Details for: PPP2R2C

Gene ID: 5522

Symbol: PPP2R2C

Ensembl ID: ENSG00000074211

Description: protein phosphatase 2 regulatory subunit Bgamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 130.9713
    Cell Significance Index: -33.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.8511
    Cell Significance Index: 258.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.3994
    Cell Significance Index: 204.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.1330
    Cell Significance Index: 89.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9316
    Cell Significance Index: 588.0900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.8846
    Cell Significance Index: 38.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3473
    Cell Significance Index: 841.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8310
    Cell Significance Index: 123.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.6715
    Cell Significance Index: 61.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6226
    Cell Significance Index: 35.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3799
    Cell Significance Index: 954.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1021
    Cell Significance Index: 30.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0151
    Cell Significance Index: 13.8500
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.5528
    Cell Significance Index: 4.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4271
    Cell Significance Index: 6.0800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.3199
    Cell Significance Index: 3.5300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2863
    Cell Significance Index: 3.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2477
    Cell Significance Index: 15.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2013
    Cell Significance Index: 3.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0409
    Cell Significance Index: 3.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0354
    Cell Significance Index: 0.8500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0119
    Cell Significance Index: -22.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0134
    Cell Significance Index: -24.7700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0147
    Cell Significance Index: -0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0158
    Cell Significance Index: -21.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0175
    Cell Significance Index: -27.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0365
    Cell Significance Index: -19.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0387
    Cell Significance Index: -24.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0403
    Cell Significance Index: -29.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0455
    Cell Significance Index: -33.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0523
    Cell Significance Index: -0.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0529
    Cell Significance Index: -40.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0542
    Cell Significance Index: -30.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0554
    Cell Significance Index: -7.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0583
    Cell Significance Index: -26.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0598
    Cell Significance Index: -37.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0694
    Cell Significance Index: -30.6800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0806
    Cell Significance Index: -1.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0926
    Cell Significance Index: -26.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1213
    Cell Significance Index: -3.9700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1251
    Cell Significance Index: -1.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1366
    Cell Significance Index: -2.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1386
    Cell Significance Index: -1.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1473
    Cell Significance Index: -26.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1618
    Cell Significance Index: -3.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1716
    Cell Significance Index: -34.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1722
    Cell Significance Index: -36.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1806
    Cell Significance Index: -26.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1995
    Cell Significance Index: -4.0100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2041
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2053
    Cell Significance Index: -35.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2124
    Cell Significance Index: -11.1500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2126
    Cell Significance Index: -2.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2215
    Cell Significance Index: -7.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2314
    Cell Significance Index: -28.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2412
    Cell Significance Index: -10.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2656
    Cell Significance Index: -34.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3040
    Cell Significance Index: -31.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3092
    Cell Significance Index: -36.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3167
    Cell Significance Index: -36.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3287
    Cell Significance Index: -34.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3315
    Cell Significance Index: -8.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3355
    Cell Significance Index: -39.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3545
    Cell Significance Index: -3.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3759
    Cell Significance Index: -8.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3807
    Cell Significance Index: -30.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3856
    Cell Significance Index: -8.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3952
    Cell Significance Index: -9.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3973
    Cell Significance Index: -6.8700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4055
    Cell Significance Index: -5.6700
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.4278
    Cell Significance Index: -4.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4370
    Cell Significance Index: -15.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4602
    Cell Significance Index: -34.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5507
    Cell Significance Index: -34.7100
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.5526
    Cell Significance Index: -6.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5541
    Cell Significance Index: -39.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5790
    Cell Significance Index: -32.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6022
    Cell Significance Index: -31.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6225
    Cell Significance Index: -16.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6444
    Cell Significance Index: -39.5100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.6519
    Cell Significance Index: -8.6900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.6553
    Cell Significance Index: -4.3500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6607
    Cell Significance Index: -13.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6875
    Cell Significance Index: -32.3100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7259
    Cell Significance Index: -9.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7422
    Cell Significance Index: -33.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7792
    Cell Significance Index: -36.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8089
    Cell Significance Index: -42.0200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8120
    Cell Significance Index: -9.7100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8261
    Cell Significance Index: -16.2600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.8336
    Cell Significance Index: -9.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9155
    Cell Significance Index: -32.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.0076
    Cell Significance Index: -31.8700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -1.0440
    Cell Significance Index: -11.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0528
    Cell Significance Index: -33.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0776
    Cell Significance Index: -31.7400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0782
    Cell Significance Index: -21.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0921
    Cell Significance Index: -31.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.0924
    Cell Significance Index: -26.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** PPP2R2C shares significant structural homology with other PP2A regulatory subunits, suggesting a conserved evolutionary role in regulating PP2A activity. 2. **Cellular Expression:** PPP2R2C is predominantly expressed in neuronal cells, including stellate neurons, granule cells, and various types of cortical interneurons, as well as macroglial cells and retinal ganglion cells. 3. **Isoform Variability:** The PPP2R2C gene encodes multiple isoforms, including a 55 kDa isoform, which is the most studied and widely expressed form. **Pathways and Functions:** 1. **PP2A Complex Formation:** PPP2R2C forms a heterotrimeric complex with PP2A and a regulatory subunit, PP2A regulatory subunit alpha (PP2AAR), to regulate PP2A activity. 2. **Signaling Pathway Modulation:** PPP2R2C modulates various signaling pathways, including the PI3K/Akt, MAPK/ERK, and NF-κB pathways, by regulating the dephosphorylation of key proteins. 3. **Neuronal Development and Function:** PPP2R2C plays a crucial role in neuronal development, differentiation, and maturation, influencing the regulation of ion channels, neurotransmitter release, and synaptic plasticity. 4. **Neurodegenerative Diseases:** Alterations in PPP2R2C expression and function have been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. **Clinical Significance:** 1. **Neurodevelopmental Disorders:** PPP2R2C mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** Alterations in PPP2R2C expression have been linked to cancer progression, particularly in brain and nervous system tumors. 3. **Neurodegenerative Diseases:** PPP2R2C has been identified as a potential therapeutic target for the treatment of neurodegenerative diseases, given its role in regulating PP2A activity and modulating signaling pathways involved in disease progression. In conclusion, PPP2R2C is a vital gene that plays a crucial role in regulating various cellular processes, particularly in the context of the nervous system. Further research is needed to fully elucidate the mechanisms by which PPP2R2C influences neuronal function and development, as well as its clinical significance in neurological disorders.

Genular Protein ID: 2451582647

Symbol: 2ABG_HUMAN

Name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

UniProtKB Accession Codes:

Q9Y2T4 A8MSY7 B7Z3Y1 Q7Z4V7 Q8NEC4 Q9H3G7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 5 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10574460

Title: Genomic structure and localization of the human phosphatase 2A BR gamma regulatory subunit.

PubMed ID: 10574460

DOI: 10.1093/dnares/6.5.323

PubMed ID: 10945473

Title: Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16.

PubMed ID: 10945473

DOI: 10.1006/geno.2000.6219

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25816751

Title: HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

PubMed ID: 25816751

DOI: 10.1016/j.febslet.2015.03.019

Sequence Information:

  • Length: 447
  • Mass: 51515
  • Checksum: DB002C2384686BBD
  • Sequence:
    • MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA 
PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI 
TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS 
VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY 
SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD 
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD SVIMTGAYNN 
FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW 
HPAENIIAIA ATNNLYIFQD KVNSDMH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.