Details for: PEX5

Gene ID: 5830

Symbol: PEX5

Ensembl ID: ENSG00000139197

Description: peroxisomal biogenesis factor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.1562
    Cell Significance Index: -14.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.7726
    Cell Significance Index: -14.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 42.3355
    Cell Significance Index: -17.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.2548
    Cell Significance Index: -13.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4579
    Cell Significance Index: -15.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6965
    Cell Significance Index: -15.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0141
    Cell Significance Index: -15.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6986
    Cell Significance Index: -11.3600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.6133
    Cell Significance Index: 8.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4127
    Cell Significance Index: 139.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2079
    Cell Significance Index: 16.4800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1550
    Cell Significance Index: 18.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1374
    Cell Significance Index: 1027.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9210
    Cell Significance Index: 184.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8602
    Cell Significance Index: 93.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8195
    Cell Significance Index: 49.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7702
    Cell Significance Index: 125.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6577
    Cell Significance Index: 77.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4577
    Cell Significance Index: 31.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4409
    Cell Significance Index: 19.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4355
    Cell Significance Index: 16.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3686
    Cell Significance Index: 42.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3374
    Cell Significance Index: 66.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3235
    Cell Significance Index: 9.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3233
    Cell Significance Index: 115.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3223
    Cell Significance Index: 8.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2792
    Cell Significance Index: 7.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2683
    Cell Significance Index: 12.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2439
    Cell Significance Index: 33.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1840
    Cell Significance Index: 11.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1796
    Cell Significance Index: 3.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1564
    Cell Significance Index: 3.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1098
    Cell Significance Index: 59.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1023
    Cell Significance Index: 45.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0997
    Cell Significance Index: 4.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0988
    Cell Significance Index: 16.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0942
    Cell Significance Index: 2.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0896
    Cell Significance Index: 16.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0890
    Cell Significance Index: 16.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0819
    Cell Significance Index: 2.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0691
    Cell Significance Index: 3.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0670
    Cell Significance Index: 4.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0581
    Cell Significance Index: 7.1500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0577
    Cell Significance Index: 0.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0540
    Cell Significance Index: 6.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0451
    Cell Significance Index: 5.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0440
    Cell Significance Index: 30.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0413
    Cell Significance Index: 0.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0347
    Cell Significance Index: 1.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0314
    Cell Significance Index: 1.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0188
    Cell Significance Index: 11.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0100
    Cell Significance Index: 18.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0082
    Cell Significance Index: 15.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0045
    Cell Significance Index: 6.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0027
    Cell Significance Index: 0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0007
    Cell Significance Index: 0.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0029
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0060
    Cell Significance Index: -2.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0108
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0112
    Cell Significance Index: -8.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0164
    Cell Significance Index: -0.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0169
    Cell Significance Index: -1.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0214
    Cell Significance Index: -12.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0328
    Cell Significance Index: -20.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0387
    Cell Significance Index: -2.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0399
    Cell Significance Index: -11.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0409
    Cell Significance Index: -4.1800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0460
    Cell Significance Index: -0.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0473
    Cell Significance Index: -1.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0556
    Cell Significance Index: -2.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0567
    Cell Significance Index: -1.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0630
    Cell Significance Index: -1.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0665
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0837
    Cell Significance Index: -17.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0904
    Cell Significance Index: -10.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0955
    Cell Significance Index: -2.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1039
    Cell Significance Index: -6.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1045
    Cell Significance Index: -1.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1330
    Cell Significance Index: -4.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1349
    Cell Significance Index: -8.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1375
    Cell Significance Index: -14.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1518
    Cell Significance Index: -3.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1725
    Cell Significance Index: -13.6600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1859
    Cell Significance Index: -1.5800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1890
    Cell Significance Index: -2.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1953
    Cell Significance Index: -6.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1979
    Cell Significance Index: -6.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2112
    Cell Significance Index: -4.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2385
    Cell Significance Index: -6.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2426
    Cell Significance Index: -8.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2495
    Cell Significance Index: -5.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2759
    Cell Significance Index: -5.5400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2768
    Cell Significance Index: -3.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2774
    Cell Significance Index: -6.9200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2782
    Cell Significance Index: -5.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2863
    Cell Significance Index: -4.1000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2975
    Cell Significance Index: -3.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Peroxisomal targeting signal-1 (PTS1) binding**: PEX5 binds to the PTS1 motif, a specific sequence found on peroxisomal proteins, facilitating their import into the peroxisomal matrix. 2. **Protein import and localization**: PEX5 is responsible for the import of peroxisomal proteins into the matrix, ensuring their correct localization and function within the peroxisome. 3. **Autophagy and degradation**: PEX5 is also involved in the regulation of autophagy and the degradation of peroxisomal proteins, maintaining peroxisomal homeostasis. 4. **Interactions with other proteins**: PEX5 interacts with various proteins, including the PTS1 receptor, to regulate peroxisomal protein import and function. **Pathways and Functions:** 1. **Peroxisomal biogenesis**: PEX5 is essential for the biogenesis of peroxisomes, ensuring the assembly and targeting of peroxisomal proteins. 2. **Fatty acid beta-oxidation**: PEX5 plays a crucial role in the regulation of fatty acid beta-oxidation, a key process in energy metabolism. 3. **Detoxification of reactive oxygen species**: PEX5 is involved in the detoxification of reactive oxygen species (ROS), protecting cells from oxidative damage. 4. **Autophagy and degradation**: PEX5 regulates autophagy and the degradation of peroxisomal proteins, maintaining peroxisomal homeostasis. 5. **Cellular development and differentiation**: PEX5 is involved in the regulation of cellular development and differentiation, particularly in the context of neuronal development and function. **Clinical Significance:** 1. **Zellweger syndrome**: Mutations in PEX5 have been associated with Zellweger syndrome, a rare genetic disorder characterized by peroxisomal biogenesis defects. 2. **Neurodegenerative diseases**: PEX5 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where peroxisomal dysfunction contributes to disease progression. 3. **Cancer**: PEX5 has been shown to play a role in cancer development and progression, particularly in the context of peroxisomal biogenesis and fatty acid metabolism. 4. **Neurological disorders**: PEX5 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder, where peroxisomal dysfunction contributes to disease pathogenesis. In conclusion, PEX5 is a critical protein involved in peroxisomal biogenesis and function, playing a key role in various cellular processes, including fatty acid beta-oxidation, detoxification of reactive oxygen species, and autophagy. Its dysregulation has been implicated in various diseases, highlighting the importance of PEX5 in maintaining cellular homeostasis and function.

Genular Protein ID: 3790829379

Symbol: PEX5_HUMAN

Name: PTS1-BP

UniProtKB Accession Codes:

P50542 A8K891 B4DZ45 B7ZAD5 D3DUT8 Q15115 Q15266 Q96FN7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 11 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 18 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7719337

Title: Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders.

PubMed ID: 7719337

DOI: 10.1038/ng0295-115

PubMed ID: 7790377

Title: Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.

PubMed ID: 7790377

DOI: 10.1083/jcb.130.1.51

PubMed ID: 7706321

Title: Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor.

PubMed ID: 7706321

DOI: 10.1074/jbc.270.13.7731

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9820813

Title: C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal.

PubMed ID: 9820813

DOI: 10.1042/bj3360367

PubMed ID: 9668159

Title: An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes.

PubMed ID: 9668159

DOI: 10.1093/hmg/7.8.1195

PubMed ID: 10562279

Title: PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import.

PubMed ID: 10562279

DOI: 10.1083/jcb.147.4.761

PubMed ID: 11336669

Title: The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol.

PubMed ID: 11336669

DOI: 10.1016/s0092-8674(01)00310-5

PubMed ID: 11438541

Title: The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14.

PubMed ID: 11438541

DOI: 10.1074/jbc.m104647200

PubMed ID: 11546814

Title: Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p.

PubMed ID: 11546814

DOI: 10.1074/jbc.m106932200

PubMed ID: 12456682

Title: PEX5 binds the PTS1 independently of Hsp70 and the peroxin PEX12.

PubMed ID: 12456682

DOI: 10.1074/jbc.m206651200

PubMed ID: 16314507

Title: Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export.

PubMed ID: 16314507

DOI: 10.1128/mcb.25.24.10822-10832.2005

PubMed ID: 19208625

Title: Properties of the ubiquitin-pex5p thiol ester conjugate.

PubMed ID: 19208625

DOI: 10.1074/jbc.m808978200

PubMed ID: 21976670

Title: PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.

PubMed ID: 21976670

DOI: 10.1074/jbc.m111.287201

PubMed ID: 22371489

Title: Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.

PubMed ID: 22371489

DOI: 10.1074/jbc.m112.340158

PubMed ID: 21980954

Title: AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase.

PubMed ID: 21980954

DOI: 10.1111/j.1600-0854.2011.01298.x

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24662292

Title: Distinct modes of ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulate PTS1 protein import.

PubMed ID: 24662292

DOI: 10.1074/jbc.m113.527937

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24118911

Title: PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein.

PubMed ID: 24118911

DOI: 10.1111/tra.12129

PubMed ID: 25538232

Title: Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.

PubMed ID: 25538232

DOI: 10.1074/jbc.m114.601575

PubMed ID: 26220973

Title: A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform.

PubMed ID: 26220973

DOI: 10.1093/hmg/ddv305

PubMed ID: 26344566

Title: ATM functions at the peroxisome to induce pexophagy in response to ROS.

PubMed ID: 26344566

DOI: 10.1038/ncb3230

PubMed ID: 27597759

Title: PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation.

PubMed ID: 27597759

DOI: 10.1083/jcb.201511034

PubMed ID: 28765278

Title: The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.

PubMed ID: 28765278

DOI: 10.1074/jbc.m117.805044

PubMed ID: 28724525

Title: TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import.

PubMed ID: 28724525

DOI: 10.1083/jcb.201611170

PubMed ID: 29884772

Title: Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.

PubMed ID: 29884772

DOI: 10.1074/jbc.ra118.003669

PubMed ID: 33389129

Title: A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes.

PubMed ID: 33389129

DOI: 10.1007/s00439-020-02238-z

PubMed ID: 11101887

Title: Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5.

PubMed ID: 11101887

DOI: 10.1038/81930

PubMed ID: 17157249

Title: Recognition of a functional peroxisome type 1 target by the dynamic import receptor Pex5p.

PubMed ID: 17157249

DOI: 10.1016/j.molcel.2006.10.024

PubMed ID: 17428317

Title: A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding.

PubMed ID: 17428317

DOI: 10.1186/1472-6807-7-24

PubMed ID: 19197237

Title: Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.

PubMed ID: 19197237

DOI: 10.1038/emboj.2009.7

PubMed ID: 24235149

Title: A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.

PubMed ID: 24235149

DOI: 10.1074/jbc.m113.499707

PubMed ID: 10462504

Title: Functional heterogeneity of C-terminal peroxisome targeting signal 1 in PEX5-defective patients.

PubMed ID: 10462504

DOI: 10.1006/bbrc.1999.1232

Sequence Information:

  • Length: 639
  • Mass: 70865
  • Checksum: 9D6951F58AED31AC
  • Sequence:
    • MAMRELVEAE CGGANPLMKL AGHFTQDKAL RQEGLRPGPW PPGAPASEAA SKPLGVASED 
ELVAEFLQDQ NAPLVSRAPQ TFKMDDLLAE MQQIEQSNFR QAPQRAPGVA DLALSENWAQ 
EFLAAGDAVD VTQDYNETDW SQEFISEVTD PLSVSPARWA EEYLEQSEEK LWLGEPEGTA 
TDRWYDEYHP EEDLQHTASD FVAKVDDPKL ANSEFLKFVR QIGEGQVSLE SGAGSGRAQA 
EQWAAEFIQQ QGTSDAWVDQ FTRPVNTSAL DMEFERAKSA IESDVDFWDK LQAELEEMAK 
RDAEAHPWLS DYDDLTSATY DKGYQFEEEN PLRDHPQPFE EGLRRLQEGD LPNAVLLFEA 
AVQQDPKHME AWQYLGTTQA ENEQELLAIS ALRRCLELKP DNQTALMALA VSFTNESLQR 
QACETLRDWL RYTPAYAHLV TPAEEGAGGA GLGPSKRILG SLLSDSLFLE VKELFLAAVR 
LDPTSIDPDV QCGLGVLFNL SGEYDKAVDC FTAALSVRPN DYLLWNKLGA TLANGNQSEE 
AVAAYRRALE LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS 
ENIWSTLRLA LSMLGQSDAY GAADARDLST LLTMFGLPQ

Genular Protein ID: 3878405

Symbol: A0A0S2Z4F3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4F3

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 Pfam 2 RefSeq 5 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 602
  • Mass: 66830
  • Checksum: EA4E6FAAF5E11C55
  • Sequence:
    • MAMRELVEAE CGGANPLMKL AGHFTQDKAL RQEGLRPGPW PPGAPASEAA SKPLGVASED 
ELVAEFLQDQ NAPLVSRAPQ TFKMDDLLAE MQQIEQSNFR QAPQRAPGVA DLALSENWAQ 
EFLAAGDAVD VTQDYNETDW SQEFISEVTD PLSVSPARWA EEYLEQSEEK LWLGEPEGTA 
TDRWYDEYHP EEDLQHTASD FVAKVDDPKL ANSEGTSDAW VDQFTRPVNT SALDMEFERA 
KSAIESDVDF WDKLQAELEE MAKRDAEAHP WLSDYDDLTS ATYDKGYQFE EENPLRDHPQ 
PFEEGLRRLQ EGDLPNAVLL FEAAVQQDPK HMEAWQYLGT TQAENEQELL AISALRRCLE 
LKPDNQTALM ALAVSFTNES LQRQACETLR DWLRYTPAYA HLVTPAEEGA GGAGLGPSKR 
ILGSLLSDSL FLEVKELFLA AVRLDPTSID PDVQCGLGVL FNLSGEYDKA VDCFTAALSV 
RPNDYLLWNK LGATLANGNQ SEEAVAAYRR ALELQPGYIR SRYNLGISCI NLGAHREAVE 
HFLEALNMQR KSRGPRGEGG AMSENIWSTL RLALSMLGQS DAYGAADARD LSTLLTMFGL 
PQ

Genular Protein ID: 960741515

Symbol: B4DR50_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DR50

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 4 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 602
  • Mass: 66772
  • Checksum: EA4E6FAAF5E371C5
  • Sequence:
    • MAMRELVEAE CGGANPLMKL AGHFTQDKAL RQEGLRPGPW PPGAPASEAA SKPLGVASED 
ELVAEFLQDQ NAPLVSRAPQ TFKMDDLLAE MQQIEQSNFR QAPQRAPGVA DLALSENWAQ 
EFLAAGDAVD VTQDYNETDW SQEFISEVTD PLSVSPARWA EEYLEQSEEK LWLGEPEGTA 
TDRWYDEYHP EEDLQHTASD FVAKVDDPKL ANSEGTSDAW VDQFTRPVNT SALDMEFERA 
KSAIESDVDF WDKLQAELEE MAKRDAEAHP WLSDYDDLTS ATYDKGYQFE EENPLRDHPQ 
PFEEGLRRLQ EGDLPNAVLL FEAAVQQDPK HMEAWQYLGT TQAENEQELL AISALRRCLE 
LKPDNQTALM ALAVSFTNES LQRQACETLR DWLRYTPAYA HLVTPAEEGA GGAGLGPSKR 
ILGSLLSDSL FLEVKELFLA AVRLDPTSID PDVQCGLGVL FNLSGEYDKA VDCFTAALSV 
RPNDYLLWNK LGATLANGNQ SEEAVAAYRR ALELQPGYIR SRYNLGISCI NLGAHREAVE 
HFLEALNMQR KSRGPRGEGG AMSENIWSTL RLALSMLGQS GAYGAADARD LSTLLTMFGL 
PQ

Genular Protein ID: 1277808453

Symbol: A0A0S2Z480_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z480

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 Pfam 2 PhylomeDB 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 631
  • Mass: 69872
  • Checksum: 9F3B705D888C484B
  • Sequence:
    • MAMRELVEAE CGGANPLMKL AGHFTQDKAL RQEGLRPGPW PPGAPASEAA SKPLGVASED 
ELVAEFLQDQ NAPLVSRAPQ TFKMDDLLAE MQQIEQSNFR QAPQRAPGVA DLALSENWAQ 
EFLAAGDAVD VTQDYNETDW SQEFISEVTD PLSVSPARWA EEYLEQSEEK LWLGEPEGTA 
TDRWYDEYHP EEDLQHTASD FVAKVDDPKL ANSEFLKFVR QIGEGQVSLE SGAGSGRAQA 
EQWAAEFIQQ QGTSDAWVDQ FTRPVNTSAL DMEFERAKSA IELQAELEEM AKRDAEAHPW 
LSDYDDLTSA TYDKGYQFEE ENPLRDHPQP FEEGLRRLQE GDLPNAVLLF EAAVQQDPKH 
MEAWQYLGTT QAENEQELLA ISALRRCLEL KPDNQTALMA LAVSFTNESL QRQACETLRD 
WLRYTPAYAH LVTPAEEGAG GAGLGPSKRI LGSLLSDSLF LEVKELFLAA VRLDPTSIDP 
DVQCGLGVLF NLSGEYDKAV DCFTAALSVR PNDYLLWNKL GATLANGNQS EEAVAAYRRA 
LELQPGYIRS RYNLGISCIN LGAHREAVEH FLEALNMQRK SRGPRGEGGA MSENIWSTLR 
LALSMLGQSD AYGAADARDL STLLTMFGLP Q

Genular Protein ID: 3766267523

Symbol: B4E0T2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E0T2

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 660
  • Mass: 73183
  • Checksum: A8282DC15D8FFA71
  • Sequence:
    • MLLCRAHRVL GLRGARELAV TMAMRELVEA ECGGANPLMK LAGHFTQDKA LRQEGLRPGP 
WPPGAPASEA ASKPLGVASE DELVAEFLQD QNAPLVSRAP QTFKMDDLLA EMQQIEQSNF 
RQAPQRAPGV ADLALSENWA QEFLAAGDAV DVTQDYNETD WSQEFISEVT DPLSVSPARW 
AEEYLEQSEE KLWLGEPEGT ATDRWYDEYH PEEDLQHTAS DFVAKVDDPK LANSEFLKFV 
RQIGEGQVSL ESGAGSGRAQ AEQWAAEFIQ QQGTSDAWVD QFTRPVNTSA LDMEFERAKS 
AIESDVDFWD KLQAELEEMA KRDAEAHPWL SDYDDLTSAT YDKGYQFEEE NPLRDHPQPF 
EEGLRRLQEG DLPNAVLLFE AAVQQDPKHM EAWQYLGTTQ AENEQELLAI SALRRCLELK 
PDNQTALMAL AVSFTNESLQ RQACETLRDW LRYTPAYAHL VTPAEEGAGG AGLGPSKRIL 
GSLLSDSLFL EVKELFLAAV RLDPTSIDPD VQCGLGVLFN LSGEYDKAVD CFTAALSVRP 
NDYLLWNKLG ATLANGNQSE EAVAAYRRAL ELQPGYIRSR YNLGISCINL GAHREAVEHF 
LEALNMQRKS RGPRGEGGAM SENIWSTLRL ALSMLGQSDA YGAADARDLS TLLTMFGLPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.