Details for: DSG1

Gene ID: 1828

Symbol: DSG1

Ensembl ID: ENSG00000134760

Description: desmoglein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 17.7418
    Cell Significance Index: 117.7700
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 16.8436
    Cell Significance Index: 19.3900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 9.1019
    Cell Significance Index: 20.5200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 6.9435
    Cell Significance Index: 20.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 5.3003
    Cell Significance Index: 75.4500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 3.9186
    Cell Significance Index: 5.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.2909
    Cell Significance Index: 56.2600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.1735
    Cell Significance Index: 27.2700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.5086
    Cell Significance Index: 32.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.4231
    Cell Significance Index: 88.9500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.3255
    Cell Significance Index: 31.8900
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.3868
    Cell Significance Index: 9.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8050
    Cell Significance Index: 355.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7758
    Cell Significance Index: 54.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6860
    Cell Significance Index: 9.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5057
    Cell Significance Index: 12.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4907
    Cell Significance Index: 30.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4295
    Cell Significance Index: -0.9400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.3510
    Cell Significance Index: 5.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2908
    Cell Significance Index: 9.3200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1926
    Cell Significance Index: 3.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1806
    Cell Significance Index: 34.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1774
    Cell Significance Index: 2.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1378
    Cell Significance Index: 3.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1333
    Cell Significance Index: 13.1900
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1278
    Cell Significance Index: 0.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0882
    Cell Significance Index: 79.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0668
    Cell Significance Index: 10.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0331
    Cell Significance Index: 3.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0299
    Cell Significance Index: 0.6200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0296
    Cell Significance Index: 0.4300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0180
    Cell Significance Index: 0.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0147
    Cell Significance Index: 1.0200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0106
    Cell Significance Index: 0.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0083
    Cell Significance Index: 0.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0046
    Cell Significance Index: 0.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0007
    Cell Significance Index: -0.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0039
    Cell Significance Index: -0.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0061
    Cell Significance Index: -3.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -3.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0082
    Cell Significance Index: -2.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0094
    Cell Significance Index: -0.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0096
    Cell Significance Index: -0.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0097
    Cell Significance Index: -0.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0119
    Cell Significance Index: -2.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0119
    Cell Significance Index: -0.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0126
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0131
    Cell Significance Index: -2.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0195
    Cell Significance Index: -2.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0202
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0220
    Cell Significance Index: -2.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0223
    Cell Significance Index: -6.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0237
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0247
    Cell Significance Index: -2.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0256
    Cell Significance Index: -3.3100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0306
    Cell Significance Index: -0.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0331
    Cell Significance Index: -0.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0332
    Cell Significance Index: -1.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0365
    Cell Significance Index: -3.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0374
    Cell Significance Index: -1.7600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0376
    Cell Significance Index: -0.5200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0386
    Cell Significance Index: -0.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0393
    Cell Significance Index: -1.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0396
    Cell Significance Index: -0.4500
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0430
    Cell Significance Index: -0.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0502
    Cell Significance Index: -0.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0504
    Cell Significance Index: -3.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0504
    Cell Significance Index: -3.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0542
    Cell Significance Index: -3.3300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0546
    Cell Significance Index: -0.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0600
    Cell Significance Index: -4.4700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0602
    Cell Significance Index: -0.9200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0648
    Cell Significance Index: -0.7100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0649
    Cell Significance Index: -0.8200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0673
    Cell Significance Index: -0.8800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0681
    Cell Significance Index: -1.1700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0712
    Cell Significance Index: -0.8600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0762
    Cell Significance Index: -0.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0780
    Cell Significance Index: -2.0900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0794
    Cell Significance Index: -1.1300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0800
    Cell Significance Index: -0.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0835
    Cell Significance Index: -2.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0838
    Cell Significance Index: -1.7900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0850
    Cell Significance Index: -0.9300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0880
    Cell Significance Index: -1.0400
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0891
    Cell Significance Index: -1.1400
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0894
    Cell Significance Index: -1.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0895
    Cell Significance Index: -1.7500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0905
    Cell Significance Index: -0.9800
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0957
    Cell Significance Index: -0.7300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0958
    Cell Significance Index: -2.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane glycoprotein**: DSG1 is a transmembrane protein composed of six extracellular cadherin domains, which are linked by short cytoplasmic tails. 2. **Cell-cell adhesion**: DSG1 forms homophilic adhesion complexes with adjacent cells, promoting cell-cell adhesion and tissue integrity. 3. **Desmosomal composition**: DSG1 is a key component of desmosomes, which are specialized cell-cell junctions that resist mechanical stress and maintain tissue structure. 4. **Expression in various cell types**: DSG1 is expressed in diverse cell types, including corneal epithelial cells, conjunctival epithelial cells, colon goblet cells, and hematopoietic stem cells. **Pathways and Functions:** 1. **Apoptotic cleavage of cell adhesion proteins**: DSG1 is involved in the regulation of apoptosis through the cleavage of cell adhesion proteins, such as desmoglein 3. 2. **Calcium-dependent cell-cell adhesion**: DSG1 facilitates calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. 3. **Homophilic cell adhesion**: DSG1 promotes homophilic cell adhesion via plasma membrane adhesion molecules, contributing to tissue integrity. 4. **Signal transduction**: DSG1 interacts with various signaling molecules, including Rho GTPases and Miro GTPases, to regulate cell behavior and tissue homeostasis. **Clinical Significance:** 1. **Pemphigus**: Mutations in the DSG1 gene are associated with pemphigus, a group of autoimmune skin diseases characterized by blistering and skin fragility. 2. **Stevens-Johnson syndrome**: DSG1 dysfunction has been implicated in Stevens-Johnson syndrome, a severe skin and mucous membrane disorder. 3. **Autoimmune disorders**: DSG1 has been linked to various autoimmune disorders, including autoimmune hemolytic anemia and autoimmune neutropenia. 4. **Cancer**: DSG1 expression has been observed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role in tumor development and progression. In conclusion, DSG1 is a crucial component of cell-cell adhesion and plays a significant role in maintaining tissue integrity and barrier function. Its dysregulation has been implicated in various immune and skin disorders, highlighting the importance of DSG1 in human health and disease. Further research is necessary to elucidate the complex mechanisms underlying DSG1 function and its implications in disease pathogenesis.

Genular Protein ID: 1797320327

Symbol: DSG1_HUMAN

Name: Desmoglein-1

UniProtKB Accession Codes:

Q02413 B7Z845

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 4 Ensembl 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1711210

Title: Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules.

PubMed ID: 1711210

DOI: 10.1073/pnas.88.11.4796

PubMed ID: 1770008

Title: Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome.

PubMed ID: 1770008

DOI: 10.1242/jcs.99.4.809

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 10332028

Title: N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma.

PubMed ID: 10332028

DOI: 10.1093/hmg/8.6.971

PubMed ID: 11790773

Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

PubMed ID: 11790773

DOI: 10.1074/jbc.m108765200

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 19759396

Title: Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes.

PubMed ID: 19759396

DOI: 10.1074/jbc.m109.047928

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23974871

Title: Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting.

PubMed ID: 23974871

DOI: 10.1038/ng.2739

PubMed ID: 26924733

Title: The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells.

PubMed ID: 26924733

DOI: 10.1038/srep22134

PubMed ID: 34368962

Title: Impaired function of epithelial plakophilin-2 is associated with periodontal disease.

PubMed ID: 34368962

DOI: 10.1111/jre.12918

Sequence Information:

  • Length: 1049
  • Mass: 113748
  • Checksum: FEA471244B9D67AE
  • Sequence:
    • MDWSFFRVVA MLFIFLVVVE VNSEFRIQVR DYNTKNGTIK WHSIRRQKRE WIKFAAACRE 
GEDNSKRNPI AKIHSDCAAN QQVTYRISGV GIDQPPYGIF VINQKTGEIN ITSIVDREVT 
PFFIIYCRAL NSMGQDLERP LELRVRVLDI NDNPPVFSMA TFAGQIEENS NANTLVMILN 
ATDADEPNNL NSKIAFKIIR QEPSDSPMFI INRNTGEIRT MNNFLDREQY GQYALAVRGS 
DRDGGADGMS AECECNIKIL DVNDNIPYME QSSYTIEIQE NTLNSNLLEI RVIDLDEEFS 
ANWMAVIFFI SGNEGNWFEI EMNERTNVGI LKVVKPLDYE AMQSLQLSIG VRNKAEFHHS 
IMSQYKLKAS AISVTVLNVI EGPVFRPGSK TYVVTGNMGS NDKVGDFVAT DLDTGRPSTT 
VRYVMGNNPA DLLAVDSRTG KLTLKNKVTK EQYNMLGGKY QGTILSIDDN LQRTCTGTIN 
INIQSFGNDD RTNTEPNTKI TTNTGRQEST SSTNYDTSTT STDSSQVYSS EPGNGAKDLL 
SDNVHFGPAG IGLLIMGFLV LGLVPFLMIC CDCGGAPRSA AGFEPVPECS DGAIHSWAVE 
GPQPEPRDIT TVIPQIPPDN ANIIECIDNS GVYTNEYGGR EMQDLGGGER MTGFELTEGV 
KTSGMPEICQ EYSGTLRRNS MRECREGGLN MNFMESYFCQ KAYAYADEDE GRPSNDCLLI 
YDIEGVGSPA GSVGCCSFIG EDLDDSFLDT LGPKFKKLAD ISLGKESYPD LDPSWPPQST 
EPVCLPQETE PVVSGHPPIS PHFGTTTVIS ESTYPSGPGV LHPKPILDPL GYGNVTVTES 
YTTSDTLKPS VHVHDNRPAS NVVVTERVVG PISGADLHGM LEMPDLRDGS NVIVTERVIA 
PSSSLPTSLT IHHPRESSNV VVTERVIQPT SGMIGSLSMH PELANAHNVI VTERVVSGAG 
VTGISGTTGI SGGIGSSGLV GTSMGAGSGA LSGAGISGGG IGLSSLGGTA SIGHMRSSSD 
HHFNQTIGSA SPSTARSRIT KYSTVQYSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.