Details for: NRTN

Gene ID: 4902

Symbol: NRTN

Ensembl ID: ENSG00000171119

Description: neurturin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.1660
    Cell Significance Index: -4.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.2433
    Cell Significance Index: -4.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.4770
    Cell Significance Index: 282.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3659
    Cell Significance Index: -4.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.8763
    Cell Significance Index: 39.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6367
    Cell Significance Index: 311.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2207
    Cell Significance Index: 120.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1291
    Cell Significance Index: 30.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9555
    Cell Significance Index: 862.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6676
    Cell Significance Index: 72.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6627
    Cell Significance Index: 10.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6487
    Cell Significance Index: 105.5100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.5145
    Cell Significance Index: 1.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5055
    Cell Significance Index: 30.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3662
    Cell Significance Index: 25.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2534
    Cell Significance Index: 138.4100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2230
    Cell Significance Index: 1.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1871
    Cell Significance Index: 8.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1667
    Cell Significance Index: 2.2800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1427
    Cell Significance Index: 1.4400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1387
    Cell Significance Index: 2.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1380
    Cell Significance Index: 16.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1239
    Cell Significance Index: 3.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1110
    Cell Significance Index: 1.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0814
    Cell Significance Index: 0.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0649
    Cell Significance Index: 12.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0545
    Cell Significance Index: 2.5400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0499
    Cell Significance Index: 0.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0482
    Cell Significance Index: 21.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0412
    Cell Significance Index: 28.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0398
    Cell Significance Index: 1.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0325
    Cell Significance Index: 3.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0300
    Cell Significance Index: 0.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0290
    Cell Significance Index: 4.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0153
    Cell Significance Index: 0.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0153
    Cell Significance Index: 0.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0132
    Cell Significance Index: 0.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0106
    Cell Significance Index: 0.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0098
    Cell Significance Index: 1.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0094
    Cell Significance Index: 0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0084
    Cell Significance Index: 6.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0060
    Cell Significance Index: 0.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0029
    Cell Significance Index: 0.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0026
    Cell Significance Index: 0.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0010
    Cell Significance Index: 0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0006
    Cell Significance Index: 1.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0035
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0051
    Cell Significance Index: -2.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0060
    Cell Significance Index: -2.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0088
    Cell Significance Index: -0.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0089
    Cell Significance Index: -2.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0094
    Cell Significance Index: -0.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0147
    Cell Significance Index: -1.0400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0151
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0151
    Cell Significance Index: -0.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0165
    Cell Significance Index: -0.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0170
    Cell Significance Index: -2.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0171
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0188
    Cell Significance Index: -3.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0220
    Cell Significance Index: -3.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0253
    Cell Significance Index: -2.9800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0278
    Cell Significance Index: -0.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0281
    Cell Significance Index: -0.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0290
    Cell Significance Index: -2.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0345
    Cell Significance Index: -0.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0364
    Cell Significance Index: -3.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0398
    Cell Significance Index: -1.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0427
    Cell Significance Index: -0.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0457
    Cell Significance Index: -1.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0475
    Cell Significance Index: -3.5400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0515
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0521
    Cell Significance Index: -3.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0537
    Cell Significance Index: -3.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0576
    Cell Significance Index: -3.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0583
    Cell Significance Index: -0.8400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0588
    Cell Significance Index: -0.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0591
    Cell Significance Index: -2.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0599
    Cell Significance Index: -3.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0690
    Cell Significance Index: -1.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0779
    Cell Significance Index: -2.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0794
    Cell Significance Index: -2.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0819
    Cell Significance Index: -2.6100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0845
    Cell Significance Index: -1.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0847
    Cell Significance Index: -2.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0873
    Cell Significance Index: -3.8600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0894
    Cell Significance Index: -1.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0903
    Cell Significance Index: -2.2600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0927
    Cell Significance Index: -1.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0953
    Cell Significance Index: -3.5000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0963
    Cell Significance Index: -1.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0973
    Cell Significance Index: -1.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1000
    Cell Significance Index: -2.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1003
    Cell Significance Index: -2.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NRTN is a secreted protein that belongs to the GDNF family of neurotrophic factors. It is expressed in a wide range of tissues, including the nervous system, kidneys, intestines, and other organs. NRTN has a unique structure, consisting of a single polypeptide chain with a C-terminal extension. This protein is highly conserved across species, suggesting its essential role in development and maintenance. **Pathways and Functions:** NRTN interacts with its receptor, GFRAL, to activate a signaling cascade that regulates various cellular processes, including: 1. **Axon guidance**: NRTN promotes the growth and guidance of axons during neuronal development. 2. **Neuronal survival**: NRTN protects neurons from apoptosis and promotes their survival. 3. **Developmental biology**: NRTN is involved in the development of the nervous system, kidneys, and intestines. 4. **Growth factor activity**: NRTN interacts with other growth factors, such as GDNF and FGFs, to regulate cellular proliferation and differentiation. 5. **Signaling receptor binding**: NRTN binds to its receptor, GFRAL, to activate a signaling cascade that regulates various cellular processes. **Clinical Significance:** Dysregulation of NRTN has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: NRTN has been linked to Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). 2. **Kidney disease**: NRTN has been shown to play a role in the development of kidney disease and renal failure. 3. **Intestinal disorders**: NRTN has been implicated in the pathogenesis of intestinal disorders, such as inflammatory bowel disease (IBD) and colon cancer. 4. **Cardiovascular disease**: NRTN has been linked to cardiovascular disease, including hypertension and atherosclerosis. In conclusion, NRTN is a critical protein that plays a widespread role in development, maintenance, and dysfunction of various tissues. Its dysregulation has been implicated in various diseases, highlighting the importance of NRTN in human health and disease. Further research is needed to fully elucidate the mechanisms of NRTN and its role in disease pathogenesis.

Genular Protein ID: 2947948634

Symbol: NRTN_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99748 B2RPE8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8945474

Title: Neurturin, a relative of glial-cell-line-derived neurotrophic factor.

PubMed ID: 8945474

DOI: 10.1038/384467a0

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10829012

Title: Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions.

PubMed ID: 10829012

DOI: 10.1074/jbc.m000306200

PubMed ID: 15242795

Title: Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent.

PubMed ID: 15242795

DOI: 10.1016/j.ydbio.2004.04.025

PubMed ID: 29414779

Title: Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.

PubMed ID: 29414779

DOI: 10.1074/jbc.ra117.000820

PubMed ID: 31535977

Title: Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.

PubMed ID: 31535977

DOI: 10.7554/elife.47650

PubMed ID: 9700200

Title: Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease.

PubMed ID: 9700200

DOI: 10.1093/hmg/7.9.1449

Sequence Information:

  • Length: 197
  • Mass: 22405
  • Checksum: 91AFAC8C3F8971FD
  • Sequence:
    • MQRWKAAALA SVLCSSVLSI WMCREGLLLS HRLGPALVPL HRLPRTLDAR IARLAQYRAL 
LQGAPDAMEL RELTPWAGRP PGPRRRAGPR RRRARARLGA RPCGLRELEV RVSELGLGYA 
SDETVLFRYC AGACEAAARV YDLGLRRLRQ RRRLRRERVR AQPCCRPTAY EDEVSFLDAH 
SRYHTVHELS ARECACV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.