H4C2 | ENSG00000278705 | NCBI 8366

Details for: H4C2

Gene ID: 8366

Symbol: H4C2

Ensembl ID: ENSG00000278705

Description: H4 clustered histone 2

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.7684
Cell Significance Index: 50.9500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.1038
Cell Significance Index: 16.5400
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.9162
Cell Significance Index: 9.9300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7455
Cell Significance Index: 16.1500
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.5879
Cell Significance Index: 5.1400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5344
Cell Significance Index: 101.7000
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.5277
Cell Significance Index: 13.1600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4251
Cell Significance Index: 19.2700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4174
Cell Significance Index: 11.1700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3909
Cell Significance Index: 38.6700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3776
Cell Significance Index: 13.2700
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.3727
Cell Significance Index: 9.5200
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.3402
Cell Significance Index: 4.7200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3107
Cell Significance Index: 18.6600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2994
Cell Significance Index: 32.5700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2637
Cell Significance Index: 17.0100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2460
Cell Significance Index: 40.0200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2391
Cell Significance Index: 215.9200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1816
Cell Significance Index: 2.6000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1705
Cell Significance Index: 20.1100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.1679
Cell Significance Index: 2.1500
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.1456
Cell Significance Index: 1.4600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1427
Cell Significance Index: 9.8700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1409
Cell Significance Index: 7.3200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1285
Cell Significance Index: 8.1000
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0962
Cell Significance Index: 1.3500
Cell Name: germ cell (CL0000586)
Fold Change: 0.0907
Cell Significance Index: 0.6900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0831
Cell Significance Index: 2.6600
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.0827
Cell Significance Index: 1.1600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0657
Cell Significance Index: 0.9900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0580
Cell Significance Index: 0.6000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0502
Cell Significance Index: 1.0700
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.0420
Cell Significance Index: 0.4500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0216
Cell Significance Index: 0.5400
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.0104
Cell Significance Index: 0.1100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0081
Cell Significance Index: 0.9300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0068
Cell Significance Index: 3.7300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0061
Cell Significance Index: 0.7800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0060
Cell Significance Index: 1.0900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0040
Cell Significance Index: 1.7800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0015
Cell Significance Index: 0.2000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0014
Cell Significance Index: 0.2500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0001
Cell Significance Index: 0.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0004
Cell Significance Index: -0.3000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0011
Cell Significance Index: -2.1100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0013
Cell Significance Index: -0.0500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0015
Cell Significance Index: -2.3100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0018
Cell Significance Index: -2.3800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0018
Cell Significance Index: -0.3900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0022
Cell Significance Index: -0.0600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0023
Cell Significance Index: -1.7700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0026
Cell Significance Index: -1.9200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0028
Cell Significance Index: -0.1700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0032
Cell Significance Index: -1.7900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0035
Cell Significance Index: -2.2400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0050
Cell Significance Index: -2.2500
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.0055
Cell Significance Index: -0.0300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0055
Cell Significance Index: -1.9900
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0077
Cell Significance Index: -0.0500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0079
Cell Significance Index: -0.8100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0100
Cell Significance Index: -2.0000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0124
Cell Significance Index: -0.3500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0137
Cell Significance Index: -1.9900
Cell Name: sensory neuron (CL0000101)
Fold Change: -0.0141
Cell Significance Index: -0.0800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0150
Cell Significance Index: -1.8400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0158
Cell Significance Index: -0.3300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0183
Cell Significance Index: -0.2500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0200
Cell Significance Index: -2.5800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0222
Cell Significance Index: -1.7000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0228
Cell Significance Index: -1.0700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0231
Cell Significance Index: -0.8100
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0238
Cell Significance Index: -0.3000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0243
Cell Significance Index: -0.6400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0250
Cell Significance Index: -1.3100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0292
Cell Significance Index: -1.6400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0292
Cell Significance Index: -1.3600
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0307
Cell Significance Index: -0.3100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0333
Cell Significance Index: -0.6900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0345
Cell Significance Index: -2.5700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0386
Cell Significance Index: -1.0300
Cell Name: Langerhans cell (CL0000453)
Fold Change: -0.0438
Cell Significance Index: -0.4200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0442
Cell Significance Index: -0.5000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0452
Cell Significance Index: -2.0000
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0457
Cell Significance Index: -1.9900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0479
Cell Significance Index: -1.2300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0483
Cell Significance Index: -1.6800
Cell Name: peg cell (CL4033014)
Fold Change: -0.0519
Cell Significance Index: -1.2000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0530
Cell Significance Index: -1.9500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0531
Cell Significance Index: -2.0100
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0565
Cell Significance Index: -0.4800
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: -0.0566
Cell Significance Index: -0.4400
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0566
Cell Significance Index: -0.8600
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0580
Cell Significance Index: -1.9000
Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: -0.0584
Cell Significance Index: -0.4200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0586
Cell Significance Index: -0.9800
Cell Name: keratocyte (CL0002363)
Fold Change: -0.0593
Cell Significance Index: -0.9400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0601
Cell Significance Index: -1.7700
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0609
Cell Significance Index: -0.4100
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0621
Cell Significance Index: -0.8900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0624
Cell Significance Index: -1.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Histone protein**: H4C2 is a member of the histone family, which forms the core of chromatin, the complex of DNA and proteins that make up chromosomes. 2. **Chromatin organization**: H4C2 contributes to the organization of chromatin, influencing gene expression and DNA replication. 3. **DNA repair**: H4C2 is involved in the repair of DNA damage, particularly in the assembly of the pre-replicative complex and the repair of base-excision repair. 4. **Cell cycle regulation**: H4C2 regulates the cell cycle, particularly in the G2/M phase, where it influences the assembly of the centromere and the condensation of prophase chromosomes. 5. **Epigenetic regulation**: H4C2 is involved in epigenetic regulation of gene expression, including the methylation and acetylation of histones. **Pathways and Functions:** 1. **Activation of anterior hox genes**: H4C2 plays a crucial role in the activation of anterior hox genes during hindbrain development during early embryogenesis. 2. **Amyloid fiber formation**: H4C2 is involved in the formation of amyloid fibers, which are associated with neurodegenerative diseases such as Alzheimer's disease. 3. **Assembly of the orc complex**: H4C2 contributes to the assembly of the orc complex at the origin of replication, which is essential for DNA replication. 4. **Base-excision repair**: H4C2 is involved in the repair of base-excision repair, particularly in the recognition and association of DNA glycosylase with damaged sites. 5. **Cellular responses to stimuli**: H4C2 regulates cellular responses to stimuli, including stress and damage, through its involvement in signaling pathways. **Clinical Significance:** 1. **Cancer**: Mutations in the H4C2 gene have been associated with various cancers, including leukemia and lymphoma. 2. **Neurodegenerative diseases**: H4C2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Aging and senescence**: H4C2 plays a role in the regulation of cellular senescence and aging, influencing the maintenance of genome stability. 4. **Infectious diseases**: H4C2 has been shown to be involved in the regulation of gene expression in response to viral infections. In conclusion, the H4C2 gene plays a critical role in maintaining genome stability and cellular homeostasis. Its involvement in various cellular processes highlights its significance in maintaining cellular balance, and its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and aging. Further research is needed to fully elucidate the role of H4C2 in maintaining genome stability and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.