Details for: NAALADL1

Gene ID: 10004

Symbol: NAALADL1

Ensembl ID: ENSG00000168060

Description: N-acetylated alpha-linked acidic dipeptidase like 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 5.45
    Marker Score: 21,092
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.25
    Marker Score: 3,475
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.46
    Marker Score: 1,170
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.12
    Marker Score: 324
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,792
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,017
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,265
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.88
    Marker Score: 4,246
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,271
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,238
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 542
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 644
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.7
    Marker Score: 504
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.67
    Marker Score: 270
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,794
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 333
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1,055
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.48
    Marker Score: 391
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.47
    Marker Score: 3,043
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.45
    Marker Score: 149
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.45
    Marker Score: 186
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.44
    Marker Score: 1,281
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.44
    Marker Score: 459
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.41
    Marker Score: 103
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.41
    Marker Score: 397
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4
    Marker Score: 209
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.39
    Marker Score: 148
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.39
    Marker Score: 2,510
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.39
    Marker Score: 168
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.38
    Marker Score: 423
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.38
    Marker Score: 99
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.37
    Marker Score: 958
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.36
    Marker Score: 4,688
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.35
    Marker Score: 1,530
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.35
    Marker Score: 970
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.34
    Marker Score: 890
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.34
    Marker Score: 119
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 637
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.33
    Marker Score: 678
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.33
    Marker Score: 511
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.33
    Marker Score: 426
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.33
    Marker Score: 447
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.32
    Marker Score: 216
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.32
    Marker Score: 358
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.32
    Marker Score: 748
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.31
    Marker Score: 116
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.31
    Marker Score: 970
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.31
    Marker Score: 87
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.31
    Marker Score: 833
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.31
    Marker Score: 164
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.3
    Marker Score: 271
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.3
    Marker Score: 3,456
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.3
    Marker Score: 84
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.29
    Marker Score: 514
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.29
    Marker Score: 66
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.29
    Marker Score: 168
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.29
    Marker Score: 3,280
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.29
    Marker Score: 280
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.29
    Marker Score: 2,916
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.29
    Marker Score: 730
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.28
    Marker Score: 349
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.28
    Marker Score: 558
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 88
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.28
    Marker Score: 64
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.28
    Marker Score: 56
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.28
    Marker Score: 342
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.28
    Marker Score: 127
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.27
    Marker Score: 236
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.27
    Marker Score: 195
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.27
    Marker Score: 298
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.27
    Marker Score: 143
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.27
    Marker Score: 74
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.27
    Marker Score: 458
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.27
    Marker Score: 2,638
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.27
    Marker Score: 133
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.26
    Marker Score: 658
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.26
    Marker Score: 219
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.26
    Marker Score: 166
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.26
    Marker Score: 820
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 149
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.26
    Marker Score: 97
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.26
    Marker Score: 116
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.26
    Marker Score: 147
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.25
    Marker Score: 167
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.25
    Marker Score: 50
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.25
    Marker Score: 58
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.25
    Marker Score: 410

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dipeptidylpeptidase activity**: NAALADL1 exhibits dipeptidylpeptidase activity, specifically cleaving dipeptides from protein substrates, which is essential for regulating immune responses and neurotransmission. 2. **Cellular localization**: NAALADL1 is predominantly expressed in neural progenitor cells, enterocytes, and various immune cells, including GABAergic interneurons and intestinal epithelial cells. 3. **Protein-protein interactions**: NAALADL1 interacts with other proteins, including zinc finger proteins, which are involved in regulating gene expression and cellular signaling. 4. **Zinc ion binding**: NAALADL1 binds to zinc ions, which is crucial for its enzymatic activity and protein-protein interactions. **Pathways and Functions:** 1. **Immune regulation**: NAALADL1 modulates immune responses by regulating the activity of immune cells, including macrophages and T-cells, and by influencing the production of cytokines and chemokines. 2. **Neurotransmission**: NAALADL1 plays a critical role in regulating neurotransmission by cleaving neurotransmitter precursors and modulating the activity of GABAergic interneurons. 3. **Cellular homeostasis**: NAALADL1 maintains cellular homeostasis by regulating the activity of various cellular processes, including protein degradation, cell proliferation, and differentiation. 4. **Apoptosis regulation**: NAALADL1 modulates apoptosis by regulating the activity of pro-apoptotic and anti-apoptotic proteins. **Clinical Significance:** 1. **Neuroinflammatory disorders**: NAALADL1 dysregulation has been implicated in various neuroinflammatory disorders, including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. 2. **Immune-mediated diseases**: NAALADL1 dysfunction has been linked to immune-mediated diseases, including rheumatoid arthritis, lupus, and Crohn's disease. 3. **Cancer**: NAALADL1 expression has been altered in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in cancer progression and metastasis. 4. **Neurodevelopmental disorders**: NAALADL1 dysregulation has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, the NAALADL1 gene plays a critical role in regulating immune responses, neurotransmission, and cellular homeostasis. Further research is necessary to elucidate the mechanisms underlying NAALADL1 dysfunction and its implications for various diseases.

Genular Protein ID: 2661529335

Symbol: NALDL_HUMAN

Name: Ileal dipeptidylpeptidase

UniProtKB Accession Codes:

Q9UQQ1 C9J8A1 C9J964 C9JL35 C9JSN0 O43176

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10085079

Title: Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity.

PubMed ID: 10085079

DOI: 10.1074/jbc.274.13.8470

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 9388249

Title: Cloning and characterization of a novel peptidase from rat and human ileum.

PubMed ID: 9388249

DOI: 10.1074/jbc.272.49.31006

PubMed ID: 25752612

Title: Structural and biochemical characterization of a novel aminopeptidase from human intestine.

PubMed ID: 25752612

DOI: 10.1074/jbc.m114.628149

Sequence Information:

  • Length: 740
  • Mass: 80558
  • Checksum: 018D59835F2C48AC
  • Sequence:
    • MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 
LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 
GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ 
GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP 
PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLCNLNG 
TLAPATWQGA LGCHYRLGPG FRPDGDFPAD SQVNVSVYNR LELRNSSNVL GIIRGAVEPD 
RYVLYGNHRD SWVHGAVDPS SGTAVLLELS RVLGTLLKKG TWRPRRSIVF ASWGAEEFGL 
IGSTEFTEEF FNKLQERTVA YINVDISVFA NATLRVQGTP PVQSVVFSAT KEIRSPGPGD 
LSIYDNWIRY FNRSSPVYGL VPSLGSLGAG SDYAPFVHFL GISSMDIAYT YDRSKTSARI 
YPTYHTAFDT FDYVDKFLDP GFSSHQAVAR TAGSVILRLS DSFFLPLKVS DYSETLRSFL 
QAAQQDLGAL LEQHSISLGP LVTAVEKFEA EAAALGQRIS TLQKGSPDPL QVRMLNDQLM 
LLERTFLNPR AFPEERYYSH VLWAPRTGSV VTFPGLSNAC SRARDTASGS EAWAEVQRQL 
SIVVTALEGA AATLRPVADL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.