Details for: ACAT1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 229.7081
Cell Significance Index: -35.7300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 167.4398
Cell Significance Index: -42.4700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 105.0363
Cell Significance Index: -49.5900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 91.4976
Cell Significance Index: -47.0700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 37.9738
Cell Significance Index: -46.8200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.1408
Cell Significance Index: -40.5600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.3769
Cell Significance Index: -48.8400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.2594
Cell Significance Index: -20.2700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.9291
Cell Significance Index: 842.7800 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.9097
Cell Significance Index: 20.2900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.8581
Cell Significance Index: 111.5500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.6928
Cell Significance Index: 28.5200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.5322
Cell Significance Index: 71.4400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.5284
Cell Significance Index: 1380.0100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3646
Cell Significance Index: 273.7300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.0539
Cell Significance Index: 80.8800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.8407
Cell Significance Index: 97.9800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8191
Cell Significance Index: 112.4800 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.7952
Cell Significance Index: 3.0400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.7928
Cell Significance Index: 21.5800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7452
Cell Significance Index: 267.3100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7380
Cell Significance Index: 146.4600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6903
Cell Significance Index: 47.7400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.5990
Cell Significance Index: 76.7900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5977
Cell Significance Index: 27.0900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.5778
Cell Significance Index: 8.5300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5641
Cell Significance Index: 96.3300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5496
Cell Significance Index: 380.1500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5460
Cell Significance Index: 88.8000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5087
Cell Significance Index: 224.9000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4553
Cell Significance Index: 248.6400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.4160
Cell Significance Index: 10.9400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3795
Cell Significance Index: 72.2200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.3557
Cell Significance Index: 8.6800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3518
Cell Significance Index: 24.8800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3476
Cell Significance Index: 18.2500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.3405
Cell Significance Index: 44.0000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3134
Cell Significance Index: 9.0300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3095
Cell Significance Index: 19.9700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2718
Cell Significance Index: 20.2600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2570
Cell Significance Index: 46.3300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2208
Cell Significance Index: 27.1500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1898
Cell Significance Index: 139.1800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1713
Cell Significance Index: 322.5500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1590
Cell Significance Index: 100.9900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1501
Cell Significance Index: 4.2000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0845
Cell Significance Index: 1.6500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0640
Cell Significance Index: 3.9400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0609
Cell Significance Index: 1.7900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0366
Cell Significance Index: 56.3900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0313
Cell Significance Index: 57.8100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0230
Cell Significance Index: 2.7100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.0219
Cell Significance Index: 1.7400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0129
Cell Significance Index: 9.7800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0089
Cell Significance Index: 4.0300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0054
Cell Significance Index: 0.1500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0008
Cell Significance Index: 1.1500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0005
Cell Significance Index: 0.0500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0103
Cell Significance Index: -7.6600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0127
Cell Significance Index: -0.1900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0171
Cell Significance Index: -10.7100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0470
Cell Significance Index: -4.8100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0499
Cell Significance Index: -28.1200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0697
Cell Significance Index: -4.3900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0725
Cell Significance Index: -1.0700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0769
Cell Significance Index: -1.6100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1357
Cell Significance Index: -28.5800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1418
Cell Significance Index: -3.0300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1482
Cell Significance Index: -21.5400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1541
Cell Significance Index: -2.6400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1657
Cell Significance Index: -7.7900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1722
Cell Significance Index: -6.0500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1878
Cell Significance Index: -4.0000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1950
Cell Significance Index: -13.1100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2546
Cell Significance Index: -11.2600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2569
Cell Significance Index: -4.3000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2693
Cell Significance Index: -30.8500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3019
Cell Significance Index: -16.9400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3188
Cell Significance Index: -10.2100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3338
Cell Significance Index: -12.6400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3650
Cell Significance Index: -41.6700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3796
Cell Significance Index: -39.5300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4837
Cell Significance Index: -12.9200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4937
Cell Significance Index: -30.2700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5256
Cell Significance Index: -13.5100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5486
Cell Significance Index: -19.0700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5748
Cell Significance Index: -29.8600 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.6187
Cell Significance Index: -4.7300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6502
Cell Significance Index: -16.6100 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.7195
Cell Significance Index: -9.7100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.7302
Cell Significance Index: -8.7100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8121
Cell Significance Index: -20.3000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.8348
Cell Significance Index: -18.0900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.8352
Cell Significance Index: -20.0300 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.8500
Cell Significance Index: -9.2600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.8697
Cell Significance Index: -24.9300 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.8698
Cell Significance Index: -6.9500 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.8900
Cell Significance Index: -6.0300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.9627
Cell Significance Index: -21.0800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.9714
Cell Significance Index: -25.9900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1392780767
Symbol: THIL_HUMAN
Name: Acetyl-CoA acetyltransferase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1979337
Title: Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency.
PubMed ID: 1979337
DOI: 10.1172/jci114946
PubMed ID: 1684944
Title: Structure and expression of the human mitochondrial acetoacetyl-CoA thiolase-encoding gene.
PubMed ID: 1684944
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15242332
Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.
PubMed ID: 15242332
DOI: 10.1042/bj20040647
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 17371050
Title: Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function.
PubMed ID: 17371050
DOI: 10.1021/bi6026192
PubMed ID: 7749408
Title: Molecular basis of beta-ketothiolase deficiency: mutations and polymorphisms in the human mitochondrial acetoacetyl-coenzyme A thiolase gene.
PubMed ID: 7749408
PubMed ID: 1346617
Title: Identification of three mutant alleles of the gene for mitochondrial acetoacetyl-coenzyme A thiolase. A complete analysis of two generations of a family with 3-ketothiolase deficiency.
PubMed ID: 1346617
DOI: 10.1172/jci115608
PubMed ID: 1715688
Title: Evidence for a structural mutation (347Ala to Thr) in a German family with 3-ketothiolase deficiency.
PubMed ID: 1715688
PubMed ID: 7728148
Title: Molecular, biochemical, and clinical characterization of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in two further patients.
PubMed ID: 7728148
PubMed ID: 9744475
Title: Characterization of N93S, I312T, and A333P missense mutations in two Japanese families with mitochondrial acetoacetyl-CoA thiolase deficiency.
PubMed ID: 9744475
DOI: 10.1002/(sici)1098-1004(1998)12:4<245::aid-humu5>3.0.co;2-e
Sequence Information:
- Length: 427
- Mass: 45200
- Checksum: 2E81168EB39D0142
- Sequence:
MAVLAALLRS GARSRSPLLR RLVQEIRYVE RSYVSKPTLK EVVIVSATRT PIGSFLGSLS LLPATKLGSI AIQGAIEKAG IPKEEVKEAY MGNVLQGGEG QAPTRQAVLG AGLPISTPCT TINKVCASGM KAIMMASQSL MCGHQDVMVA GGMESMSNVP YVMNRGSTPY GGVKLEDLIV KDGLTDVYNK IHMGSCAENT AKKLNIARNE QDAYAINSYT RSKAAWEAGK FGNEVIPVTV TVKGQPDVVV KEDEEYKRVD FSKVPKLKTV FQKENGTVTA ANASTLNDGA AALVLMTADA AKRLNVTPLA RIVAFADAAV EPIDFPIAPV YAASMVLKDV GLKKEDIAMW EVNEAFSLVV LANIKMLEID PQKVNINGGA VSLGHPIGMS GARIVGHLTH ALKQGEYGLA SICNGGGGAS AMLIQKL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.