Details for: ETV7

Gene ID: 51513

Symbol: ETV7

Ensembl ID: ENSG00000010030

Description: ETS variant transcription factor 7

Associated with

  • Animal organ morphogenesis
    (GO:0009887)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 41.0170
    Cell Significance Index: -6.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.1929
    Cell Significance Index: -6.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 8.8820
    Cell Significance Index: -5.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6592
    Cell Significance Index: 164.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6092
    Cell Significance Index: -6.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5556
    Cell Significance Index: 80.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3880
    Cell Significance Index: 1253.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0400
    Cell Significance Index: 113.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8812
    Cell Significance Index: 143.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5821
    Cell Significance Index: 40.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4889
    Cell Significance Index: 6.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4403
    Cell Significance Index: 12.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3508
    Cell Significance Index: 7.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2211
    Cell Significance Index: 6.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1984
    Cell Significance Index: 2.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1842
    Cell Significance Index: 2.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1469
    Cell Significance Index: 64.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1445
    Cell Significance Index: 2.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1284
    Cell Significance Index: 3.6800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1207
    Cell Significance Index: 1.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1081
    Cell Significance Index: 20.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1015
    Cell Significance Index: 1.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0993
    Cell Significance Index: 7.0200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0979
    Cell Significance Index: 1.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0911
    Cell Significance Index: 1.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0909
    Cell Significance Index: 2.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0672
    Cell Significance Index: 7.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0620
    Cell Significance Index: 2.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0578
    Cell Significance Index: 7.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0555
    Cell Significance Index: 7.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0522
    Cell Significance Index: 9.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0450
    Cell Significance Index: 2.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0384
    Cell Significance Index: 0.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0341
    Cell Significance Index: 4.0200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0303
    Cell Significance Index: 0.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0264
    Cell Significance Index: 1.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0136
    Cell Significance Index: 9.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0086
    Cell Significance Index: 0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0052
    Cell Significance Index: 1.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0021
    Cell Significance Index: 1.1300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0005
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0009
    Cell Significance Index: -0.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0013
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0021
    Cell Significance Index: -0.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -8.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0060
    Cell Significance Index: -1.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0083
    Cell Significance Index: -5.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0083
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0094
    Cell Significance Index: -1.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0104
    Cell Significance Index: -3.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0115
    Cell Significance Index: -1.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0119
    Cell Significance Index: -5.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0138
    Cell Significance Index: -8.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0144
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0172
    Cell Significance Index: -2.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0184
    Cell Significance Index: -2.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0216
    Cell Significance Index: -6.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0227
    Cell Significance Index: -0.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0251
    Cell Significance Index: -0.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0322
    Cell Significance Index: -4.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0357
    Cell Significance Index: -7.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0362
    Cell Significance Index: -2.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0413
    Cell Significance Index: -1.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0428
    Cell Significance Index: -1.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0471
    Cell Significance Index: -2.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0522
    Cell Significance Index: -1.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0591
    Cell Significance Index: -3.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0620
    Cell Significance Index: -6.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0750
    Cell Significance Index: -5.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0765
    Cell Significance Index: -4.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0894
    Cell Significance Index: -1.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0898
    Cell Significance Index: -1.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0930
    Cell Significance Index: -6.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0968
    Cell Significance Index: -7.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0971
    Cell Significance Index: -5.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1121
    Cell Significance Index: -6.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1242
    Cell Significance Index: -6.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1251
    Cell Significance Index: -6.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1284
    Cell Significance Index: -5.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1311
    Cell Significance Index: -2.7200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1385
    Cell Significance Index: -1.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1404
    Cell Significance Index: -4.9200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1451
    Cell Significance Index: -3.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1463
    Cell Significance Index: -3.7600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1491
    Cell Significance Index: -1.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1496
    Cell Significance Index: -5.6700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1527
    Cell Significance Index: -1.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1532
    Cell Significance Index: -4.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1591
    Cell Significance Index: -5.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1730
    Cell Significance Index: -6.0100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1738
    Cell Significance Index: -1.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1753
    Cell Significance Index: -5.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ETV7 is a transcription factor that belongs to the ETS family of proteins, characterized by the presence of a DNA-binding domain. This domain allows ETV7 to bind to specific DNA sequences, regulating gene expression in response to various signals. ETV7 is primarily expressed in hematopoietic cells, epithelial cells, and urothelial cells, where it plays a crucial role in cell differentiation and survival. The protein is highly conserved across species, suggesting its essential role in maintaining tissue homeostasis. **Pathways and Functions:** ETV7 is involved in several key pathways that regulate immune cell development and function. These include: 1. **Animal organ morphogenesis:** ETV7 is essential for the development and morphogenesis of various organs, including the hematopoietic system, epithelial tissues, and urothelial cells. 2. **Cell differentiation:** ETV7 regulates the differentiation of hematopoietic cells, epithelial cells, and urothelial cells, ensuring proper tissue function and homeostasis. 3. **Chromatin:** ETV7 interacts with chromatin, regulating gene expression and transcriptional activity. 4. **RNA polymerase II-specific transcription:** ETV7 is involved in the transcriptional regulation of genes by RNA polymerase II, a critical enzyme in the transcriptional machinery. 5. **Negative regulation of transcription by RNA polymerase II:** ETV7 can repress transcription by RNA polymerase II, fine-tuning gene expression in response to changing cellular conditions. **Clinical Significance:** Dysregulation of ETV7 has been implicated in various diseases, including: 1. **Cancer:** ETV7 mutations have been identified in several types of cancer, including leukemia, lymphoma, and solid tumors. 2. **Autoimmune disorders:** ETV7 dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Immunodeficiency:** ETV7 deficiency has been associated with impaired immune function and increased susceptibility to infections. In conclusion, ETV7 is a critical transcription factor that regulates immune cell development and function. Its dysregulation has significant clinical implications, highlighting the need for further research into the molecular mechanisms underlying ETV7-related diseases.

Genular Protein ID: 973466762

Symbol: ETV7_HUMAN

Name: Transcription factor ETV7

UniProtKB Accession Codes:

Q9Y603 B3KVC2 B4DVB6 B4E1G4 Q5R3L3 Q5R3L4 Q9NZ65 Q9NZ66 Q9NZ68 Q9NZR8 Q9UNJ7 Q9Y5K4 Q9Y604

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 8 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 8 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10828014

Title: Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6.

PubMed ID: 10828014

PubMed ID: 11108721

Title: Tel-2, a novel transcriptional repressor related to the Ets factor Tel/ETV-6.

PubMed ID: 11108721

DOI: 10.1074/jbc.m010070200

PubMed ID: 11032031

Title: Characterization of a novel ETS gene, TELB encoding a protein structurally and functionally related to TEL.

PubMed ID: 11032031

DOI: 10.1038/sj.onc.1203830

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 341
  • Mass: 38998
  • Checksum: 941983E83E45EBED
  • Sequence:
    • MQEGELAISP ISPVAAMPPL GTHVQARCEA QINLLGEGGI CKLPGRLRIQ PALWSREDVL 
HWLRWAEQEY SLPCTAEHGF EMNGRALCIL TKDDFRHRAP SSGDVLYELL QYIKTQRRAL 
VCGPFFGGIF RLKTPTQHSP VPPEEVTGPS QMDTRRGHLL QPPDPGLTSN FGHLDDPGLA 
RWTPGKEESL NLCHCAELGC RTQGVCSFPA MPQAPIDGRI ADCRLLWDYV YQLLLDTRYE 
PYIKWEDKDA KIFRVVDPNG LARLWGNHKN RVNMTYEKMS RALRHYYKLN IIKKEPGQKL 
LFRFLKTPGK MVQDKHSHLE PLESQEQDRI EFKDKRPEIS P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.