Details for: SLC25A4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 329.0040
Cell Significance Index: -51.1800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 201.3063
Cell Significance Index: -51.0600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 104.7080
Cell Significance Index: -49.4400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 96.8106
Cell Significance Index: -39.3300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 73.6712
Cell Significance Index: -49.4400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.8280
Cell Significance Index: -39.9400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.6641
Cell Significance Index: -51.3700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.2107
Cell Significance Index: -46.1100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.1296
Cell Significance Index: -51.8100 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 5.7720
Cell Significance Index: 44.4900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 5.6375
Cell Significance Index: 83.2300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.9566
Cell Significance Index: 260.2400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 4.3444
Cell Significance Index: 106.0000 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 3.1763
Cell Significance Index: 51.2500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.5775
Cell Significance Index: 197.8000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.5129
Cell Significance Index: 68.4000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.0242
Cell Significance Index: 121.5200 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 1.7550
Cell Significance Index: 6.7200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.6358
Cell Significance Index: 103.1000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.5400
Cell Significance Index: 71.8000 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.1520
Cell Significance Index: 12.2400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1011
Cell Significance Index: 601.3600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0763
Cell Significance Index: 175.0500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0385
Cell Significance Index: 127.6900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9988
Cell Significance Index: 200.3500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.8116
Cell Significance Index: 42.2800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8047
Cell Significance Index: 145.0600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.7879
Cell Significance Index: 62.4000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6817
Cell Significance Index: 615.5400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5742
Cell Significance Index: 12.4400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.5700
Cell Significance Index: 417.8900 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.5339
Cell Significance Index: 1.5300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4413
Cell Significance Index: 195.0900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3997
Cell Significance Index: 143.3800 - Cell Name: peg cell (CL4033014)
Fold Change: 0.3813
Cell Significance Index: 8.8100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3656
Cell Significance Index: 25.2900 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.3482
Cell Significance Index: 44.9800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3272
Cell Significance Index: 11.3700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3063
Cell Significance Index: 21.6600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2940
Cell Significance Index: 15.2700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2891
Cell Significance Index: 49.3600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2888
Cell Significance Index: 13.5800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2556
Cell Significance Index: 48.6400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2240
Cell Significance Index: 26.4200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2113
Cell Significance Index: 15.7500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1793
Cell Significance Index: 22.9800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1477
Cell Significance Index: 9.0800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1311
Cell Significance Index: 99.2200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1148
Cell Significance Index: 5.2100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1025
Cell Significance Index: 3.6000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0741
Cell Significance Index: 1.2700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0388
Cell Significance Index: 17.6100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0364
Cell Significance Index: 68.6100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0075
Cell Significance Index: -11.5200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0127
Cell Significance Index: -9.4000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0148
Cell Significance Index: -9.3700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0174
Cell Significance Index: -32.0300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0188
Cell Significance Index: -25.5500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0238
Cell Significance Index: -14.8900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0289
Cell Significance Index: -19.9800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0402
Cell Significance Index: -7.9800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0404
Cell Significance Index: -4.0000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0503
Cell Significance Index: -28.3600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0577
Cell Significance Index: -7.9300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0791
Cell Significance Index: -8.0900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0813
Cell Significance Index: -17.1200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0814
Cell Significance Index: -0.9700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0922
Cell Significance Index: -2.3700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1261
Cell Significance Index: -2.6400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1345
Cell Significance Index: -15.4100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1419
Cell Significance Index: -40.8300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1431
Cell Significance Index: -3.8200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1438
Cell Significance Index: -16.4100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1522
Cell Significance Index: -17.7400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1925
Cell Significance Index: -5.3800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2065
Cell Significance Index: -30.0200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2252
Cell Significance Index: -15.1500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2648
Cell Significance Index: -8.4800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3589
Cell Significance Index: -3.3100 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.3798
Cell Significance Index: -3.1900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4287
Cell Significance Index: -44.6400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.4354
Cell Significance Index: -5.4000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4816
Cell Significance Index: -27.0300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5047
Cell Significance Index: -13.2700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5555
Cell Significance Index: -11.8300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5557
Cell Significance Index: -35.8500 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.5705
Cell Significance Index: -4.5600 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.6573
Cell Significance Index: -5.7900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6627
Cell Significance Index: -40.6300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6629
Cell Significance Index: -29.3200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7434
Cell Significance Index: -21.2200 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.7643
Cell Significance Index: -9.8000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8276
Cell Significance Index: -31.3400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.8989
Cell Significance Index: -15.8900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.9061
Cell Significance Index: -21.7300 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -1.0054
Cell Significance Index: -10.9300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.0155
Cell Significance Index: -37.2800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.0291
Cell Significance Index: -29.5000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0582
Cell Significance Index: -34.6500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.0595
Cell Significance Index: -30.5300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1230512303
Symbol: ADT1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2823266
Title: cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes.
PubMed ID: 2823266
PubMed ID: 2541251
Title: DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.
PubMed ID: 2541251
PubMed ID: 2547778
Title: A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed.
PubMed ID: 2547778
PubMed ID: 20843780
Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.
PubMed ID: 20843780
DOI: 10.1093/nar/gkq750
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2829183
Title: Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.
PubMed ID: 2829183
PubMed ID: 16120388
Title: Mitochondrial membrane permeabilization by HIV-1 Vpr.
PubMed ID: 16120388
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21586654
Title: adPEO mutations in ANT1 impair ADP-ATP translocation in muscle mitochondria.
PubMed ID: 21586654
DOI: 10.1093/hmg/ddr200
PubMed ID: 22187496
Title: Complete loss of expression of the ANT1 gene causing cardiomyopathy and myopathy.
PubMed ID: 22187496
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27693233
Title: Recurrent de novo dominant mutations in SLC25A4 cause severe early-onset mitochondrial disease and loss of mitochondrial DNA copy number.
PubMed ID: 27693233
PubMed ID: 27641616
Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.
PubMed ID: 27641616
DOI: 10.1038/srep33516
PubMed ID: 31883789
Title: Human-specific ARHGAP11B acts in mitochondria to expand neocortical progenitors by glutaminolysis.
PubMed ID: 31883789
PubMed ID: 10926541
Title: Role of adenine nucleotide translocator 1 in mtDNA maintenance.
PubMed ID: 10926541
PubMed ID: 11756613
Title: A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family.
PubMed ID: 11756613
PubMed ID: 12112115
Title: A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ophthalmoplegia patients with mitochondrial DNA with multiple deletions.
PubMed ID: 12112115
DOI: 10.1002/ana.10172
PubMed ID: 12707443
Title: Mutations of ANT1, Twinkle, and POLG1 in sporadic progressive external ophthalmoplegia (PEO).
PubMed ID: 12707443
PubMed ID: 16155110
Title: Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial myopathy and cardiomyopathy.
PubMed ID: 16155110
DOI: 10.1093/hmg/ddi341
PubMed ID: 15792871
Title: A novel ANT1 gene mutation with probable germline mosaicism in autosomal dominant progressive external ophthalmoplegia.
PubMed ID: 15792871
PubMed ID: 18575922
Title: Novel Twinkle (PEO1) gene mutations in Mendelian progressive external ophthalmoplegia.
PubMed ID: 18575922
PubMed ID: 25732997
Title: Two novel mutations in the SLC25A4 gene in a patient with mitochondrial myopathy.
PubMed ID: 25732997
Sequence Information:
- Length: 298
- Mass: 33064
- Checksum: 59F0DFAEC4E7CFBB
- Sequence:
MGDHAWSFLK DFLAGGVAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQLFL GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA QREFHGLGDC IIKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG MLPDPKNVHI FVSWMIAQSV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM YTGTVDCWRK IAKDEGAKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.