Details for: VSNL1

Gene ID: 7447

Symbol: VSNL1

Ensembl ID: ENSG00000163032

Description: visinin like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.2071
    Cell Significance Index: -35.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.5507
    Cell Significance Index: 99.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0623
    Cell Significance Index: 614.3000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.7636
    Cell Significance Index: 36.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.7522
    Cell Significance Index: 37.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.1313
    Cell Significance Index: 60.8200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.8138
    Cell Significance Index: 25.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7543
    Cell Significance Index: 348.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6852
    Cell Significance Index: 604.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.5698
    Cell Significance Index: 19.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4767
    Cell Significance Index: 77.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3969
    Cell Significance Index: 265.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.2359
    Cell Significance Index: 21.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9416
    Cell Significance Index: 651.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9368
    Cell Significance Index: 92.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9183
    Cell Significance Index: 24.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8898
    Cell Significance Index: 59.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8846
    Cell Significance Index: 54.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7865
    Cell Significance Index: 347.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7614
    Cell Significance Index: 16.2800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.7124
    Cell Significance Index: 7.8600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4896
    Cell Significance Index: 6.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4587
    Cell Significance Index: 74.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4253
    Cell Significance Index: 10.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3318
    Cell Significance Index: 36.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0576
    Cell Significance Index: 4.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0321
    Cell Significance Index: 1.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0015
    Cell Significance Index: -0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0177
    Cell Significance Index: -33.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0183
    Cell Significance Index: -33.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0222
    Cell Significance Index: -34.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0224
    Cell Significance Index: -1.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0247
    Cell Significance Index: -33.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0276
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0465
    Cell Significance Index: -34.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0486
    Cell Significance Index: -1.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0513
    Cell Significance Index: -38.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0522
    Cell Significance Index: -33.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0626
    Cell Significance Index: -39.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0655
    Cell Significance Index: -36.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0671
    Cell Significance Index: -30.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0726
    Cell Significance Index: -39.6600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0789
    Cell Significance Index: -1.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0860
    Cell Significance Index: -3.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0880
    Cell Significance Index: -2.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0952
    Cell Significance Index: -2.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0982
    Cell Significance Index: -1.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1051
    Cell Significance Index: -18.9500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1083
    Cell Significance Index: -1.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1131
    Cell Significance Index: -32.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1359
    Cell Significance Index: -19.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1414
    Cell Significance Index: -2.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1514
    Cell Significance Index: -3.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1584
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1837
    Cell Significance Index: -38.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1873
    Cell Significance Index: -24.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2091
    Cell Significance Index: -35.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2101
    Cell Significance Index: -9.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2192
    Cell Significance Index: -6.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2663
    Cell Significance Index: -8.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2796
    Cell Significance Index: -5.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2808
    Cell Significance Index: -38.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3080
    Cell Significance Index: -35.8900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3224
    Cell Significance Index: -2.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3249
    Cell Significance Index: -22.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3332
    Cell Significance Index: -38.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3369
    Cell Significance Index: -34.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3522
    Cell Significance Index: -11.2800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3651
    Cell Significance Index: -6.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3711
    Cell Significance Index: -8.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3971
    Cell Significance Index: -41.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4178
    Cell Significance Index: -33.0900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4263
    Cell Significance Index: -5.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4274
    Cell Significance Index: -9.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4307
    Cell Significance Index: -26.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4441
    Cell Significance Index: -56.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4550
    Cell Significance Index: -33.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4602
    Cell Significance Index: -21.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4606
    Cell Significance Index: -11.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5071
    Cell Significance Index: -31.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5189
    Cell Significance Index: -27.0300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5211
    Cell Significance Index: -4.9400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5237
    Cell Significance Index: -6.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5613
    Cell Significance Index: -36.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5743
    Cell Significance Index: -20.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6214
    Cell Significance Index: -16.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6414
    Cell Significance Index: -35.9900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6548
    Cell Significance Index: -6.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6586
    Cell Significance Index: -29.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6622
    Cell Significance Index: -34.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6661
    Cell Significance Index: -16.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7061
    Cell Significance Index: -8.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7217
    Cell Significance Index: -33.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7502
    Cell Significance Index: -27.5400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.7768
    Cell Significance Index: -9.2900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.7945
    Cell Significance Index: -10.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7953
    Cell Significance Index: -30.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8179
    Cell Significance Index: -17.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9012
    Cell Significance Index: -24.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0015
    Cell Significance Index: -34.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Similarity:** VSNL1 shares structural similarity with visinin, a protein known for its calcium-binding properties. This similarity suggests that VSNL1 may also play a role in calcium regulation, which is essential for neuronal function. 2. **Cellular Localization:** VSNL1 is predominantly expressed in neurons and interneurons, including specific subtypes such as GABAergic cortical interneurons and dopaminergic neurons. 3. **Regulatory Functions:** VSNL1 is involved in the regulation of insulin secretion, negative regulation of insulin secretion, and positive regulation of exocytosis. These functions highlight its role in maintaining glucose homeostasis and neural signaling. 4. **Interactions with Other Proteins:** VSNL1 interacts with various proteins, including calcium-binding proteins, which further underscores its role in calcium regulation and neural function. **Pathways and Functions:** 1. **Calcium Ion Binding:** VSNL1's calcium-binding properties are essential for its role in regulating calcium-dependent cellular processes, including neurotransmitter release and insulin secretion. 2. **Exocytosis Regulation:** VSNL1's involvement in the regulation of exocytosis highlights its role in maintaining neural function and homeostasis. 3. **Insulin Secretion Regulation:** VSNL1's negative regulation of insulin secretion and positive regulation of insulin secretion involved in the cellular response to glucose stimulus underscore its role in glucose homeostasis. 4. **Neurotransmitter Release:** VSNL1's interaction with calcium-binding proteins suggests its role in regulating neurotransmitter release, which is critical for neural signaling. **Clinical Significance:** 1. **Neurological Disorders:** Abnormalities in VSNL1 expression or function may contribute to neurological disorders, such as Parkinson's disease, diabetes, and epilepsy. 2. **Insulin Resistance:** Alterations in VSNL1 expression may contribute to insulin resistance, a hallmark of type 2 diabetes. 3. **Neuroprotection:** VSNL1's role in regulating calcium-dependent cellular processes suggests its potential as a neuroprotective agent in neurodegenerative disorders. 4. **Therapeutic Targeting:** Further research is needed to explore the therapeutic potential of VSNL1 as a target for the treatment of neurological and metabolic disorders. In conclusion, the visinin-like 1 gene (VSNL1) is a complex gene with multiple regulatory functions, particularly in the regulation of calcium ion binding, exocytosis, and insulin secretion. Its clinical significance is underscored by its potential role in neurological disorders, insulin resistance, and neuroprotection. Further research is necessary to fully elucidate the functions and therapeutic potential of VSNL1.

Genular Protein ID: 393740391

Symbol: VISL1_HUMAN

Name: Visinin-like protein 1

UniProtKB Accession Codes:

P62760 D6W515 P28677 P29103 P42323 Q9UM20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 15 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530085

Title: Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1.

PubMed ID: 8530085

DOI: 10.1006/geno.1995.1244

PubMed ID: 10520747

Title: Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes.

PubMed ID: 10520747

DOI: 10.3109/10425179809072192

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18703769

Title: The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients.

PubMed ID: 18703769

DOI: 10.1373/clinchem.2008.104497

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 191
  • Mass: 22142
  • Checksum: ACDC3B4FE8C79265
  • Sequence:
    • MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD 
ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE 
MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS 
IVLLLQCDIQ K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.