Details for: CELSR1

Gene ID: 9620

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CELSR1

Ensembl ID: ENSG00000075275

Description: cadherin EGF LAG seven-pass G-type receptor 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

  • Apical protein localization
    (GO:0045176)
  • Calcium ion binding
    (GO:0005509)
  • Cell-cell adhesion
    (GO:0098609)
  • Central nervous system development
    (GO:0007417)
  • Establishment of body hair planar orientation
    (GO:0048105)
  • Establishment of planar polarity
    (GO:0001736)
  • Establishment of planar polarity of embryonic epithelium
    (GO:0042249)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Homophilic cell adhesion via plasma membrane adhesion molecules
    (GO:0007156)
  • Lateral sprouting involved in lung morphogenesis
    (GO:0060490)
  • Membrane
    (GO:0016020)
  • Neural tube closure
    (GO:0001843)
  • Neuron migration
    (GO:0001764)
  • Nucleoplasm
    (GO:0005654)
  • Orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
    (GO:0060488)
  • Planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
    (GO:0060489)
  • Plasma membrane
    (GO:0005886)
  • Protein localization involved in establishment of planar polarity
    (GO:0090251)
  • Regulation of actin cytoskeleton organization
    (GO:0032956)
  • Rho protein signal transduction
    (GO:0007266)
  • Wnt signaling pathway, planar cell polarity pathway
    (GO:0060071)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • goblet cell CL0000160
    CSI 15.46
    rCSI 14.6%
    PRS 95.24
  • astrocyte CL0000127
    CSI 9.27
    rCSI 19.76%
    PRS 83.27
  • respiratory basal cell CL0002633
    CSI 7.79
    rCSI 8.07%
    PRS 97.36
  • secretory cell CL0000151
    CSI 6.5
    rCSI 6.79%
    PRS 96.15
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 5.49
    rCSI 6.35%
    PRS 92.1
  • glioblast CL0000030
    CSI 4.82
    rCSI 7.69%
    PRS 92.29
  • duct epithelial cell CL0000068
    CSI 4.12
    rCSI 6.03%
    PRS 98.12
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.88
    rCSI 11.51%
    PRS 98.64
  • epithelial cell of proximal tubule CL0002306
    CSI 3.85
    rCSI 9.4%
    PRS 92.5
  • respiratory suprabasal cell CL4033048
    CSI 3.54
    rCSI 4.54%
    PRS 97.3
  • ependymal cell CL0000065
    CSI 3.49
    rCSI 7.08%
    PRS 85.46
  • epithelial cell of lower respiratory tract CL0002632
    CSI 3.48
    rCSI 2.7%
    PRS 97.97
  • lung secretory cell CL1000272
    CSI 3.31
    rCSI 8.2%
    PRS 97.62
  • epithelial cell of lung CL0000082
    CSI 3.28
    rCSI 2.72%
    PRS 97.53
  • multi-ciliated epithelial cell CL0005012
    CSI 3.21
    rCSI 3.2%
    PRS 93.33
  • nasal mucosa goblet cell CL0002480
    CSI 3.17
    rCSI 3.68%
    PRS 96.08
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 3.11
    rCSI 4.4%
    PRS 95.64
  • ionocyte CL0005006
    CSI 3.07
    rCSI 3.29%
    PRS 97.06
  • luminal epithelial cell of mammary gland CL0002326
    CSI 3.03
    rCSI 5.51%
    PRS 98.22
  • keratinocyte CL0000312
    CSI 2.94
    rCSI 2.46%
    PRS 95.96
  • ciliated cell CL0000064
    CSI 2.94
    rCSI 4.76%
    PRS 92.29
  • lung ciliated cell CL1000271
    CSI 2.92
    rCSI 3.37%
    PRS 93.43
  • conjunctival epithelial cell CL1000432
    CSI 2.89
    rCSI 4.41%
    PRS 95.75
  • tracheal goblet cell CL1000329
    CSI 2.69
    rCSI 5.88%
    PRS 97.07
  • blood vessel endothelial cell CL0000071
    CSI 2.68
    rCSI 5.57%
    PRS 95.71
  • mucus secreting cell CL0000319
    CSI 2.64
    rCSI 4.19%
    PRS 98.31
  • ciliated epithelial cell CL0000067
    CSI 2.44
    rCSI 2.14%
    PRS 91.52
  • respiratory hillock cell CL4030023
    CSI 2.4
    rCSI 4.28%
    PRS 97.82
  • renal beta-intercalated cell CL0002201
    CSI 2.3
    rCSI 5.49%
    PRS 96.45
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.25
    rCSI 14.03%
    PRS 92.59
  • squamous epithelial cell CL0000076
    CSI 2.16
    rCSI 5.12%
    PRS 93.3
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.03
    rCSI 5.16%
    PRS 93.82
  • basal cell CL0000646
    CSI 1.92
    rCSI 2.57%
    PRS 94.94
  • renal principal cell CL0005009
    CSI 1.9
    rCSI 4.94%
    PRS 96.06
  • corneal epithelial cell CL0000575
    CSI 1.89
    rCSI 5.41%
    PRS 96.63
  • pulmonary alveolar type 2 cell CL0002063
    CSI 1.83
    rCSI 2.85%
    PRS 96.62
  • club cell CL0000158
    CSI 1.83
    rCSI 2.67%
    PRS 94.8
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.81
    rCSI 4.68%
    PRS 95.38
  • inhibitory interneuron CL0000498
    CSI 1.69
    rCSI 3.9%
    PRS 91.59
  • parietal epithelial cell CL1000452
    CSI 1.38
    rCSI 3.67%
    PRS 94.2
  • deuterosomal cell CL4033044
    CSI 1.28
    rCSI 4.34%
    PRS 92.31
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.23
    rCSI 7.07%
    PRS 94.88
  • neural progenitor cell CL0011020
    CSI 1.11
    rCSI 4.87%
    PRS 89.21
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 1.1
    rCSI 2.51%
    PRS 91.78
  • podocyte CL0000653
    CSI 1.07
    rCSI 4.77%
    PRS 96.51
  • respiratory goblet cell CL0002370
    CSI 0.39
    rCSI 4.23%
    PRS 97.81

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CELSR1](/details-gene/9620) (cadherin EGF LAG seven-pass G-type receptor 1) is a protein-coding gene located on chromosome 22q13.31. It encodes a large, atypical cadherin that functions as a G protein-coupled receptor (GPCR) and is a key component of the core planar cell polarity (PCP) signaling pathway ([Link](https://doi.org/10.1002/humu.21662)). Its primary functions involve mediating [cell-cell adhesion](/details-cell/CL0000151) ([GO:0098609](https://www.ebi.ac.uk/QuickGO/term/GO:0098609)) and establishing tissue organization during development, particularly in the nervous system and lungs. **Overall**, expression data reveals that [CELSR1](/details-gene/9620) is a highly significant marker for secretory epithelial cells, such as [goblet cells](/details-cell/CL0000160), and various neural cell types, including [astrocytes](/details-cell/CL0000127), reflecting its critical role in developmental morphogenesis and tissue architecture. ## Cellular Roles and Expression Landscape The expression profile of [CELSR1](/details-gene/9620) highlights its importance in two major biological systems: epithelial tissues and the central nervous system. **Overall**, its most significant expression is observed in specialized secretory and epithelial cells of the respiratory and digestive tracts. It is a top marker for [goblet cells](/details-cell/CL0000160) (CSI: 15.46), which are responsible for mucus production. High significance is also noted in [respiratory basal cells](/details-cell/CL0002633) (CSI: 7.79), [secretory cells](/details-cell/CL0000151) (CSI: 6.50), and various other lung epithelial cell types, including [lung secretory cells](/details-cell/CL1000272) and [multi-ciliated epithelial cells](/details-cell/CL0005012). This pattern suggests a fundamental role for [CELSR1](/details-gene/9620) in establishing and maintaining the organized, polarized structure of mucosal epithelia. In the nervous system, [CELSR1](/details-gene/9620) shows high significance in glial and progenitor cells. It is a prominent marker in [astrocytes](/details-cell/CL0000127) (CSI: 9.27), [neuroblasts](/details-cell/CL0000338) (CSI: 5.49), [glioblasts](/details-cell/CL0000030) (CSI: 4.82), and [ependymal cells](/details-cell/CL0000065) (CSI: 3.49). This expression pattern is consistent with its established function in [central nervous system development](/details-cell/CL0000338) ([GO:0007417](https://www.ebi.ac.uk/QuickGO/term/GO:0007417)) and [neuron migration](/details-cell/CL0001764) ([GO:0001764](https://www.ebi.ac.uk/QuickGO/term/GO:0001764)), where it helps guide cellular positioning and tissue formation. ## Pathways and Molecular Function [CELSR1](/details-gene/9620) is a multifunctional protein with roles in cell adhesion and signal transduction. Its molecular identity as a cadherin underpins its function in [homophilic cell adhesion](/details-cell/CL0000151) ([GO:0007156](https://www.ebi.ac.uk/QuickGO/term/GO:0007156)), while its seven-transmembrane structure confers [G protein-coupled receptor activity](/details-cell/CL0000151) ([GO:0004930](https://www.ebi.ac.uk/QuickGO/term/GO:0004930)). The primary signaling pathway associated with [CELSR1](/details-gene/9620) is the [Wnt signaling pathway, planar cell polarity pathway](/details-cell/CL0000151) ([GO:0060071](https://www.ebi.ac.uk/QuickGO/term/GO:0060071)). This pathway is crucial for coordinating cell orientation within a tissue plane, a process vital for development. This is reflected in its involvement in biological processes such as [establishment of planar polarity](/details-cell/CL0000151) ([GO:0001736](https://www.ebi.ac.uk/QuickGO/term/GO:0001736)), [neural tube closure](/details-cell/CL0000151) ([GO:0001843](https://www.ebi.ac.uk/QuickGO/term/GO:0001843)), and lung morphogenesis ([GO:0060490](https://www.ebi.ac.uk/QuickGO/term/GO:0060490)). Indeed, mutations in [CELSR1](/details-gene/9620) are associated with severe neural tube defects ([Link](https://doi.org/10.1002/humu.21662)). The protein also plays a role in regulating the cytoskeleton via [Rho protein signal transduction](/details-cell/CL0000151) ([GO:0007266](https://www.ebi.ac.uk/QuickGO/term/GO:0007266)), which is essential for translating external adhesion cues into internal cellular structure. ## Research Directions The established role of [CELSR1](/details-gene/9620) in developmental disorders, such as neural tube defects and hereditary lymphedema ([Link](https://doi.org/10.1186/s13221-016-0035-5)), underscores its clinical importance. Its specific expression pattern in mature tissues suggests it may also have homeostatic functions that are currently less understood. Based on the available data, several testable hypotheses can be proposed: 1. Given its high significance in [goblet cells](/details-cell/CL0000160) and other respiratory epithelial cells, loss-of-function variants in [CELSR1](/details-gene/9620) may disrupt the coordinated organization of the mucociliary escalator, leading to impaired mucus clearance and increased susceptibility to chronic respiratory diseases like asthma or COPD. 2. The high expression of [CELSR1](/details-gene/9620) in [astrocytes](/details-cell/CL0000127) suggests it is critical for establishing and maintaining the glial scaffold in the mature brain. Dysregulation of [CELSR1](/details-gene/9620) in astrocytes following brain injury may impair glial scar formation and neuronal recovery. To test the first hypothesis regarding respiratory function, a key experiment could involve the use of air-liquid interface (ALI) cultures of primary human bronchial epithelial cells. Using CRISPR-Cas9 to knock down [CELSR1](/details-gene/9620) expression, researchers could assess the impact on epithelial layer integrity, the spatial organization of [goblet](/details-cell/CL0000160) and [multi-ciliated epithelial cells](/details-cell/CL0005012) via immunofluorescence, and functional outcomes such as ciliary beat frequency and directed mucus transport. From a therapeutic perspective, [CELSR1](/details-gene/9620) presents a challenging target. The associated pathologies are primarily caused by loss-of-function mutations ([Link](https://doi.org/10.1002/ajmg.a.61269)), suggesting a need for activation or gene replacement therapies rather than inhibition. Due to the protein's large size and complex transmembrane structure, pharmacological activation is difficult. Therefore, its therapeutic potential is likely limited to gene therapy approaches for severe congenital disorders, which would require careful consideration of developmental timing and off-target effects.

Genular Protein ID: 395363018

Symbol: CELR1_HUMAN

Name: Cadherin EGF LAG seven-pass G-type receptor 1

UniProtKB Accession Codes:

Q9NYQ6 O95722 Q5TH47 Q9BWQ5 Q9Y506 Q9Y526

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 2 PRO 1 PROSITE 12 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SASBDB 1 SMART 7 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10716726

Title: Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PubMed ID: 10716726

DOI: 10.1073/pnas.97.7.3124

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 26855770

Title: A novel mutation in CELSR1 is associated with hereditary lymphedema.

PubMed ID: 26855770

DOI: 10.1186/s13221-016-0035-5

PubMed ID: 22095531

Title: Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.

PubMed ID: 22095531

DOI: 10.1002/humu.21662

PubMed ID: 31215153

Title: Increasing evidence of hereditary lymphedema caused by CELSR1 loss-of-function variants.

PubMed ID: 31215153

DOI: 10.1002/ajmg.a.61269

Sequence Information:

  • Length: 3014
  • Mass: 329486
  • Checksum: C34691AD3A1DFF3A
  • Sequence:
    • MAPPPPPVLP VLLLLAAAAA LPAMGLRAAA WEPRVPGGTR AFALRPGCTY AVGAACTPRA 
PRELLDVGRD GRLAGRRRVS GAGRPLPLQV RLVARSAPTA LSRRLRARTH LPGCGARARL 
CGTGARLCGA LCFPVPGGCA AAQHSALAAP TTLPACRCPP RPRPRCPGRP ICLPPGGSVR 
LRLLCALRRA AGAVRVGLAL EAATAGTPSA SPSPSPPLPP NLPEARAGPA RRARRGTSGR 
GSLKFPMPNY QVALFENEPA GTLILQLHAH YTIEGEEERV SYYMEGLFDE RSRGYFRIDS 
ATGAVSTDSV LDRETKETHV LRVKAVDYST PPRSATTYIT VLVKDTNDHS PVFEQSEYRE 
RVRENLEVGY EVLTIRASDR DSPINANLRY RVLGGAWDVF QLNESSGVVS TRAVLDREEA 
AEYQLLVEAN DQGRNPGPLS ATATVYIEVE DENDNYPQFS EQNYVVQVPE DVGLNTAVLR 
VQATDRDQGQ NAAIHYSILS GNVAGQFYLH SLSGILDVIN PLDFEDVQKY SLSIKAQDGG 
RPPLINSSGV VSVQVLDVND NEPIFVSSPF QATVLENVPL GYPVVHIQAV DADSGENARL 
HYRLVDTAST FLGGGSAGPK NPAPTPDFPF QIHNSSGWIT VCAELDREEV EHYSFGVEAV 
DHGSPPMSSS TSVSITVLDV NDNDPVFTQP TYELRLNEDA AVGSSVLTLQ ARDRDANSVI 
TYQLTGGNTR NRFALSSQRG GGLITLALPL DYKQEQQYVL AVTASDGTRS HTAHVLINVT 
DANTHRPVFQ SSHYTVSVSE DRPVGTSIAT LSANDEDTGE NARITYVIQD PVPQFRIDPD 
SGTMYTMMEL DYENQVAYTL TIMAQDNGIP QKSDTTTLEI LILDANDNAP QFLWDFYQGS 
IFEDAPPSTS ILQVSATDRD SGPNGRLLYT FQGGDDGDGD FYIEPTSGVI RTQRRLDREN 
VAVYNLWALA VDRGSPTPLS ASVEIQVTIL DINDNAPMFE KDELELFVEE NNPVGSVVAK 
IRANDPDEGP NAQIMYQIVE GDMRHFFQLD LLNGDLRAMV ELDFEVRREY VLVVQATSAP 
LVSRATVHIL LVDQNDNPPV LPDFQILFNN YVTNKSNSFP TGVIGCIPAH DPDVSDSLNY 
TFVQGNELRL LLLDPATGEL QLSRDLDNNR PLEALMEVSV SDGIHSVTAF CTLRVTIITD 
DMLTNSITVR LENMSQEKFL SPLLALFVEG VAAVLSTTKD DVFVFNVQND TDVSSNILNV 
TFSALLPGGV RGQFFPSEDL QEQIYLNRTL LTTISTQRVL PFDDNICLRE PCENYMKCVS 
VLRFDSSAPF LSSTTVLFRP IHPINGLRCR CPPGFTGDYC ETEIDLCYSD PCGANGRCRS 
REGGYTCECF EDFTGEHCEV DARSGRCANG VCKNGGTCVN LLIGGFHCVC PPGEYERPYC 
EVTTRSFPPQ SFVTFRGLRQ RFHFTISLTF ATQERNGLLL YNGRFNEKHD FIALEIVDEQ 
VQLTFSAGET TTTVAPKVPS GVSDGRWHSV QVQYYNKPNI GHLGLPHGPS GEKMAVVTVD 
DCDTTMAVRF GKDIGNYSCA AQGTQTGSKK SLDLTGPLLL GGVPNLPEDF PVHNRQFVGC 
MRNLSVDGKN VDMAGFIANN GTREGCAARR NFCDGRRCQN GGTCVNRWNM YLCECPLRFG 
GKNCEQAMPH PQLFSGESVV SWSDLNIIIS VPWYLGLMFR TRKEDSVLME ATSGGPTSFR 
LQILNNYLQF EVSHGPSDVE SVMLSGLRVT DGEWHHLLIE LKNVKEDSEM KHLVTMTLDY 
GMDQNKADIG GMLPGLTVRS VVVGGASEDK VSVRRGFRGC MQGVRMGGTP TNVATLNMNN 
ALKVRVKDGC DVDDPCTSSP CPPNSRCHDA WEDYSCVCDK GYLGINCVDA CHLNPCENMG 
ACVRSPGSPQ GYVCECGPSH YGPYCENKLD LPCPRGWWGN PVCGPCHCAV SKGFDPDCNK 
TNGQCQCKEN YYKLLAQDTC LPCDCFPHGS HSRTCDMATG QCACKPGVIG RQCNRCDNPF 
AEVTTLGCEV IYNGCPKAFE AGIWWPQTKF GQPAAVPCPK GSVGNAVRHC SGEKGWLPPE 
LFNCTTISFV DLRAMNEKLS RNETQVDGAR ALQLVRALRS ATQHTGTLFG NDVRTAYQLL 
GHVLQHESWQ QGFDLAATQD ADFHEDVIHS GSALLAPATR AAWEQIQRSE GGTAQLLRRL 
EGYFSNVARN VRRTYLRPFV IVTANMILAV DIFDKFNFTG ARVPRFDTIH EEFPRELESS 
VSFPADFFRP PEEKEGPLLR PAGRRTTPQT TRPGPGTERE APISRRRRHP DDAGQFAVAL 
VIIYRTLGQL LPERYDPDRR SLRLPHRPII NTPMVSTLVY SEGAPLPRPL ERPVLVEFAL 
LEVEERTKPV CVFWNHSLAV GGTGGWSARG CELLSRNRTH VACQCSHTAS FAVLMDISRR 
ENGEVLPLKI VTYAAVSLSL AALLVAFVLL SLVRMLRSNL HSIHKHLAVA LFLSQLVFVI 
GINQTENPFL CTVVAILLHY IYMSTFAWTL VESLHVYRML TEVRNIDTGP MRFYYVVGWG 
IPAIVTGLAV GLDPQGYGNP DFCWLSLQDT LIWSFAGPIG AVIIINTVTS VLSAKVSCQR 
KHHYYGKKGI VSLLRTAFLL LLLISATWLL GLLAVNRDAL SFHYLFAIFS GLQGPFVLLF 
HCVLNQEVRK HLKGVLGGRK LHLEDSATTR ATLLTRSLNC NTTFGDGPDM LRTDLGESTA 
SLDSIVRDEG IQKLGVSSGL VRGSHGEPDA SLMPRSCKDP PGHDSDSDSE LSLDEQSSSY 
ASSHSSDSED DGVGAEEKWD PARGAVHSTP KGDAVANHVP AGWPDQSLAE SDSEDPSGKP 
RLKVETKVSV ELHREEQGSH RGEYPPDQES GGAARLASSQ PPEQRKGILK NKVTYPPPLT 
LTEQTLKGRL REKLADCEQS PTSSRTSSLG SGGPDCAITV KSPGREPGRD HLNGVAMNVR 
TGSAQADGSD SEKP