Details for: PTH1R

Gene ID: 5745

Symbol: PTH1R

Ensembl ID: ENSG00000160801

Description: parathyroid hormone 1 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.8554
    Cell Significance Index: -10.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.8549
    Cell Significance Index: -10.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.4691
    Cell Significance Index: -10.9500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.8275
    Cell Significance Index: 23.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7496
    Cell Significance Index: -10.8500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.5498
    Cell Significance Index: 14.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.4477
    Cell Significance Index: 12.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3191
    Cell Significance Index: 27.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0398
    Cell Significance Index: 67.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.9148
    Cell Significance Index: 13.1000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7983
    Cell Significance Index: 4.9600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.7009
    Cell Significance Index: 7.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4242
    Cell Significance Index: 6.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3666
    Cell Significance Index: 8.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3002
    Cell Significance Index: 220.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.2626
    Cell Significance Index: 20.8000
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2598
    Cell Significance Index: 2.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2418
    Cell Significance Index: 4.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1684
    Cell Significance Index: 8.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1576
    Cell Significance Index: 21.6400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.1338
    Cell Significance Index: 0.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0637
    Cell Significance Index: 28.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0558
    Cell Significance Index: 11.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0499
    Cell Significance Index: 2.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0476
    Cell Significance Index: 32.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0325
    Cell Significance Index: 4.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0182
    Cell Significance Index: 0.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0156
    Cell Significance Index: 0.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0124
    Cell Significance Index: 4.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -12.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -11.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0089
    Cell Significance Index: -12.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0151
    Cell Significance Index: -11.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0161
    Cell Significance Index: -10.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0173
    Cell Significance Index: -9.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0205
    Cell Significance Index: -5.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0221
    Cell Significance Index: -0.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0339
    Cell Significance Index: -6.7300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0432
    Cell Significance Index: -0.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0452
    Cell Significance Index: -8.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0555
    Cell Significance Index: -11.7000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0561
    Cell Significance Index: -0.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0586
    Cell Significance Index: -1.6800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0642
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0697
    Cell Significance Index: -11.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0724
    Cell Significance Index: -10.5300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0735
    Cell Significance Index: -0.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0751
    Cell Significance Index: -3.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0757
    Cell Significance Index: -8.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0782
    Cell Significance Index: -7.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0788
    Cell Significance Index: -10.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0806
    Cell Significance Index: -9.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0821
    Cell Significance Index: -8.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1011
    Cell Significance Index: -11.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1053
    Cell Significance Index: -8.0800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1121
    Cell Significance Index: -1.0100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1152
    Cell Significance Index: -0.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1166
    Cell Significance Index: -7.3500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1191
    Cell Significance Index: -1.4500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1286
    Cell Significance Index: -1.4100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1318
    Cell Significance Index: -1.5300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1330
    Cell Significance Index: -1.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1375
    Cell Significance Index: -10.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1377
    Cell Significance Index: -6.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1400
    Cell Significance Index: -7.8600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1459
    Cell Significance Index: -1.2400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1497
    Cell Significance Index: -1.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1537
    Cell Significance Index: -10.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1646
    Cell Significance Index: -10.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1683
    Cell Significance Index: -2.6700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1881
    Cell Significance Index: -1.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1965
    Cell Significance Index: -6.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2095
    Cell Significance Index: -7.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2172
    Cell Significance Index: -4.6100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2256
    Cell Significance Index: -3.9000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2361
    Cell Significance Index: -4.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2444
    Cell Significance Index: -10.8100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2587
    Cell Significance Index: -2.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2630
    Cell Significance Index: -6.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2642
    Cell Significance Index: -12.3200
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.2662
    Cell Significance Index: -2.8000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2744
    Cell Significance Index: -3.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2804
    Cell Significance Index: -8.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2826
    Cell Significance Index: -7.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2850
    Cell Significance Index: -9.3300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.2860
    Cell Significance Index: -2.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2873
    Cell Significance Index: -10.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3016
    Cell Significance Index: -11.0700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3026
    Cell Significance Index: -3.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3035
    Cell Significance Index: -8.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3118
    Cell Significance Index: -3.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3145
    Cell Significance Index: -8.7900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3232
    Cell Significance Index: -1.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3244
    Cell Significance Index: -11.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3333
    Cell Significance Index: -8.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3361
    Cell Significance Index: -7.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3400
    Cell Significance Index: -5.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Structure:** PTH1R is a G-protein coupled receptor (GPCR) with seven transmembrane domains, which enables it to bind to PTH and its related peptides. 2. **Ligand Binding:** PTH1R binds to PTH and parathyroid hormone-related peptides (PTHrP), triggering a signaling cascade that regulates various cellular processes. 3. **Signaling Pathways:** PTH1R activates adenylate cyclase, leading to increased cAMP levels, and modulates other signaling pathways, including phospholipase C and protein kinase C. 4. **Cellular Expression:** PTH1R is expressed in various cell types, including renal epithelial cells, osteoblasts, and vascular smooth muscle cells. **Pathways and Functions:** 1. **Mineral Metabolism:** PTH1R plays a crucial role in regulating calcium and phosphate homeostasis, essential for maintaining bone health and muscle function. 2. **Bone Resorption and Formation:** PTH1R mediates the effects of PTH on osteoclasts, promoting bone resorption, and osteoblasts, promoting bone formation. 3. **Cell Growth and Differentiation:** PTH1R regulates cell proliferation and differentiation in various cell types, including renal epithelial cells and osteoblasts. 4. **Nervous System Function:** PTH1R is expressed in the nervous system, where it modulates calcium signaling and neuronal function. **Clinical Significance:** 1. **Hyperparathyroidism:** Mutations in the PTH1R gene can lead to hyperparathyroidism, a condition characterized by elevated PTH levels and bone resorption. 2. **Bone Diseases:** Alterations in PTH1R expression or function can contribute to bone diseases, such as osteoporosis and osteomalacia. 3. **Kidney Disease:** PTH1R dysregulation can contribute to kidney disease, including chronic kidney disease and acute kidney injury. 4. **Cancer:** PTH1R has been implicated in the development and progression of certain cancers, including breast and lung cancer. In conclusion, the Parathyroid Hormone 1 Receptor (PTH1R) is a critical gene that regulates various physiological processes, including mineral metabolism, cell growth, and differentiation. Understanding the functions and dysregulation of PTH1R can provide valuable insights into the pathogenesis of various diseases and inform the development of novel therapeutic strategies.

Genular Protein ID: 2108445028

Symbol: PTH1R_HUMAN

Name: Parathyroid hormone/parathyroid hormone-related peptide receptor

UniProtKB Accession Codes:

Q03431 Q2M1U3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 15 EMDB 21 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 33 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8386612

Title: Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor.

PubMed ID: 8386612

DOI: 10.1210/endo.132.5.8386612

PubMed ID: 8397094

Title: Cloning and functional expression of a human parathyroid hormone receptor.

PubMed ID: 8397094

DOI: 10.1016/0922-4106(93)90092-n

PubMed ID: 7745008

Title: Pseudohypoparathyroidism type Ib is not caused by mutations in the coding exons of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene.

PubMed ID: 7745008

DOI: 10.1210/jcem.80.5.7745008

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10913300

Title: The N-terminal fragment of human parathyroid hormone receptor 1 constitutes a hormone binding domain and reveals a distinct disulfide pattern.

PubMed ID: 10913300

DOI: 10.1021/bi0001426

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9737850

Title: Binding domain of human parathyroid hormone receptor: from conformation to function.

PubMed ID: 9737850

DOI: 10.1021/bi981265h

PubMed ID: 18375760

Title: Molecular recognition of parathyroid hormone by its G protein-coupled receptor.

PubMed ID: 18375760

DOI: 10.1073/pnas.0801027105

PubMed ID: 18611381

Title: Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.

PubMed ID: 18611381

DOI: 10.1016/j.str.2008.04.010

PubMed ID: 21827955

Title:

PubMed ID: 21827955

DOI: 10.1016/j.str.2011.07.010

PubMed ID: 19674967

Title: Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides.

PubMed ID: 19674967

DOI: 10.1074/jbc.m109.022905

PubMed ID: 20172855

Title: Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation.

PubMed ID: 20172855

DOI: 10.1074/jbc.m109.093138

PubMed ID: 7701349

Title: A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia.

PubMed ID: 7701349

DOI: 10.1126/science.7701349

PubMed ID: 8703170

Title: Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia.

PubMed ID: 8703170

DOI: 10.1056/nejm199609053351004

PubMed ID: 9178745

Title: Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia.

PubMed ID: 9178745

DOI: 10.1210/mend.11.7.9934

PubMed ID: 9745456

Title: A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia.

PubMed ID: 9745456

DOI: 10.1210/jcem.83.9.5243

PubMed ID: 10487664

Title: A novel parathyroid hormone (PTH)/PTH-related peptide receptor mutation in Jansen's metaphyseal chondrodysplasia.

PubMed ID: 10487664

DOI: 10.1210/jcem.84.9.6000

PubMed ID: 11850620

Title: A mutant PTH/PTHrP type I receptor in enchondromatosis.

PubMed ID: 11850620

DOI: 10.1038/ng844

PubMed ID: 15523647

Title: Enchondromatosis (Ollier disease, Maffucci syndrome) is not caused by the PTHR1 mutation p.R150C.

PubMed ID: 15523647

DOI: 10.1002/humu.20095

PubMed ID: 15240651

Title: A form of Jansen's metaphyseal chondrodysplasia with limited metabolic and skeletal abnormalities is caused by a novel activating parathyroid hormone (PTH)/PTH-related peptide receptor mutation.

PubMed ID: 15240651

DOI: 10.1210/jc.2004-0036

PubMed ID: 15525660

Title: Recessive mutations in PTHR1 cause contrasting skeletal dysplasias in Eiken and Blomstrand syndromes.

PubMed ID: 15525660

DOI: 10.1093/hmg/ddi001

PubMed ID: 19061984

Title: PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption.

PubMed ID: 19061984

DOI: 10.1016/j.ajhg.2008.11.006

PubMed ID: 27160269

Title: Characterization of a PTH1R missense mutation responsible for Jansen type metaphyseal chondrodysplasia.

PubMed ID: 27160269

DOI: 10.1007/s10266-016-0247-4

Sequence Information:

  • Length: 593
  • Mass: 66361
  • Checksum: DA1400640A6C7F2B
  • Sequence:
    • MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK RLKEVLQRPA 
SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG SRYRGRPCLP EWDHILCWPL 
GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR NGSWELVPGH NRTWANYSEC VKFLTNETRE 
REVFDRLGMI YTVGYSVSLA SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK 
DAVLYSGATL DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL 
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG CWDLSSGNKK 
WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR QQYRKLLKST LVLMPLFGVH 
YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA 
LDFKRKARSG SSSYSYGPMV SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP 
GTPALETLET TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM

Genular Protein ID: 868654366

Symbol: Q0VGD7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0VGD7

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 593
  • Mass: 66289
  • Checksum: DA81DF2F6B0C7F2B
  • Sequence:
    • MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCGK RLKEVLQRPA 
SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG SRYRGRPCLP EWDHILCWPL 
GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR NGSWELVPGH NRTWANYSEC VKFLTNETRE 
REVFDRLGMI YTVGYSVSLA SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK 
DAVLYSGATL DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL 
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG CWDLSSGNKK 
WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR QQYRKLLKST LVLMPLFGVH 
YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA 
LDFKRKARSG SSSYSYGPMV SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP 
GTPALETLET TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.