Details for: MYEOV

Gene ID: 26579

Symbol: MYEOV

Ensembl ID: ENSG00000172927

Description: myeloma overexpressed

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 10.8362
    Cell Significance Index: 14.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.5922
    Cell Significance Index: 53.8300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.4819
    Cell Significance Index: 40.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.8630
    Cell Significance Index: -3.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.1616
    Cell Significance Index: 30.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9361
    Cell Significance Index: 225.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4509
    Cell Significance Index: 276.1100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.2022
    Cell Significance Index: 16.6800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.1737
    Cell Significance Index: 11.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9324
    Cell Significance Index: 92.2400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.8561
    Cell Significance Index: 1.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8086
    Cell Significance Index: 730.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7652
    Cell Significance Index: 10.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5596
    Cell Significance Index: 60.8700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.5019
    Cell Significance Index: 6.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4917
    Cell Significance Index: 79.9700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3892
    Cell Significance Index: 5.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3595
    Cell Significance Index: 46.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3306
    Cell Significance Index: 15.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3238
    Cell Significance Index: 176.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3074
    Cell Significance Index: 21.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2306
    Cell Significance Index: 16.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2262
    Cell Significance Index: 4.9000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.2067
    Cell Significance Index: 0.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1906
    Cell Significance Index: 9.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1899
    Cell Significance Index: 5.4700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1522
    Cell Significance Index: 1.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1331
    Cell Significance Index: 16.3600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.1175
    Cell Significance Index: 1.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1112
    Cell Significance Index: 5.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0552
    Cell Significance Index: 1.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0410
    Cell Significance Index: 0.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0383
    Cell Significance Index: 16.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0379
    Cell Significance Index: 1.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0258
    Cell Significance Index: 0.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -2.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0047
    Cell Significance Index: -3.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0049
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0053
    Cell Significance Index: -3.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0055
    Cell Significance Index: -1.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0056
    Cell Significance Index: -2.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0058
    Cell Significance Index: -0.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0059
    Cell Significance Index: -3.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0063
    Cell Significance Index: -1.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0089
    Cell Significance Index: -1.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0101
    Cell Significance Index: -2.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0101
    Cell Significance Index: -1.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0109
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0128
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0153
    Cell Significance Index: -3.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0170
    Cell Significance Index: -1.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0188
    Cell Significance Index: -2.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0230
    Cell Significance Index: -0.5900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0255
    Cell Significance Index: -0.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0270
    Cell Significance Index: -3.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0272
    Cell Significance Index: -2.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0341
    Cell Significance Index: -3.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0375
    Cell Significance Index: -1.9000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0394
    Cell Significance Index: -0.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0400
    Cell Significance Index: -1.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0467
    Cell Significance Index: -3.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0490
    Cell Significance Index: -2.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0491
    Cell Significance Index: -3.0100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0491
    Cell Significance Index: -0.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0498
    Cell Significance Index: -3.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0501
    Cell Significance Index: -1.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0515
    Cell Significance Index: -0.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0540
    Cell Significance Index: -2.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0608
    Cell Significance Index: -3.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0648
    Cell Significance Index: -3.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0662
    Cell Significance Index: -1.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0710
    Cell Significance Index: -1.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0747
    Cell Significance Index: -1.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0781
    Cell Significance Index: -3.2000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0782
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0807
    Cell Significance Index: -1.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0816
    Cell Significance Index: -2.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0825
    Cell Significance Index: -2.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0832
    Cell Significance Index: -3.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0835
    Cell Significance Index: -2.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0838
    Cell Significance Index: -3.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0881
    Cell Significance Index: -2.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0913
    Cell Significance Index: -3.2000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0921
    Cell Significance Index: -1.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0964
    Cell Significance Index: -3.6500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0979
    Cell Significance Index: -0.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0992
    Cell Significance Index: -1.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1022
    Cell Significance Index: -3.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1045
    Cell Significance Index: -3.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1051
    Cell Significance Index: -1.3800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1098
    Cell Significance Index: -1.8100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1100
    Cell Significance Index: -1.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1105
    Cell Significance Index: -3.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MYEOV gene is characterized by its significant expression in multiple cell types, including hematopoietic stem cells, retinal bipolar neurons, and cardiac endothelial cells. Its expression is also notable for its overexpression in myeloma cells, which is a type of blood cancer. The gene is encoded by an Ensembl ID of ENSG00000172927 and has been associated with several proteins, including MYEOV_HUMAN, F5H0B3_HUMAN, and A8K256_HUMAN. **Pathways and Functions:** The MYEOV gene is involved in various cellular processes, including protein binding, which is a key mechanism for regulating protein-protein interactions. The gene's expression in different cell types suggests that it plays a role in maintaining cellular homeostasis and regulating cell growth, differentiation, and survival. Specifically, MYEOV has been implicated in the regulation of hematopoiesis, the process by which blood cells are produced. Its overexpression in myeloma cells has been linked to the development of this disease. **Clinical Significance:** The MYEOV gene has significant clinical implications, particularly in the context of myeloma and other hematological disorders. The gene's overexpression in myeloma cells has been associated with disease progression and poor prognosis. Understanding the mechanisms by which MYEOV contributes to myeloma development and progression is crucial for the development of novel therapeutic strategies. Furthermore, the gene's expression in other cell types suggests that it may play a role in other diseases, including cancer, cardiovascular disease, and neurological disorders. **Implications for Immunology:** The MYEOV gene has implications for immunology, particularly in the context of cancer immunotherapy. The gene's expression in myeloma cells has been linked to immune evasion mechanisms, which enable cancer cells to evade the immune system. Understanding the role of MYEOV in immune evasion may provide insights into the development of novel immunotherapies that target this gene. **Future Directions:** Future research should focus on elucidating the mechanisms by which MYEOV contributes to myeloma development and progression. This includes investigating the gene's role in regulating protein binding, cell growth, and differentiation. Additionally, the gene's expression in other cell types should be further explored to determine its broader clinical significance. In conclusion, the MYEOV gene is a complex and multifaceted gene whose expression has significant implications for our understanding of cellular biology and disease. Further research is needed to fully elucidate the gene's role in the human body and to develop novel therapeutic strategies for diseases associated with its overexpression.

Genular Protein ID: 1396690309

Symbol: MYEOV_HUMAN

Name: Myeloma-overexpressed gene protein

UniProtKB Accession Codes:

Q96EZ4 Q9UGN6 Q9UGN7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 6 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10753852

Title: Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32).

PubMed ID: 10753852

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 313
  • Mass: 33556
  • Checksum: 292ABC0D6AFA52B0
  • Sequence:
    • MALRICVTYT PALPIGLCTR CCLCLEQSPS WCHCLRGVSF LTFHLHQSVP LGDRDSLLMF 
TRQAGHFVEG SKAGRSRGRL CLSQALRVAV RGAFVSLWFA AGAGDRERNK GDKGAQTGAG 
LSQEAEDVDV SRARRVTDAP QGTLCGTGNR NSGSQSARVV GVAHLGEAFR VGVEQAISSC 
PEEVHGRHGL SMEIMWARMD VALRSPGRGL LAGAGALCMT LAESSCPDYE RGRRACLTLH 
RHPTPHCSTW GLPLRVAGSW LTVVTVEALG GWRMGVRRTG QVGPTMHPPP VSGASPLLLH 
HLLLLLLIII LTC

Genular Protein ID: 1466433137

Symbol: A8K256_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K256

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 6 SAM 1

Sequence Information:

  • Length: 313
  • Mass: 33528
  • Checksum: 293381BBA8AA52B0
  • Sequence:
    • MALRICVTYT PALPIGLCTR CCLCLEQSPS WCHCLRGVSF LTFHLHQSVP LGDRDSLLMF 
TRQAGHFVEG SKAGRSRGRL CLSQALRVAV RGAFVSLWFA AGAGDRERNK GDKGAQTGAG 
LSQEAEDVDV SRARRVTDAP QGTLCGTGNR NSGSQSARVV GVAHLGEAFR VGVEQAISSC 
PEEVHGRHGL SMEIMWARMD VALRSPGRGL LAGAGALCMT LAESSCPDYE RGRRACLTLH 
RHPTPHCSTW GLPLRVAGSW LTVATVEALG GWRMGVRRTG QVGPTMHPPP VSGASPLLLH 
HLLLLLLIII LTC

Genular Protein ID: 1467266335

Symbol: F5H0B3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H0B3

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 HOGENOM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Proteomes 2 RefSeq 4 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 255
  • Mass: 27097
  • Checksum: 0DE7DFE89E55EBC1
  • Sequence:
    • MFTRQAGHFV EGSKAGRSRG RLCLSQALRV AVRGAFVSLW FAAGAGDRER NKGDKGAQTG 
AGLSQEAEDV DVSRARRVTD APQGTLCGTG NRNSGSQSAR VVGVAHLGEA FRVGVEQAIS 
SCPEEVHGRH GLSMEIMWAR MDVALRSPGR GLLAGAGALC MTLAESSCPD YERGRRACLT 
LHRHPTPHCS TWGLPLRVAG SWLTVVTVEA LGGWRMGVRR TGQVGPTMHP PPVSGASPLL 
LHHLLLLLLI IILTC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.