Gene GPC5 - ENSG00000179399 | NCBI Gene ID: 2262

Details for: GPC5

Gene ID: 2262

Symbol: GPC5

Ensembl ID: ENSG00000179399

Description: glypican 5

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Attachment and entry
(R-HSA-9694614)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective ext1 causes exostoses 1, trps2 and chds
(R-HSA-3656253)
Defective ext2 causes exostoses 2
(R-HSA-3656237)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Early sars-cov-2 infection events
(R-HSA-9772572)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Hs-gag biosynthesis
(R-HSA-2022928)
Hs-gag degradation
(R-HSA-2024096)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Release of hh-np from the secreting cell
(R-HSA-5362798)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Retinoid metabolism and transport
(R-HSA-975634)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Sensory perception
(R-HSA-9709957)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Viral infection pathways
(R-HSA-9824446)
Visual phototransduction
(R-HSA-2187338)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Extracellular region
(GO:0005576)
Golgi lumen
(GO:0005796)
Lysosomal lumen
(GO:0043202)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Protein binding
(GO:0005515)
Regulation of protein localization to membrane
(GO:1905475)
Side of membrane
(GO:0098552)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hepatoblast (CL0005026)
Fold Change: 10.03
Marker Score: 32870.5
Cell Name: granule cell (CL0000120)
Fold Change: 7.32
Marker Score: 55195.5
Cell Name: macroglial cell (CL0000126)
Fold Change: 7.17
Marker Score: 16481.5
Cell Name: mature astrocyte (CL0002627)
Fold Change: 7
Marker Score: 4609
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 6.77
Marker Score: 35525
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 6.76
Marker Score: 28167.5
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 5.27
Marker Score: 3970
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 4.25
Marker Score: 15095
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.96
Marker Score: 4790
Cell Name: astrocyte (CL0000127)
Fold Change: 3.72
Marker Score: 3224
Cell Name: anterior lens cell (CL0002223)
Fold Change: 3.68
Marker Score: 4949.5
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.41
Marker Score: 28799
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.24
Marker Score: 69208
Cell Name: stellate neuron (CL0000122)
Fold Change: 3.12
Marker Score: 16777
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 2.92
Marker Score: 38888
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.89
Marker Score: 8253
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.89
Marker Score: 5478
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.82
Marker Score: 50069
Cell Name: microglial cell (CL0000129)
Fold Change: 2.6
Marker Score: 4731
Cell Name: erythroblast (CL0000765)
Fold Change: 2.33
Marker Score: 1454
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.14
Marker Score: 1646
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.1
Marker Score: 2422.5
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.06
Marker Score: 21236
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.03
Marker Score: 4451
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.97
Marker Score: 66402
Cell Name: monocyte (CL0000576)
Fold Change: 1.85
Marker Score: 2409
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.84
Marker Score: 3748.5
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.79
Marker Score: 6366
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.79
Marker Score: 10732
Cell Name: lactocyte (CL0002325)
Fold Change: 1.75
Marker Score: 28132
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.74
Marker Score: 1045
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.72
Marker Score: 1177
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.67
Marker Score: 102651.5
Cell Name: neuron (CL0000540)
Fold Change: 1.64
Marker Score: 6675.5
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.56
Marker Score: 2620
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167047
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.45
Marker Score: 3424
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.45
Marker Score: 32299.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.44
Marker Score: 12380
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 871
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.34
Marker Score: 365
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20157
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.29
Marker Score: 753
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.29
Marker Score: 2476
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.29
Marker Score: 403
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.26
Marker Score: 735
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.23
Marker Score: 45554.5
Cell Name: interneuron (CL0000099)
Fold Change: 1.22
Marker Score: 556
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.21
Marker Score: 635
Cell Name: T cell (CL0000084)
Fold Change: 1.2
Marker Score: 2070
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.19
Marker Score: 656
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.12
Marker Score: 629
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.1
Marker Score: 1562
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.08
Marker Score: 2903
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.07
Marker Score: 2564
Cell Name: connective tissue cell (CL0002320)
Fold Change: 1.05
Marker Score: 272
Cell Name: podocyte (CL0000653)
Fold Change: 1.03
Marker Score: 381
Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.02
Marker Score: 324
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.02
Marker Score: 369
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.01
Marker Score: 9547
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71790
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48014
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.99
Marker Score: 19702
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.98
Marker Score: 466
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.95
Marker Score: 1028
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.95
Marker Score: 1150
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.94
Marker Score: 395
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.94
Marker Score: 8935
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.94
Marker Score: 1162
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5317
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.91
Marker Score: 330
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.89
Marker Score: 683.5
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.88
Marker Score: 4084
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.88
Marker Score: 759
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.87
Marker Score: 32963.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.87
Marker Score: 1336
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.86
Marker Score: 251
Cell Name: club cell (CL0000158)
Fold Change: 0.86
Marker Score: 999
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.84
Marker Score: 801.5
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.82
Marker Score: 753
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.82
Marker Score: 865
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.81
Marker Score: 3378
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.81
Marker Score: 2314
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.81
Marker Score: 616
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.79
Marker Score: 2708.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1262
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 705
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.75
Marker Score: 437
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.72
Marker Score: 320
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.72
Marker Score: 5538.5
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.72
Marker Score: 157
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 182
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.7
Marker Score: 222
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.7
Marker Score: 339
Cell Name: macrophage (CL0000235)
Fold Change: 0.69
Marker Score: 762

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**Key characteristics:** * GPC5 is a transmembrane protein that is expressed in the plasma membrane of cells. * It is a glycoprotein that is composed of a single extracellular domain and a transmembrane domain. * The extracellular domain is responsible for binding to chondroitin sulfate and dermatan sulfate, which are components of GAGs. * The transmembrane domain is responsible for the protein's interaction with other proteins that are involved in the metabolism of GAGs. **Pathways and functions:** * GPC5 is involved in the regulation of GAG synthesis and degradation. * It is a key regulator of the production of proteoglycans, which are large proteins that are made up of GAGs. * GPC5 is also involved in the regulation of the turnover of GAGs. * It is a key regulator of the inflammatory response, and it is involved in the development of fibrosis. **Clinical significance:** * Mutations in the GPC5 gene have been linked to several diseases, including Marfan syndrome, which is characterized by the formation of abnormal blood vessels and tissues. * GPC5 is also involved in the pathogenesis of several types of cancer, including breast cancer and lung cancer. * Targeting GPC5 has been shown to be a promising strategy for treating these diseases. **Additional notes:** * GPC5 is a highly conserved protein, and it is found in organisms from flies to humans. * It is a multi-functional protein that is involved in a variety of cellular processes. * GPC5 is a promising target for the treatment of diseases that are characterized by abnormal GAG metabolism.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Glypican-5

Genular Protein ID: 3110600351

Symbol: GPC5_HUMAN

Name: Glypican-5

UniProtKB Accession Codes:

P78333 B2R726 O60436 Q9BX27

Database IDs:

Citations:

PubMed ID: 9070915

Title: Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family.

PubMed ID: 9070915

DOI: 10.1006/geno.1996.4518

PubMed ID: 9331333

Title: Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain.

PubMed ID: 9331333

DOI: 10.1006/dbio.1997.8690

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 572
Mass: 63707
Checksum: A17969FE0DD0D308
Sequence:

MDAQTWPVGF RCLLLLALVG SARSEGVQTC EEVRKLFQWR LLGAVRGLPD SPRAGPDLQV 
CISKKPTCCT RKMEERYQIA ARQDMQQFLQ TSSSTLKFLI SRNAAAFQET LETLIKQAEN 
YTSILFCSTY RNMALEAAAS VQEFFTDVGL YLFGADVNPE EFVNRFFDSL FPLVYNHLIN 
PGVTDSSLEY SECIRMARRD VSPFGNIPQR VMGQMGRSLL PSRTFLQALN LGIEVINTTD 
YLHFSKECSR ALLKMQYCPH CQGLALTKPC MGYCLNVMRG CLAHMAELNP HWHAYIRSLE 
ELSDAMHGTY DIGHVLLNFH LLVNDAVLQA HLNGQKLLEQ VNRICGRPVR TPTQSPRCSF 
DQSKEKHGMK TTTRNSEETL ANRRKEFINS LRLYRSFYGG LADQLCANEL AAADGLPCWN 
GEDIVKSYTQ RVVGNGIKAQ SGNPEVKVKG IDPVINQIID KLKHVVQLLQ GRSPKPDKWE 
LLQLGSGGGM VEQVSGDCDD EDGCGGSGSG EVKRTLKITD WMPDDMNFSD VKQIHQTDTG 
STLDTTGAGC AVATESMTFT LISVVMLLPG IW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GPC5

Associated with

Cells (max top 100)

Other Information

Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family. PubMed ID: 9070915

Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. PubMed ID: 9331333

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039