Details for: REEP5

Gene ID: 7905

Symbol: REEP5

Ensembl ID: ENSG00000129625

Description: receptor accessory protein 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 510.2696
    Cell Significance Index: -79.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 327.1720
    Cell Significance Index: -82.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 205.4023
    Cell Significance Index: -84.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 186.8029
    Cell Significance Index: -75.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 183.0880
    Cell Significance Index: -86.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 163.7877
    Cell Significance Index: -84.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 129.3400
    Cell Significance Index: -86.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 79.6654
    Cell Significance Index: -76.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 67.9668
    Cell Significance Index: -83.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.4975
    Cell Significance Index: -84.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.7654
    Cell Significance Index: -63.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4341
    Cell Significance Index: -54.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.1246
    Cell Significance Index: -35.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.0815
    Cell Significance Index: 283.5500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.0219
    Cell Significance Index: 37.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.3829
    Cell Significance Index: 125.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.6163
    Cell Significance Index: 269.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7949
    Cell Significance Index: 76.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.7197
    Cell Significance Index: 25.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5945
    Cell Significance Index: 121.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5602
    Cell Significance Index: 75.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3083
    Cell Significance Index: 416.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1639
    Cell Significance Index: 57.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9545
    Cell Significance Index: 101.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9524
    Cell Significance Index: 391.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7247
    Cell Significance Index: 941.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6652
    Cell Significance Index: 204.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6124
    Cell Significance Index: 221.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4999
    Cell Significance Index: 78.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3538
    Cell Significance Index: 95.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3471
    Cell Significance Index: 174.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2118
    Cell Significance Index: 155.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1643
    Cell Significance Index: 21.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1402
    Cell Significance Index: 504.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0798
    Cell Significance Index: 127.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9425
    Cell Significance Index: 338.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9181
    Cell Significance Index: 149.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8402
    Cell Significance Index: 581.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8031
    Cell Significance Index: 159.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7929
    Cell Significance Index: 135.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7908
    Cell Significance Index: 18.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3896
    Cell Significance Index: 38.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3275
    Cell Significance Index: 21.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3021
    Cell Significance Index: 23.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2967
    Cell Significance Index: 19.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2923
    Cell Significance Index: 17.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2223
    Cell Significance Index: 6.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2132
    Cell Significance Index: 40.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1005
    Cell Significance Index: 73.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0942
    Cell Significance Index: 71.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0569
    Cell Significance Index: 107.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0095
    Cell Significance Index: -17.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0306
    Cell Significance Index: -22.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0317
    Cell Significance Index: -20.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0331
    Cell Significance Index: -44.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0368
    Cell Significance Index: -3.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0724
    Cell Significance Index: -45.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0836
    Cell Significance Index: -47.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1141
    Cell Significance Index: -51.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1648
    Cell Significance Index: -34.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2402
    Cell Significance Index: -27.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2557
    Cell Significance Index: -73.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2789
    Cell Significance Index: -9.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2978
    Cell Significance Index: -7.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3182
    Cell Significance Index: -5.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3693
    Cell Significance Index: -53.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3994
    Cell Significance Index: -46.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4440
    Cell Significance Index: -19.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4945
    Cell Significance Index: -27.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5117
    Cell Significance Index: -14.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5580
    Cell Significance Index: -10.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5781
    Cell Significance Index: -65.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5804
    Cell Significance Index: -21.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6697
    Cell Significance Index: -42.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7017
    Cell Significance Index: -12.0300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.7101
    Cell Significance Index: -14.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7808
    Cell Significance Index: -81.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8121
    Cell Significance Index: -36.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9095
    Cell Significance Index: -72.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9136
    Cell Significance Index: -12.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9370
    Cell Significance Index: -14.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9666
    Cell Significance Index: -33.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9733
    Cell Significance Index: -50.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.0254
    Cell Significance Index: -70.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0416
    Cell Significance Index: -24.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1537
    Cell Significance Index: -25.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1845
    Cell Significance Index: -31.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.2372
    Cell Significance Index: -7.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.3098
    Cell Significance Index: -23.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.3514
    Cell Significance Index: -35.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3911
    Cell Significance Index: -85.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.5233
    Cell Significance Index: -43.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5268
    Cell Significance Index: -48.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6262
    Cell Significance Index: -40.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6503
    Cell Significance Index: -42.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.7106
    Cell Significance Index: -35.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.7916
    Cell Significance Index: -38.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.8021
    Cell Significance Index: -26.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.8163
    Cell Significance Index: -46.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** REEP5 is highly expressed in diverse cell types, including fibroblasts of mammary gland, thyroid follicular cells, progenitor cells of mammary luminal epithelium, and mature T cells. 2. **Cellular Localizations:** REEP5 is predominantly found in the endoplasmic reticulum (ER) and ER-associated compartments, such as the ER membrane, tubular network, and sarcoplasmic reticulum. 3. **Protein Binding:** REEP5 interacts with various proteins, including receptors, chaperones, and transport proteins, to regulate ER organization and function. **Pathways and Functions:** 1. **Endoplasmic Reticulum Organization:** REEP5 is involved in the formation and maintenance of the ER tubular network, ensuring proper ER organization and function. 2. **Regulation of Intracellular Transport:** REEP5 modulates the trafficking of proteins and lipids within the ER, influencing cellular homeostasis and signaling. 3. **Immune System Function:** REEP5 plays a role in the regulation of immune cell function, including T cell activation and differentiation. 4. **Endoplasmic Reticulum Membrane Organization:** REEP5 is essential for the proper functioning of ER membranes, including the sarcoplasmic reticulum. **Clinical Significance:** 1. **Immunological Disorders:** Dysregulation of REEP5 has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where immune system dysfunction plays a critical role. 2. **Cancer:** Alterations in REEP5 expression have been observed in various cancers, including breast and prostate cancer, where ER organization and function are crucial for tumor progression. 3. **Neurological Disorders:** REEP5 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where ER dysfunction and immune system dysregulation contribute to disease pathogenesis. 4. **Protein Misfolding:** REEP5 may play a role in protein misfolding diseases, such as cystic fibrosis and Huntington's disease, where ER dysfunction and immune system activation contribute to disease progression. In conclusion, REEP5 is a multifunctional gene that plays a critical role in maintaining cellular homeostasis, regulating immune system function, and influencing disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which REEP5 regulates ER organization, intracellular transport, and immune system function, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1619708612

Symbol: REEP5_HUMAN

Name: Receptor expression-enhancing protein 5

UniProtKB Accession Codes:

Q00765 B7Z681 D3DT04 Q04198 Q5QGT0 Q9BWH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1678319

Title: Identification of deletion mutations and three new genes at the familial polyposis locus.

PubMed ID: 1678319

DOI: 10.1016/0092-8674(81)90022-2

PubMed ID: 1651562

Title: Identification of FAP locus genes from chromosome 5q21.

PubMed ID: 1651562

DOI: 10.1126/science.1651562

PubMed ID: 15550249

Title: RTP family members induce functional expression of mammalian odorant receptors.

PubMed ID: 15550249

DOI: 10.1016/j.cell.2004.11.021

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16720576

Title: Members of RTP and REEP gene families influence functional bitter taste receptor expression.

PubMed ID: 16720576

DOI: 10.1074/jbc.m513637200

PubMed ID: 19665976

Title: A class of dynamin-like GTPases involved in the generation of the tubular ER network.

PubMed ID: 19665976

DOI: 10.1016/j.cell.2009.05.025

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23969831

Title: Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation.

PubMed ID: 23969831

DOI: 10.1073/pnas.1307391110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32075961

Title: REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects.

PubMed ID: 32075961

DOI: 10.1038/s41467-019-14143-9

Sequence Information:

  • Length: 189
  • Mass: 21493
  • Checksum: F4E57E500CB7C831
  • Sequence:
    • MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV FGYGASLLCN 
LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE FFSDIFLSWF PFYYMLKCGF 
LLWCMAPSPS NGAELLYKRI IRPFFLKHES QMDSVVKDLK DKAKETADAI TKEAKKATVN 
LLGEEKKST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.