Details for: GFI1B

Gene ID: 8328

Symbol: GFI1B

Ensembl ID: ENSG00000165702

Description: growth factor independent 1B transcriptional repressor

Associated with

  • Chromatin organization
    (GO:0006325)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of g1/s transition of mitotic cell cycle
    (GO:2000134)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear matrix
    (GO:0016363)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of hemopoiesis
    (GO:1903706)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 43.4118
    Cell Significance Index: 19.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 5.2184
    Cell Significance Index: -2.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 4.8018
    Cell Significance Index: -2.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.9785
    Cell Significance Index: 376.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6951
    Cell Significance Index: 25.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3797
    Cell Significance Index: 136.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2256
    Cell Significance Index: 1106.6700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.8478
    Cell Significance Index: 14.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7249
    Cell Significance Index: 117.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7090
    Cell Significance Index: 77.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7083
    Cell Significance Index: 15.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.6349
    Cell Significance Index: 16.2200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.5749
    Cell Significance Index: 5.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.5094
    Cell Significance Index: -2.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4348
    Cell Significance Index: 26.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4222
    Cell Significance Index: 29.2000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4089
    Cell Significance Index: 5.8600
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.3756
    Cell Significance Index: 2.7000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2038
    Cell Significance Index: 2.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1957
    Cell Significance Index: 4.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1944
    Cell Significance Index: 8.8100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.1926
    Cell Significance Index: 2.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1412
    Cell Significance Index: 2.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1327
    Cell Significance Index: 2.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1069
    Cell Significance Index: 2.8100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0557
    Cell Significance Index: 0.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0458
    Cell Significance Index: 1.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0389
    Cell Significance Index: 1.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0322
    Cell Significance Index: 1.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0308
    Cell Significance Index: 6.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0192
    Cell Significance Index: 3.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0168
    Cell Significance Index: 6.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0147
    Cell Significance Index: 0.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0105
    Cell Significance Index: 0.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0096
    Cell Significance Index: 0.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0089
    Cell Significance Index: 1.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0078
    Cell Significance Index: 0.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0059
    Cell Significance Index: 1.1700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0052
    Cell Significance Index: 0.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0013
    Cell Significance Index: 2.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0016
    Cell Significance Index: -0.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0019
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0028
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0033
    Cell Significance Index: -1.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0036
    Cell Significance Index: -2.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0037
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0047
    Cell Significance Index: -0.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0048
    Cell Significance Index: -0.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0063
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0084
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0099
    Cell Significance Index: -2.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0130
    Cell Significance Index: -1.7900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0150
    Cell Significance Index: -0.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0153
    Cell Significance Index: -0.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0164
    Cell Significance Index: -0.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0165
    Cell Significance Index: -0.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0168
    Cell Significance Index: -1.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0171
    Cell Significance Index: -2.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0172
    Cell Significance Index: -0.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0202
    Cell Significance Index: -1.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0220
    Cell Significance Index: -0.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0226
    Cell Significance Index: -2.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0226
    Cell Significance Index: -1.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0245
    Cell Significance Index: -1.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0273
    Cell Significance Index: -1.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0285
    Cell Significance Index: -1.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0307
    Cell Significance Index: -2.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0326
    Cell Significance Index: -1.0500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0331
    Cell Significance Index: -0.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0335
    Cell Significance Index: -1.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0336
    Cell Significance Index: -1.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0347
    Cell Significance Index: -1.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0360
    Cell Significance Index: -1.1800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0367
    Cell Significance Index: -0.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0374
    Cell Significance Index: -1.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0376
    Cell Significance Index: -1.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0415
    Cell Significance Index: -2.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0438
    Cell Significance Index: -2.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0462
    Cell Significance Index: -0.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0473
    Cell Significance Index: -0.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0503
    Cell Significance Index: -1.2600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0509
    Cell Significance Index: -1.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0517
    Cell Significance Index: -0.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0532
    Cell Significance Index: -1.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0534
    Cell Significance Index: -1.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0538
    Cell Significance Index: -1.3700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0555
    Cell Significance Index: -0.7400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0575
    Cell Significance Index: -1.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0588
    Cell Significance Index: -1.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GFI1B is a member of the GFI family of transcription factors, which are characterized by their ability to regulate transcription by binding to specific DNA sequences. The protein contains a zinc finger motif that allows it to recognize and bind to specific DNA sequences. GFI1B is primarily a transcriptional repressor, but it can also act as a transcriptional activator in certain contexts. The protein is highly conserved across species, suggesting that it has evolved to play a critical role in regulating cellular processes. **Pathways and Functions:** GFI1B is involved in various cellular processes, including: 1. **Regulation of Cell Cycle:** GFI1B acts as a negative regulator of the G1/S transition of the mitotic cell cycle, preventing excessive cell proliferation. 2. **Transcriptional Regulation:** GFI1B regulates the expression of target genes by binding to specific DNA sequences and recruiting co-repressors to form a transcriptional complex. 3. **Hemopoiesis:** GFI1B is involved in the regulation of hematopoiesis, particularly in the development of erythroid progenitor cells. 4. **Neurogenesis:** GFI1B is expressed in neural cells, including GABAergic interneurons and radial glial cells, suggesting its involvement in neurogenesis. 5. **Chromatin Organization:** GFI1B is involved in the regulation of chromatin organization, which is critical for gene expression. **Clinical Significance:** GFI1B has been implicated in various diseases, including: 1. **Cancer:** GFI1B has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 2. **Neurological Disorders:** GFI1B has been implicated in the regulation of neurogenesis and has been shown to be associated with neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Hematological Disorders:** GFI1B has been shown to be involved in the regulation of hematopoiesis and has been implicated in hematological disorders, including anemia and leukemia. In conclusion, GFI1B is a critical regulator of transcription and cellular processes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of GFI1B in regulating cellular processes and its potential as a therapeutic target for diseases.

Genular Protein ID: 3575135073

Symbol: GFI1B_HUMAN

Name: Zinc finger protein Gfi-1b

UniProtKB Accession Codes:

Q5VTD9 O95270 Q5VTD8 Q6FHZ2 Q6T888

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9878267

Title: The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases.

PubMed ID: 9878267

DOI: 10.1006/geno.1998.5601

PubMed ID: 15280509

Title: GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene.

PubMed ID: 15280509

DOI: 10.1093/nar/gkh719

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12351384

Title: Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis.

PubMed ID: 12351384

DOI: 10.1182/blood-2002-01-0182

PubMed ID: 12874834

Title: Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism.

PubMed ID: 12874834

DOI: 10.1002/jcb.10548

PubMed ID: 16177182

Title: GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells.

PubMed ID: 16177182

DOI: 10.1093/nar/gki838

PubMed ID: 16688220

Title: Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin.

PubMed ID: 16688220

DOI: 10.1038/sj.emboj.7601124

PubMed ID: 16782810

Title: Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development.

PubMed ID: 16782810

DOI: 10.1073/pnas.0603728103

PubMed ID: 17646546

Title: Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1.

PubMed ID: 17646546

DOI: 10.1182/blood-2006-11-058602

PubMed ID: 17272506

Title: Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.

PubMed ID: 17272506

DOI: 10.1182/blood-2006-08-043331

PubMed ID: 17156408

Title: Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate.

PubMed ID: 17156408

DOI: 10.1111/j.1365-2141.2006.06407.x

PubMed ID: 17420275

Title: GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription.

PubMed ID: 17420275

DOI: 10.1128/mcb.02212-06

PubMed ID: 22399799

Title: A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain.

PubMed ID: 22399799

DOI: 10.1242/jcs.095877

PubMed ID: 23927492

Title: GFI1B mutation causes a bleeding disorder with abnormal platelet function.

PubMed ID: 23927492

DOI: 10.1111/jth.12368

PubMed ID: 24325358

Title: A dominant-negative GFI1B mutation in the gray platelet syndrome.

PubMed ID: 24325358

DOI: 10.1056/nejmoa1308130

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 330
  • Mass: 37492
  • Checksum: 947DD9C34B5BD962
  • Sequence:
    • MPRSFLVKSK KAHTYHQPRV QEDEPLWPPA LTPVPRDQAP SNSPVLSTLF PNQCLDWTNL 
KREPELEQDQ NLARMAPAPE GPIVLSRPQD GDSPLSDSPP FYKPSFSWDT LATTYGHSYR 
QAPSTMQSAF LEHSVSLYGS PLVPSTEPAL DFSLRYSPGM DAYHCVKCNK VFSTPHGLEV 
HVRRSHSGTR PFACDICGKT FGHAVSLEQH THVHSQERSF ECRMCGKAFK RSSTLSTHLL 
IHSDTRPYPC QFCGKRFHQK SDMKKHTYIH TGEKPHKCQV CGKAFSQSSN LITHSRKHTG 
FKPFSCELCT KGFQRKVDLR RHRESQHNLK

Genular Protein ID: 603810059

Symbol: A0A024R8F3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024R8F3

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 4 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 352
  • Mass: 39699
  • Checksum: 7170EC47BD29217C
  • Sequence:
    • MPRSFLVKSK KAHTYHQPRV QEDEPLWPPA LTPVPRDQAP SNSPVLSTLF PNQCLDWTNL 
KREPELEQDQ NLARMAPAPE GPIVLSRPQD GDSPLSDSPP FYKPSFSWDT LATTYGHSYR 
QAPSTMQSAF LEHSVSLYGS PLVPSTEPAL DFSLRYSPGM DAYHCVKCNK VFSTPHGLEV 
HVRRSHSGTR PFACDICGKT FGHAVSLEQH THVHSQGIPA GSSPEPAPDP PGPHFLRQER 
SFECRMCGKA FKRSSTLSTH LLIHSDTRPY PCQFCGKRFH QKSDMKKHTY IHTGEKPHKC 
QVCGKAFSQS SNLITHSRKH TGFKPFSCEL CTKGFQRKVD LRRHRESQHN LK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.