Gene DSG1 - ENSG00000134760 | NCBI Gene ID: 1828

Details for: DSG1

Gene ID: 1828

Symbol: DSG1

Ensembl ID: ENSG00000134760

Description: desmoglein 1

Associated with

Apoptosis
(R-HSA-109581)
Apoptotic cleavage of cell adhesion proteins
(R-HSA-351906)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
Developmental biology
(R-HSA-1266738)
Formation of the cornified envelope
(R-HSA-6809371)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Keratinization
(R-HSA-6805567)
Neutrophil degranulation
(R-HSA-6798695)
Programmed cell death
(R-HSA-5357801)
Rho gtpase cycle
(R-HSA-9012999)
Rnd2 gtpase cycle
(R-HSA-9696270)
Rnd3 gtpase cycle
(R-HSA-9696264)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Apical plasma membrane
(GO:0016324)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Calcium ion binding
(GO:0005509)
Cell-cell adhesion
(GO:0098609)
Cell-cell junction
(GO:0005911)
Cell-cell junction assembly
(GO:0007043)
Cornified envelope
(GO:0001533)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Desmosome
(GO:0030057)
Ficolin-1-rich granule membrane
(GO:0101003)
Gamma-catenin binding
(GO:0045295)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Lateral plasma membrane
(GO:0016328)
Maternal process involved in female pregnancy
(GO:0060135)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Response to progesterone
(GO:0032570)
Toxic substance binding
(GO:0015643)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythrocyte (CL0000232)
Fold Change: 7.61
Marker Score: 4216
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.01
Marker Score: 4151
Cell Name: megakaryocyte (CL0000556)
Fold Change: 2.69
Marker Score: 1527
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.07
Marker Score: 2290
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.04
Marker Score: 1072
Cell Name: plasma cell (CL0000786)
Fold Change: 1.97
Marker Score: 2199.5
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1171
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.48
Marker Score: 617
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.39
Marker Score: 1466
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 856
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.24
Marker Score: 2357
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 487
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4816
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 503
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.08
Marker Score: 366
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.06
Marker Score: 16514
Cell Name: precursor B cell (CL0000817)
Fold Change: 1.02
Marker Score: 672
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71827
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48052
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.96
Marker Score: 799.5
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5334
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.88
Marker Score: 6833
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5289
Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 492
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.77
Marker Score: 6618
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.73
Marker Score: 1480
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.72
Marker Score: 1155
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.69
Marker Score: 303
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.63
Marker Score: 505
Cell Name: goblet cell (CL0000160)
Fold Change: 0.62
Marker Score: 4148
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.61
Marker Score: 366
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 278
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.44
Marker Score: 907
Cell Name: macrophage (CL0000235)
Fold Change: 0.44
Marker Score: 485
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.38
Marker Score: 374
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.36
Marker Score: 134
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.36
Marker Score: 100
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.31
Marker Score: 147
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.28
Marker Score: 163
Cell Name: pericyte (CL0000669)
Fold Change: 0.25
Marker Score: 148.5
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.19
Marker Score: 86
Cell Name: melanocyte (CL0000148)
Fold Change: 0.16
Marker Score: 65
Cell Name: B cell (CL0000236)
Fold Change: 0.16
Marker Score: 148
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.15
Marker Score: 134
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.15
Marker Score: 114
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.15
Marker Score: 37
Cell Name: stromal cell (CL0000499)
Fold Change: 0.15
Marker Score: 173
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.14
Marker Score: 75
Cell Name: leukocyte (CL0000738)
Fold Change: 0.14
Marker Score: 78
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.13
Marker Score: 306
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.13
Marker Score: 88
Cell Name: fibroblast (CL0000057)
Fold Change: 0.13
Marker Score: 126
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.13
Marker Score: 40
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.12
Marker Score: 65
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.12
Marker Score: 133
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.11
Marker Score: 249
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.1
Marker Score: 92
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.1
Marker Score: 22
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.1
Marker Score: 30
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.1
Marker Score: 24
Cell Name: T cell (CL0000084)
Fold Change: 0.1
Marker Score: 166.5
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.1
Marker Score: 119.5
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.09
Marker Score: 32
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.09
Marker Score: 60
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.09
Marker Score: 28
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.08
Marker Score: 138
Cell Name: basal cell (CL0000646)
Fold Change: 0.08
Marker Score: 108
Cell Name: podocyte (CL0000653)
Fold Change: 0.08
Marker Score: 29
Cell Name: reticular cell (CL0000432)
Fold Change: 0.08
Marker Score: 28
Cell Name: male germ cell (CL0000015)
Fold Change: 0.08
Marker Score: 22
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.07
Marker Score: 23
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.07
Marker Score: 75
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.07
Marker Score: 54
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.07
Marker Score: 48
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.07
Marker Score: 24
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.07
Marker Score: 21
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.07
Marker Score: 24
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.07
Marker Score: 17
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.06
Marker Score: 63
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.06
Marker Score: 23
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.06
Marker Score: 24
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.06
Marker Score: 22
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.06
Marker Score: 25
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.06
Marker Score: 14
Cell Name: tongue muscle cell (CL0002673)
Fold Change: 0.06
Marker Score: 23

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**Key characteristics:** - Type: Protein - Ensembl ID: ENSG00000134760 - Protein length: 134 amino acids - Domain structure: IgV domain, cytoplasmic domain, extracellular domain - Function: Regulates epithelial cell adhesion and migration **Pathways and functions:** - Apoptosis: DSG1 is involved in the regulation of apoptosis, a process by which cells die on their own. It is expressed in cells that are about to undergo apoptosis and is thought to play a role in maintaining epithelial cell integrity and preventing cancer. - Cell migration: In non-epithelial cells, DSG1 is required for the migration of cells along epithelial basement membranes. - Tissue morphogenesis: In epithelial cells, DSG1 is essential for the formation of the cornified envelope, a specialized layer that protects the underlying tissues. - Immune function: DSG1 is expressed in immune cells, where it plays a role in the regulation of inflammation and tissue repair. - Signaling: DSG1 is a key regulator of the Rho GTPase signaling pathway, which is involved in cell migration, proliferation, and differentiation. **Clinical significance:** - Genetic variants in the DSG1 gene have been linked to several human diseases, including psoriasis, skin cancer, and inflammatory bowel disease. - Mutations in the DSG1 gene have been shown to disrupt epithelial cell adhesion, leading to cell migration and tumor formation. - Therefore, targeting the DSG1 gene has emerged as a potential therapeutic strategy for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Desmoglein-1

Genular Protein ID: 1797320327

Symbol: DSG1_HUMAN

Name: Desmoglein-1

UniProtKB Accession Codes:

Q02413 B7Z845

Database IDs:

Citations:

PubMed ID: 1711210

Title: Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules.

PubMed ID: 1711210

DOI: 10.1073/pnas.88.11.4796

PubMed ID: 1770008

Title: Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome.

PubMed ID: 1770008

DOI: 10.1242/jcs.99.4.809

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 10332028

Title: N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma.

PubMed ID: 10332028

DOI: 10.1093/hmg/8.6.971

PubMed ID: 11790773

Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

PubMed ID: 11790773

DOI: 10.1074/jbc.m108765200

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 19759396

Title: Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes.

PubMed ID: 19759396

DOI: 10.1074/jbc.m109.047928

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23974871

Title: Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting.

PubMed ID: 23974871

DOI: 10.1038/ng.2739

PubMed ID: 26924733

Title: The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells.

PubMed ID: 26924733

DOI: 10.1038/srep22134

PubMed ID: 34368962

Title: Impaired function of epithelial plakophilin-2 is associated with periodontal disease.

PubMed ID: 34368962

DOI: 10.1111/jre.12918

Sequence Information:

Length: 1049
Mass: 113748
Checksum: FEA471244B9D67AE
Sequence:

MDWSFFRVVA MLFIFLVVVE VNSEFRIQVR DYNTKNGTIK WHSIRRQKRE WIKFAAACRE 
GEDNSKRNPI AKIHSDCAAN QQVTYRISGV GIDQPPYGIF VINQKTGEIN ITSIVDREVT 
PFFIIYCRAL NSMGQDLERP LELRVRVLDI NDNPPVFSMA TFAGQIEENS NANTLVMILN 
ATDADEPNNL NSKIAFKIIR QEPSDSPMFI INRNTGEIRT MNNFLDREQY GQYALAVRGS 
DRDGGADGMS AECECNIKIL DVNDNIPYME QSSYTIEIQE NTLNSNLLEI RVIDLDEEFS 
ANWMAVIFFI SGNEGNWFEI EMNERTNVGI LKVVKPLDYE AMQSLQLSIG VRNKAEFHHS 
IMSQYKLKAS AISVTVLNVI EGPVFRPGSK TYVVTGNMGS NDKVGDFVAT DLDTGRPSTT 
VRYVMGNNPA DLLAVDSRTG KLTLKNKVTK EQYNMLGGKY QGTILSIDDN LQRTCTGTIN 
INIQSFGNDD RTNTEPNTKI TTNTGRQEST SSTNYDTSTT STDSSQVYSS EPGNGAKDLL 
SDNVHFGPAG IGLLIMGFLV LGLVPFLMIC CDCGGAPRSA AGFEPVPECS DGAIHSWAVE 
GPQPEPRDIT TVIPQIPPDN ANIIECIDNS GVYTNEYGGR EMQDLGGGER MTGFELTEGV 
KTSGMPEICQ EYSGTLRRNS MRECREGGLN MNFMESYFCQ KAYAYADEDE GRPSNDCLLI 
YDIEGVGSPA GSVGCCSFIG EDLDDSFLDT LGPKFKKLAD ISLGKESYPD LDPSWPPQST 
EPVCLPQETE PVVSGHPPIS PHFGTTTVIS ESTYPSGPGV LHPKPILDPL GYGNVTVTES 
YTTSDTLKPS VHVHDNRPAS NVVVTERVVG PISGADLHGM LEMPDLRDGS NVIVTERVIA 
PSSSLPTSLT IHHPRESSNV VVTERVIQPT SGMIGSLSMH PELANAHNVI VTERVVSGAG 
VTGISGTTGI SGGIGSSGLV GTSMGAGSGA LSGAGISGGG IGLSSLGGTA SIGHMRSSSD 
HHFNQTIGSA SPSTARSRIT KYSTVQYSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DSG1

Associated with

Cells (max top 100)

Other Information

Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules. PubMed ID: 1711210

Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome. PubMed ID: 1770008

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 18. PubMed ID: 16177791

N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma. PubMed ID: 10332028

Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling. PubMed ID: 11790773

Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. PubMed ID: 16740002

Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes. PubMed ID: 19759396

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting. PubMed ID: 23974871

The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells. PubMed ID: 26924733

Impaired function of epithelial plakophilin-2 is associated with periodontal disease. PubMed ID: 34368962