H3C1 | ENSG00000275714 | NCBI 8350

Details for: H3C1

Gene ID: 8350

Symbol: H3C1

Ensembl ID: ENSG00000275714

Description: H3 clustered histone 1

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-7 signaling
(R-HSA-1266695)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Chromatin organization
(GO:0006325)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Nucleosome assembly
(GO:0006334)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.1065
Cell Significance Index: 16.5800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.0893
Cell Significance Index: 31.3900
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.8666
Cell Significance Index: 21.6100
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.8373
Cell Significance Index: 7.3200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7062
Cell Significance Index: 15.3000
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.7059
Cell Significance Index: 7.6500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3674
Cell Significance Index: 12.9100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3670
Cell Significance Index: 23.6800
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.2932
Cell Significance Index: 2.9400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2680
Cell Significance Index: 7.1700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2425
Cell Significance Index: 5.0300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2067
Cell Significance Index: 39.3400
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.1588
Cell Significance Index: 1.6900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1379
Cell Significance Index: 13.6400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1336
Cell Significance Index: 8.0200
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.1321
Cell Significance Index: 1.3700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1261
Cell Significance Index: 4.0400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1248
Cell Significance Index: 13.5700
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.1236
Cell Significance Index: 1.2800
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1074
Cell Significance Index: 1.4900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1071
Cell Significance Index: 12.6300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1047
Cell Significance Index: 17.0400
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.0825
Cell Significance Index: 0.4500
Cell Name: germ cell (CL0000586)
Fold Change: 0.0656
Cell Significance Index: 0.5000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0619
Cell Significance Index: 55.9400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0618
Cell Significance Index: 3.2100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0420
Cell Significance Index: 1.9100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0292
Cell Significance Index: 0.4400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0283
Cell Significance Index: 1.9600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0208
Cell Significance Index: 2.6700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0192
Cell Significance Index: 0.4800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0161
Cell Significance Index: 2.2100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0157
Cell Significance Index: 0.2300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0095
Cell Significance Index: 5.1700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0080
Cell Significance Index: 0.1700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0040
Cell Significance Index: 1.7500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0003
Cell Significance Index: 0.0400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0001
Cell Significance Index: -0.0500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0015
Cell Significance Index: -0.3100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0020
Cell Significance Index: -0.1000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0022
Cell Significance Index: -4.0600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0026
Cell Significance Index: -4.7800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0029
Cell Significance Index: -4.4200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0046
Cell Significance Index: -2.5700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0051
Cell Significance Index: -3.8700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0054
Cell Significance Index: -3.9300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0056
Cell Significance Index: -1.0100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0066
Cell Significance Index: -4.2000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0074
Cell Significance Index: -0.2100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0092
Cell Significance Index: -4.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0092
Cell Significance Index: -3.3100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0118
Cell Significance Index: -2.0200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0125
Cell Significance Index: -2.5100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0128
Cell Significance Index: -0.1800
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0146
Cell Significance Index: -2.8900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0168
Cell Significance Index: -0.7300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0170
Cell Significance Index: -1.2000
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0230
Cell Significance Index: -0.2900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0245
Cell Significance Index: -3.0100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0257
Cell Significance Index: -1.6200
Cell Name: PP cell (CL0000696)
Fold Change: -0.0275
Cell Significance Index: -0.2800
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0278
Cell Significance Index: -0.3900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0285
Cell Significance Index: -4.1400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0305
Cell Significance Index: -1.8700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0327
Cell Significance Index: -4.2300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0331
Cell Significance Index: -1.5600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0344
Cell Significance Index: -0.4700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0349
Cell Significance Index: -3.5700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0383
Cell Significance Index: -0.4400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0388
Cell Significance Index: -1.0600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0392
Cell Significance Index: -4.0900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0476
Cell Significance Index: -2.2200
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0493
Cell Significance Index: -0.3300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0518
Cell Significance Index: -3.9800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0529
Cell Significance Index: -4.1900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0547
Cell Significance Index: -0.7000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0573
Cell Significance Index: -4.2700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0573
Cell Significance Index: -1.2000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0615
Cell Significance Index: -3.2300
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0619
Cell Significance Index: -0.8800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0620
Cell Significance Index: -3.4800
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.0626
Cell Significance Index: -0.6100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0666
Cell Significance Index: -1.7500
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0782
Cell Significance Index: -0.5100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0795
Cell Significance Index: -2.0300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0947
Cell Significance Index: -4.1900
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0965
Cell Significance Index: -0.8200
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1013
Cell Significance Index: -3.5500
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.1034
Cell Significance Index: -0.6400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1041
Cell Significance Index: -2.7800
Cell Name: peg cell (CL4033014)
Fold Change: -0.1043
Cell Significance Index: -2.4100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1090
Cell Significance Index: -3.1300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1109
Cell Significance Index: -4.2000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1111
Cell Significance Index: -1.8600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1114
Cell Significance Index: -3.8700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1152
Cell Significance Index: -4.2300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1161
Cell Significance Index: -3.8000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1163
Cell Significance Index: -3.4300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.1167
Cell Significance Index: -0.9800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1171
Cell Significance Index: -3.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** H3C1 exhibits several key characteristics, including: 1. **Histone H3 family member**: H3C1 is part of the histone H3 family, which consists of five histone H3 variants (H3.1-3.5). 2. **DNA binding**: H3C1 has a high affinity for DNA, allowing it to interact with other proteins and modulate gene expression. 3. **Acetylation and methylation**: H3C1 can undergo acetylation and methylation, which play crucial roles in regulating chromatin structure and gene expression. 4. **Transcriptional regulation**: H3C1 is involved in the regulation of transcription, particularly in the context of androgen receptor-regulated genes. 5. **Cell cycle and mitosis**: H3C1 is essential for proper cell cycle progression and mitosis, ensuring accurate chromosome segregation. **Pathways and Functions** H3C1 is involved in numerous cellular pathways and functions, including: 1. **Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes**: H3C1 interacts with the androgen receptor (AR) to regulate transcription of AR-target genes. 2. **Activation of anterior hox genes in hindbrain development during early embryogenesis**: H3C1 is required for the proper expression of anterior Hox genes during hindbrain development. 3. **Assembly of the orc complex at the origin of replication**: H3C1 is involved in the assembly of the origin of replication complex (ORC) and the initiation of DNA replication. 4. **Amyloid fiber formation**: H3C1 is implicated in the formation of amyloid fibers, a hallmark of neurodegenerative diseases. 5. **Cytokine signaling in immune system**: H3C1 is involved in the regulation of cytokine signaling pathways in the immune system. **Clinical Significance** H3C1 has significant implications for various diseases and conditions, including: 1. **Neurodegenerative diseases**: H3C1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer**: H3C1 is involved in the regulation of gene expression in cancer cells, influencing tumor progression and metastasis. 3. **Immune system disorders**: H3C1 plays a crucial role in the regulation of cytokine signaling pathways in the immune system, which is essential for maintaining immune homeostasis. 4. **Developmental biology**: H3C1 is required for proper development and differentiation of various cell types, including neurons and immune cells. In summary, H3C1 is a multifunctional protein involved in various cellular processes, including transcriptional regulation, chromatin organization, and DNA replication. Its dysregulation has significant implications for various diseases and conditions, highlighting the importance of H3C1 in maintaining cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H3.1

Genular Protein ID: 1008323204

Symbol: H31_HUMAN

Name: Histone H3.1

UniProtKB Accession Codes:

P68431 A0PJT7 A5PLR1 P02295 P02296 P16106 Q6ISV8 Q6NWP8 Q6NWP9 Q6NXU4 Q71DJ3 Q93081

Database IDs:

Citations:

PubMed ID: 6647026

Title: The primary structure and expression of four cloned human histone genes.

PubMed ID: 6647026

DOI: 10.1093/nar/11.21.7409

PubMed ID: 3013246

Title: Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences.

PubMed ID: 3013246

DOI: 10.1139/o86-039

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 8227173

Title: Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones.

PubMed ID: 8227173

DOI: 10.1002/jcb.240520402

PubMed ID: 9031620

Title: Characterization of the H1.5 gene completes the set of human H1 subtype genes.

PubMed ID: 9031620

DOI: 10.1016/s0378-1119(96)00582-3

PubMed ID: 9119399

Title: Human histone gene organization: nonregular arrangement within a large cluster.

PubMed ID: 9119399

DOI: 10.1006/geno.1996.4592

PubMed ID: 9439656

Title: The human histone gene cluster at the D6S105 locus.

PubMed ID: 9439656

DOI: 10.1007/s004390050630

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7309716

Title: Human spleen histone H3. Isolation and amino acid sequence.

PubMed ID: 7309716

DOI: 10.1093/oxfordjournals.jbchem.a133573

PubMed ID: 16185088

Title: Modifications of human histone H3 variants during mitosis.

PubMed ID: 16185088

DOI: 10.1021/bi050906n

PubMed ID: 10464286

Title: Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.

PubMed ID: 10464286

DOI: 10.1074/jbc.274.36.25543

PubMed ID: 11242053

Title: Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

PubMed ID: 11242053

DOI: 10.1038/35065132

PubMed ID: 11856369

Title: Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation.

PubMed ID: 11856369

DOI: 10.1046/j.1356-9597.2001.00498.x

PubMed ID: 12560483

Title: Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.

PubMed ID: 12560483

DOI: 10.1093/nar/gkg176

PubMed ID: 15471871

Title: Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.

PubMed ID: 15471871

DOI: 10.1074/jbc.m410021200

PubMed ID: 15525939

Title: Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.

PubMed ID: 15525939

DOI: 10.1038/nature03114

PubMed ID: 15345777

Title: Human PAD4 regulates histone arginine methylation levels via demethylimination.

PubMed ID: 15345777

DOI: 10.1126/science.1101400

PubMed ID: 15681610

Title: The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.

PubMed ID: 15681610

DOI: 10.1101/gad.1267105

PubMed ID: 15684425

Title: Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.

PubMed ID: 15684425

DOI: 10.1074/jbc.m410521200

PubMed ID: 15983376

Title: Protein identification using sequential ion/ion reactions and tandem mass spectrometry.

PubMed ID: 15983376

DOI: 10.1073/pnas.0503189102

PubMed ID: 16267050

Title: Expression patterns and post-translational modifications associated with mammalian histone H3 variants.

PubMed ID: 16267050

DOI: 10.1074/jbc.m509266200

PubMed ID: 16457588

Title: Mass spectrometric characterization of human histone H3: a bird's eye view.

PubMed ID: 16457588

DOI: 10.1021/pr050266a

PubMed ID: 16678110

Title: Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.

PubMed ID: 16678110

DOI: 10.1016/j.molcel.2006.03.035

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 16497732

Title: Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.

PubMed ID: 16497732

DOI: 10.1210/me.2005-0365

PubMed ID: 16567635

Title: Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4.

PubMed ID: 16567635

DOI: 10.1073/pnas.0509639103

PubMed ID: 18079182

Title: PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation.

PubMed ID: 18079182

DOI: 10.1101/gad.447007

PubMed ID: 17194708

Title: Organismal differences in post-translational modifications in histones H3 and H4.

PubMed ID: 17194708

DOI: 10.1074/jbc.m607900200

PubMed ID: 17189264

Title: Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification.

PubMed ID: 17189264

DOI: 10.1074/jbc.m607909200

PubMed ID: 17898714

Title: Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.

PubMed ID: 17898714

DOI: 10.1038/nature06166

PubMed ID: 18243098

Title: Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.

PubMed ID: 18243098

DOI: 10.1016/j.cell.2007.12.013

PubMed ID: 18077460

Title: Arginine methylation of the histone H3 tail impedes effector binding.

PubMed ID: 18077460

DOI: 10.1074/jbc.c700192200

PubMed ID: 18066052

Title: Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation.

PubMed ID: 18066052

DOI: 10.1038/ncb1668

PubMed ID: 19520870

Title: Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding.

PubMed ID: 19520870

DOI: 10.1074/jbc.m109.003202

PubMed ID: 19783980

Title: JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.

PubMed ID: 19783980

DOI: 10.1038/nature08448

PubMed ID: 20850016

Title: Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

PubMed ID: 20850016

DOI: 10.1016/j.cell.2010.08.020

PubMed ID: 20228790

Title: Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

PubMed ID: 20228790

DOI: 10.1038/nature08839

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22901803

Title: PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.

PubMed ID: 22901803

DOI: 10.1016/j.cell.2012.07.018

PubMed ID: 22387026

Title: Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.

PubMed ID: 22387026

DOI: 10.1016/j.molcel.2012.01.019

PubMed ID: 22483618

Title: Lysyl oxidase-like 2 deaminates lysine 4 in histone H3.

PubMed ID: 22483618

DOI: 10.1016/j.molcel.2012.03.002

PubMed ID: 27392148

Title:

PubMed ID: 27392148

DOI: 10.1016/j.molcel.2016.06.013

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 22286216

Title: Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.

PubMed ID: 22286216

DOI: 10.1038/ng.1102

PubMed ID: 23415232

Title: Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.

PubMed ID: 23415232

DOI: 10.1016/j.cell.2013.01.032

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27735137

Title: Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.

PubMed ID: 27735137

DOI: 10.1111/febs.13922

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 27436229

Title: SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.

PubMed ID: 27436229

DOI: 10.1038/ncomms12235

PubMed ID: 27174990

Title: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.

PubMed ID: 27174990

DOI: 10.1126/science.aac7272

PubMed ID: 28497810

Title: Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

PubMed ID: 28497810

DOI: 10.1038/cr.2017.68

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 29211711

Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.

PubMed ID: 29211711

DOI: 10.1038/nature25003

PubMed ID: 30257210

Title: Interplay of histone marks with serine ADP-ribosylation.

PubMed ID: 30257210

DOI: 10.1016/j.celrep.2018.08.092

PubMed ID: 29480802

Title: Serine is the major residue for ADP-ribosylation upon DNA damage.

PubMed ID: 29480802

DOI: 10.7554/elife.34334

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 30867594

Title: Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

PubMed ID: 30867594

DOI: 10.1038/s41586-019-1024-7

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 31527692

Title: VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes.

PubMed ID: 31527692

DOI: 10.1038/s41598-019-49821-7

PubMed ID: 32273471

Title: Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking.

PubMed ID: 32273471

DOI: 10.1126/science.aaw8806

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

PubMed ID: 33857403

Title: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.

PubMed ID: 33857403

DOI: 10.1016/j.molcel.2021.03.041

PubMed ID: 35939806

Title: Potent Activation of NAD+-Dependent Deacetylase Sirt7 by Nucleosome Binding.

PubMed ID: 35939806

DOI: 10.1021/acschembio.2c00348

PubMed ID: 16246723

Title: Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.

PubMed ID: 16246723

DOI: 10.1016/j.molcel.2005.08.032

PubMed ID: 16372014

Title: Double chromodomains cooperate to recognize the methylated histone H3 tail.

PubMed ID: 16372014

DOI: 10.1038/nature04290

PubMed ID: 15951514

Title: Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle.

PubMed ID: 15951514

DOI: 10.1093/nar/gki663

PubMed ID: 22195965

Title: A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain.

PubMed ID: 22195965

DOI: 10.1016/j.molcel.2011.11.021

PubMed ID: 33051594

Title: Structural basis for nucleosome-mediated inhibition of cGAS activity.

PubMed ID: 33051594

DOI: 10.1038/s41422-020-00422-4

PubMed ID: 33141820

Title: Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.

PubMed ID: 33141820

DOI: 10.1371/journal.pone.0240932

PubMed ID: 32912999

Title: Structural basis for the inhibition of cGAS by nucleosomes.

PubMed ID: 32912999

DOI: 10.1126/science.abd0237

PubMed ID: 23603901

Title: The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

PubMed ID: 23603901

DOI: 10.1101/gad.217778.113

PubMed ID: 28067913

Title: Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

PubMed ID: 28067913

DOI: 10.1038/ng.3757

Sequence Information:

Length: 136
Mass: 15404
Checksum: 9B89008EA50A0EF6
Sequence:

MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE 
LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEACEAY LVGLFEDTNL CAIHAKRVTI 
MPKDIQLARR IRGERA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H3C1

Associated with

Cells (max top 100)

Other Information

The primary structure and expression of four cloned human histone genes. PubMed ID: 6647026

Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences. PubMed ID: 3013246

Isolation and characterization of two human H1 histone genes within clusters of core histone genes. PubMed ID: 1916825

Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones. PubMed ID: 8227173

Characterization of the H1.5 gene completes the set of human H1 subtype genes. PubMed ID: 9031620

Human histone gene organization: nonregular arrangement within a large cluster. PubMed ID: 9119399

The human histone gene cluster at the D6S105 locus. PubMed ID: 9439656

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human spleen histone H3. Isolation and amino acid sequence. PubMed ID: 7309716

Modifications of human histone H3 variants during mitosis. PubMed ID: 16185088

Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. PubMed ID: 10464286

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. PubMed ID: 11242053

Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. PubMed ID: 11856369

Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. PubMed ID: 12560483

Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. PubMed ID: 15471871

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. PubMed ID: 15525939

Human PAD4 regulates histone arginine methylation levels via demethylimination. PubMed ID: 15345777

The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. PubMed ID: 15681610

Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. PubMed ID: 15684425

Protein identification using sequential ion/ion reactions and tandem mass spectrometry. PubMed ID: 15983376

Expression patterns and post-translational modifications associated with mammalian histone H3 variants. PubMed ID: 16267050

Mass spectrometric characterization of human histone H3: a bird's eye view. PubMed ID: 16457588

Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. PubMed ID: 16678110

Quantitative proteomic analysis of post-translational modifications of human histones. PubMed ID: 16627869

Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. PubMed ID: 16497732

Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. PubMed ID: 16567635

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. PubMed ID: 18079182

Organismal differences in post-translational modifications in histones H3 and H4. PubMed ID: 17194708

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. PubMed ID: 17189264

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. PubMed ID: 17898714

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. PubMed ID: 18243098

Arginine methylation of the histone H3 tail impedes effector binding. PubMed ID: 18077460

Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. PubMed ID: 18066052

Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding. PubMed ID: 19520870

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. PubMed ID: 19783980

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. PubMed ID: 20850016

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. PubMed ID: 20228790

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. PubMed ID: 22901803

Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. PubMed ID: 22387026

Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. PubMed ID: 22483618