Details for: ANG

Gene ID: 283

Symbol: ANG

Ensembl ID: ENSG00000214274

Description: angiogenin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 130.0586
    Cell Significance Index: -20.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.8706
    Cell Significance Index: -20.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.3240
    Cell Significance Index: -19.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.0005
    Cell Significance Index: -19.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.4158
    Cell Significance Index: -20.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1495
    Cell Significance Index: -20.3200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.9644
    Cell Significance Index: 49.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.8406
    Cell Significance Index: 132.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3290
    Cell Significance Index: 139.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2916
    Cell Significance Index: 35.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.0840
    Cell Significance Index: 16.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0246
    Cell Significance Index: 46.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0242
    Cell Significance Index: 101.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9606
    Cell Significance Index: 71.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9424
    Cell Significance Index: 65.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8610
    Cell Significance Index: 110.3700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.7780
    Cell Significance Index: 4.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7522
    Cell Significance Index: 12.4000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3661
    Cell Significance Index: 5.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3592
    Cell Significance Index: 18.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3353
    Cell Significance Index: 63.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2787
    Cell Significance Index: 13.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2717
    Cell Significance Index: 4.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2291
    Cell Significance Index: 6.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2265
    Cell Significance Index: 38.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2168
    Cell Significance Index: 35.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2164
    Cell Significance Index: 95.6600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2107
    Cell Significance Index: 2.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1817
    Cell Significance Index: 5.8200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1641
    Cell Significance Index: 2.7700
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.1542
    Cell Significance Index: 1.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1216
    Cell Significance Index: 16.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0996
    Cell Significance Index: 62.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0934
    Cell Significance Index: 1.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0923
    Cell Significance Index: 10.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0820
    Cell Significance Index: 1.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0807
    Cell Significance Index: 44.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0439
    Cell Significance Index: 7.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0397
    Cell Significance Index: 2.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0357
    Cell Significance Index: 4.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0338
    Cell Significance Index: 4.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0162
    Cell Significance Index: 12.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0123
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0111
    Cell Significance Index: -20.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0124
    Cell Significance Index: -1.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0181
    Cell Significance Index: -13.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0235
    Cell Significance Index: -1.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0341
    Cell Significance Index: -1.4000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0357
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0409
    Cell Significance Index: -8.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0424
    Cell Significance Index: -4.9400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0570
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0591
    Cell Significance Index: -17.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0597
    Cell Significance Index: -21.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0649
    Cell Significance Index: -29.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0740
    Cell Significance Index: -1.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0773
    Cell Significance Index: -0.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1011
    Cell Significance Index: -20.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1139
    Cell Significance Index: -13.0000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1152
    Cell Significance Index: -1.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1192
    Cell Significance Index: -2.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1392
    Cell Significance Index: -3.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1581
    Cell Significance Index: -18.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1649
    Cell Significance Index: -23.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2024
    Cell Significance Index: -12.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2192
    Cell Significance Index: -17.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2696
    Cell Significance Index: -5.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2813
    Cell Significance Index: -21.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3094
    Cell Significance Index: -19.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3292
    Cell Significance Index: -5.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3627
    Cell Significance Index: -22.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3687
    Cell Significance Index: -22.6600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3756
    Cell Significance Index: -3.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3758
    Cell Significance Index: -19.7300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.3770
    Cell Significance Index: -1.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3774
    Cell Significance Index: -21.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3871
    Cell Significance Index: -10.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4014
    Cell Significance Index: -10.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4174
    Cell Significance Index: -8.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4364
    Cell Significance Index: -18.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4586
    Cell Significance Index: -16.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4679
    Cell Significance Index: -6.7000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.4682
    Cell Significance Index: -4.8300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.4761
    Cell Significance Index: -5.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4794
    Cell Significance Index: -7.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4935
    Cell Significance Index: -17.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5022
    Cell Significance Index: -17.4500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.5421
    Cell Significance Index: -3.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5454
    Cell Significance Index: -10.6500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5537
    Cell Significance Index: -13.8300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.5559
    Cell Significance Index: -6.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5608
    Cell Significance Index: -10.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5613
    Cell Significance Index: -8.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6091
    Cell Significance Index: -17.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6268
    Cell Significance Index: -20.5200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.6335
    Cell Significance Index: -3.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6337
    Cell Significance Index: -18.6100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6344
    Cell Significance Index: -8.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ANG is a small, secreted protein with a molecular weight of approximately 14 kDa. It is highly basic, with a pI of around 9.5, and contains a unique sequence of amino acids that confers its angiogenic activity. ANG is also highly glycosylated, with multiple carbohydrate chains attached to its surface. This glycosylation is essential for its function and stability. ANG is a potent activator of various cellular processes, including cell migration, proliferation, and differentiation. It is also involved in the regulation of immune responses, particularly in the context of innate immunity. ANG has been shown to induce the production of pro-inflammatory cytokines and chemokines, which are essential for the recruitment of immune cells to sites of inflammation. **Pathways and Functions** ANG is involved in various signaling pathways, including: 1. **Angiogenesis**: ANG induces the formation of new blood vessels from pre-existing ones, a process that is essential for tissue growth and repair. 2. **Cell migration**: ANG promotes the migration of cells, including immune cells, which is essential for the recruitment of immune cells to sites of inflammation. 3. **Cell proliferation**: ANG regulates cell proliferation, particularly in the context of tissue growth and repair. 4. **Immune responses**: ANG is involved in the regulation of immune responses, particularly in the context of innate immunity. 5. **Cell differentiation**: ANG regulates cell differentiation, particularly in the context of tissue growth and repair. ANG's functions can be broadly categorized into the following: 1. **Angiogenic activity**: ANG induces the formation of new blood vessels from pre-existing ones. 2. **Immune modulation**: ANG regulates immune responses, particularly in the context of innate immunity. 3. **Cell migration and proliferation**: ANG promotes the migration and proliferation of cells, particularly in the context of tissue growth and repair. 4. **Cell differentiation**: ANG regulates cell differentiation, particularly in the context of tissue growth and repair. **Clinical Significance** ANG has been implicated in various diseases, including: 1. **Cancer**: ANG is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Inflammatory diseases**: ANG is involved in the regulation of immune responses, particularly in the context of inflammatory diseases such as arthritis and asthma. 3. **Neurological diseases**: ANG has been implicated in the regulation of neuronal cell migration and differentiation, particularly in the context of neurological diseases such as Alzheimer's disease. 4. **Reproductive diseases**: ANG is involved in the regulation of ovarian follicle development and is associated with infertility. In summary, ANG is a multifunctional protein that plays a crucial role in various cellular processes, including angiogenesis, cell migration, and immune responses. Its dysregulation has been implicated in various diseases, including cancer, inflammatory diseases, neurological diseases, and reproductive diseases.

Genular Protein ID: 4178871568

Symbol: ANGI_HUMAN

Name: Angiogenin

UniProtKB Accession Codes:

P03950 Q05CV1 Q53X86 Q6P5T2 Q8WXE7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 51 PDBsum 51 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2866795

Title: Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor.

PubMed ID: 2866795

DOI: 10.1021/bi00341a032

PubMed ID: 11919285

Title: Diversifying selection of the tumor-growth promoter angiogenin in primate evolution.

PubMed ID: 11919285

DOI: 10.1093/oxfordjournals.molbev.a004099

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2866794

Title: Amino acid sequence of human tumor derived angiogenin.

PubMed ID: 2866794

DOI: 10.1021/bi00341a031

PubMed ID: 2440105

Title: Tissue distribution and developmental expression of the messenger RNA encoding angiogenin.

PubMed ID: 2440105

DOI: 10.1126/science.2440105

PubMed ID: 1400510

Title: Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily.

PubMed ID: 1400510

DOI: 10.1016/s0021-9258(19)36710-9

PubMed ID: 7945327

Title: Identification of the nucleolar targeting signal of human angiogenin.

PubMed ID: 7945327

DOI: 10.1006/bbrc.1994.2391

PubMed ID: 8127865

Title: Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity.

PubMed ID: 8127865

DOI: 10.1073/pnas.91.5.1677

PubMed ID: 9050852

Title: Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A.

PubMed ID: 9050852

DOI: 10.1073/pnas.94.5.1761

PubMed ID: 10413501

Title: Superadditive and subadditive effects of 'hot spot' mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A.

PubMed ID: 10413501

DOI: 10.1021/bi990762a

PubMed ID: 12051708

Title: The nuclear function of angiogenin in endothelial cells is related to rRNA production.

PubMed ID: 12051708

DOI: 10.1016/s0006-291x(02)00479-5

PubMed ID: 19354288

Title: Ribonuclease inhibitor regulates neovascularization by human angiogenin.

PubMed ID: 19354288

DOI: 10.1021/bi9005094

PubMed ID: 21855800

Title: Angiogenin-induced tRNA fragments inhibit translation initiation.

PubMed ID: 21855800

DOI: 10.1016/j.molcel.2011.06.022

PubMed ID: 8159679

Title: Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease.

PubMed ID: 8159679

DOI: 10.1073/pnas.91.8.2915

PubMed ID: 9311977

Title: Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution.

PubMed ID: 9311977

DOI: 10.1093/emboj/16.17.5162

PubMed ID: 9918722

Title: Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth.

PubMed ID: 9918722

DOI: 10.1006/jmbi.1998.2378

PubMed ID: 11468363

Title: Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography.

PubMed ID: 11468363

DOI: 10.1110/ps.13601

PubMed ID: 11851402

Title: Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency.

PubMed ID: 11851402

DOI: 10.1021/bi015768q

PubMed ID: 12842050

Title: The crystal structure of human angiogenin in complex with an antitumor neutralizing antibody.

PubMed ID: 12842050

DOI: 10.1016/s0969-2126(03)00131-x

PubMed ID: 14756559

Title: Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41.

PubMed ID: 14756559

DOI: 10.1021/bi035654+

PubMed ID: 9461294

Title: Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy -- characterization of histidine protonation states and pKa values.

PubMed ID: 9461294

DOI: 10.1111/j.1432-1033.1997.00712.x

PubMed ID: 22384259

Title: Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis.

PubMed ID: 22384259

DOI: 10.1371/journal.pone.0032479

PubMed ID: 15557516

Title: A novel candidate region for ALS on chromosome 14q11.2.

PubMed ID: 15557516

DOI: 10.1212/01.wnl.0000144344.39103.f6

PubMed ID: 16501576

Title: ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

PubMed ID: 16501576

DOI: 10.1038/ng1742

PubMed ID: 17886298

Title: Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis.

PubMed ID: 17886298

DOI: 10.1002/ana.21221

PubMed ID: 17900154

Title: Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.

PubMed ID: 17900154

DOI: 10.1021/bi701333h

PubMed ID: 18087731

Title: Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis.

PubMed ID: 18087731

DOI: 10.1007/s10048-007-0111-3

PubMed ID: 17703939

Title: A novel angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy.

PubMed ID: 17703939

DOI: 10.1016/j.nmd.2007.07.003

PubMed ID: 22292843

Title: SOD1, ANG, TARDBP and FUS mutations in amyotrophic lateral sclerosis: a United States clinical testing lab experience.

PubMed ID: 22292843

DOI: 10.3109/17482968.2011.643899

PubMed ID: 25372031

Title: Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis.

PubMed ID: 25372031

DOI: 10.1371/journal.pone.0111963

Sequence Information:

  • Length: 147
  • Mass: 16550
  • Checksum: 9C462DA3C8D39ACC
  • Sequence:
    • MVMGLGVLLL VFVLGLGLTP PTLAQDNSRY THFLTQHYDA KPQGRDDRYC ESIMRRRGLT 
SPCKDINTFI HGNKRSIKAI CENKNGNPHR ENLRISKSSF QVTTCKLHGG SPWPPCQYRA 
TAGFRNVVVA CENGLPVHLD QSIFRRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.