Details for: RGS20

Gene ID: 8601

Symbol: RGS20

Ensembl ID: ENSG00000147509

Description: regulator of G protein signaling 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 4.5089
    Cell Significance Index: 63.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9865
    Cell Significance Index: 132.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.7525
    Cell Significance Index: 104.2300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.0518
    Cell Significance Index: 13.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7637
    Cell Significance Index: -3.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4971
    Cell Significance Index: 84.0100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.4882
    Cell Significance Index: 21.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9036
    Cell Significance Index: 56.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7333
    Cell Significance Index: 49.3100
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.7109
    Cell Significance Index: 7.9000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.7004
    Cell Significance Index: 12.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6890
    Cell Significance Index: 9.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6145
    Cell Significance Index: 220.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5357
    Cell Significance Index: 370.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3872
    Cell Significance Index: 23.8000
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.2118
    Cell Significance Index: 1.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1866
    Cell Significance Index: 4.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1757
    Cell Significance Index: 2.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1345
    Cell Significance Index: 3.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1178
    Cell Significance Index: 23.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0701
    Cell Significance Index: 13.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0246
    Cell Significance Index: 45.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0190
    Cell Significance Index: 0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0159
    Cell Significance Index: 21.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0111
    Cell Significance Index: 4.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0075
    Cell Significance Index: 11.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0029
    Cell Significance Index: 5.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0027
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0095
    Cell Significance Index: -1.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0186
    Cell Significance Index: -11.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0204
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0207
    Cell Significance Index: -15.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0215
    Cell Significance Index: -16.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0254
    Cell Significance Index: -15.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0269
    Cell Significance Index: -15.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0273
    Cell Significance Index: -12.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0305
    Cell Significance Index: -4.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0360
    Cell Significance Index: -10.3700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0550
    Cell Significance Index: -0.6300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0691
    Cell Significance Index: -0.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0751
    Cell Significance Index: -5.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0815
    Cell Significance Index: -17.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0848
    Cell Significance Index: -11.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0864
    Cell Significance Index: -14.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1018
    Cell Significance Index: -12.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1047
    Cell Significance Index: -2.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1095
    Cell Significance Index: -14.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1157
    Cell Significance Index: -3.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1158
    Cell Significance Index: -13.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1206
    Cell Significance Index: -12.5600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1244
    Cell Significance Index: -1.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1325
    Cell Significance Index: -13.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1325
    Cell Significance Index: -3.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1335
    Cell Significance Index: -1.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1387
    Cell Significance Index: -6.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1414
    Cell Significance Index: -10.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1432
    Cell Significance Index: -16.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1660
    Cell Significance Index: -2.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1927
    Cell Significance Index: -14.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1998
    Cell Significance Index: -4.2700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2132
    Cell Significance Index: -1.5500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2227
    Cell Significance Index: -2.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2423
    Cell Significance Index: -11.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2523
    Cell Significance Index: -13.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2657
    Cell Significance Index: -13.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2710
    Cell Significance Index: -5.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2850
    Cell Significance Index: -4.8000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2940
    Cell Significance Index: -3.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3000
    Cell Significance Index: -6.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3172
    Cell Significance Index: -6.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3200
    Cell Significance Index: -11.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3293
    Cell Significance Index: -6.9900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3330
    Cell Significance Index: -4.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3387
    Cell Significance Index: -8.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3419
    Cell Significance Index: -12.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3432
    Cell Significance Index: -7.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3488
    Cell Significance Index: -11.4200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.3563
    Cell Significance Index: -5.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3678
    Cell Significance Index: -10.0100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3680
    Cell Significance Index: -4.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3699
    Cell Significance Index: -11.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3887
    Cell Significance Index: -20.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4118
    Cell Significance Index: -2.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4142
    Cell Significance Index: -8.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4299
    Cell Significance Index: -8.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4303
    Cell Significance Index: -15.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4406
    Cell Significance Index: -15.3100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4450
    Cell Significance Index: -6.3300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4588
    Cell Significance Index: -14.5100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4754
    Cell Significance Index: -6.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4821
    Cell Significance Index: -13.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4891
    Cell Significance Index: -12.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4898
    Cell Significance Index: -21.3000
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.4952
    Cell Significance Index: -4.6400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4998
    Cell Significance Index: -3.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5079
    Cell Significance Index: -14.9600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5195
    Cell Significance Index: -10.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5298
    Cell Significance Index: -5.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5310
    Cell Significance Index: -15.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS20 is a protein that belongs to the regulator of G protein signaling (RGS) family, which is characterized by its ability to regulate GPCR signaling by accelerating the GTPase activity of Gα subunits. RGS20 is specifically expressed in various cell types, including astrocytes, epithelial cells, and immune cells, such as granulocyte monocyte progenitor cells and early T lineage precursors. The protein is highly conserved across species, with high sequence similarity to other RGS family members. **Pathways and Functions:** RGS20 plays a critical role in regulating GPCR signaling pathways, which are involved in various cellular processes, including cell proliferation, differentiation, and survival. The protein interacts with Gα subunits and accelerates their GTPase activity, leading to the termination of GPCR signaling. RGS20 is also involved in the regulation of other signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. RGS20 has been shown to modulate the activity of various GPCRs, including those involved in immune responses, such as the chemokine receptor CCR5. The protein has also been implicated in the regulation of neurotransmitter release and synaptic plasticity in the nervous system. **Clinical Significance:** RGS20 has been implicated in various immune-related diseases, including multiple sclerosis, rheumatoid arthritis, and asthma. The protein's ability to regulate GPCR signaling pathways makes it a potential target for the treatment of these diseases. Additionally, RGS20 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where dysregulation of GPCR signaling pathways is thought to contribute to disease progression. Furthermore, RGS20 has been shown to play a role in the regulation of immune cell function, including the activation and differentiation of T cells and the production of cytokines. The protein's ability to modulate immune cell function makes it a potential target for the treatment of autoimmune diseases, such as lupus and rheumatoid arthritis. **Conclusion:** In conclusion, RGS20 is a critical gene involved in the regulation of GPCR signaling pathways, which plays a significant role in various physiological and pathological processes, including immune responses and neurological disorders. The protein's ability to modulate GPCR signaling pathways makes it a potential target for the treatment of immune-related diseases and neurological conditions. Further research is needed to fully understand the role of RGS20 in these diseases and to explore its potential as a therapeutic target. **Future Directions:** Future studies should focus on the following areas: 1. Investigating the role of RGS20 in immune-related diseases, including multiple sclerosis, rheumatoid arthritis, and asthma. 2. Exploring the protein's role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. Investigating the protein's ability to modulate immune cell function and its potential as a therapeutic target for autoimmune diseases. 4. Developing novel therapeutic strategies that target RGS20 and its downstream signaling pathways. By further understanding the role of RGS20 in these diseases, researchers can develop novel therapeutic strategies that target this critical gene and its downstream signaling pathways, leading to improved treatment outcomes for patients with immune-related diseases and neurological conditions.

Genular Protein ID: 2202204152

Symbol: RGS20_HUMAN

Name: Regulator of G-protein signaling 20

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9748280

Title: RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily.

PubMed ID: 9748280

DOI: 10.1074/jbc.273.40.26014

PubMed ID: 11735229

Title: RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20.

PubMed ID: 11735229

DOI: 10.1006/geno.2001.6659

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9748279

Title: RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.

PubMed ID: 9748279

DOI: 10.1074/jbc.273.40.26008

PubMed ID: 12379657

Title: Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.

PubMed ID: 12379657

DOI: 10.1074/jbc.m206116200

Sequence Information:

  • Length: 388
  • Mass: 43692
  • Checksum: F44796D271F1765F
  • Sequence:
  • MPQLSQDNQE CLQKHFSRPS IWTQFLPLFR AQRYNTDIHQ ITENEGDLRA VPDIKSFPPA 
    QLPDSPAAPK LFGLLSSPLS SLARFFSHLL RRPPPEAPRR RLDFSPLLPA LPAARLSRGH 
    EELPGRLSLL LGAALALPGR PSGGRPLRPP HPVAKPREED ATAGQSSPMP QMGSERMEMR 
    KRQMPAAQDT PGAAPGQPGA GSRGSNACCF CWCCCCSCSC LTVRNQEDQR PTIASHELRA 
    DLPTWEESPA PTLEEVNAWA QSFDKLMVTP AGRNAFREFL RTEFSEENML FWMACEELKK 
    EANKNIIEEK ARIIYEDYIS ILSPKEVSLD SRVREVINRN MVEPSQHIFD DAQLQIYTLM 
    HRDSYPRFMN SAVYKDLLQS LSEKSIEA

Genular Protein ID: 664430194

Symbol: H9NIM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 241
  • Mass: 27060
  • Checksum: 776410A4D698D622
  • Sequence:
  • MRTADGGEPA GASSPAGRVD GGLQMGSERM EMRKRQMPAA QDTPGAAPGQ PGAGSRGSNA 
    CCFCWCCCCS CSCLTVRNQE DQRPTIASHE LRADLPTWEE SPAPTLEEVN AWAQSFDKLM 
    VTPAGRNAFR EFLRTEFSEE NMLFWMACEE LKKEANKNII EEKARIIYED YISILSPKEV 
    SLDSRVREVI NRNMVEPSQH IFDDAQLQIY TLMHRDSYPR FMNSAVYKDL LQSLSEKSIE 
    A

Genular Protein ID: 1452477294

Symbol: B3KSW4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 122
  • Mass: 14442
  • Checksum: 356AF5A61450FED1
  • Sequence:
  • MVTPAGRNAF REFLRTEFSE ENMLFWMACE ELKKEANKNI IEEKARIIYE DYISILSPKE 
    VSLDSRVREV INRNMVEPSQ HIFDDAQLQI YTLMHRDSYP RFMNSAVYKD LLQSLSEKSI 
    EA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.