H3C12 | ENSG00000197153 | NCBI 8356

Details for: H3C12

Gene ID: 8356

Symbol: H3C12

Ensembl ID: ENSG00000197153

Description: H3 clustered histone 12

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-7 signaling
(R-HSA-1266695)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Chromatin organization
(GO:0006325)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Nucleosome assembly
(GO:0006334)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 6.8995
Cell Significance Index: -1.7500
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 6.1718
Cell Significance Index: -0.9600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.2338
Cell Significance Index: 20.5700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 1.4112
Cell Significance Index: -1.7400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9201
Cell Significance Index: 26.5100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7180
Cell Significance Index: 129.4400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.4066
Cell Significance Index: 10.1400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3744
Cell Significance Index: 10.0200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3700
Cell Significance Index: 70.4100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.3341
Cell Significance Index: 6.9300
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.3232
Cell Significance Index: 3.2600
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.3149
Cell Significance Index: 4.4200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3128
Cell Significance Index: 30.9400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2582
Cell Significance Index: 28.0800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2553
Cell Significance Index: 8.9700
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.2436
Cell Significance Index: 2.1300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2410
Cell Significance Index: 39.1900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2326
Cell Significance Index: 5.0400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2300
Cell Significance Index: 6.0500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2212
Cell Significance Index: 26.0900
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.2058
Cell Significance Index: 1.1700
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.2049
Cell Significance Index: 1.4900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1934
Cell Significance Index: 12.4800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1836
Cell Significance Index: 11.0200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1787
Cell Significance Index: 161.3500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1699
Cell Significance Index: 2.5600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1602
Cell Significance Index: 2.4000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1415
Cell Significance Index: 3.9600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1264
Cell Significance Index: 4.0500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1232
Cell Significance Index: 3.0800
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1146
Cell Significance Index: 1.5900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0665
Cell Significance Index: 3.0200
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.0544
Cell Significance Index: 0.5900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0525
Cell Significance Index: 10.4200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0280
Cell Significance Index: 1.5700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0239
Cell Significance Index: 0.5100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0147
Cell Significance Index: 1.0200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0129
Cell Significance Index: 0.1700
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 0.0075
Cell Significance Index: 0.0800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0057
Cell Significance Index: 0.7100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0051
Cell Significance Index: 0.1500
Cell Name: melanocyte of skin (CL1000458)
Fold Change: 0.0036
Cell Significance Index: 0.0500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0032
Cell Significance Index: 0.9300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0012
Cell Significance Index: 0.6600
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0004
Cell Significance Index: -0.0200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0008
Cell Significance Index: -1.4800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0010
Cell Significance Index: -0.4300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0011
Cell Significance Index: -1.9900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0012
Cell Significance Index: -1.9100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0015
Cell Significance Index: -1.9900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0021
Cell Significance Index: -0.7500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0022
Cell Significance Index: -0.3700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0026
Cell Significance Index: -1.9600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0033
Cell Significance Index: -2.1200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0037
Cell Significance Index: -0.1000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0043
Cell Significance Index: -1.9600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0044
Cell Significance Index: -0.8800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0052
Cell Significance Index: -0.6700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0056
Cell Significance Index: -0.2300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0058
Cell Significance Index: -0.2900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0083
Cell Significance Index: -0.4300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0107
Cell Significance Index: -0.2800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0112
Cell Significance Index: -1.5400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0129
Cell Significance Index: -0.7900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0136
Cell Significance Index: -1.9700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0146
Cell Significance Index: -1.4900
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0147
Cell Significance Index: -0.2100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0148
Cell Significance Index: -0.3100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0163
Cell Significance Index: -0.7600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0183
Cell Significance Index: -0.2500
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0213
Cell Significance Index: -0.3100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0213
Cell Significance Index: -0.2700
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0232
Cell Significance Index: -0.2300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0233
Cell Significance Index: -1.7900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0247
Cell Significance Index: -0.6300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0280
Cell Significance Index: -1.4700
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0280
Cell Significance Index: -0.2900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0287
Cell Significance Index: -1.3500
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.0300
Cell Significance Index: -0.2400
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0343
Cell Significance Index: -0.2800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0359
Cell Significance Index: -0.3900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0371
Cell Significance Index: -1.0100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0385
Cell Significance Index: -1.7100
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0400
Cell Significance Index: -0.6900
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0411
Cell Significance Index: -0.5200
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0412
Cell Significance Index: -0.3500
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: -0.0412
Cell Significance Index: -0.4900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0424
Cell Significance Index: -0.7100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0435
Cell Significance Index: -1.4300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0441
Cell Significance Index: -1.6700
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.0444
Cell Significance Index: -0.6100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0460
Cell Significance Index: -1.6000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0483
Cell Significance Index: -0.5000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0488
Cell Significance Index: -1.7100
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0517
Cell Significance Index: -1.0100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0518
Cell Significance Index: -1.9000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0523
Cell Significance Index: -1.6700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0528
Cell Significance Index: -1.2800
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0538
Cell Significance Index: -0.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H3C12 is a member of the histone H3 family, which is a class of histone proteins that play a critical role in the structure and function of chromatin. The H3C12 protein is characterized by its ability to bind to DNA and histone proteins, facilitating the assembly of the pre-replicative complex and the formation of the beta-catenin:Tcf transactivating complex. This protein is also involved in the regulation of gene expression, particularly in the context of cellular responses to stimuli and stress. **Pathways and Functions** The H3C12 gene is involved in various cellular pathways, including: 1. **Transcriptional regulation**: H3C12 is involved in the regulation of gene expression, particularly in the context of cellular responses to stimuli and stress. 2. **Chromatin organization**: H3C12 is involved in the assembly of the pre-replicative complex and the formation of the beta-catenin:Tcf transactivating complex, which are essential for the regulation of gene expression. 3. **Cell cycle progression**: H3C12 is involved in the regulation of cell cycle progression, particularly in the context of mitotic prophase and the condensation of prophase chromosomes. 4. **Immune system**: H3C12 is involved in the regulation of gene expression in immune cells, including T cells and B cells. 5. **Viral infection**: H3C12 is involved in the regulation of gene expression in response to viral infections, particularly in the context of HCMV (Human Cytomegalovirus) infection. **Clinical Significance** The H3C12 gene has significant implications for the understanding and treatment of various diseases, including: 1. **Immunodeficiency disorders**: Mutations in the H3C12 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: H3C12 is involved in the regulation of gene expression in cancer cells, and alterations in this gene have been associated with cancer progression. 3. **Viral infections**: H3C12 is involved in the regulation of gene expression in response to viral infections, and alterations in this gene have been associated with viral infections, such as HCMV. 4. **Neurological disorders**: H3C12 is involved in the regulation of gene expression in neurons, and alterations in this gene have been associated with neurological disorders, such as Alzheimer's disease. In conclusion, the H3C12 gene plays a critical role in various cellular processes, including transcriptional regulation, chromatin organization, and cell cycle progression. Its significance in the context of the immune system and its implications for the understanding and treatment of various diseases make it an essential area of research for immunologists and clinicians.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.