Details for: ARSB

Gene ID: 411

Symbol: ARSB

Ensembl ID: ENSG00000113273

Description: arylsulfatase B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.92
    Marker Score: 4211.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.51
    Marker Score: 14237
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.5
    Marker Score: 22418
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.49
    Marker Score: 5760
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168943
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.46
    Marker Score: 3449
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.42
    Marker Score: 5783
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.4
    Marker Score: 53270
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.36
    Marker Score: 10419
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.33
    Marker Score: 82087
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.31
    Marker Score: 2664
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.31
    Marker Score: 13490
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.3
    Marker Score: 1568
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.26
    Marker Score: 46621
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.24
    Marker Score: 4397
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.23
    Marker Score: 5104
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.19
    Marker Score: 4960
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.18
    Marker Score: 11193
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.18
    Marker Score: 23432
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.18
    Marker Score: 1818
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.13
    Marker Score: 9681
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.11
    Marker Score: 550
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.07
    Marker Score: 344
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16345
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.03
    Marker Score: 34804
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.03
    Marker Score: 2460
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.02
    Marker Score: 3431
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.02
    Marker Score: 319
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71783
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.99
    Marker Score: 4589
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.99
    Marker Score: 487
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.97
    Marker Score: 20668
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.96
    Marker Score: 347
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.92
    Marker Score: 4948
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5529
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.91
    Marker Score: 1127
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.9
    Marker Score: 537
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5122
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.89
    Marker Score: 2539
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.86
    Marker Score: 5505
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.84
    Marker Score: 416
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 486
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.81
    Marker Score: 1352
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.8
    Marker Score: 451
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.8
    Marker Score: 467
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.78
    Marker Score: 4117
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3263
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.76
    Marker Score: 241
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.76
    Marker Score: 818
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.75
    Marker Score: 1434
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.71
    Marker Score: 715
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.69
    Marker Score: 737
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.66
    Marker Score: 192
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.65
    Marker Score: 1130
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.64
    Marker Score: 773.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 553
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.63
    Marker Score: 244
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.63
    Marker Score: 723
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 297
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.62
    Marker Score: 2668
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.62
    Marker Score: 296
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.61
    Marker Score: 981
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.61
    Marker Score: 230
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.6
    Marker Score: 395
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.59
    Marker Score: 4447
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.58
    Marker Score: 338
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.56
    Marker Score: 142
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.55
    Marker Score: 345
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.54
    Marker Score: 534
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 224
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.53
    Marker Score: 1313
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.53
    Marker Score: 29822
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.53
    Marker Score: 1880
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.53
    Marker Score: 397
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.53
    Marker Score: 2832
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.52
    Marker Score: 497
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.52
    Marker Score: 699
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.51
    Marker Score: 743
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.5
    Marker Score: 171
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.48
    Marker Score: 125
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.48
    Marker Score: 866
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.47
    Marker Score: 10586
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.46
    Marker Score: 308
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.45
    Marker Score: 11637
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.45
    Marker Score: 1040

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Other Information

**Key characteristics:** - ARSB is a glycosidase that is involved in the degradation of glycosaminoglycans. - It is a transmembrane protein that is expressed on the surface of cells. - It is a highly conserved enzyme that is found in organisms from yeast to humans. **Pathways and functions:** - ARSB is involved in the degradation of dermatan sulfate, which is a component of the extracellular matrix. - It is also involved in the degradation of glycoproteins, including those that are involved in cell adhesion and signaling. - It is involved in the activation of the immune system. **Clinical significance:** - Mutations in the ARSB gene have been linked to a number of human diseases, including Maroteaux-Lamyndrome, mucopolysaccharidoses, and neurodegenerative diseases. - ARSB inhibitors are being investigated as a treatment for these diseases. - By understanding the function of ARSB, scientists hope to develop new therapies for these diseases.

Genular Protein ID: 1737859220

Symbol: ARSB_HUMAN

Name: Arylsulfatase B

UniProtKB Accession Codes:

P15848 B2RC20 Q8N322 Q9UDI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EC 2 EMBL 18 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2303452

Title: Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B.

PubMed ID: 2303452

DOI: 10.1016/s0021-9258(19)39778-9

PubMed ID: 1968043

Title: Human arylsulfatase B: MOPAC cloning, nucleotide sequence of a full-length cDNA, and regions of amino acid identity with arylsulfatases A and C.

PubMed ID: 1968043

DOI: 10.1016/0888-7543(90)90460-c

PubMed ID: 7687847

Title: Structure of the human arylsulfatase B gene.

PubMed ID: 7687847

DOI: 10.1515/bchm3.1993.374.1-6.327

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1930244

Title: Human N-acetylgalactosamine-4-sulphatase: protein maturation and isolation of genomic clones.

PubMed ID: 1930244

PubMed ID: 1390929

Title: Components and proteolytic processing sites of arylsulfatase B from human placenta.

PubMed ID: 1390929

DOI: 10.1016/0167-4838(92)90051-e

PubMed ID: 7628016

Title: A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency.

PubMed ID: 7628016

DOI: 10.1016/0092-8674(95)90314-3

PubMed ID: 15146462

Title: Molecular and functional analysis of SUMF1 mutations in multiple sulfatase deficiency.

PubMed ID: 15146462

DOI: 10.1002/humu.20040

PubMed ID: 19306108

Title: Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation.

PubMed ID: 19306108

DOI: 10.1007/s10585-009-9253-z

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9032078

Title: Structure of a human lysosomal sulfatase.

PubMed ID: 9032078

DOI: 10.1016/s0969-2126(97)00185-8

PubMed ID: 1718978

Title: Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). An intermediate clinical phenotype caused by substitution of valine for glycine at position 137 of arylsulfatase B.

PubMed ID: 1718978

DOI: 10.1016/s0021-9258(18)54649-4

PubMed ID: 1550123

Title: Mucopolysaccharidosis type VI: identification of three mutations in the arylsulfatase B gene of patients with the severe and mild phenotypes provides molecular evidence for genetic heterogeneity.

PubMed ID: 1550123

PubMed ID: 8116615

Title: Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes.

PubMed ID: 8116615

PubMed ID: 8125475

Title: Four novel mutant alleles of the arylsulfatase B gene in two patients with intermediate form of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome).

PubMed ID: 8125475

DOI: 10.1007/bf00212019

PubMed ID: 8541342

Title: N-acetylgalactosamine-4-sulfatase: identification of four new mutations within the conserved sulfatase region causing mucopolysaccharidosis type VI.

PubMed ID: 8541342

DOI: 10.1016/0925-4439(95)00070-4

PubMed ID: 8651289

Title: Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS6 patients.

PubMed ID: 8651289

PubMed ID: 10206678

Title: Two novel mutations of the arylsulfatase B gene in two Italian patients with severe form of mucopolysaccharidosis.

PubMed ID: 10206678

DOI: 10.1002/(sici)1098-1004(1998)11:5<410::aid-humu9>3.0.co;2-q

PubMed ID: 9582121

Title: Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome.

PubMed ID: 9582121

DOI: 10.1126/science.280.5366.1077

PubMed ID: 10036316

Title: Maroteaux-Lamy syndrome: five novel mutations and their structural localization.

PubMed ID: 10036316

DOI: 10.1016/s0925-4439(98)00099-4

PubMed ID: 10738004

Title: A novel mutation (Q239R) identified in a Taiwan Chinese patient with type VI mucopolysaccharidosis (Maroteaux-Lamy syndrome).

PubMed ID: 10738004

DOI: 10.1002/(sici)1098-1004(200004)15:4<389::aid-humu31>3.0.co;2-0

PubMed ID: 11802522

Title: Mucopolysaccharidosis type VI: report of two Taiwanese patients and identification of one novel mutation.

PubMed ID: 11802522

PubMed ID: 14974081

Title: Mutational analysis of mucopolysaccharidosis type VI patients undergoing a trial of enzyme replacement therapy.

PubMed ID: 14974081

DOI: 10.1002/humu.10313

PubMed ID: 19259130

Title: Segregation analysis in a family at risk for the Maroteaux-Lamy syndrome conclusively reveals c.1151G>A (p.S384N) as to be a polymorphism.

PubMed ID: 19259130

DOI: 10.1038/ejhg.2009.19

Sequence Information:

  • Length: 533
  • Mass: 59687
  • Checksum: 5983FB6911C4789A
  • Sequence:
    • MGPRGAASLP RGPGPRRLLL PVVLPLLLLL LLAPPGSGAG ASRPPHLVFL LADDLGWNDV 
GFHGSRIRTP HLDALAAGGV LLDNYYTQPL CTPSRSQLLT GRYQIRTGLQ HQIIWPCQPS 
CVPLDEKLLP QLLKEAGYTT HMVGKWHLGM YRKECLPTRR GFDTYFGYLL GSEDYYSHER 
CTLIDALNVT RCALDFRDGE EVATGYKNMY STNIFTKRAI ALITNHPPEK PLFLYLALQS 
VHEPLQVPEE YLKPYDFIQD KNRHHYAGMV SLMDEAVGNV TAALKSSGLW NNTVFIFSTD 
NGGQTLAGGN NWPLRGRKWS LWEGGVRGVG FVASPLLKQK GVKNRELIHI SDWLPTLVKL 
ARGHTNGTKP LDGFDVWKTI SEGSPSPRIE LLHNIDPNFV DSSPCPRNSM APAKDDSSLP 
EYSAFNTSVH AAIRHGNWKL LTGYPGCGYW FPPPSQYNVS EIPSSDPPTK TLWLFDIDRD 
PEERHDLSRE YPHIVTKLLS RLQFYHKHSV PVYFPAQDPR CDPKATGVWG PWM

Genular Protein ID: 3146334092

Symbol: A8K4A0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K4A0

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 413
  • Mass: 46028
  • Checksum: D4B6A96052E6FC68
  • Sequence:
    • MGPRGAASLP RGPGPRRLLL PVVLPLLLLL LLAPPGSGAG ASRPPHLVFL LADDLGWNDV 
GFHGSRIRTP HLDALAAGGV LLDNYYTQPL CTPSRSQLLT GRYQIRTGLQ HQIIWPCQPS 
CVPLDEKLLP QLLKEAGYTT HMVGKWHLGM YRKECLPTRR GFDTYFGYLL GSEDYYSHER 
CTLIDALNVT RCALDFRDGE EVATGYKNMY STNIFTKRAI ALITNHPPEK PLFLYLALQS 
VHEPLQVPEE YLKPYDFIQD KNRHHYAGMV SLMDEAVGNV TAALKSSGLW NNTVFIFSTD 
NGGQTLAGGN NWPLRGRKWS LWEGGVRGVG FVASPLLKQK GVKNRELIHI SDWLPTLVKL 
ARGHTNGTKP LDGFDMWKTI SEGSPSPRIE LLHNIDPNFV DSSPYWPECS LLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.