Details for: GPC5

Gene ID: 2262

Symbol: GPC5

Ensembl ID: ENSG00000179399

Description: glypican 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 177.9270
    Cell Significance Index: -45.1300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 17.2969
    Cell Significance Index: 241.8700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 11.2942
    Cell Significance Index: 189.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 8.3192
    Cell Significance Index: 367.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 8.1880
    Cell Significance Index: 310.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4282
    Cell Significance Index: -11.8800
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.0514
    Cell Significance Index: 45.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.4208
    Cell Significance Index: 3726.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5676
    Cell Significance Index: 314.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.3635
    Cell Significance Index: 2514.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.1539
    Cell Significance Index: 32.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0560
    Cell Significance Index: 209.5700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.0116
    Cell Significance Index: 17.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8892
    Cell Significance Index: 615.0400
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.8156
    Cell Significance Index: 9.2900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.7697
    Cell Significance Index: 11.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7088
    Cell Significance Index: 54.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.6031
    Cell Significance Index: 273.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5846
    Cell Significance Index: 15.6700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.5721
    Cell Significance Index: 8.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2838
    Cell Significance Index: 101.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1355
    Cell Significance Index: 184.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1206
    Cell Significance Index: 7.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0751
    Cell Significance Index: 47.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0458
    Cell Significance Index: 2.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0384
    Cell Significance Index: 0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0196
    Cell Significance Index: 36.8900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0171
    Cell Significance Index: 0.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0082
    Cell Significance Index: 0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0166
    Cell Significance Index: -0.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0609
    Cell Significance Index: -26.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0620
    Cell Significance Index: -45.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0707
    Cell Significance Index: -53.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0839
    Cell Significance Index: -45.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0841
    Cell Significance Index: -52.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0887
    Cell Significance Index: -50.0000
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.1049
    Cell Significance Index: -1.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1247
    Cell Significance Index: -35.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1413
    Cell Significance Index: -25.4700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1464
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2388
    Cell Significance Index: -50.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2485
    Cell Significance Index: -30.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2552
    Cell Significance Index: -43.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2804
    Cell Significance Index: -4.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2984
    Cell Significance Index: -38.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3040
    Cell Significance Index: -31.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3299
    Cell Significance Index: -4.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3345
    Cell Significance Index: -45.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3635
    Cell Significance Index: -24.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3984
    Cell Significance Index: -4.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4027
    Cell Significance Index: -47.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4249
    Cell Significance Index: -33.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4256
    Cell Significance Index: -49.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4267
    Cell Significance Index: -48.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4506
    Cell Significance Index: -46.0300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.4576
    Cell Significance Index: -4.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4816
    Cell Significance Index: -10.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5065
    Cell Significance Index: -14.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5126
    Cell Significance Index: -10.8800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6114
    Cell Significance Index: -8.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6142
    Cell Significance Index: -20.1100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6331
    Cell Significance Index: -7.9900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6382
    Cell Significance Index: -7.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7297
    Cell Significance Index: -38.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7530
    Cell Significance Index: -18.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7603
    Cell Significance Index: -39.9200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.7714
    Cell Significance Index: -10.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8236
    Cell Significance Index: -26.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8576
    Cell Significance Index: -38.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8610
    Cell Significance Index: -40.4700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8749
    Cell Significance Index: -10.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8932
    Cell Significance Index: -22.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9006
    Cell Significance Index: -31.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9235
    Cell Significance Index: -43.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9786
    Cell Significance Index: -19.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9792
    Cell Significance Index: -25.1700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -1.0009
    Cell Significance Index: -9.0200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.0119
    Cell Significance Index: -12.9800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.0384
    Cell Significance Index: -12.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.0808
    Cell Significance Index: -34.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.0834
    Cell Significance Index: -10.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1352
    Cell Significance Index: -16.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.1708
    Cell Significance Index: -41.1400
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -1.2192
    Cell Significance Index: -13.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2230
    Cell Significance Index: -42.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.2460
    Cell Significance Index: -33.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2608
    Cell Significance Index: -15.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.3000
    Cell Significance Index: -26.1000
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -1.3011
    Cell Significance Index: -15.0700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.3229
    Cell Significance Index: -27.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3657
    Cell Significance Index: -40.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3665
    Cell Significance Index: -26.6700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -1.3712
    Cell Significance Index: -18.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.3895
    Cell Significance Index: -30.0200
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -1.4459
    Cell Significance Index: -14.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.5449
    Cell Significance Index: -44.2900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.5600
    Cell Significance Index: -19.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.5702
    Cell Significance Index: -45.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPC5 is a member of the glypican family, which consists of heparan sulfate proteoglycans (HSPGs) that are attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. GPC5 is characterized by its unique tetrasaccharide linker sequence, which is essential for its function in cell signaling. The protein is highly expressed in various cell types, including hepatoblasts, granule cells, macroglial cells, and epithelial cells of the lower respiratory tract. **Pathways and Functions** GPC5 is involved in several cellular pathways, including: 1. **Hedgehog signaling**: GPC5 acts as a positive regulator of the Hedgehog signaling pathway, which is crucial for embryonic development, tissue patterning, and cancer progression. 2. **Cell migration**: GPC5 is involved in cell migration, particularly in the context of cancer metastasis, where it facilitates the migration of cancer cells. 3. **Glycosaminoglycan metabolism**: GPC5 is involved in the biosynthesis and degradation of heparan sulfate, a key glycosaminoglycan involved in cell signaling and cell migration. 4. **Viral infection**: GPC5 is involved in the attachment and entry of viruses, such as Respiratory Syncytial Virus (RSV) and SARS-CoV-2, into host cells. **Clinical Significance** GPC5 has been implicated in various diseases, including: 1. **Cancer**: GPC5 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Neurological disorders**: GPC5 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Respiratory diseases**: GPC5 is involved in the pathogenesis of respiratory diseases, such as RSV infection and SARS-CoV-2 infection. 4. **Progeroid syndromes**: GPC5 has been linked to progeroid syndromes, such as Edwards syndrome and Sjögren-Larsson syndrome. In conclusion, GPC5 is a multifunctional glycoprotein that plays a crucial role in various cellular processes, including cell signaling, migration, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of GPC5 as a potential therapeutic target.

Genular Protein ID: 3110600351

Symbol: GPC5_HUMAN

Name: Glypican-5

UniProtKB Accession Codes:

P78333 B2R726 O60436 Q9BX27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9070915

Title: Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family.

PubMed ID: 9070915

DOI: 10.1006/geno.1996.4518

PubMed ID: 9331333

Title: Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain.

PubMed ID: 9331333

DOI: 10.1006/dbio.1997.8690

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 572
  • Mass: 63707
  • Checksum: A17969FE0DD0D308
  • Sequence:
    • MDAQTWPVGF RCLLLLALVG SARSEGVQTC EEVRKLFQWR LLGAVRGLPD SPRAGPDLQV 
CISKKPTCCT RKMEERYQIA ARQDMQQFLQ TSSSTLKFLI SRNAAAFQET LETLIKQAEN 
YTSILFCSTY RNMALEAAAS VQEFFTDVGL YLFGADVNPE EFVNRFFDSL FPLVYNHLIN 
PGVTDSSLEY SECIRMARRD VSPFGNIPQR VMGQMGRSLL PSRTFLQALN LGIEVINTTD 
YLHFSKECSR ALLKMQYCPH CQGLALTKPC MGYCLNVMRG CLAHMAELNP HWHAYIRSLE 
ELSDAMHGTY DIGHVLLNFH LLVNDAVLQA HLNGQKLLEQ VNRICGRPVR TPTQSPRCSF 
DQSKEKHGMK TTTRNSEETL ANRRKEFINS LRLYRSFYGG LADQLCANEL AAADGLPCWN 
GEDIVKSYTQ RVVGNGIKAQ SGNPEVKVKG IDPVINQIID KLKHVVQLLQ GRSPKPDKWE 
LLQLGSGGGM VEQVSGDCDD EDGCGGSGSG EVKRTLKITD WMPDDMNFSD VKQIHQTDTG 
STLDTTGAGC AVATESMTFT LISVVMLLPG IW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.