Details for: ANG

Gene ID: 283

Symbol: ANG

Ensembl ID: ENSG00000214274

Description: angiogenin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 3.14
    Marker Score: 4504
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.84
    Marker Score: 1759
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.72
    Marker Score: 641
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.7
    Marker Score: 10871
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.57
    Marker Score: 625
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.56
    Marker Score: 3535
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.54
    Marker Score: 3128
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.41
    Marker Score: 3203
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.37
    Marker Score: 573
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.31
    Marker Score: 301
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.3
    Marker Score: 447
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.28
    Marker Score: 405
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.26
    Marker Score: 2967
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.23
    Marker Score: 5922
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.22
    Marker Score: 2157
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.2
    Marker Score: 2960
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.19
    Marker Score: 4585
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.19
    Marker Score: 2251
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.12
    Marker Score: 9725
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.12
    Marker Score: 354
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.11
    Marker Score: 304
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.04
    Marker Score: 2478.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.04
    Marker Score: 512
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48012
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.99
    Marker Score: 579
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.98
    Marker Score: 4232
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.98
    Marker Score: 283
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15021
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.95
    Marker Score: 5654
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.95
    Marker Score: 810
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.93
    Marker Score: 6151
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.89
    Marker Score: 2922
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.87
    Marker Score: 670
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.87
    Marker Score: 1393
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.87
    Marker Score: 214
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.85
    Marker Score: 265
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.84
    Marker Score: 247
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.83
    Marker Score: 995
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.83
    Marker Score: 266
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 803
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.81
    Marker Score: 862
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.8
    Marker Score: 2106
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.78
    Marker Score: 776
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.76
    Marker Score: 1165
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.76
    Marker Score: 2373
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.72
    Marker Score: 750
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.71
    Marker Score: 369
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2950
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 420
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.7
    Marker Score: 1325
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 636
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.7
    Marker Score: 4535
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.69
    Marker Score: 253
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.69
    Marker Score: 452
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.68
    Marker Score: 1002
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.68
    Marker Score: 322
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.68
    Marker Score: 304
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 440
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.63
    Marker Score: 362
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.63
    Marker Score: 192.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.6
    Marker Score: 2944
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.6
    Marker Score: 225
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.59
    Marker Score: 931
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.58
    Marker Score: 612
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.58
    Marker Score: 145
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.58
    Marker Score: 145
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.58
    Marker Score: 3032
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.57
    Marker Score: 2025
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.57
    Marker Score: 548
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 269
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.55
    Marker Score: 402
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.55
    Marker Score: 731
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.55
    Marker Score: 1337
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.53
    Marker Score: 280
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.52
    Marker Score: 364
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.52
    Marker Score: 243
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.52
    Marker Score: 976
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.49
    Marker Score: 325
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.49
    Marker Score: 175
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.48
    Marker Score: 266
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.47
    Marker Score: 423

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Other Information

**Key characteristics:** - Protein type: Protein - Ensembl ID: ENSG00000214274 - Pathway ontology: Actin binding, Adherens junctions interactions, Cell-cell communication, Cell-cell junction organization, Cell junction organization, Copper ion binding, Dna binding, Endonuclease activity, Gene expression (transcription), Gene silencing by rna, Heparin binding, Peptide binding, Protein binding, Protein homodimerization activity, Rna endonuclease activity, Rna nuclease activity, Rrna binding, Signaling receptor binding, Trna-derived small rna (tsrna or trna-related fragment, trf) biogenesis **Pathways and functions:** - Cell-cell communication: Angiogenin is involved in cell-cell communication through the adherens junction. It is a key component of the adherens junction, which is a complex of cell adhesion molecules that holds cells together in tissues. - Tissue development: Angiogenin is also involved in tissue development. It is expressed in a variety of cell types during development, including respiratory cells, intestinal cells, and endocrine cells. - Signal transduction: Angiogenin is involved in signal transduction in some cell types. For example, in the intestine, angiogenin is expressed in epithelial cells and is involved in the regulation of epithelial cell migration. **Clinical significance:** - Angiogenin is a potential therapeutic target for cancer. It is expressed in a number of cancer cells, and inhibitors of angiogenin have been shown to be effective in inhibiting cancer cell growth. - Angiogenin is also involved in the development of atherosclerosis, a condition in which plaque builds up in the arteries and leads to heart disease and stroke. Inhibitors of angiogenin have been shown to be effective in preventing atherosclerosis.

Genular Protein ID: 4178871568

Symbol: ANGI_HUMAN

Name: Angiogenin

UniProtKB Accession Codes:

P03950 Q05CV1 Q53X86 Q6P5T2 Q8WXE7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 14 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 48 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 52 PDBsum 51 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2866795

Title: Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor.

PubMed ID: 2866795

DOI: 10.1021/bi00341a032

PubMed ID: 11919285

Title: Diversifying selection of the tumor-growth promoter angiogenin in primate evolution.

PubMed ID: 11919285

DOI: 10.1093/oxfordjournals.molbev.a004099

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2866794

Title: Amino acid sequence of human tumor derived angiogenin.

PubMed ID: 2866794

DOI: 10.1021/bi00341a031

PubMed ID: 2440105

Title: Tissue distribution and developmental expression of the messenger RNA encoding angiogenin.

PubMed ID: 2440105

DOI: 10.1126/science.2440105

PubMed ID: 1400510

Title: Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily.

PubMed ID: 1400510

DOI: 10.1016/s0021-9258(19)36710-9

PubMed ID: 7945327

Title: Identification of the nucleolar targeting signal of human angiogenin.

PubMed ID: 7945327

DOI: 10.1006/bbrc.1994.2391

PubMed ID: 8127865

Title: Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity.

PubMed ID: 8127865

DOI: 10.1073/pnas.91.5.1677

PubMed ID: 9050852

Title: Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A.

PubMed ID: 9050852

DOI: 10.1073/pnas.94.5.1761

PubMed ID: 10413501

Title: Superadditive and subadditive effects of 'hot spot' mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A.

PubMed ID: 10413501

DOI: 10.1021/bi990762a

PubMed ID: 12051708

Title: The nuclear function of angiogenin in endothelial cells is related to rRNA production.

PubMed ID: 12051708

DOI: 10.1016/s0006-291x(02)00479-5

PubMed ID: 19354288

Title: Ribonuclease inhibitor regulates neovascularization by human angiogenin.

PubMed ID: 19354288

DOI: 10.1021/bi9005094

PubMed ID: 21855800

Title: Angiogenin-induced tRNA fragments inhibit translation initiation.

PubMed ID: 21855800

DOI: 10.1016/j.molcel.2011.06.022

PubMed ID: 8159679

Title: Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease.

PubMed ID: 8159679

DOI: 10.1073/pnas.91.8.2915

PubMed ID: 9311977

Title: Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution.

PubMed ID: 9311977

DOI: 10.1093/emboj/16.17.5162

PubMed ID: 9918722

Title: Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth.

PubMed ID: 9918722

DOI: 10.1006/jmbi.1998.2378

PubMed ID: 11468363

Title: Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography.

PubMed ID: 11468363

DOI: 10.1110/ps.13601

PubMed ID: 11851402

Title: Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency.

PubMed ID: 11851402

DOI: 10.1021/bi015768q

PubMed ID: 12842050

Title: The crystal structure of human angiogenin in complex with an antitumor neutralizing antibody.

PubMed ID: 12842050

DOI: 10.1016/s0969-2126(03)00131-x

PubMed ID: 14756559

Title: Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41.

PubMed ID: 14756559

DOI: 10.1021/bi035654+

PubMed ID: 9461294

Title: Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy -- characterization of histidine protonation states and pKa values.

PubMed ID: 9461294

DOI: 10.1111/j.1432-1033.1997.00712.x

PubMed ID: 22384259

Title: Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis.

PubMed ID: 22384259

DOI: 10.1371/journal.pone.0032479

PubMed ID: 15557516

Title: A novel candidate region for ALS on chromosome 14q11.2.

PubMed ID: 15557516

DOI: 10.1212/01.wnl.0000144344.39103.f6

PubMed ID: 16501576

Title: ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

PubMed ID: 16501576

DOI: 10.1038/ng1742

PubMed ID: 17886298

Title: Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis.

PubMed ID: 17886298

DOI: 10.1002/ana.21221

PubMed ID: 17900154

Title: Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.

PubMed ID: 17900154

DOI: 10.1021/bi701333h

PubMed ID: 18087731

Title: Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis.

PubMed ID: 18087731

DOI: 10.1007/s10048-007-0111-3

PubMed ID: 17703939

Title: A novel angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy.

PubMed ID: 17703939

DOI: 10.1016/j.nmd.2007.07.003

PubMed ID: 22292843

Title: SOD1, ANG, TARDBP and FUS mutations in amyotrophic lateral sclerosis: a United States clinical testing lab experience.

PubMed ID: 22292843

DOI: 10.3109/17482968.2011.643899

PubMed ID: 25372031

Title: Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis.

PubMed ID: 25372031

DOI: 10.1371/journal.pone.0111963

Sequence Information:

  • Length: 147
  • Mass: 16550
  • Checksum: 9C462DA3C8D39ACC
  • Sequence:
    • MVMGLGVLLL VFVLGLGLTP PTLAQDNSRY THFLTQHYDA KPQGRDDRYC ESIMRRRGLT 
SPCKDINTFI HGNKRSIKAI CENKNGNPHR ENLRISKSSF QVTTCKLHGG SPWPPCQYRA 
TAGFRNVVVA CENGLPVHLD QSIFRRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.