome, including severe congenital cataract, dental anomalies, and mental retardation.
PubMed ID: 14564667
DOI: 10.1086/379381
PubMed ID: 16675532
Title: Nance-Horan syndrome protein, NHS, associates with epithelial cell junctions.
PubMed ID: 16675532
DOI: 10.1093/hmg/ddl120
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15466011
Title: Identification of the gene for Nance-Horan syndrome (NHS).
PubMed ID: 15466011
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19447104
Title: NHS-A isoform of the NHS gene is a novel interactor of ZO-1.
PubMed ID: 19447104
PubMed ID: 19414485
Title: X-linked cataract and Nance-Horan syndrome are allelic disorders.
PubMed ID: 19414485
DOI: 10.1093/hmg/ddp206
PubMed ID: 20332100
Title: The Nance-Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology.
PubMed ID: 20332100
DOI: 10.1093/hmg/ddq125
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 23092983
Title: Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.
PubMed ID: 23092983
DOI: 10.1038/tp.2012.102
PubMed ID: 26566883
Title: Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family.
PubMed ID: 26566883
Sequence Information:
- Length: 1651
- Mass: 179135
- Checksum: 9B98C97BA0109F82
- Sequence:
MPFAKRIVEP QWLCRQRRPA PGPAVDASGG SAEPPPPLQP PGRRDLDEVE APGPEEPARA VPAPSGLPPP PPPLPAPADQ TQPPHGEASV AGEESTAGIP EAAPAAGEAS SAAAAAAVLL MLDLCAVSNA ALARVLRQLS DVARHACSLF QELESDIQLT HRRVWALQGK LGGVQRVLST LDPKQEAVPV SNLDIESKLS VYYRAPWHQQ RNIFLPATRP PCVEELHRHA RQSLQALRRE HRSRSDRREQ RAAAPLSIAA PPLPAYPPAH SQRRREFKDR HFLTFNSTRS PSPTECCHMT PWSRKSHPPE DEDTDVMLGQ RPKNPIHNIP STLDKQTNWS KALPLPTPEE KMKQDAQVIS SCIIPINVTG VGFDREASIR CSLVHSQSVL QRRRKLRRRK TISGIPRRVQ QEIDSDESPV ARERNVIVHT NPDPSNTVNR ISGTRDSECQ TEDILIAAPS RRRIRAQRGQ SIAASLSHSA GNISALADKG DTMFTPAVSS RTRSRSLPRE GNRGGDAEPK VGAKPSAYEE GESFVGDHER TPNDFSEAPS SPSAQDHQPT LGLACSQHLH SPQHKLSERG RSRLSRMAAD SGSCDISSNS DTFGSPIHCI STAGVLLSSH MDQKDDHQSS SGNWSGSSST CPSQTSETIP PAASPPLTGS SHCDSELSLN TAPHANEDAS VFVTEQYNDH LDKVRGHRAN SFTSTVADLL DDPNNSNTSD SEWNYLHHHH DASCRQDFSP ERPKADSLGC PSFTSMATYD SFLEKSPSDK ADTSSHFSVD TEGYYTSMHF DCGLKGNKSY VCHYAALGPE NGQGVGASPG LPDCAWQDYL DHKRQGRPSI SFRKPKAKPT PPKRSSSLRK SDGNADISEK KEPKISSGQH LPHSSREMKL PLDFANTPSR MENANLPTKQ EPSWINQSEQ GIKEPQLDAS DIPPFKDEVA ESTHYADLWL LNDLKTNDPY RSLSNSSTAT GTTVIECIKS PESSESQTSQ SESRATTPSL PSVDNEFKLA SPEKLAGLAS PSSGYSSQSE TPTSSFPTAF FSGPLSPGGS KRKPKVPERK SSLQQPSLKD GTISLSKDLE LPIIPPTHLD LSALHNVLNK PFHHRHPLHV FTHNKQNTVG ETLRSNPPPS LAITPTILKS VNLRSINKSE EVKQKEENNT DLPYLEESTL TTAALSPSKI RPHTANKSVS RQYSTEDTIL SFLDSSAVEM GPDKLHLEKN STFDVKNRCD PETITSAGSS LLDSNVTKDQ VRTETEPIPE NTPTKNCAFP TEGFQRVSAA RPNDLDGKII QYGPGPDETL EQVQKAPSAG LEEVAQPESV DVITSQSDSP TRATDVSNQF KHQFVMSRHH DKVPGTISYE SEITSVNSFP EKCSKQENIA SGISAKSASD NSKAEETQGN VDEASLKESS PSDDSIISPL SEDSQAEAEG VFVSPNKPRT TEDLFAVIHR SKRKVLGRKD SGDMSVRSKS RAPLSSSSSS ASSITSPSSN VTTPNSQRSP GLIYRNAKKS NTSNEEFKLL LLKKGSRSDS SYRMSATEIL KSPILPKPPG ELTAESPQST DDAHQGSQGA EALSPLSPCS PRVNAEGFSS KSFATSASAR VGRSRAPPAA SSSRYSVRCR LYNTPMQAIS EGETENSDGS PHDDRSSQSS T
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.