Details for: HMX2

Gene ID: 3167

Symbol: HMX2

Ensembl ID: ENSG00000188816

Description: H6 family homeobox 2

Associated with

  • Brain development
    (GO:0007420)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Epithelial cell proliferation
    (GO:0050673)
  • Inner ear morphogenesis
    (GO:0042472)
  • Nucleus
    (GO:0005634)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of mrna splicing, via spliceosome
    (GO:0048026)
  • Positive regulation of stem cell proliferation
    (GO:2000648)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Stem cell proliferation
    (GO:0072089)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 9.5382
    Cell Significance Index: 238.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.2300
    Cell Significance Index: 146.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2902
    Cell Significance Index: 435.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5780
    Cell Significance Index: 156.1000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.8496
    Cell Significance Index: 10.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8372
    Cell Significance Index: 136.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8091
    Cell Significance Index: 88.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7332
    Cell Significance Index: 15.6200
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.5928
    Cell Significance Index: 4.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4893
    Cell Significance Index: 33.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4687
    Cell Significance Index: 28.1400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1794
    Cell Significance Index: 2.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1683
    Cell Significance Index: 2.4100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0758
    Cell Significance Index: 0.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0404
    Cell Significance Index: 1.0100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0377
    Cell Significance Index: 0.3800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0169
    Cell Significance Index: 0.2100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.0116
    Cell Significance Index: 0.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0050
    Cell Significance Index: 0.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0008
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0007
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0037
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7200
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0066
    Cell Significance Index: -0.0600
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: -0.0076
    Cell Significance Index: -0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0092
    Cell Significance Index: -1.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0093
    Cell Significance Index: -1.1000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0095
    Cell Significance Index: -0.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0133
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0141
    Cell Significance Index: -2.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0226
    Cell Significance Index: -3.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0253
    Cell Significance Index: -1.6300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0257
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0260
    Cell Significance Index: -1.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0268
    Cell Significance Index: -0.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0327
    Cell Significance Index: -3.3400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0416
    Cell Significance Index: -0.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0452
    Cell Significance Index: -1.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0463
    Cell Significance Index: -2.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0551
    Cell Significance Index: -1.4700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0587
    Cell Significance Index: -0.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0613
    Cell Significance Index: -1.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0628
    Cell Significance Index: -1.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0669
    Cell Significance Index: -1.4200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0671
    Cell Significance Index: -0.7600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0687
    Cell Significance Index: -0.7300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0692
    Cell Significance Index: -0.7300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0701
    Cell Significance Index: -0.6800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0715
    Cell Significance Index: -0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0723
    Cell Significance Index: -3.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0738
    Cell Significance Index: -0.7000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0768
    Cell Significance Index: -1.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0782
    Cell Significance Index: -1.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0785
    Cell Significance Index: -2.1000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0792
    Cell Significance Index: -0.9400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0831
    Cell Significance Index: -0.8600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0850
    Cell Significance Index: -0.9300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0858
    Cell Significance Index: -0.9300
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.0890
    Cell Significance Index: -0.8800
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0898
    Cell Significance Index: -0.8600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0907
    Cell Significance Index: -0.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0912
    Cell Significance Index: -3.1700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0922
    Cell Significance Index: -1.0300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0934
    Cell Significance Index: -0.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0944
    Cell Significance Index: -2.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0995
    Cell Significance Index: -2.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0998
    Cell Significance Index: -2.6300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1041
    Cell Significance Index: -1.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1181
    Cell Significance Index: -3.0100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1197
    Cell Significance Index: -1.7200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1202
    Cell Significance Index: -1.4500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1219
    Cell Significance Index: -1.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1270
    Cell Significance Index: -3.7300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1276
    Cell Significance Index: -1.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1404
    Cell Significance Index: -3.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1414
    Cell Significance Index: -2.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1446
    Cell Significance Index: -2.4200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1451
    Cell Significance Index: -1.8000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1469
    Cell Significance Index: -1.8500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1485
    Cell Significance Index: -1.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1506
    Cell Significance Index: -3.1300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1511
    Cell Significance Index: -1.8400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1584
    Cell Significance Index: -2.6100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1595
    Cell Significance Index: -1.6500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1607
    Cell Significance Index: -2.0800
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1660
    Cell Significance Index: -1.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1668
    Cell Significance Index: -1.7300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1698
    Cell Significance Index: -3.3200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1698
    Cell Significance Index: -2.7300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1765
    Cell Significance Index: -2.4200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1769
    Cell Significance Index: -2.2100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1794
    Cell Significance Index: -1.3800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1795
    Cell Significance Index: -2.2500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1816
    Cell Significance Index: -2.3000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1823
    Cell Significance Index: -1.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1823
    Cell Significance Index: -3.0700
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: -0.1849
    Cell Significance Index: -1.6200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1858
    Cell Significance Index: -2.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Homeobox Gene**: HMX2 belongs to the H6 family of homeobox genes, which are transcription factors that control the expression of genes involved in embryonic development, tissue differentiation, and cell fate determination. 2. **Tissue-Specific Expression**: HMX2 is highly expressed in microglial cells, dendritic cells, and epithelial cells, suggesting its role in immune cell development and tissue maintenance. 3. **Transcriptional Regulation**: HMX2 acts as a transcription factor, regulating the expression of genes involved in cell proliferation, differentiation, and survival. 4. **Positive Regulation of Epithelial Cell Proliferation**: HMX2 is involved in the positive regulation of epithelial cell proliferation, which is essential for maintaining tissue homeostasis and regeneration. **Pathways and Functions:** 1. **Brain Development**: HMX2 is involved in the regulation of brain development, particularly in the inner ear morphogenesis, which is critical for auditory function. 2. **Cell Differentiation**: HMX2 regulates the differentiation of immune cells, such as dendritic cells and microglial cells, ensuring proper immune function. 3. **Chromatin and Transcriptional Regulation**: HMX2 interacts with chromatin and RNA polymerase II to regulate gene expression, controlling the transcription of target genes involved in cell proliferation and differentiation. 4. **RNA Polymerase II Transcription Regulatory Region Sequence-Specific DNA Binding**: HMX2 binds to specific DNA sequences in the transcriptional regulatory regions of target genes, influencing their expression. **Clinical Significance:** 1. **Immune System Disorders**: Dysregulation of HMX2 expression has been implicated in various immune system disorders, including autoimmune diseases and cancer. 2. **Neurological Disorders**: Alterations in HMX2 expression have been linked to neurological disorders, such as hearing loss and neurodevelopmental disorders. 3. **Cancer**: HMX2 has been identified as a potential oncogene, with its overexpression contributing to cancer progression and metastasis. 4. **Epithelial Tissue Maintenance**: HMX2 plays a crucial role in maintaining epithelial tissue homeostasis, and its dysregulation can lead to epithelial diseases, such as inflammatory bowel disease. In conclusion, HMX2 is a critical regulator of immune cell development, epithelial cell proliferation, and stem cell maintenance. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 3133454594

Symbol: HMX2_HUMAN

Name: Homeobox protein HMX2

UniProtKB Accession Codes:

A2RU54 B2RNV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 273
  • Mass: 29598
  • Checksum: 1100C836F8D131F1
  • Sequence:
    • MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS SEEEEPDDGW 
KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP GGLERTPFLS PSHSDFKEEK 
ERLLPAGSPS PGSERPRDGG AERQAGAAKK KTRTVFSRSQ VYQLESTFDM KRYLSSSERA 
CLASSLQLTE TQVKTWFQNR RNKWKRQLSA ELEAANMAHA SAQTLVSMPL VFRDSSLLRV 
PVPRSLAFPA PLYYPGSNLS ALPLYNLYNK LDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.