Details for: ERICH5

Gene ID: 203111

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ERICH5

Ensembl ID: ENSG00000177459

Description: glutamate rich 5

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • corneal epithelial cell CL0000575
    CSI 10.53
    rCSI 30.11%
    PRS 96.57
  • basal cell CL0000646
    CSI 6.01
    rCSI 8.04%
    PRS 94.87
  • secretory cell CL0000151
    CSI 4.02
    rCSI 4.2%
    PRS 96.03
  • conjunctival epithelial cell CL1000432
    CSI 3.88
    rCSI 5.92%
    PRS 95.64
  • ciliated epithelial cell CL0000067
    CSI 3.68
    rCSI 3.23%
    PRS 91.42
  • multi-ciliated epithelial cell CL0005012
    CSI 3.09
    rCSI 3.08%
    PRS 93.23
  • intrahepatic cholangiocyte CL0002538
    CSI 2.95
    rCSI 7.07%
    PRS 95.98
  • lung ciliated cell CL1000271
    CSI 2.63
    rCSI 3.04%
    PRS 93.35
  • ciliated cell CL0000064
    CSI 2.5
    rCSI 4.04%
    PRS 92.19
  • club cell CL0000158
    CSI 2.45
    rCSI 3.58%
    PRS 94.72
  • pancreatic ductal cell CL0002079
    CSI 1.76
    rCSI 3.42%
    PRS 96.68
  • type B pancreatic cell CL0000169
    CSI 1.43
    rCSI 3.17%
    PRS 96.32
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.86
    rCSI 1.95%
    PRS 91.69

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ERICH5](/details-gene/203111) (Glutamate rich 5) is a protein-coding gene located on chromosome 8q22.2, first identified through large-scale cDNA sequencing projects [Link](https://doi.org/10.1038/ng1285). The function of the encoded protein is not well characterized, with current annotations limited to a general role in protein binding ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)). Expression data reveals a highly specific profile, with [ERICH5](/details-gene/203111) serving as a significant marker for various epithelial cell populations. **Overall**, it shows particularly strong and specific expression in the [corneal epithelial cell](/details-cell/CL0000575) of the eye, as well as in secretory and ciliated cells of the respiratory and glandular systems, suggesting a specialized function in maintaining the integrity and function of these epithelial barriers. ## Cellular Roles and Expression Landscape The expression pattern of [ERICH5](/details-gene/203111) strongly indicates a specialized role within epithelial biology across multiple tissues. The most significant expression is observed in ocular surface epithelia, where it is a top marker for [corneal epithelial cell](/details-cell/CL0000575) (CSI: 10.53) and [conjunctival epithelial cell](/details-cell/CL1000432) (CSI: 3.88). This pronounced enrichment suggests a crucial function in the unique environment of the cornea, possibly related to structural support, barrier function, or transparency. Beyond the eye, [ERICH5](/details-gene/203111) is a significant marker for various ciliated and secretory epithelial cells that line mucosal surfaces. Its high significance in [ciliated epithelial cell](/details-cell/CL0000067), [lung ciliated cell](/details-cell/CL1000271), and [club cell](/details-cell/CL0000158) points towards a potential role in the respiratory system, likely related to mucociliary clearance. This pattern is extended to ductal systems, with notable expression in [intrahepatic cholangiocyte](/details-cell/CL0002538) and [pancreatic ductal cell](/details-cell/CL0002079). Furthermore, its high significance in [basal cell](/details-cell/CL0000646) (CSI: 6.01), which often act as tissue progenitors, may indicate that [ERICH5](/details-gene/203111) is involved in the differentiation or maintenance of these specialized epithelial lineages. ## Pathways and Molecular Function The functional annotation for [ERICH5](/details-gene/203111) is currently limited. The primary molecular function attributed to its protein product is protein binding ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)). This broad categorization suggests it acts as an adaptor or scaffold protein, but its specific binding partners and the downstream cellular pathways it influences remain unknown. The gene's name, "Glutamate rich 5," implies the protein contains domains rich in glutamic acid, which could mediate specific protein-protein interactions. Elucidating these interactions within the context of the epithelial cells where it is highly expressed is critical to understanding its precise biological role. ## Research Directions The highly specific expression pattern of [ERICH5](/details-gene/203111) in distinct epithelial populations provides a strong foundation for targeted functional investigation. **Proposed Hypotheses:** 1. Given its exceptional expression in the cornea, [ERICH5](/details-gene/203111) is hypothesized to be a key structural or junctional component required for maintaining the integrity and barrier function of the corneal epithelium. 2. Based on its consistent high expression in multiple ciliated cell types, [ERICH5](/details-gene/203111) may play a role in ciliogenesis or the regulation of ciliary beating, thereby contributing to mucociliary transport in the respiratory tract and other ciliated tissues. 3. The high significance in [basal cell](/details-cell/CL0000646) suggests that [ERICH5](/details-gene/203111) could be a factor involved in the commitment or terminal differentiation of epithelial stem cells into specialized cell types like ciliated or secretory cells. **Key Experimental Approach:** To test the hypothesis that [ERICH5](/details-gene/203111) is critical for corneal epithelial integrity, a targeted knockdown or knockout approach in a relevant model system is warranted. Using an *in vitro* 3D organotypic culture of human corneal epithelial cells, CRISPR-Cas9 could be employed to ablate [ERICH5](/details-gene/203111) expression. The resulting cultures would be assessed for defects in stratification, cell-cell adhesion (via immunofluorescence for E-cadherin and ZO-1), and barrier function using a transepithelial electrical resistance (TEER) assay. Furthermore, a scratch wound assay on these cultures could reveal any role for [ERICH5](/details-gene/203111) in epithelial migration and wound healing. **Therapeutic Potential:** The highly restricted expression of [ERICH5](/details-gene/203111), particularly in the cornea, minimizes the risk of off-target effects and makes it an attractive potential therapeutic target for ocular surface diseases. If its function in maintaining the corneal barrier is confirmed, it could be a target for therapies aimed at promoting corneal repair following injury or in chronic conditions like dry eye syndrome. Therapeutic strategies might involve the topical application of a recombinant [ERICH5](/details-gene/203111) protein or the use of small molecules designed to enhance its expression or stabilize its function, thereby strengthening the epithelial barrier.

Genular Protein ID: 2926507847

Symbol: ERIC5_HUMAN

Name: Glutamate-rich protein 5

UniProtKB Accession Codes:

Q6P6B1 G3V1K4 Q8N1L8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 EMBL 5 Ensembl 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 374
  • Mass: 39936
  • Checksum: 78FEE6D3CEF9011A
  • Sequence:
    • MGCSSSALNK AGDSSRFPSV TSNEHFSTAE ESESCFAQPK PHALGRESTV DGNVQRESRP 
PLQKLKVSAE PTANGVKPLQ EQPLAKDVAP GRDATDQSGS TEKTQPGEGL EESGPPQPGG 
KEDAPAAEGK KKDAGAGTEA ESLKGNAEAQ PLGPEAKGQP LQAAVEKDSL RAVEVTENPQ 
TAAEMKPLGT TENVLTLQIA GELQPQGTVG KDEQAPLLET ISKENESPEI LEGSQFVETA 
EEQQLQATLG KEEQPQLLER IPKENVTPEV LDRSQLVEKP VMNDPFHKTP EGPGNMEQIQ 
PEGIVGSMEH PARNVEAGAY VEMIRNIHTN EEDQRIEGET GEKVETDMEN EKVSEGAETK 
EEETGEVVDL SAAT