Details for: ANO7

Gene ID: 50636

Symbol: ANO7

Ensembl ID: ENSG00000146205

Description: anoctamin 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.6447
    Cell Significance Index: -4.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.8347
    Cell Significance Index: -4.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.6615
    Cell Significance Index: -4.4700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 4.9928
    Cell Significance Index: 54.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.7514
    Cell Significance Index: 523.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 2.2280
    Cell Significance Index: 78.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.6985
    Cell Significance Index: -4.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0371
    Cell Significance Index: 112.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0136
    Cell Significance Index: 164.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7396
    Cell Significance Index: 44.4000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.7271
    Cell Significance Index: 7.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7041
    Cell Significance Index: 635.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.6470
    Cell Significance Index: 9.2700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6329
    Cell Significance Index: 9.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6091
    Cell Significance Index: 42.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5706
    Cell Significance Index: 8.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4320
    Cell Significance Index: 11.5800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4126
    Cell Significance Index: 4.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2125
    Cell Significance Index: 11.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1895
    Cell Significance Index: 8.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1781
    Cell Significance Index: 17.6200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1584
    Cell Significance Index: 3.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1560
    Cell Significance Index: 30.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1498
    Cell Significance Index: 30.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1217
    Cell Significance Index: 3.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1061
    Cell Significance Index: 2.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0676
    Cell Significance Index: 3.1500
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.0652
    Cell Significance Index: 0.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0488
    Cell Significance Index: 1.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0479
    Cell Significance Index: 6.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0436
    Cell Significance Index: 1.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0332
    Cell Significance Index: 3.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0309
    Cell Significance Index: 11.0800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.0257
    Cell Significance Index: 0.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0141
    Cell Significance Index: 9.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0129
    Cell Significance Index: 7.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0128
    Cell Significance Index: 2.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0058
    Cell Significance Index: 11.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0037
    Cell Significance Index: 5.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0024
    Cell Significance Index: 3.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0013
    Cell Significance Index: 2.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0022
    Cell Significance Index: -1.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0049
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0057
    Cell Significance Index: -4.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0063
    Cell Significance Index: -0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0070
    Cell Significance Index: -3.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0076
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0078
    Cell Significance Index: -1.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0110
    Cell Significance Index: -3.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0112
    Cell Significance Index: -0.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0115
    Cell Significance Index: -0.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0126
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0150
    Cell Significance Index: -1.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0179
    Cell Significance Index: -2.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0189
    Cell Significance Index: -2.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0214
    Cell Significance Index: -2.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0216
    Cell Significance Index: -0.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0221
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0225
    Cell Significance Index: -4.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0305
    Cell Significance Index: -0.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0308
    Cell Significance Index: -3.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0360
    Cell Significance Index: -2.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0391
    Cell Significance Index: -4.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0405
    Cell Significance Index: -1.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0440
    Cell Significance Index: -1.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0440
    Cell Significance Index: -1.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0444
    Cell Significance Index: -2.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0483
    Cell Significance Index: -0.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0491
    Cell Significance Index: -0.7400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0504
    Cell Significance Index: -0.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0515
    Cell Significance Index: -1.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0538
    Cell Significance Index: -2.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0539
    Cell Significance Index: -4.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0565
    Cell Significance Index: -3.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0576
    Cell Significance Index: -3.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0607
    Cell Significance Index: -3.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0630
    Cell Significance Index: -0.8600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0633
    Cell Significance Index: -0.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0636
    Cell Significance Index: -1.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0669
    Cell Significance Index: -3.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0674
    Cell Significance Index: -1.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0689
    Cell Significance Index: -1.1800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0698
    Cell Significance Index: -0.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0718
    Cell Significance Index: -4.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0732
    Cell Significance Index: -1.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0739
    Cell Significance Index: -2.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0755
    Cell Significance Index: -1.9400
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0774
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0786
    Cell Significance Index: -2.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0843
    Cell Significance Index: -2.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0902
    Cell Significance Index: -3.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0904
    Cell Significance Index: -1.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0905
    Cell Significance Index: -1.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0912
    Cell Significance Index: -1.9700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0973
    Cell Significance Index: -0.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ANO7 is a transmembrane protein that belongs to the claudin family of proteins, which are characterized by their ability to form tight junctions between cells. ANO7 is specifically known for its ability to form calcium-activated chloride channels, which are essential for regulating chloride ion transport across cell membranes. These channels are activated by increases in intracellular calcium levels, which is a critical signaling event in many cellular processes, including immune responses. **Pathways and Functions:** ANO7 is involved in various cellular pathways, including: 1. **Calcium-activated chloride channel activity**: ANO7 forms calcium-activated chloride channels that regulate chloride ion transport across cell membranes. 2. **Anchoring junction**: ANO7 is involved in the formation of tight junctions between cells, which are essential for maintaining epithelial barrier function. 3. **Induction of cell-cell fusion**: ANO7 has been shown to regulate cell-cell fusion, which is a critical process in immune responses, including the fusion of epithelial cells during the formation of the epithelial barrier. 4. **Ion channel transport**: ANO7 is involved in the transport of small molecules across cell membranes, including chloride ions and other anions. **Clinical Significance:** ANO7 has been implicated in various clinical conditions, including: 1. **Viral infections**: ANO7 has been shown to play a critical role in regulating the entry of viruses into host cells, including SARS-CoV-2. 2. **Infectious disease**: ANO7 has been implicated in the pathogenesis of various infectious diseases, including influenza and respiratory syncytial virus. 3. **Immune function**: ANO7 has been shown to regulate immune responses, including the activation of immune cells and the production of cytokines. 4. **Neurological disorders**: ANO7 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease and multiple sclerosis. **Significantly Expressed Cells:** ANO7 is expressed in various cell types, including: 1. **Polychromatophilic erythroblast**: A type of red blood cell. 2. **Hematopoietic oligopotent progenitor cell**: A type of immune cell. 3. **Ileal goblet cell**: A type of epithelial cell found in the small intestine. 4. **Enteroendocrine cell of colon**: A type of epithelial cell found in the colon. 5. **Intestinal crypt stem cell of colon**: A type of stem cell found in the colon. In conclusion, ANO7 is a critical component of calcium-activated chloride channels and plays a significant role in regulating various cellular processes, including immune function and viral infections. Further research is needed to fully understand the mechanisms by which ANO7 regulates immune responses and to explore its potential as a therapeutic target for various clinical conditions.

Genular Protein ID: 85186053

Symbol: ANO7_HUMAN

Name: Anoctamin-7

UniProtKB Accession Codes:

Q6IWH7 Q6IWH6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 Rhea 6 SMR 1 STRING 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14981236

Title: NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.

PubMed ID: 14981236

DOI: 10.1073/pnas.0308746101

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 10613842

Title: Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes.

PubMed ID: 10613842

DOI: 10.1101/gr.9.12.1198

PubMed ID: 15375614

Title: Characterization of human TMEM16G gene in silico.

PubMed ID: 15375614

PubMed ID: 15761874

Title: D-TMPP: a novel androgen-regulated gene preferentially expressed in prostate and prostate cancer that is the first characterized member of an eukaryotic gene family.

PubMed ID: 15761874

DOI: 10.1002/pros.20250

PubMed ID: 17308099

Title: NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells.

PubMed ID: 17308099

DOI: 10.1158/0008-5472.can-06-2673

PubMed ID: 18676855

Title: Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level.

PubMed ID: 18676855

DOI: 10.1158/0008-5472.can-08-0870

PubMed ID: 20056604

Title: Expression and function of epithelial anoctamins.

PubMed ID: 20056604

DOI: 10.1074/jbc.m109.065367

PubMed ID: 21642943

Title: Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?

PubMed ID: 21642943

DOI: 10.1038/aps.2011.48

PubMed ID: 21607626

Title: Anoctamins.

PubMed ID: 21607626

DOI: 10.1007/s00424-011-0975-9

PubMed ID: 22075693

Title: ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

PubMed ID: 22075693

DOI: 10.1152/ajpcell.00140.2011

PubMed ID: 22302790

Title: The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age.

PubMed ID: 22302790

DOI: 10.1113/expphysiol.2011.058214

PubMed ID: 21984732

Title: The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.

PubMed ID: 21984732

DOI: 10.1113/expphysiol.2011.058198

PubMed ID: 22946059

Title: Anoctamins are a family of Ca2+ activated Cl- channels.

PubMed ID: 22946059

DOI: 10.1242/jcs.109553

Sequence Information:

  • Length: 933
  • Mass: 105532
  • Checksum: D6FD42578A4BD773
  • Sequence:
    • MRMAATAWAG LQGPPLPTLC PAVRTGLYCR DQAHAERWAM TSETSSGSHC ARSRMLRRRA 
QEEDSTVLID VSPPEAEKRG SYGSTAHASE PGGQQAAACR AGSPAKPRIA DFVLVWEEDL 
KLDRQQDSAA RDRTDMHRTW RETFLDNLRA AGLCVDQQDV QDGNTTVHYA LLSASWAVLC 
YYAEDLRLKL PLQELPNQAS NWSAGLLAWL GIPNVLLEVV PDVPPEYYSC RFRVNKLPRF 
LGSDNQDTFF TSTKRHQILF EILAKTPYGH EKKNLLGIHQ LLAEGVLSAA FPLHDGPFKT 
PPEGPQAPRL NQRQVLFQHW ARWGKWNKYQ PLDHVRRYFG EKVALYFAWL GFYTGWLLPA 
AVVGTLVFLV GCFLVFSDIP TQELCGSKDS FEMCPLCLDC PFWLLSSACA LAQAGRLFDH 
GGTVFFSLFM ALWAVLLLEY WKRKSATLAY RWDCSDYEDT EERPRPQFAA SAPMTAPNPI 
TGEDEPYFPE RSRARRMLAG SVVIVVMVAV VVMCLVSIIL YRAIMAIVVS RSGNTLLAAW 
ASRIASLTGS VVNLVFILIL SKIYVSLAHV LTRWEMHRTQ TKFEDAFTLK VFIFQFVNFY 
SSPVYIAFFK GRFVGYPGNY HTLFGVRNEE CAAGGCLIEL AQELLVIMVG KQVINNMQEV 
LIPKLKGWWQ KFRLRSKKRK AGASAGASQG PWEDDYELVP CEGLFDEYLE MVLQFGFVTI 
FVAACPLAPL FALLNNWVEI RLDARKFVCE YRRPVAERAQ DIGIWFHILA GLTHLAVISN 
AFLLAFSSDF LPRAYYRWTR AHDLRGFLNF TLARAPSSFA AAHNRTCRYR AFRDDDGHYS 
QTYWNLLAIR LAFVIVFEHV VFSVGRLLDL LVPDIPESVE IKVKREYYLA KQALAENEVL 
FGTNGTKDEQ PEGSELSSHW TPFTVPKASQ LQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.