Details for: GPI

Gene ID: 2821

Symbol: GPI

Ensembl ID: ENSG00000105220

Description: glucose-6-phosphate isomerase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 441.4150
    Cell Significance Index: -68.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 250.3515
    Cell Significance Index: -63.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 168.1525
    Cell Significance Index: -69.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 155.3834
    Cell Significance Index: -73.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 151.9973
    Cell Significance Index: -61.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 136.7652
    Cell Significance Index: -70.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 109.8921
    Cell Significance Index: -73.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 65.7245
    Cell Significance Index: -62.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 55.8658
    Cell Significance Index: -68.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.7172
    Cell Significance Index: -63.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.3124
    Cell Significance Index: -65.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.5796
    Cell Significance Index: -69.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 9.9027
    Cell Significance Index: 2849.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2382
    Cell Significance Index: -18.0300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 5.1974
    Cell Significance Index: 64.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.1142
    Cell Significance Index: 284.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1356
    Cell Significance Index: 92.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.9393
    Cell Significance Index: 43.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4653
    Cell Significance Index: 494.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.4131
    Cell Significance Index: 144.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3146
    Cell Significance Index: 177.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9870
    Cell Significance Index: 712.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8799
    Cell Significance Index: 98.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8210
    Cell Significance Index: 1259.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4974
    Cell Significance Index: 20.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4822
    Cell Significance Index: 267.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.3110
    Cell Significance Index: 19.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2704
    Cell Significance Index: 156.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1766
    Cell Significance Index: 25.4900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1170
    Cell Significance Index: 8.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0160
    Cell Significance Index: 165.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8816
    Cell Significance Index: 481.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8663
    Cell Significance Index: 1631.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8279
    Cell Significance Index: 36.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7868
    Cell Significance Index: 22.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7524
    Cell Significance Index: 88.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7049
    Cell Significance Index: 36.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6486
    Cell Significance Index: 24.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6187
    Cell Significance Index: 17.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5686
    Cell Significance Index: 35.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5646
    Cell Significance Index: 249.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5152
    Cell Significance Index: 102.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4656
    Cell Significance Index: 5.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4057
    Cell Significance Index: 55.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3781
    Cell Significance Index: 17.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3513
    Cell Significance Index: 477.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3479
    Cell Significance Index: 314.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2818
    Cell Significance Index: 53.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2779
    Cell Significance Index: 427.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2270
    Cell Significance Index: 22.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1826
    Cell Significance Index: 82.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1541
    Cell Significance Index: 284.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1335
    Cell Significance Index: 9.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1033
    Cell Significance Index: 3.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0875
    Cell Significance Index: 55.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0774
    Cell Significance Index: 13.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0667
    Cell Significance Index: 3.1100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0401
    Cell Significance Index: 0.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0399
    Cell Significance Index: 29.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0222
    Cell Significance Index: 2.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0329
    Cell Significance Index: -24.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0532
    Cell Significance Index: -5.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0568
    Cell Significance Index: -43.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0569
    Cell Significance Index: -35.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0912
    Cell Significance Index: -51.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0938
    Cell Significance Index: -2.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1046
    Cell Significance Index: -5.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1720
    Cell Significance Index: -22.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1865
    Cell Significance Index: -39.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2232
    Cell Significance Index: -32.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2330
    Cell Significance Index: -15.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2530
    Cell Significance Index: -28.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3203
    Cell Significance Index: -10.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3285
    Cell Significance Index: -24.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3781
    Cell Significance Index: -39.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3799
    Cell Significance Index: -19.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4027
    Cell Significance Index: -22.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4302
    Cell Significance Index: -11.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4527
    Cell Significance Index: -52.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4543
    Cell Significance Index: -21.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4651
    Cell Significance Index: -12.2300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4936
    Cell Significance Index: -6.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5912
    Cell Significance Index: -46.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6226
    Cell Significance Index: -71.0700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6557
    Cell Significance Index: -4.2800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.7418
    Cell Significance Index: -10.0100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7588
    Cell Significance Index: -9.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7999
    Cell Significance Index: -13.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8451
    Cell Significance Index: -22.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8735
    Cell Significance Index: -16.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9011
    Cell Significance Index: -15.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9608
    Cell Significance Index: -58.9100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.0234
    Cell Significance Index: -15.5700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.0461
    Cell Significance Index: -8.6400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0528
    Cell Significance Index: -11.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1018
    Cell Significance Index: -35.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.1301
    Cell Significance Index: -19.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1672
    Cell Significance Index: -38.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1790
    Cell Significance Index: -40.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** GPI is primarily found in the cytosol of cells, with some expression in the extracellular region and secretory granules. 2. **Subcellular localization:** GPI is highly expressed in pigmented epithelial cells, glycinergic neurons, and various immune cells, including neutrophils and macrophages. 3. **Expression patterns:** GPI is significantly upregulated in response to stress, such as immobilization and muscle stretch, and is also involved in the regulation of cell migration and cytokine production. 4. **Function:** GPI catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate, playing a critical role in glycolysis and glucose homeostasis. **Pathways and Functions:** 1. **Glycolysis:** GPI is a key enzyme in the glycolytic pathway, where it catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate. 2. **Immune system:** GPI modulates cytokine activity, cell migration, and immune response regulation, particularly in the context of neutrophil and macrophage function. 3. **Cell signaling:** GPI is involved in the regulation of cell signaling pathways, including the negative regulation of neuron apoptotic process and the positive regulation of endothelial cell migration. 4. **Response to stress:** GPI is upregulated in response to stress, such as immobilization and muscle stretch, highlighting its role in adapting to environmental changes. **Clinical Significance:** 1. **Diabetes:** Alterations in GPI expression may contribute to the development of diabetes, as dysregulation of glycolysis can lead to insulin resistance and glucose homeostasis disturbances. 2. **Immune disorders:** GPI's role in immune function highlights its potential as a therapeutic target in immune-related disorders, such as autoimmune diseases and immunodeficiencies. 3. **Neurological disorders:** GPI's involvement in neuron apoptosis and cell migration suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer:** GPI's expression in various cancer types, including ovarian cancer, suggests its potential as a biomarker or therapeutic target. In conclusion, glucose-6-phosphate isomerase (GPI) is a critical enzyme involved in glycolysis and immune function. Its significant expression in various cell types and its modulation of cytokine activity, cell migration, and immune response regulation highlight its importance in maintaining glucose homeostasis and immune function. Further studies are necessary to fully elucidate the role of GPI in human diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 568552359

Symbol: G6PI_HUMAN

Name: N/A

UniProtKB Accession Codes:

P06744 B4DG39 Q9BRD3 Q9BSK5 Q9UHE6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 1 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EC 1 EMBL 8 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 5 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10727272

Title: Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination.

PubMed ID: 10727272

DOI: 10.1095/biolreprod62.4.1016

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2387591

Title: Characterization of the 5' end of the gene for human glucose phosphate isomerase (GPI).

PubMed ID: 2387591

DOI: 10.1016/0888-7543(90)90212-d

PubMed ID: 3352745

Title: Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences.

PubMed ID: 3352745

DOI: 10.1038/332455a0

PubMed ID: 11004567

Title: Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein.

PubMed ID: 11004567

DOI: 10.1016/s0167-4838(00)00075-3

PubMed ID: 11437381

Title: Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility.

PubMed ID: 11437381

DOI: 10.1006/bbrc.2001.5135

PubMed ID: 12163179

Title: Species specificity of the cytokine function of phosphoglucose isomerase.

PubMed ID: 12163179

DOI: 10.1016/s0014-5793(02)03072-7

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15637053

Title: Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation.

PubMed ID: 15637053

DOI: 10.1074/jbc.m409457200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29775581

Title: p300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis.

PubMed ID: 29775581

DOI: 10.1016/j.molcel.2018.04.011

PubMed ID: 11371164

Title: The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia.

PubMed ID: 11371164

DOI: 10.1006/jmbi.2001.4680

PubMed ID: 12054796

Title: Inhibition mechanism of cytokine activity of human autocrine motility factor examined by crystal structure analyses and site-directed mutagenesis studies.

PubMed ID: 12054796

DOI: 10.1016/s0022-2836(02)00186-9

PubMed ID: 12777791

Title: The structure of human phosphoglucose isomerase complexed with a transition-state analogue.

PubMed ID: 12777791

DOI: 10.1107/s0907444903007352

PubMed ID: 12573240

Title: Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps.

PubMed ID: 12573240

DOI: 10.1016/s1570-9639(02)00464-8

PubMed ID: 8499925

Title: DNA sequence abnormalities in human glucose 6-phosphate isomerase deficiency.

PubMed ID: 8499925

DOI: 10.1093/hmg/2.3.327

PubMed ID: 7989588

Title: The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia.

PubMed ID: 7989588

DOI: 10.1172/jci117597

PubMed ID: 8822952

Title: Study of the molecular defects in glucose phosphate isomerase-deficient patients affected by chronic hemolytic anemia.

PubMed ID: 8822952

PubMed ID: 8822954

Title: Molecular analysis of glucose phosphate isomerase deficiency associated with hereditary hemolytic anemia.

PubMed ID: 8822954

PubMed ID: 9446754

Title: Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA).

PubMed ID: 9446754

DOI: 10.1006/bcmd.1997.0157

PubMed ID: 9856489

Title: Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency.

PubMed ID: 9856489

DOI: 10.1007/s004390050849

PubMed ID: 28803808

Title: Two novel mutations (p.(Ser160Pro) and p.(Arg472Cys)) causing glucose-6-phosphate isomerase deficiency are associated with erythroid dysplasia and inappropriately suppressed hepcidin.

PubMed ID: 28803808

DOI: 10.1016/j.bcmd.2017.04.003

Sequence Information:

  • Length: 558
  • Mass: 63147
  • Checksum: 7C8E95277BDC79A6
  • Sequence:
    • MAALTRDPQF QKLQQWYREH RSELNLRRLF DANKDRFNHF SLTLNTNHGH ILVDYSKNLV 
TEDVMRMLVD LAKSRGVEAA RERMFNGEKI NYTEGRAVLH VALRNRSNTP ILVDGKDVMP 
EVNKVLDKMK SFCQRVRSGD WKGYTGKTIT DVINIGIGGS DLGPLMVTEA LKPYSSGGPR 
VWYVSNIDGT HIAKTLAQLN PESSLFIIAS KTFTTQETIT NAETAKEWFL QAAKDPSAVA 
KHFVALSTNT TKVKEFGIDP QNMFEFWDWV GGRYSLWSAI GLSIALHVGF DNFEQLLSGA 
HWMDQHFRTT PLEKNAPVLL ALLGIWYINC FGCETHAMLP YDQYLHRFAA YFQQGDMESN 
GKYITKSGTR VDHQTGPIVW GEPGTNGQHA FYQLIHQGTK MIPCDFLIPV QTQHPIRKGL 
HHKILLANFL AQTEALMRGK STEEARKELQ AAGKSPEDLE RLLPHKVFEG NRPTNSIVFT 
KLTPFMLGAL VAMYEHKIFV QGIIWDINSF DQWGVELGKQ LAKKIEPELD GSAQVTSHDA 
STNGLINFIK QQREARVQ

Genular Protein ID: 3659159084

Symbol: B4DE36_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DE36

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 2 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 9 Gene3D 1 HAMAP 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 1 RuleBase 1 SMR 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 530
  • Mass: 60186
  • Checksum: 1F3427E5C76EFD87
  • Sequence:
    • MAALTRDPQF QKLQQWYREH RSELNLRRLF DANKDRFNHF SLTLNTNHGH ILVDYSKNLV 
TEDVMRMLVD LAKSRGVEAA RERMFNGEKI NYTEGRAVLH VALRNRSNTP ILVDGKDVMP 
EVNKVLDKMK SFCQGPLMVT EALKPYSSGG PRVWYVSNID GTHIAKTLAQ LNPESSLFII 
ASKTFTTQET ITNAETAKEW FLQAAKDPSA VAKHFVALST NTTKVKEFGI DPQNMFEFWD 
WVGGRYSLWS AIGLSIALHV GFDNFEQLLS GAHWMDQHFR TTPLEKNAPV LLALLGIWYI 
NCFGCETHAM LPYDQYLHRF AAYFQQGDME SNGKYITKSG TRVDHQTGPI VWGEPGTNGQ 
HAFYQLIHQG TKMIPCDFLI PVQTQHPIRK GLHHKILLAN FLAQTEALMR GKSTEEARKE 
LQAAGKSPED LERLLPHKVF EGNRPTNSIV FTKLTPFMLG ALVAMYEHKI FVQGIIWDIN 
SFDQWGVELG KQLAKKIEPE LDGSAQVTSH DASTNGLINF IKQQREARVQ

Genular Protein ID: 94659253

Symbol: A0A2U3TZU2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2U3TZU2

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 HAMAP 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 Rhea 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 597
  • Mass: 67286
  • Checksum: E8639E5C41EAC8D2
  • Sequence:
    • MVALCSLQHL GSSDPRALPT LPTATSGQRP AKRRRKSPAM AALTRDPQFQ KLQQWYREHR 
SELNLRRLFD ANKDRFNHFS LTLNTNHGHI LVDYSKNLVT EDVMRMLVDL AKSRGVEAAR 
ERMFNGEKIN YTEGRAVLHV ALRNRSNTPI LVDGKDVMPE VNKVLDKMKS FCQRVRSGDW 
KGYTGKTITD VINIGIGGSD LGPLMVTEAL KPYSSGGPRV WYVSNIDGTH IAKTLAQLNP 
ESSLFIIASK TFTTQETITN AETAKEWFLQ AAKDPSAVAK HFVALSTNTT KVKEFGIDPQ 
NMFEFWDWVG GRYSLWSAIG LSIALHVGFD NFEQLLSGAH WMDQHFRTTP LEKNAPVLLA 
LLGIWYINCF GCETHAMLPY DQYLHRFAAY FQQGDMESNG KYITKSGTRV DHQTGPIVWG 
EPGTNGQHAF YQLIHQGTKM IPCDFLIPVQ TQHPIRKGLH HKILLANFLA QTEALMRGKS 
TEEARKELQA AGKSPEDLER LLPHKVFEGN RPTNSIVFTK LTPFMLGALV AMYEHKIFVQ 
GIIWDINSFD QWGVELGKQL AKKIEPELDG SAQVTSHDAS TNGLINFIKQ QREARVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.