Details for: RGS13

Gene ID: 6003

Symbol: RGS13

Ensembl ID: ENSG00000127074

Description: regulator of G protein signaling 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centroblast (CL0009112)
    Fold Change: 27.6718
    Cell Significance Index: 64.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.2289
    Cell Significance Index: -4.3700
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 9.6392
    Cell Significance Index: 29.7200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 7.2522
    Cell Significance Index: 73.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.1616
    Cell Significance Index: 608.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.4579
    Cell Significance Index: 658.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.3399
    Cell Significance Index: 231.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.6088
    Cell Significance Index: 24.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2454
    Cell Significance Index: 202.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2120
    Cell Significance Index: 131.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.1117
    Cell Significance Index: 23.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7252
    Cell Significance Index: 50.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7178
    Cell Significance Index: 43.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4935
    Cell Significance Index: -1.0800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0726
    Cell Significance Index: 1.0400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0485
    Cell Significance Index: 0.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0478
    Cell Significance Index: 0.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0337
    Cell Significance Index: 0.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0286
    Cell Significance Index: 53.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0280
    Cell Significance Index: 5.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0221
    Cell Significance Index: 1.0000
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.0212
    Cell Significance Index: 0.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0204
    Cell Significance Index: 0.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0131
    Cell Significance Index: 0.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0111
    Cell Significance Index: 7.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0014
    Cell Significance Index: -2.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0057
    Cell Significance Index: -0.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0060
    Cell Significance Index: -2.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0065
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0118
    Cell Significance Index: -7.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0122
    Cell Significance Index: -4.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0124
    Cell Significance Index: -3.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0126
    Cell Significance Index: -2.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0159
    Cell Significance Index: -2.8600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0242
    Cell Significance Index: -3.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0249
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0291
    Cell Significance Index: -6.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0311
    Cell Significance Index: -0.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0332
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0332
    Cell Significance Index: -5.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0345
    Cell Significance Index: -3.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0384
    Cell Significance Index: -4.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0393
    Cell Significance Index: -4.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0397
    Cell Significance Index: -1.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0402
    Cell Significance Index: -5.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0428
    Cell Significance Index: -1.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0449
    Cell Significance Index: -2.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0488
    Cell Significance Index: -2.0000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0497
    Cell Significance Index: -1.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0510
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0511
    Cell Significance Index: -5.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0590
    Cell Significance Index: -3.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0647
    Cell Significance Index: -4.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0656
    Cell Significance Index: -0.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0669
    Cell Significance Index: -1.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0683
    Cell Significance Index: -5.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0709
    Cell Significance Index: -4.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0709
    Cell Significance Index: -3.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0807
    Cell Significance Index: -3.5700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0810
    Cell Significance Index: -1.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0829
    Cell Significance Index: -3.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0846
    Cell Significance Index: -2.0500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0873
    Cell Significance Index: -1.2400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0955
    Cell Significance Index: -1.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0959
    Cell Significance Index: -5.3800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0981
    Cell Significance Index: -1.2700
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.1043
    Cell Significance Index: -0.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1073
    Cell Significance Index: -2.8700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1088
    Cell Significance Index: -1.5800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1125
    Cell Significance Index: -1.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1136
    Cell Significance Index: -1.2900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1214
    Cell Significance Index: -1.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1239
    Cell Significance Index: -4.3400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1271
    Cell Significance Index: -0.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1297
    Cell Significance Index: -4.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1408
    Cell Significance Index: -3.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1428
    Cell Significance Index: -4.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1437
    Cell Significance Index: -3.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1465
    Cell Significance Index: -6.8300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1469
    Cell Significance Index: -1.4800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1522
    Cell Significance Index: -1.9900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1527
    Cell Significance Index: -2.0600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1528
    Cell Significance Index: -0.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1534
    Cell Significance Index: -3.9200
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1567
    Cell Significance Index: -1.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1610
    Cell Significance Index: -5.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1685
    Cell Significance Index: -4.9500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1695
    Cell Significance Index: -2.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1704
    Cell Significance Index: -4.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1708
    Cell Significance Index: -4.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1721
    Cell Significance Index: -4.9100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1737
    Cell Significance Index: -1.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RGS domain:** RGS13 contains a characteristic RGS domain, which is responsible for its ability to regulate G protein signaling. 2. **High expression in immune cells:** RGS13 is significantly expressed in immune cells, including basophils, germinal center B cells, and granulocytes. 3. **Negative regulation of GPCR signaling:** RGS13 acts as a negative regulator of GPCR signaling, modulating the activity of G proteins and influencing downstream signaling pathways. 4. **Cellular localization:** RGS13 is found in both the cytosol and nucleus, suggesting its involvement in multiple cellular processes. **Pathways and Functions:** RGS13 is involved in various signaling pathways, including: 1. **G alpha (i) signaling events:** RGS13 regulates the activity of G alpha (i) proteins, which are involved in inhibitory signaling pathways. 2. **G alpha (q) signaling events:** RGS13 modulates the activity of G alpha (q) proteins, which are involved in excitatory signaling pathways. 3. **GPCR downstream signaling:** RGS13 regulates the activity of GPCRs, influencing downstream signaling pathways and cellular responses. 4. **Signaling by GPCRs:** RGS13 acts as a negative regulator of GPCR signaling, modulating the activity of G proteins and influencing downstream signaling pathways. **Clinical Significance:** RGS13 has been implicated in various disease processes, including: 1. **Allergic disorders:** RGS13 has been shown to play a role in allergic responses, particularly in the regulation of mast cell function. 2. **Autoimmune diseases:** RGS13 may be involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, by modulating immune cell function. 3. **Cancer:** RGS13 has been implicated in cancer progression, particularly in the regulation of cell growth and survival. 4. **Neurological disorders:** RGS13 may be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease, by modulating signaling pathways involved in neuronal function. In conclusion, RGS13 is a multifunctional protein that plays a crucial role in regulating GPCR signaling pathways and immune cell function. Its involvement in various disease processes highlights the potential for RGS13 as a therapeutic target for the treatment of allergic disorders, autoimmune diseases, cancer, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which RGS13 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1782710867

Symbol: RGS13_HUMAN

Name: Regulator of G-protein signaling 13

UniProtKB Accession Codes:

O14921 Q6PGR2 Q8TD63 Q9BX45

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 159
  • Mass: 19135
  • Checksum: A7AEFD70DB8450C3
  • Sequence:
    • MSRRNCWICK MCRDESKRPP SNLTLEEVLQ WAQSFENLMA TKYGPVVYAA YLKMEHSDEN 
IQFWMACETY KKIASRWSRI SRAKKLYKIY IQPQSPREIN IDSSTRETII RNIQEPTETC 
FEEAQKIVYM HMERDSYPRF LKSEMYQKLL KTMQSNNSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.