Details for: LAMB1

Gene ID: 3912

Symbol: LAMB1

Ensembl ID: ENSG00000091136

Description: laminin subunit beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.33
    Marker Score: 3509
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.14
    Marker Score: 2302
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.42
    Marker Score: 2809
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.37
    Marker Score: 1906
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.37
    Marker Score: 2597
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.07
    Marker Score: 1787
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.89
    Marker Score: 3503
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.82
    Marker Score: 3508
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.44
    Marker Score: 2108
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.35
    Marker Score: 1313
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.27
    Marker Score: 1194.5
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.22
    Marker Score: 811
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.02
    Marker Score: 2771
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2
    Marker Score: 3853.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.94
    Marker Score: 4882
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.91
    Marker Score: 721
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.86
    Marker Score: 20996.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.83
    Marker Score: 1046
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.83
    Marker Score: 1224
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.82
    Marker Score: 4871.5
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.77
    Marker Score: 5926
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.76
    Marker Score: 639
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.75
    Marker Score: 4311
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.69
    Marker Score: 1946
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.68
    Marker Score: 1811
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.66
    Marker Score: 6949
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.65
    Marker Score: 7131
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.65
    Marker Score: 6864.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.61
    Marker Score: 1077
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.58
    Marker Score: 5857
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.57
    Marker Score: 20758
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.55
    Marker Score: 6085
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.53
    Marker Score: 9983
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.53
    Marker Score: 370
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.52
    Marker Score: 2346.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.48
    Marker Score: 502.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167667
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.46
    Marker Score: 2064
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.43
    Marker Score: 1522
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.42
    Marker Score: 894
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.41
    Marker Score: 330
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.38
    Marker Score: 4910
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.37
    Marker Score: 1455
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.37
    Marker Score: 388
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.36
    Marker Score: 654
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.36
    Marker Score: 3548
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.35
    Marker Score: 2079
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.32
    Marker Score: 1782
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.3
    Marker Score: 418
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.3
    Marker Score: 2152
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.29
    Marker Score: 1212
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.28
    Marker Score: 617
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.25
    Marker Score: 42445.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.24
    Marker Score: 1335.5
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.24
    Marker Score: 288
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.24
    Marker Score: 305
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.22
    Marker Score: 659.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2
    Marker Score: 21387
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.18
    Marker Score: 2779
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.16
    Marker Score: 6093
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.13
    Marker Score: 454
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.11
    Marker Score: 293
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.1
    Marker Score: 1357
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.1
    Marker Score: 1140
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.09
    Marker Score: 1611
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.09
    Marker Score: 438
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.08
    Marker Score: 525
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.08
    Marker Score: 1028
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.08
    Marker Score: 373
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16831.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.05
    Marker Score: 1527
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.04
    Marker Score: 270
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251738.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.03
    Marker Score: 2432
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.03
    Marker Score: 857
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.02
    Marker Score: 4245
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71761
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47986
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.99
    Marker Score: 3246.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.97
    Marker Score: 5809
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.96
    Marker Score: 305
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.96
    Marker Score: 35461
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1007.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.94
    Marker Score: 2691
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1523
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.93
    Marker Score: 390
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.93
    Marker Score: 4969.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.92
    Marker Score: 1927
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.92
    Marker Score: 935
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.92
    Marker Score: 347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.91
    Marker Score: 531
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5142
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.89
    Marker Score: 862
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.89
    Marker Score: 799
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320

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Other Information

**Key characteristics:** * The protein is a secreted protein that is found in the extracellular matrix (ECM). * It is a large protein with a molecular weight of approximately 140 kDa. * It is a transmembrane protein that is expressed on the surface of cells. * It is a key component of the extracellular matrix, where it helps to organize and hold cells together. **Pathways and functions:** * The LAMB1 gene is involved in axon guidance, where it helps to regulate the direction of nerve cell growth. * It is also involved in the degradation of the extracellular matrix, which is essential for the migration and differentiation of nerve cells. * It is involved in the regulation of cell motility, and is a key factor in the development of the nervous system. * It is also involved in the organization of the extracellular matrix, and is a key component of the structural integrity of tissues. **Clinical significance:** * Mutations in the LAMB1 gene have been linked to a number of human diseases, including autism, schizophrenia, and developmental disorders. * These mutations can lead to changes in the structure and function of the extracellular matrix, which can disrupt nerve cell function and lead to disease. * Therefore, understanding the role of the LAMB1 gene in cell adhesion, migration, and differentiation is important for the development of new treatments for these disorders.

Genular Protein ID: 3948831348

Symbol: LAMB1_HUMAN

Name: Laminin subunit beta-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1975589

Title: Structure of the human laminin B1 chain gene.

PubMed ID: 1975589

DOI: 10.1016/s0021-9258(18)55441-7

PubMed ID: 3611077

Title: Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7.

PubMed ID: 3611077

DOI: 10.1016/s0021-9258(18)60982-2

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3661559

Title: Isolation of a cDNA clone for the human laminin-B1 chain and its gene localization.

PubMed ID: 3661559

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 23472759

Title: Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities.

PubMed ID: 23472759

DOI: 10.1016/j.ajhg.2013.02.005

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 1786
  • Mass: 198038
  • Checksum: 8F8EF96E765B9A0D
  • Sequence:
  • MGLLQLLAFS FLALCRARVR AQEPEFSYGC AEGSCYPATG DLLIGRAQKL SVTSTCGLHK 
    PEPYCIVSHL QEDKKCFICN SQDPYHETLN PDSHLIENVV TTFAPNRLKI WWQSENGVEN 
    VTIQLDLEAE FHFTHLIMTF KTFRPAAMLI ERSSDFGKTW GVYRYFAYDC EASFPGISTG 
    PMKKVDDIIC DSRYSDIEPS TEGEVIFRAL DPAFKIEDPY SPRIQNLLKI TNLRIKFVKL 
    HTLGDNLLDS RMEIREKYYY AVYDMVVRGN CFCYGHASEC APVDGFNEEV EGMVHGHCMC 
    RHNTKGLNCE LCMDFYHDLP WRPAEGRNSN ACKKCNCNEH SISCHFDMAV YLATGNVSGG 
    VCDDCQHNTM GRNCEQCKPF YYQHPERDIR DPNFCERCTC DPAGSQNEGI CDSYTDFSTG 
    LIAGQCRCKL NVEGEHCDVC KEGFYDLSSE DPFGCKSCAC NPLGTIPGGN PCDSETGHCY 
    CKRLVTGQHC DQCLPEHWGL SNDLDGCRPC DCDLGGALNN SCFAESGQCS CRPHMIGRQC 
    NEVEPGYYFA TLDHYLYEAE EANLGPGVSI VERQYIQDRI PSWTGAGFVR VPEGAYLEFF 
    IDNIPYSMEY DILIRYEPQL PDHWEKAVIT VQRPGRIPTS SRCGNTIPDD DNQVVSLSPG 
    SRYVVLPRPV CFEKGTNYTV RLELPQYTSS DSDVESPYTL IDSLVLMPYC KSLDIFTVGG 
    SGDGVVTNSA WETFQRYRCL ENSRSVVKTP MTDVCRNIIF SISALLHQTG LACECDPQGS 
    LSSVCDPNGG QCQCRPNVVG RTCNRCAPGT FGFGPSGCKP CECHLQGSVN AFCNPVTGQC 
    HCFQGVYARQ CDRCLPGHWG FPSCQPCQCN GHADDCDPVT GECLNCQDYT MGHNCERCLA 
    GYYGDPIIGS GDHCRPCPCP DGPDSGRQFA RSCYQDPVTL QLACVCDPGY IGSRCDDCAS 
    GYFGNPSEVG GSCQPCQCHN NIDTTDPEAC DKETGRCLKC LYHTEGEHCQ FCRFGYYGDA 
    LQQDCRKCVC NYLGTVQEHC NGSDCQCDKA TGQCLCLPNV IGQNCDRCAP NTWQLASGTG 
    CDPCNCNAAH SFGPSCNEFT GQCQCMPGFG GRTCSECQEL FWGDPDVECR ACDCDPRGIE 
    TPQCDQSTGQ CVCVEGVEGP RCDKCTRGYS GVFPDCTPCH QCFALWDVII AELTNRTHRF 
    LEKAKALKIS GVIGPYRETV DSVERKVSEI KDILAQSPAA EPLKNIGNLF EEAEKLIKDV 
    TEMMAQVEVK LSDTTSQSNS TAKELDSLQT EAESLDNTVK ELAEQLEFIK NSDIRGALDS 
    ITKYFQMSLE AEERVNASTT EPNSTVEQSA LMRDRVEDVM MERESQFKEK QEEQARLLDE 
    LAGKLQSLDL SAAAEMTCGT PPGASCSETE CGGPNCRTDE GERKCGGPGC GGLVTVAHNA 
    WQKAMDLDQD VLSALAEVEQ LSKMVSEAKL RADEAKQSAE DILLKTNATK EKMDKSNEEL 
    RNLIKQIRNF LTQDSADLDS IEAVANEVLK MEMPSTPQQL QNLTEDIRER VESLSQVEVI 
    LQHSAADIAR AEMLLEEAKR ASKSATDVKV TADMVKEALE EAEKAQVAAE KAIKQADEDI 
    QGTQNLLTSI ESETAASEET LFNASQRISE LERNVEELKR KAAQNSGEAE YIEKVVYTVK 
    QSAEDVKKTL DGELDEKYKK VENLIAKKTE ESADARRKAE MLQNEAKTLL AQANSKLQLL 
    KDLERKYEDN QRYLEDKAQE LARLEGEVRS LLKDISQKVA VYSTCL

Genular Protein ID: 3756278606

Symbol: Q8TAS6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1083
  • Mass: 118913
  • Checksum: 80F48466F457C222
  • Sequence:
  • LVLMPYCKSL DIFTVGGSGD GVVTNSAWET FQRYRCLENS RSVVKTPMTD VCRNIIFSIS 
    ALLHQTGLAC ECDPQGSLSS VCDPNGGQCQ CRPNVVGRTC NRCAPGTFGF GPSGCKPCEC 
    HLQGSVNAFC NPVTGQCHCF QGVYARQCDR CLPGHWGFPS CQPCQCNGHA DDCDPVTGEC 
    LNCQDYTMGH NCERCLAGYY GDPIIGSGDH CRPCPCPDGP DSGRQFARSC YQDPVTLQLA 
    CVCDPGYIGS RCDDCASGYF GNPSEVGGSC QPCQCHNNID TTDPEACDKE TGRCLKCLYH 
    TEGEHCQFCR FGYYGDALQQ DCRKCVCNYL GTVQEHCNGS DCQCDKATGQ CLCLPNVIGQ 
    NCDRCAPNTW QLASGTGCDP CNCNAAHSFG PSCNEFTGQC QCMPGFGGRT CSECQELFWG 
    DPDVECRACD CDPRGIETPQ CDQSTGQCVC VEGVEGPRCD KCTRGYSGVF PDCTPCHQCF 
    ALWDVIIAEL TNRTHRFLEK AKALKISGVI GPYRETVDSV ERKVSEIKDI LAQSPAAEPL 
    KNIGNLFEEA EKLIKDVTEM MAQVEVKLSD TTSQSNSTAK ELDSLQTEAE SLDNTVKELA 
    EQLEFIKNSD IRGALDSITK YFQMSLEAEE RVNASTTEPN STVEQSALMR DRVEDVMMER 
    ESQFKEKQEE QARLLYELAG KLQSLDLSAA AEMTCGTPPG ASCSETECGG PNCRTDEGER 
    KCGGPGCGGL VTVAHNAWQK AMDLDQDVLS ALAEVEQLSK MVSEAKLRAD EAKQSAEDIL 
    LKTNATKEKM DKSNEELRNL IKQIRNFLTQ DSADLDSIEA VANEVLKMEM PSTPQQLQNL 
    TEDIRERVES LSQVEVILQH SAADIARAEM LLEEAKRASK SATDVKVTAD MVKEALEEAE 
    KAQVAAEKAI KQADEDIQGT QNLLTSIESE TAASEETLFN ASQRISELER NVEELKRKAA 
    QNSGEAEYIE KVVYTVKQSA EDVKKTLDGE LDEKYKKVEN LIAKKTEESA DARRKAEMLQ 
    NEAKTLLAQA NSKLQLLKDL ERKYEDNQRY LEDKAQELAR LEGEVRSLLK DISQKVAVYS 
    TCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.