Details for: CAPS

Gene ID: 828

Symbol: CAPS

Ensembl ID: ENSG00000105519

Description: calcyphosine

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 97.0136
    Cell Significance Index: -15.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.1919
    Cell Significance Index: -14.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.7102
    Cell Significance Index: -12.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.2875
    Cell Significance Index: -15.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 8.2850
    Cell Significance Index: 430.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.2881
    Cell Significance Index: 168.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1738
    Cell Significance Index: -13.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.8818
    Cell Significance Index: 44.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.9110
    Cell Significance Index: 2135.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8596
    Cell Significance Index: -15.2300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.6071
    Cell Significance Index: 35.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.5746
    Cell Significance Index: 48.7700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.5176
    Cell Significance Index: 9.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1802
    Cell Significance Index: 393.0200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.7421
    Cell Significance Index: 17.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3426
    Cell Significance Index: 165.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2201
    Cell Significance Index: 198.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0891
    Cell Significance Index: 983.3900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.0221
    Cell Significance Index: 10.0000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.7398
    Cell Significance Index: 6.8000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.7377
    Cell Significance Index: 8.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7357
    Cell Significance Index: 44.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5500
    Cell Significance Index: 8.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4223
    Cell Significance Index: 29.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4060
    Cell Significance Index: 5.7800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3341
    Cell Significance Index: 3.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3198
    Cell Significance Index: 14.9100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.3094
    Cell Significance Index: 3.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2616
    Cell Significance Index: 25.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2352
    Cell Significance Index: 10.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2039
    Cell Significance Index: 28.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1860
    Cell Significance Index: 5.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1594
    Cell Significance Index: 4.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1391
    Cell Significance Index: 3.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1010
    Cell Significance Index: 19.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0626
    Cell Significance Index: 2.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0602
    Cell Significance Index: 11.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0587
    Cell Significance Index: 11.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0514
    Cell Significance Index: 18.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0417
    Cell Significance Index: 2.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0284
    Cell Significance Index: 2.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0275
    Cell Significance Index: 3.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0113
    Cell Significance Index: 15.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0102
    Cell Significance Index: 0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0076
    Cell Significance Index: 14.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0037
    Cell Significance Index: 1.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0036
    Cell Significance Index: 2.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0028
    Cell Significance Index: 4.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0024
    Cell Significance Index: -1.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0031
    Cell Significance Index: -2.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0078
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0217
    Cell Significance Index: -16.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0225
    Cell Significance Index: -0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0228
    Cell Significance Index: -12.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0252
    Cell Significance Index: -11.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0253
    Cell Significance Index: -4.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0259
    Cell Significance Index: -16.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0308
    Cell Significance Index: -3.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0349
    Cell Significance Index: -0.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0372
    Cell Significance Index: -4.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0376
    Cell Significance Index: -4.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0390
    Cell Significance Index: -3.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0413
    Cell Significance Index: -11.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0632
    Cell Significance Index: -9.1800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0704
    Cell Significance Index: -0.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0763
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0849
    Cell Significance Index: -17.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0866
    Cell Significance Index: -2.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0953
    Cell Significance Index: -11.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1022
    Cell Significance Index: -7.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1323
    Cell Significance Index: -6.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1369
    Cell Significance Index: -14.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1539
    Cell Significance Index: -12.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1549
    Cell Significance Index: -9.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1598
    Cell Significance Index: -9.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1790
    Cell Significance Index: -12.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1921
    Cell Significance Index: -11.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1945
    Cell Significance Index: -13.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2110
    Cell Significance Index: -3.1800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2249
    Cell Significance Index: -3.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2269
    Cell Significance Index: -12.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2277
    Cell Significance Index: -11.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2632
    Cell Significance Index: -11.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2657
    Cell Significance Index: -10.8900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2811
    Cell Significance Index: -3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2953
    Cell Significance Index: -10.2600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2966
    Cell Significance Index: -3.8200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3115
    Cell Significance Index: -2.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3243
    Cell Significance Index: -12.2800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.3270
    Cell Significance Index: -2.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3394
    Cell Significance Index: -12.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3537
    Cell Significance Index: -9.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3727
    Cell Significance Index: -9.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3739
    Cell Significance Index: -10.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3848
    Cell Significance Index: -6.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3950
    Cell Significance Index: -7.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4059
    Cell Significance Index: -14.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Calciphosine, or CALCYPHOSINE (CAPS), is a calcium-binding protein that exhibits a unique molecular structure. The protein consists of a calcium-binding domain, which is responsible for its ability to interact with calcium ions. This interaction is crucial for the regulation of various cellular processes, including intracellular signal transduction and cytoskeleton organization. The expression of CALCYPHOSINE is significantly observed in ciliated columnar cells of the tracheobronchial tree, multi-ciliated epithelial cells, bladder urothelial cells, and kidney collecting duct principal cells, suggesting its role in maintaining epithelial homeostasis. **Pathways and Functions** The pathways and functions of calciphosine are multifaceted and involve various cellular processes. The protein's ability to bind calcium ions enables it to participate in intracellular signal transduction, regulating the activity of various proteins and enzymes. This, in turn, affects the organization of the cytoskeleton, which is essential for maintaining cell shape and structure. Additionally, calciphosine's interaction with calcium ions influences the functioning of various cellular compartments, including the nucleus and plasma membrane. The involvement of calciphosine in calcium ion binding and cytoskeleton organization suggests its potential role in maintaining epithelial homeostasis. This is particularly relevant in the tracheobronchial tree, where ciliated columnar cells are responsible for clearing mucus and debris from the airways. Dysregulation of calciphosine expression or function may contribute to airway diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. **Clinical Significance** The clinical significance of calciphosine lies in its potential role in immune response and disease pathogenesis. The protein's involvement in calcium ion binding and cytoskeleton organization suggests its potential role in modulating immune responses, particularly in the context of epithelial homeostasis. Dysregulation of calciphosine expression or function may contribute to various diseases, including airway diseases, kidney diseases, and bladder disorders. Furthermore, the identification of calciphosine as a potential biomarker for disease diagnosis and prognosis is warranted. The protein's expression in various epithelial cells suggests its potential use as a marker for epithelial homeostasis. Additionally, the protein's involvement in calcium ion binding and cytoskeleton organization suggests its potential role in modulating immune responses, making it a potential therapeutic target for immune-related diseases. In conclusion, calciphosine, or CALCYPHOSINE (CAPS), is a gene that encodes a calcium-binding protein with a unique molecular structure and multiple cellular functions. The protein's involvement in calcium ion binding, cytoskeleton organization, and epithelial homeostasis highlights its potential role in immune response and disease pathogenesis. Further research is needed to fully elucidate the clinical significance of calciphosine and its potential applications in disease diagnosis and therapy.

Genular Protein ID: 1926177980

Symbol: CAYP1_HUMAN

Name: Calcyphosin

UniProtKB Accession Codes:

Q13938 A0A0X1KG78 K7EL21 Q3MJA7 Q8NF12 Q8WUZ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 14 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9224948

Title: Cloning and sequence analysis of human calcyphosine complementary DNA.

PubMed ID: 9224948

DOI: 10.1016/s0167-4781(97)00073-0

PubMed ID: 18775726

Title: Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family.

PubMed ID: 18775726

DOI: 10.1016/j.jmb.2008.08.048

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

Sequence Information:

  • Length: 275
  • Mass: 30240
  • Checksum: EF8DF483ED4F7FD9
  • Sequence:
    • MQCHRDLALS QALWGWQLSK QSGWAHPSLP HSPLPSTVHS CSWAPPHLQR HLPLATVSPG 
TTQLTQGPAG RTLGQTQASC PEPRPSMDAV DATMEKLRAQ CLSRGASGIQ GLARFFRQLD 
RDGSRSLDAD EFRQGLAKLG LVLDQAEAEG VCRKWDRNGS GTLDLEEFLR ALRPPMSQAR 
EAVIAAAFAK LDRSGDGVVT VDDLRGVYSG RAHPKVRSGE WTEDEVLRRF LDNFDSSEKD 
GQVTLAEFQD YYSGVSASMN TDEEFVAMMT SAWQL

Genular Protein ID: 2909145078

Symbol: A0A384NYV7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384NYV7

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 5 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 189
  • Mass: 20967
  • Checksum: E57291A996D7D1D5
  • Sequence:
    • MDAVDATMEK LRAQCLSRGA SGIQGLARFF RQLDRDGSRS LDADEFRQGL AKLGLVLDQA 
EAEGVCRKWD RNGSGTLDLE EFLRALRPPM SQAREAVIAA AFAKLDRSGD GVVTVDDLRG 
VYSGRAHPKV RSGEWTEDEV LRRFLDNFDS SEKDGQVTLA EFQDYYSGVS ASMNTDEEFV 
AMMTSAWQL

Genular Protein ID: 318986914

Symbol: Q96ET4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96ET4

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 164
  • Mass: 18376
  • Checksum: 84BD852648A006D1
  • Sequence:
    • LARFFRQLDR DGSRSLDADE FRQGLAKLGL VLDQAEAEGV CRKWDRNGSG TLDLEEFLRA 
LRPPMSQARE AVIAAAFAKL DRSGDGVVTV DDLRGVYSGR AHPKVRSGEW TEDEVLRRFL 
DNFDSSEKDG QVTLAEFQDY YSGVSASMNT DEEFVAMMTS AWQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.