Details for: HMX2

Gene ID: 3167

Symbol: HMX2

Ensembl ID: ENSG00000188816

Description: H6 family homeobox 2

Associated with

  • Brain development
    (GO:0007420)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Epithelial cell proliferation
    (GO:0050673)
  • Inner ear morphogenesis
    (GO:0042472)
  • Nucleus
    (GO:0005634)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of mrna splicing, via spliceosome
    (GO:0048026)
  • Positive regulation of stem cell proliferation
    (GO:2000648)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Stem cell proliferation
    (GO:0072089)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6847
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2234
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2002
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.72
    Marker Score: 1187.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.67
    Marker Score: 2172
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1177
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.37
    Marker Score: 1538.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7688
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4823
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.15
    Marker Score: 727.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 803
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.01
    Marker Score: 599
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1
    Marker Score: 458
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1183
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 392
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 513
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.64
    Marker Score: 301
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.51
    Marker Score: 489.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.5
    Marker Score: 292
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.36
    Marker Score: 174.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.36
    Marker Score: 324
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.35
    Marker Score: 353
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.3
    Marker Score: 503
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3
    Marker Score: 200
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.3
    Marker Score: 159
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.24
    Marker Score: 460
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.24
    Marker Score: 152
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.24
    Marker Score: 481
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 114
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.21
    Marker Score: 3244
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.21
    Marker Score: 362
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.19
    Marker Score: 125
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 98
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.17
    Marker Score: 249
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 356
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.17
    Marker Score: 165
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.17
    Marker Score: 311
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.16
    Marker Score: 53
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 148
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 915
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.13
    Marker Score: 158
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 185
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 121
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.1
    Marker Score: 66
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.08
    Marker Score: 81
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.08
    Marker Score: 190
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 128
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.05
    Marker Score: 67
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.05
    Marker Score: 139
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.05
    Marker Score: 69
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 14

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Other Information

**Key characteristics:** - HMX2 is a homeobox gene, which are a family of transcription factors that are involved in a wide range of cellular processes, including cell differentiation, tissue specification, and stem cell proliferation. - HMX2 is a highly conserved gene, with a similar gene found in vertebrates. - It is a key transcription factor in the development of the central nervous system. - It is involved in the regulation of neural differentiation, survival, and plasticity. **Pathways and functions:** - HMX2 is a key transcription factor in the development of the central nervous system. - It is essential for the specification of neural cell fate and the survival of neural progenitor cells. - It is also involved in the regulation of neuronal differentiation, migration, and plasticity. - HMX2 is also involved in the development of the inner ear and the regulation of stem cell proliferation in the developing embryo. **Clinical significance:** - Mutations in HMX2 have been linked to several neurological disorders, including autism, intellectual disability, and epilepsy. - HMX2 is a potential therapeutic target for these disorders, as it can be used to correct the genetic defects that cause these diseases. **Additional notes:** - HMX2 is a highly dynamic gene, with its expression levels changing in response to various stimuli. - It is also involved in the regulation of stem cell proliferation and differentiation. - HMX2 is a complex gene, with multiple isoforms that are expressed in different cell types.

Genular Protein ID: 3133454594

Symbol: HMX2_HUMAN

Name: Homeobox protein HMX2

UniProtKB Accession Codes:

A2RU54 B2RNV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 273
  • Mass: 29598
  • Checksum: 1100C836F8D131F1
  • Sequence:
    • MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS SEEEEPDDGW 
KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP GGLERTPFLS PSHSDFKEEK 
ERLLPAGSPS PGSERPRDGG AERQAGAAKK KTRTVFSRSQ VYQLESTFDM KRYLSSSERA 
CLASSLQLTE TQVKTWFQNR RNKWKRQLSA ELEAANMAHA SAQTLVSMPL VFRDSSLLRV 
PVPRSLAFPA PLYYPGSNLS ALPLYNLYNK LDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.