Details for: PKP1

Gene ID: 5317

Symbol: PKP1

Ensembl ID: ENSG00000081277

Description: plakophilin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 22.0982
    Cell Significance Index: 49.8200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 13.1677
    Cell Significance Index: 113.1500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 6.8561
    Cell Significance Index: 20.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.2430
    Cell Significance Index: 90.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.9302
    Cell Significance Index: 61.8200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.9178
    Cell Significance Index: 27.3000
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 1.7721
    Cell Significance Index: 2.0400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.6408
    Cell Significance Index: 13.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3388
    Cell Significance Index: -2.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2791
    Cell Significance Index: 565.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2717
    Cell Significance Index: 15.1600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.2273
    Cell Significance Index: 9.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1984
    Cell Significance Index: 32.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0417
    Cell Significance Index: 198.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8316
    Cell Significance Index: 52.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.8177
    Cell Significance Index: 11.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7074
    Cell Significance Index: 50.0300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.6973
    Cell Significance Index: 6.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6469
    Cell Significance Index: 15.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6455
    Cell Significance Index: 63.8500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.6029
    Cell Significance Index: 0.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5827
    Cell Significance Index: 12.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5447
    Cell Significance Index: 491.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4678
    Cell Significance Index: 24.3000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.4650
    Cell Significance Index: 5.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4082
    Cell Significance Index: 50.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3832
    Cell Significance Index: 41.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3451
    Cell Significance Index: 56.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3410
    Cell Significance Index: 61.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3330
    Cell Significance Index: 19.9900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.2666
    Cell Significance Index: 1.6500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2314
    Cell Significance Index: 3.2500
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.2185
    Cell Significance Index: 1.6800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2013
    Cell Significance Index: 2.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1936
    Cell Significance Index: 13.3900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1363
    Cell Significance Index: 1.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1222
    Cell Significance Index: 1.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0909
    Cell Significance Index: 11.7500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0568
    Cell Significance Index: 0.5000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0237
    Cell Significance Index: 0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0124
    Cell Significance Index: 0.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0016
    Cell Significance Index: 0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0005
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0025
    Cell Significance Index: -0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0042
    Cell Significance Index: -0.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0052
    Cell Significance Index: -0.2600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0075
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -5.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0111
    Cell Significance Index: -1.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0121
    Cell Significance Index: -5.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0123
    Cell Significance Index: -6.7200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0136
    Cell Significance Index: -0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0147
    Cell Significance Index: -5.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0207
    Cell Significance Index: -5.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0223
    Cell Significance Index: -3.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0247
    Cell Significance Index: -1.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0276
    Cell Significance Index: -3.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0302
    Cell Significance Index: -6.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0304
    Cell Significance Index: -6.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0330
    Cell Significance Index: -5.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0354
    Cell Significance Index: -1.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0384
    Cell Significance Index: -1.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0408
    Cell Significance Index: -3.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0457
    Cell Significance Index: -6.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0459
    Cell Significance Index: -5.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0521
    Cell Significance Index: -1.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0534
    Cell Significance Index: -6.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0663
    Cell Significance Index: -6.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0777
    Cell Significance Index: -3.1900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0815
    Cell Significance Index: -0.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0829
    Cell Significance Index: -1.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0948
    Cell Significance Index: -4.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0964
    Cell Significance Index: -6.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0973
    Cell Significance Index: -5.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0983
    Cell Significance Index: -3.6100
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.1046
    Cell Significance Index: -0.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1066
    Cell Significance Index: -8.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1145
    Cell Significance Index: -2.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1316
    Cell Significance Index: -6.9100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1320
    Cell Significance Index: -3.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1378
    Cell Significance Index: -7.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1619
    Cell Significance Index: -7.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1657
    Cell Significance Index: -4.2600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1676
    Cell Significance Index: -1.7800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1710
    Cell Significance Index: -5.4100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1720
    Cell Significance Index: -2.9400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1738
    Cell Significance Index: -2.6400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1791
    Cell Significance Index: -2.5100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1824
    Cell Significance Index: -2.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1890
    Cell Significance Index: -6.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Desmosomal protein**: PKP1 is a key component of desmosomes, which are crucial for maintaining the structural and functional cohesion of epithelial cells. 2. **Cell-cell adhesion**: PKP1 mediates cell-cell adhesion by interacting with other desmosomal proteins, such as plakoglobin and plakophilin-2. 3. **Apoptosis regulation**: PKP1 has been implicated in the regulation of apoptosis, particularly in the context of epithelial tissues. 4. **Gene expression regulation**: PKP1 can influence gene expression by interacting with other transcriptional regulators. 5. **Interactions with other proteins**: PKP1 interacts with a wide range of proteins, including intermediate filaments, lamin, and various signaling molecules. **Pathways and Functions:** 1. **Adherens junction formation**: PKP1 plays a crucial role in the formation and maintenance of adherens junctions, which are essential for cell-cell adhesion. 2. **Cell-cell adhesion**: PKP1 mediates cell-cell adhesion by interacting with other desmosomal proteins and intermediate filaments. 3. **Apoptosis regulation**: PKP1 can modulate apoptosis by interacting with pro-apoptotic and anti-apoptotic proteins. 4. **Gene expression regulation**: PKP1 can influence gene expression by interacting with transcriptional regulators and signaling molecules. 5. **Immune responses**: PKP1 has been implicated in the regulation of immune responses, particularly in the context of epithelial tissues. **Clinical Significance:** 1. **Skin disorders**: PKP1 mutations have been associated with skin disorders, such as epidermolysis bullosa simplex (EBS) and dystrophic epidermolysis bullosa (DEB). 2. **Cancer**: PKP1 has been implicated in cancer, particularly in the context of epithelial cancers, where it may contribute to tumorigenesis and metastasis. 3. **Inflammatory diseases**: PKP1 has been implicated in inflammatory diseases, such as psoriasis and atopic dermatitis, where it may contribute to the development of skin lesions. 4. **Neurological disorders**: PKP1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the development of neurodegenerative symptoms. In conclusion, PKP1 is a multifunctional protein that plays a critical role in maintaining epithelial integrity and function. Its involvement in various cellular processes, including cell-cell adhesion, apoptosis, and gene expression regulation, highlights its importance in maintaining tissue homeostasis. Further research on PKP1 is necessary to fully elucidate its role in various diseases, including skin disorders, cancer, inflammatory diseases, and neurological disorders.

Genular Protein ID: 4234155938

Symbol: PKP1_HUMAN

Name: Plakophilin-1

UniProtKB Accession Codes:

Q13835 O00645 Q14CA0 Q15152

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7527055

Title: Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family.

PubMed ID: 7527055

DOI: 10.1242/jcs.107.8.2259

PubMed ID: 9369526

Title: Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components.

PubMed ID: 9369526

DOI: 10.1007/s004410050956

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9326952

Title: Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome.

PubMed ID: 9326952

DOI: 10.1038/ng1097-240

PubMed ID: 10852826

Title: Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.

PubMed ID: 10852826

DOI: 10.1242/jcs.113.13.2471

PubMed ID: 11790773

Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

PubMed ID: 11790773

DOI: 10.1074/jbc.m108765200

PubMed ID: 25225333

Title: Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.

PubMed ID: 25225333

DOI: 10.1128/mcb.00766-14

PubMed ID: 15663951

Title: Structure of the armadillo repeat domain of plakophilin 1.

PubMed ID: 15663951

DOI: 10.1016/j.jmb.2004.11.048

Sequence Information:

  • Length: 747
  • Mass: 82861
  • Checksum: 60C1BCCC50AB4E6F
  • Sequence:
    • MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQSS 
TLSHSNRGSM YDGLADNYNY GTTSRSSYYS KFQAGNGSWG YPIYNGTLKR EPDNRRFSSY 
SQMENWSRHY PRGSCNTTGA GSDICFMQKI KASRSEPDLY CDPRGTLRKG TLGSKGQKTT 
QNRYSFYSTC SGQKAIKKCP VRPPSCASKQ DPVYIPPISC NKDLSFGHSR ASSKICSEDI 
ECSGLTIPKA VQYLSSQDEK YQAIGAYYIQ HTCFQDESAK QQVYQLGGIC KLVDLLRSPN 
QNVQQAAAGA LRNLVFRSTT NKLETRRQNG IREAVSLLRR TGNAEIQKQL TGLLWNLSST 
DELKEELIAD ALPVLADRVI IPFSGWCDGN SNMSREVVDP EVFFNATGCL RKRLGMRELL 
ALVPQRATSS RVNLSSADAG RQTMRNYSGL IDSLMAYVQN CVAASRCDDK SVENCMCVLH 
NLSYRLDAEV PTRYRQLEYN ARNAYTEKSS TGCFSNKSDK MMNNNYDCPL PEEETNPKGS 
GWLYHSDAIR TYLNLMGKSK KDATLEACAG ALQNLTASKG LMSSGMSQLI GLKEKGLPQI 
ARLLQSGNSD VVRSGASLLS NMSRHPLLHR VMGNQVFPEV TRLLTSHTGN TSNSEDILSS 
ACYTVRNLMA SQPQLAKQYF SSSMLNNIIN LCRSSASPKA AEAARLLLSD MWSSKELQGV 
LRQQGFDRNM LGTLAGANSL RNFTSRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.