GNG13 | ENSG00000127588 | NCBI 51764

Details for: GNG13

Gene ID: 51764

Symbol: GNG13

Ensembl ID: ENSG00000127588

Description: G protein subunit gamma 13

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G-protein activation
(R-HSA-202040)
G-protein beta:gamma signalling
(R-HSA-397795)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
G beta:gamma signalling through btk
(R-HSA-8964315)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon-type ligand receptors
(R-HSA-420092)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Gper1 signaling
(R-HSA-9634597)
G protein gated potassium channels
(R-HSA-1296059)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Incretin synthesis, secretion, and inactivation
(R-HSA-400508)
Infectious disease
(R-HSA-5663205)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Integration of energy metabolism
(R-HSA-163685)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Olfactory signaling pathway
(R-HSA-381753)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Peptide hormone metabolism
(R-HSA-2980736)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet homeostasis
(R-HSA-418346)
Potassium channels
(R-HSA-1296071)
Presynaptic function of kainate receptors
(R-HSA-500657)
Prostacyclin signalling through prostacyclin receptor
(R-HSA-392851)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Sensory perception
(R-HSA-9709957)
Sensory perception of sweet, bitter, and umami (glutamate) taste
(R-HSA-9717207)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
(R-HSA-381771)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Dendrite
(GO:0030425)
G-protein beta-subunit binding
(GO:0031681)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heterotrimeric g-protein complex
(GO:0005834)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Sensory perception of taste
(GO:0050909)
Synapse
(GO:0045202)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 10.7591
Cell Significance Index: 82.9300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.9713
Cell Significance Index: 565.4500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.0137
Cell Significance Index: 199.2000
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.7504
Cell Significance Index: 24.5900
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1.1866
Cell Significance Index: 11.9700
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.1814
Cell Significance Index: 14.3200
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 1.1080
Cell Significance Index: 9.7600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0673
Cell Significance Index: 173.5900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0224
Cell Significance Index: 111.2100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7738
Cell Significance Index: 16.4800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6115
Cell Significance Index: 42.2900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5713
Cell Significance Index: 34.3000
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1267
Cell Significance Index: 1.5100
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.1142
Cell Significance Index: 1.2900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0977
Cell Significance Index: 5.1300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0577
Cell Significance Index: 6.8100
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.0449
Cell Significance Index: 0.5800
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0401
Cell Significance Index: 1.0000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0282
Cell Significance Index: 5.6700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0278
Cell Significance Index: 0.8000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0201
Cell Significance Index: 0.9100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0162
Cell Significance Index: 0.3500
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.0096
Cell Significance Index: 0.1100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0083
Cell Significance Index: 0.2900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0074
Cell Significance Index: 2.1200
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.0033
Cell Significance Index: 0.0200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0028
Cell Significance Index: -0.0700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0045
Cell Significance Index: -2.0600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0074
Cell Significance Index: -2.6700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0077
Cell Significance Index: -5.7300
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0093
Cell Significance Index: -5.0800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0101
Cell Significance Index: -5.7200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0131
Cell Significance Index: -2.7500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0166
Cell Significance Index: -2.8400
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0192
Cell Significance Index: -0.2900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0218
Cell Significance Index: -1.1300
Cell Name: invaginating midget bipolar cell (CL4033034)
Fold Change: -0.0259
Cell Significance Index: -0.3200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0319
Cell Significance Index: -2.0100
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0321
Cell Significance Index: -6.3800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0340
Cell Significance Index: -3.9000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0401
Cell Significance Index: -5.5000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0463
Cell Significance Index: -5.4000
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.0494
Cell Significance Index: -0.4700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0512
Cell Significance Index: -1.6400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0538
Cell Significance Index: -2.5100
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.0560
Cell Significance Index: -0.6400
Cell Name: thymocyte (CL0000893)
Fold Change: -0.0574
Cell Significance Index: -0.7300
Cell Name: neuron (CL0000540)
Fold Change: -0.0601
Cell Significance Index: -0.5700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0698
Cell Significance Index: -1.0300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0701
Cell Significance Index: -4.3000
Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.0715
Cell Significance Index: -0.7000
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.0719
Cell Significance Index: -0.7600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0722
Cell Significance Index: -4.0500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0876
Cell Significance Index: -5.8900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0945
Cell Significance Index: -5.8100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1057
Cell Significance Index: -2.6400
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1068
Cell Significance Index: -4.3800
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.1244
Cell Significance Index: -1.4700
Cell Name: Mueller cell (CL0000636)
Fold Change: -0.1300
Cell Significance Index: -1.0000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1362
Cell Significance Index: -2.8500
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.1387
Cell Significance Index: -1.5200
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1570
Cell Significance Index: -1.7100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1614
Cell Significance Index: -5.6100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1654
Cell Significance Index: -5.8000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1679
Cell Significance Index: -4.5000
Cell Name: neural cell (CL0002319)
Fold Change: -0.1744
Cell Significance Index: -2.0400
Cell Name: neuroplacodal cell (CL0000032)
Fold Change: -0.1762
Cell Significance Index: -2.1700
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.1779
Cell Significance Index: -1.8900
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.1797
Cell Significance Index: -1.8100
Cell Name: adipocyte (CL0000136)
Fold Change: -0.1860
Cell Significance Index: -2.4800
Cell Name: mural cell (CL0008034)
Fold Change: -0.1865
Cell Significance Index: -2.2700
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.1883
Cell Significance Index: -2.5100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1884
Cell Significance Index: -2.5700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1922
Cell Significance Index: -5.6600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1926
Cell Significance Index: -4.0000
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1942
Cell Significance Index: -2.4900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1976
Cell Significance Index: -6.4700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2025
Cell Significance Index: -6.4500
Cell Name: neural crest cell (CL0011012)
Fold Change: -0.2054
Cell Significance Index: -2.2300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2060
Cell Significance Index: -5.8800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2067
Cell Significance Index: -5.5200
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.2077
Cell Significance Index: -2.6300
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2097
Cell Significance Index: -4.1000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2159
Cell Significance Index: -5.5000
Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: -0.2172
Cell Significance Index: -2.7000
Cell Name: brush cell (CL0002204)
Fold Change: -0.2182
Cell Significance Index: -2.0000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2206
Cell Significance Index: -5.9000
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.2239
Cell Significance Index: -2.8200
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.2260
Cell Significance Index: -2.9100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2289
Cell Significance Index: -6.0200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2425
Cell Significance Index: -5.3100
Cell Name: parietal cell (CL0000162)
Fold Change: -0.2431
Cell Significance Index: -2.3000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2454
Cell Significance Index: -2.5400
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.2473
Cell Significance Index: -2.8500
Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
Fold Change: -0.2520
Cell Significance Index: -2.7200
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: -0.2548
Cell Significance Index: -2.8500
Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
Fold Change: -0.2555
Cell Significance Index: -2.6700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2577
Cell Significance Index: -5.4700
Cell Name: interneuron (CL0000099)
Fold Change: -0.2577
Cell Significance Index: -3.0100
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2578
Cell Significance Index: -6.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key characteristics** The GNG13 gene is a member of the GNG family of genes, which encode for the gamma subunit of G proteins. The gamma subunit is characterized by its ability to interact with GPCRs and modulate their activity. The GNG13 gene is highly expressed in various tissues, including the retina, intestine, and pancreas. The gamma subunit is also involved in regulating the activity of various ion channels, including potassium channels, and neurotransmitter receptors, such as GABA receptors. **Pathways and functions** The GNG13 gene is involved in a wide range of signaling pathways, including: 1. **G protein-coupled receptor signaling**: The gamma subunit interacts with GPCRs, modulating their activity and influencing downstream signaling pathways. 2. **Potassium channel activation**: The gamma subunit is involved in regulating the activity of potassium channels, including inwardly rectifying K+ channels. 3. **Neurotransmitter receptor function**: The gamma subunit interacts with neurotransmitter receptors, including GABA receptors, influencing neurotransmission. 4. **Metabolism**: The gamma subunit is involved in regulating metabolic processes, including insulin secretion and glucagon-like peptide-1 (GLP-1) regulation. 5. **Inflammation**: The gamma subunit is involved in modulating inflammatory responses, including the production of anti-inflammatory cytokines. 6. **Leishmania parasite growth and survival**: The gamma subunit is involved in regulating the growth and survival of Leishmania parasites. **Clinical significance** The GNG13 gene has been implicated in various diseases, including: 1. **Diabetes**: Mutations in the GNG13 gene have been associated with diabetes, highlighting the importance of the gamma subunit in regulating insulin secretion. 2. **Leishmaniasis**: The gamma subunit has been shown to play a critical role in regulating Leishmania parasite growth and survival, highlighting the potential for targeting the gamma subunit in the treatment of this disease. 3. **Neurological disorders**: The gamma subunit has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease, highlighting the importance of the gamma subunit in regulating neurotransmission. 4. **Cancer**: The gamma subunit has been shown to be involved in regulating cancer cell growth and survival, highlighting the potential for targeting the gamma subunit in the treatment of cancer. In conclusion, the GNG13 gene plays a critical role in regulating various signaling pathways, including G protein-coupled receptor signaling, potassium channel activation, and neurotransmitter receptor function. The gamma subunit has been implicated in various diseases, including diabetes, Leishmaniasis, neurological disorders, and cancer, highlighting the importance of further research into the function and regulation of the GNG13 gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Genular Protein ID: 3778560055

Symbol: GBG13_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

UniProtKB Accession Codes:

Q9P2W3 B2R5C8 Q52LX0 Q9UJJ3

Database IDs:

Citations:

PubMed ID: 10570481

Title: Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.

PubMed ID: 10570481

DOI: 10.1038/15981

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 67
Mass: 7949
Checksum: 080E0C34A8F70327
Sequence:

MEEWDVPQMK KEVESLKYQL AFQREMASKT IPELLKWIED GIPKDPFLNP DLMKNNPWVE 
KGKCTIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GNG13

Associated with

Cells (max top 100)

Other Information

Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. PubMed ID: 10570481

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. PubMed ID: 11157797