Details for: KRT3

Gene ID: 3850

Symbol: KRT3

Ensembl ID: ENSG00000186442

Description: keratin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 6.8169
    Cell Significance Index: 97.0400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 3.4614
    Cell Significance Index: 44.7200
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.0200
    Cell Significance Index: 7.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8825
    Cell Significance Index: 14.0000
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.5601
    Cell Significance Index: 4.4200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.4414
    Cell Significance Index: 2.9300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.3904
    Cell Significance Index: 5.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.2190
    Cell Significance Index: 8.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1592
    Cell Significance Index: 2.2800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1557
    Cell Significance Index: 1.9700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0742
    Cell Significance Index: 0.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0579
    Cell Significance Index: 0.7900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0568
    Cell Significance Index: 0.9200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0509
    Cell Significance Index: 0.8700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.0363
    Cell Significance Index: 0.3900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0072
    Cell Significance Index: 0.0900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0030
    Cell Significance Index: 0.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0016
    Cell Significance Index: -0.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0016
    Cell Significance Index: -0.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0029
    Cell Significance Index: -0.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0029
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0049
    Cell Significance Index: -0.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0050
    Cell Significance Index: -0.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0051
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0068
    Cell Significance Index: -0.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0081
    Cell Significance Index: -0.4200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0115
    Cell Significance Index: -0.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0139
    Cell Significance Index: -0.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0140
    Cell Significance Index: -0.9400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0144
    Cell Significance Index: -0.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0153
    Cell Significance Index: -0.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0166
    Cell Significance Index: -0.5800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0172
    Cell Significance Index: -0.1900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0174
    Cell Significance Index: -0.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0181
    Cell Significance Index: -0.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0181
    Cell Significance Index: -0.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0185
    Cell Significance Index: -0.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0208
    Cell Significance Index: -1.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0215
    Cell Significance Index: -1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0217
    Cell Significance Index: -0.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0229
    Cell Significance Index: -0.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0229
    Cell Significance Index: -1.2000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0247
    Cell Significance Index: -0.3000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0252
    Cell Significance Index: -0.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0254
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0255
    Cell Significance Index: -0.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0265
    Cell Significance Index: -0.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0297
    Cell Significance Index: -0.9500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0303
    Cell Significance Index: -0.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0305
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0310
    Cell Significance Index: -0.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0316
    Cell Significance Index: -0.9300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0326
    Cell Significance Index: -0.3500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0329
    Cell Significance Index: -0.4300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0335
    Cell Significance Index: -0.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0336
    Cell Significance Index: -0.9600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0342
    Cell Significance Index: -0.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0345
    Cell Significance Index: -0.8600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0359
    Cell Significance Index: -0.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0369
    Cell Significance Index: -0.9700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0378
    Cell Significance Index: -0.4500
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0383
    Cell Significance Index: -0.4100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0386
    Cell Significance Index: -0.5300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0397
    Cell Significance Index: -0.3800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0400
    Cell Significance Index: -0.5600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0408
    Cell Significance Index: -0.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0410
    Cell Significance Index: -1.0200
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.0414
    Cell Significance Index: -0.3100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0415
    Cell Significance Index: -0.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0416
    Cell Significance Index: -0.8300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0419
    Cell Significance Index: -0.8300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0419
    Cell Significance Index: -0.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0430
    Cell Significance Index: -0.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0430
    Cell Significance Index: -1.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0452
    Cell Significance Index: -0.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0453
    Cell Significance Index: -0.9100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0465
    Cell Significance Index: -0.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0470
    Cell Significance Index: -0.9800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0471
    Cell Significance Index: -0.4900
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0471
    Cell Significance Index: -0.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0480
    Cell Significance Index: -0.9500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0482
    Cell Significance Index: -0.5600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0485
    Cell Significance Index: -0.5700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0486
    Cell Significance Index: -0.6400
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0486
    Cell Significance Index: -0.4100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0495
    Cell Significance Index: -0.5700
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0504
    Cell Significance Index: -0.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT3 is a type II keratin, characterized by its unique structure and function. It is a coiled-coil protein that forms dimers and trimers, which then associate with other keratin subunits to form the intermediate filament network. This network provides mechanical strength, resistance to mechanical stress, and protection against environmental toxins. KRT3 is also known to interact with various proteins, including p120 catenin, which regulates cell adhesion and migration. **Pathways and Functions:** KRT3 is involved in several critical cellular processes, including: 1. **Epithelial cell differentiation**: KRT3 plays a crucial role in the development and maturation of epithelial cells, particularly during keratinization. 2. **Cytoskeleton organization**: KRT3 contributes to the formation and maintenance of the intermediate filament network, which provides structural support and resistance to mechanical stress. 3. **Cell adhesion**: KRT3 interacts with p120 catenin, regulating cell adhesion and migration. 4. **Extracellular exosome formation**: KRT3 is involved in the formation of exosomes, which are small vesicles that regulate intercellular communication. **Clinical Significance:** Dysregulation of KRT3 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: KRT3 has been associated with autoimmune diseases, such as pemphigus, where autoantibodies target KRT3, leading to skin blistering. 2. **Cancer**: KRT3 has been identified as a tumor suppressor gene, with aberrant expression observed in various types of cancer, including breast and prostate cancer. 3. **Neurological disorders**: KRT3 has been implicated in neurological disorders, such as neurodegenerative diseases, where abnormal KRT3 expression is associated with neuronal dysfunction and death. In conclusion, KRT3 is a multifunctional protein that plays a critical role in maintaining the structural integrity and function of epithelial cells. Its dysregulation has been implicated in various immune-related disorders, highlighting the need for further research into the immunological significance of KRT3.

Genular Protein ID: 3980806257

Symbol: K2C3_HUMAN

Name: Keratin, type II cytoskeletal 3

UniProtKB Accession Codes:

P12035 A6NIS2 Q701L8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2439698

Title: Evolution of keratin genes: different protein domains evolve by different pathways.

PubMed ID: 2439698

DOI: 10.1007/bf02134130

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15737194

Title: Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.

PubMed ID: 15737194

DOI: 10.1111/j.0022-202x.2004.23530.x

PubMed ID: 9171831

Title: Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy.

PubMed ID: 9171831

DOI: 10.1038/ng0697-184

PubMed ID: 16227835

Title: Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy.

PubMed ID: 16227835

DOI: 10.1097/01.ico.0000159732.29930.26

Sequence Information:

  • Length: 628
  • Mass: 64417
  • Checksum: 65FDB8CAA7F3C960
  • Sequence:
    • MSRQASKTSG GGSQGFSGRS AVVSGSSRMS CVAHSGGAGG GAYGFRSGAG GFGSRSLYNL 
GGNKSISISV AAGGSRAGGF GGGRSSCAFA GGYGGGFGSG YGGGFGGGFG GGRGMGGGFG 
GAGGFGGAGG FGGAGGFGGP GGFGGSGGFG GPGSLGSPGG FGPGGFPGGI QEVTINQSLL 
QPLNVEIDPQ IGQVKAQERE QIKTLNNKFA SFIDKVRFLE QQNKVLETKW NLLQQQGTSS 
ISGTNNLEPL FENHINYLRS YLDNILGERG RLDSELKNME DLVEDFKKKY EDEINKRTAA 
ENEFVTLKKD VDSAYMNKVE LQAKVDALID EIDFLRTLYD AELSQMQSHI SDTSVVLSMD 
NNRSLDLDSI IAEVRAQYED IAQRSKAEAE ALYQTKLGEL QTTAGRHGDD LRNTKSEIIE 
LNRMIQRLRA EIEGVKKQNA NLQTAIAEAE QHGEMALKDA NAKLQELQAA LQQAKDDLAR 
LLRDYQELMN VKLALDVEIA TYRKLLEGEE YRMSGECPSA VSISVVSSST TSASAGGYGG 
GYGGGMGGGL GGGFSAGGGS GSGFGRGGGG GIGGGFGGGS SGFSGGSGFG SISGARYGVS 
GGGFSSASNR GGSIKFSQSS QSSQRYSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.