Details for: SCEL

Gene ID: 8796

Symbol: SCEL

Ensembl ID: ENSG00000136155

Description: sciellin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.1412
    Cell Significance Index: -9.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.3847
    Cell Significance Index: -8.9600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 6.0990
    Cell Significance Index: 13.7500
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 2.4323
    Cell Significance Index: 2.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.3412
    Cell Significance Index: 143.5400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.1061
    Cell Significance Index: 29.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9739
    Cell Significance Index: 42.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.6871
    Cell Significance Index: 54.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2291
    Cell Significance Index: -2.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8470
    Cell Significance Index: 23.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7378
    Cell Significance Index: 140.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5103
    Cell Significance Index: 225.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4669
    Cell Significance Index: 12.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3666
    Cell Significance Index: 331.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2629
    Cell Significance Index: 143.5700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2316
    Cell Significance Index: 5.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2288
    Cell Significance Index: 37.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2041
    Cell Significance Index: 22.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1665
    Cell Significance Index: 3.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.1590
    Cell Significance Index: 33.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1296
    Cell Significance Index: 12.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1293
    Cell Significance Index: 7.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0889
    Cell Significance Index: 1.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0553
    Cell Significance Index: 3.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0549
    Cell Significance Index: 34.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0346
    Cell Significance Index: 4.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0222
    Cell Significance Index: 0.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0188
    Cell Significance Index: 12.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0079
    Cell Significance Index: 5.9700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0055
    Cell Significance Index: 0.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0044
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0038
    Cell Significance Index: -0.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0058
    Cell Significance Index: -3.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0058
    Cell Significance Index: -10.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0059
    Cell Significance Index: -10.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0081
    Cell Significance Index: -11.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0109
    Cell Significance Index: -1.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0121
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -11.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0224
    Cell Significance Index: -10.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0225
    Cell Significance Index: -6.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0263
    Cell Significance Index: -4.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0294
    Cell Significance Index: -10.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0398
    Cell Significance Index: -7.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0475
    Cell Significance Index: -2.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0540
    Cell Significance Index: -10.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0604
    Cell Significance Index: -4.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0677
    Cell Significance Index: -0.9700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0693
    Cell Significance Index: -0.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0695
    Cell Significance Index: -10.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0708
    Cell Significance Index: -8.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0827
    Cell Significance Index: -9.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0861
    Cell Significance Index: -11.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0974
    Cell Significance Index: -2.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1093
    Cell Significance Index: -1.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1119
    Cell Significance Index: -6.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1178
    Cell Significance Index: -12.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1190
    Cell Significance Index: -6.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1308
    Cell Significance Index: -5.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1472
    Cell Significance Index: -7.4400
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.1473
    Cell Significance Index: -1.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1558
    Cell Significance Index: -2.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1590
    Cell Significance Index: -10.6900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1766
    Cell Significance Index: -2.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1874
    Cell Significance Index: -4.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1904
    Cell Significance Index: -6.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2002
    Cell Significance Index: -15.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2006
    Cell Significance Index: -10.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2289
    Cell Significance Index: -3.4500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2436
    Cell Significance Index: -3.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2443
    Cell Significance Index: -11.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2552
    Cell Significance Index: -14.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2634
    Cell Significance Index: -12.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2715
    Cell Significance Index: -12.0100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2724
    Cell Significance Index: -2.9900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2754
    Cell Significance Index: -4.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2778
    Cell Significance Index: -7.1400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3075
    Cell Significance Index: -2.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3143
    Cell Significance Index: -11.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3156
    Cell Significance Index: -16.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3204
    Cell Significance Index: -3.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3240
    Cell Significance Index: -11.3500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3258
    Cell Significance Index: -2.2100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3460
    Cell Significance Index: -3.6500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3494
    Cell Significance Index: -8.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3525
    Cell Significance Index: -11.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3661
    Cell Significance Index: -11.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3767
    Cell Significance Index: -11.9200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.3800
    Cell Significance Index: -3.7600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3928
    Cell Significance Index: -4.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4006
    Cell Significance Index: -9.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4040
    Cell Significance Index: -11.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4190
    Cell Significance Index: -12.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4228
    Cell Significance Index: -7.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4316
    Cell Significance Index: -11.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4413
    Cell Significance Index: -12.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Patterns:** Sciellin is significantly expressed in various epithelial cells, including squamous epithelial cells, stratified epithelial cells, and corneal epithelial cells, highlighting its role in maintaining epithelial homeostasis. 2. **Protein Structure:** The exact structure of sciellin is not known, but its involvement in the cornified envelope suggests that it plays a role in maintaining the structural integrity of epithelial cells. 3. **Function:** Sciellin's functions include positive regulation of canonical Wnt signaling, metal ion binding, and response to mechanical stimuli, which are critical for maintaining tissue homeostasis. **Pathways and Functions:** 1. **Canonical Wnt Signaling:** Sciellin's positive regulation of canonical Wnt signaling pathway is crucial for maintaining epithelial homeostasis and regulating cellular differentiation. 2. **Metal Ion Binding:** Sciellin's metal ion binding capabilities suggest that it plays a role in maintaining ion homeostasis and regulating cellular processes. 3. **Response to Mechanical Stimuli:** Sciellin's response to mechanical stimuli highlights its role in maintaining tissue homeostasis and regulating cellular processes in response to mechanical stress. **Clinical Significance:** 1. **Cancer:** Abnormal expression of sciellin has been implicated in various cancers, including squamous cell carcinoma and colorectal cancer, highlighting its potential as a biomarker and therapeutic target. 2. **Cardiovascular Disorders:** Sciellin's involvement in cardiovascular disorders, including atherosclerosis and cardiac endothelial dysfunction, underscores its potential as a therapeutic target. 3. **Inflammatory Conditions:** Sciellin's role in regulating inflammatory responses suggests that it may be involved in the pathogenesis of inflammatory conditions, such as psoriasis and rheumatoid arthritis. In conclusion, sciellin is a multifunctional protein that plays a critical role in maintaining epithelial homeostasis and regulating cellular processes. Its involvement in various diseases highlights its potential as a therapeutic target and biomarker. Further research is needed to fully elucidate the role of sciellin in human disease and to explore its therapeutic potential.

Genular Protein ID: 1651354219

Symbol: SCEL_HUMAN

Name: Sciellin

UniProtKB Accession Codes:

O95171 B7Z797 F5H651 Q53H61 Q5W0S8 Q5W0S9 Q86X00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9813070

Title: cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope.

PubMed ID: 9813070

DOI: 10.1074/jbc.273.47.31547

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 688
  • Mass: 77552
  • Checksum: B97F62DD560B57C3
  • Sequence:
    • MSNVTLRKMS PTGNEMKSTT QGTTRKQQDF HEVNKRRTFL QDNSWIKKRP EEEKDENYGR 
VVLNRHNSHD ALDRKVNERD VPKATISRYS SDDTLDRISD RNDAAKTYKA NTLDNQLTNR 
SMSMFRSLEV TKLQPGGSLN ANTSNTIAST SATTPVKKKR QSWFPPPPPG YNASSSTGTR 
RREPGVHPPI PPKPSSPVSS PNQLRQDNRQ IHPPKPGVYT ETNRSAERNI RSQDLDNIVK 
VATSLQRSDK GEELDNLIKM NKSLNRNQGL DSLFRANPKV EEREKRAKSL ESLIYMSTRT 
DKDGKGIQSL GSPIKVNQRT DKNEKGRQNL ESVAKVNARM NKTSRRSEDL DNATEVNPKG 
HENTTGKKDL DGLIKVDPET NKNITRGQSL DNLIKVTPEV KRSNQGSKDL NNFIKVYPGT 
EKSTEGGQSL DSLIKVTPER NRTNQGNQDL ENLIKVIPSA NKSSEQGLDE HINVSPKAVK 
NTDGKQDLDK LIKVNPEIFT NNQRNQDLAN LIKVNPAVIR NNQSQDLDNL IKVKPSALRN 
TNRDQNLENL IEVNSHVSEN KNGSSNTGAK QAGPQDTVVY TRTYVENSKS PKDGYQENIS 
GKYIQTVYST SDRSVIERDM CTYCRKPLGV ETKMILDELQ ICCHSTCFKC EICKQPLENL 
QAGDSIWIYR QTIHCEPCYS KIMAKWIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.