Details for: F2RL1

Gene ID: 2150

Symbol: F2RL1

Ensembl ID: ENSG00000164251

Description: F2R like trypsin receptor 1

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Blood coagulation
    (GO:0007596)
  • Cell-cell junction maintenance
    (GO:0045217)
  • Defense response to virus
    (GO:0051607)
  • Early endosome
    (GO:0005769)
  • Establishment of endothelial barrier
    (GO:0061028)
  • G-protein alpha-subunit binding
    (GO:0001965)
  • G-protein beta-subunit binding
    (GO:0031681)
  • Golgi apparatus
    (GO:0005794)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Leukocyte migration
    (GO:0050900)
  • Leukocyte proliferation
    (GO:0070661)
  • Mature conventional dendritic cell differentiation
    (GO:0097029)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of insulin secretion
    (GO:0046676)
  • Negative regulation of jnk cascade
    (GO:0046329)
  • Negative regulation of toll-like receptor 3 signaling pathway
    (GO:0034140)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Neutrophil activation
    (GO:0042119)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of actin filament depolymerization
    (GO:0030836)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of chemotaxis
    (GO:0050921)
  • Positive regulation of cytokine production involved in immune response
    (GO:0002720)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of eosinophil degranulation
    (GO:0043311)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of glomerular filtration
    (GO:0003104)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of leukocyte chemotaxis
    (GO:0002690)
  • Positive regulation of neutrophil mediated killing of gram-negative bacterium
    (GO:0070963)
  • Positive regulation of phagocytosis, engulfment
    (GO:0060100)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of positive chemotaxis
    (GO:0050927)
  • Positive regulation of pseudopodium assembly
    (GO:0031274)
  • Positive regulation of renin secretion into blood stream
    (GO:1900135)
  • Positive regulation of rho protein signal transduction
    (GO:0035025)
  • Positive regulation of superoxide anion generation
    (GO:0032930)
  • Positive regulation of toll-like receptor 2 signaling pathway
    (GO:0034137)
  • Positive regulation of toll-like receptor 3 signaling pathway
    (GO:0034141)
  • Positive regulation of toll-like receptor 4 signaling pathway
    (GO:0034145)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Potassium channel activating, g protein-coupled receptor signaling pathway
    (GO:0099109)
  • Protease binding
    (GO:0002020)
  • Protein binding
    (GO:0005515)
  • Pseudopodium
    (GO:0031143)
  • Regulation of blood coagulation
    (GO:0030193)
  • Regulation of canonical nf-kappab signal transduction
    (GO:0043122)
  • Regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000341)
  • Regulation of jnk cascade
    (GO:0046328)
  • Signaling receptor activity
    (GO:0038023)
  • Signaling receptor binding
    (GO:0005102)
  • T cell activation involved in immune response
    (GO:0002286)
  • Thrombin-activated receptor activity
    (GO:0015057)
  • Thrombin-activated receptor signaling pathway
    (GO:0070493)
  • Vasodilation
    (GO:0042311)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.6962
    Cell Significance Index: -7.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.9707
    Cell Significance Index: -6.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.2776
    Cell Significance Index: -7.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.3275
    Cell Significance Index: 276.7500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 4.3073
    Cell Significance Index: 12.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4.1505
    Cell Significance Index: 89.9200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.8534
    Cell Significance Index: 57.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9656
    Cell Significance Index: 134.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1972
    Cell Significance Index: 357.3600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.9827
    Cell Significance Index: 15.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7397
    Cell Significance Index: 50.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.3584
    Cell Significance Index: 28.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3273
    Cell Significance Index: 144.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1443
    Cell Significance Index: 1033.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9699
    Cell Significance Index: 26.4000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.9448
    Cell Significance Index: 2.1300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.8212
    Cell Significance Index: 8.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7662
    Cell Significance Index: 52.9900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7308
    Cell Significance Index: 5.8400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.7021
    Cell Significance Index: 4.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4677
    Cell Significance Index: 14.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4393
    Cell Significance Index: 4.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.4349
    Cell Significance Index: 49.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4107
    Cell Significance Index: 14.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3868
    Cell Significance Index: 211.2200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3285
    Cell Significance Index: 3.4000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3178
    Cell Significance Index: 4.4100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3011
    Cell Significance Index: 3.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2550
    Cell Significance Index: 2.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2391
    Cell Significance Index: 23.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2178
    Cell Significance Index: 3.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2152
    Cell Significance Index: 16.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2112
    Cell Significance Index: 38.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1947
    Cell Significance Index: 23.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1770
    Cell Significance Index: 78.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1376
    Cell Significance Index: 3.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1370
    Cell Significance Index: 85.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1044
    Cell Significance Index: 19.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0999
    Cell Significance Index: 4.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0972
    Cell Significance Index: 16.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0699
    Cell Significance Index: 9.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0491
    Cell Significance Index: 5.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0414
    Cell Significance Index: 2.9300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0210
    Cell Significance Index: 0.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0160
    Cell Significance Index: 1.0100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.0052
    Cell Significance Index: 0.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0039
    Cell Significance Index: -2.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -9.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0081
    Cell Significance Index: -1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0099
    Cell Significance Index: -6.2700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0138
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0142
    Cell Significance Index: -3.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0150
    Cell Significance Index: -0.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0151
    Cell Significance Index: -5.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0160
    Cell Significance Index: -1.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0166
    Cell Significance Index: -1.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0176
    Cell Significance Index: -5.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0184
    Cell Significance Index: -0.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0189
    Cell Significance Index: -8.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0213
    Cell Significance Index: -0.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0260
    Cell Significance Index: -0.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0267
    Cell Significance Index: -5.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0268
    Cell Significance Index: -3.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0310
    Cell Significance Index: -0.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0320
    Cell Significance Index: -4.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0491
    Cell Significance Index: -3.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0491
    Cell Significance Index: -7.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0607
    Cell Significance Index: -2.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0735
    Cell Significance Index: -7.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0748
    Cell Significance Index: -3.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0933
    Cell Significance Index: -7.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1023
    Cell Significance Index: -7.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1129
    Cell Significance Index: -7.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1131
    Cell Significance Index: -2.8900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1195
    Cell Significance Index: -1.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1245
    Cell Significance Index: -4.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1301
    Cell Significance Index: -8.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1307
    Cell Significance Index: -3.8500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1339
    Cell Significance Index: -1.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1401
    Cell Significance Index: -8.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1513
    Cell Significance Index: -8.4900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1545
    Cell Significance Index: -3.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1557
    Cell Significance Index: -3.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1576
    Cell Significance Index: -5.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1669
    Cell Significance Index: -2.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1684
    Cell Significance Index: -7.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1773
    Cell Significance Index: -1.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1783
    Cell Significance Index: -9.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1915
    Cell Significance Index: -6.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1929
    Cell Significance Index: -2.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1930
    Cell Significance Index: -1.3100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1936
    Cell Significance Index: -1.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** F2RL1 shares structural similarities with other GPCRs, such as the F2RL3 receptor, and exhibits a high degree of homology with the proteinase-activated receptor 2 (PAR2) from humans. This suggests that F2RL1 may be involved in similar signaling pathways as PAR2. The gene is encoded in the human genome (Ensembl ID: ENSG00000164251) and is part of the class A/1 (rhodopsin-like receptors) and G-protein-coupled receptor activity pathways. **Pathways and Functions** F2RL1 is involved in numerous signaling pathways, including: 1. **Blood coagulation**: F2RL1 regulates blood coagulation by interacting with thrombin and other coagulation factors, leading to the activation of platelets and the formation of blood clots. 2. **Inflammation**: F2RL1 modulates inflammatory responses by regulating the production of chemokines, cytokines, and other inflammatory mediators. 3. **Immune responses**: F2RL1 is involved in the regulation of immune cell functions, including leukocyte migration, proliferation, and activation. 4. **Endothelial barrier maintenance**: F2RL1 helps maintain the integrity of the endothelial barrier by regulating the expression of adhesion molecules and the production of inflammatory mediators. 5. **Cell migration**: F2RL1 regulates cell migration by interacting with various signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. **Clinical Significance** F2RL1 has been implicated in various diseases and disorders, including: 1. **Cardiovascular diseases**: F2RL1 may play a role in the development of cardiovascular diseases, such as atherosclerosis and thrombosis, by regulating blood coagulation and inflammation. 2. **Inflammatory disorders**: F2RL1 may contribute to the pathogenesis of inflammatory disorders, such as rheumatoid arthritis and asthma, by modulating inflammatory responses. 3. **Cancer**: F2RL1 may be involved in the regulation of tumor growth and metastasis by interacting with various signaling pathways. 4. **Neurological disorders**: F2RL1 may play a role in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease, by regulating inflammation and immune responses. In conclusion, F2RL1 is a multifunctional gene that plays a crucial role in various cellular processes, including signal transduction, immune responses, blood coagulation, and cell migration. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the functions and mechanisms of F2RL1.

Genular Protein ID: 3833560313

Symbol: PAR2_HUMAN

Name: Proteinase-activated receptor 2

UniProtKB Accession Codes:

P55085 Q13317 Q13346 Q53XJ8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 65 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7556175

Title: Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2.

PubMed ID: 7556175

DOI: 10.1111/j.1432-1033.1995.tb20784.x

PubMed ID: 8615752

Title: Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2.

PubMed ID: 8615752

DOI: 10.1042/bj3141009

PubMed ID: 16410250

Title: Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1.

PubMed ID: 16410250

DOI: 10.1074/jbc.m510784200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8784787

Title: Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster.

PubMed ID: 8784787

DOI: 10.1007/bf03401632

PubMed ID: 9020112

Title: Interactions of mast cell tryptase with thrombin receptors and PAR-2.

PubMed ID: 9020112

DOI: 10.1074/jbc.272.7.4043

PubMed ID: 10086357

Title: A protective role for protease-activated receptors in the airways.

PubMed ID: 10086357

DOI: 10.1038/18223

PubMed ID: 10788464

Title: Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

PubMed ID: 10788464

DOI: 10.1074/jbc.275.18.13502

PubMed ID: 10725339

Title: beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.

PubMed ID: 10725339

DOI: 10.1083/jcb.148.6.1267

PubMed ID: 10831593

Title: Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates.

PubMed ID: 10831593

DOI: 10.1074/jbc.m002941200

PubMed ID: 10805786

Title: Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa.

PubMed ID: 10805786

DOI: 10.1073/pnas.97.10.5255

PubMed ID: 11447194

Title: Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion.

PubMed ID: 11447194

DOI: 10.1128/iai.69.8.5121-5130.2001

PubMed ID: 11413129

Title: Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes.

PubMed ID: 11413129

DOI: 10.1074/jbc.m100377200

PubMed ID: 11441110

Title: Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells.

PubMed ID: 11441110

DOI: 10.4049/jimmunol.167.2.1014

PubMed ID: 11714832

Title: Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.

PubMed ID: 11714832

DOI: 10.4049/jimmunol.167.11.6615

PubMed ID: 12171601

Title: Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling.

PubMed ID: 12171601

DOI: 10.1042/bj20020706

PubMed ID: 11859856

Title: Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear.

PubMed ID: 11859856

DOI: 10.1254/jjp.88.77

PubMed ID: 12594060

Title: Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.

PubMed ID: 12594060

DOI: 10.1165/rcmb.4908

PubMed ID: 14519665

Title: Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo.

PubMed ID: 14519665

DOI: 10.1096/fj.02-1112com

PubMed ID: 12832443

Title: Expression of and functional responses to protease-activated receptors on human eosinophils.

PubMed ID: 12832443

DOI: 10.1189/jlb.0702351

PubMed ID: 14607272

Title: The role of the C-terminal tail in protease-activated receptor-2-mediated Ca2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity.

PubMed ID: 14607272

DOI: 10.1016/s0898-6568(03)00095-0

PubMed ID: 15155775

Title: Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices.

PubMed ID: 15155775

DOI: 10.1189/jlb.0503221

PubMed ID: 15708858

Title: c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2.

PubMed ID: 15708858

DOI: 10.1074/jbc.m500109200

PubMed ID: 16359518

Title: Protease-activated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling.

PubMed ID: 16359518

DOI: 10.1111/j.1538-7836.2005.01610.x

PubMed ID: 15919826

Title: A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.

PubMed ID: 15919826

DOI: 10.1073/pnas.0409535102

PubMed ID: 15879675

Title: Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice.

PubMed ID: 15879675

DOI: 10.1254/jphs.scz050138

PubMed ID: 16714334

Title: PAR2 activation interrupts E-cadherin adhesion and compromises the airway epithelial barrier: protective effect of beta-agonists.

PubMed ID: 16714334

DOI: 10.1152/ajplung.00046.2006

PubMed ID: 16478888

Title: Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway.

PubMed ID: 16478888

DOI: 10.1182/blood-2005-05-1875

PubMed ID: 16476770

Title: Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.

PubMed ID: 16476770

DOI: 10.1084/jem.20052148

PubMed ID: 17500066

Title: Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2.

PubMed ID: 17500066

DOI: 10.1074/jbc.m701391200

PubMed ID: 17693410

Title: p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking.

PubMed ID: 17693410

DOI: 10.1074/jbc.m703205200

PubMed ID: 17404307

Title: Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2.

PubMed ID: 17404307

DOI: 10.4049/jimmunol.178.8.5237

PubMed ID: 18474671

Title: Chitinase activates protease-activated receptor-2 in human airway epithelial cells.

PubMed ID: 18474671

DOI: 10.1165/rcmb.2007-0410oc

PubMed ID: 18424071

Title: G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes.

PubMed ID: 18424071

DOI: 10.1016/j.cellsig.2008.02.015

PubMed ID: 18622013

Title: Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity.

PubMed ID: 18622013

DOI: 10.1074/jbc.m804800200

PubMed ID: 18453611

Title: Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection.

PubMed ID: 18453611

DOI: 10.4049/jimmunol.180.10.6903

PubMed ID: 18434511

Title: Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors.

PubMed ID: 18434511

DOI: 10.1523/jneurosci.0716-08.2008

PubMed ID: 19684015

Title: Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.

PubMed ID: 19684015

DOI: 10.1074/jbc.m109.025692

PubMed ID: 19815543

Title: Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization.

PubMed ID: 19815543

DOI: 10.1074/jbc.m109.048942

PubMed ID: 19494303

Title: Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway.

PubMed ID: 19494303

DOI: 10.4049/jimmunol.0803743

PubMed ID: 19864598

Title: Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils.

PubMed ID: 19864598

DOI: 10.4049/jimmunol.0901220

PubMed ID: 20584806

Title: Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis.

PubMed ID: 20584806

DOI: 10.1136/ard.2010.130336

PubMed ID: 19781631

Title: Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - a novel paradigm for G(q/11) linked GPCRs.

PubMed ID: 19781631

DOI: 10.1016/j.cellsig.2009.09.028

PubMed ID: 20826780

Title: Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1.

PubMed ID: 20826780

DOI: 10.1074/jbc.m110.163642

PubMed ID: 20530726

Title: Protease-activated receptor-2 (PAR(2)) in human periodontitis.

PubMed ID: 20530726

DOI: 10.1177/0022034510373765

PubMed ID: 19865078

Title: Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo.

PubMed ID: 19865078

DOI: 10.1038/mi.2009.120

PubMed ID: 21501162

Title: Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-gamma on human neutrophils and monocytes.

PubMed ID: 21501162

DOI: 10.1111/j.1365-2567.2011.03443.x

PubMed ID: 21627585

Title: Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor triggered ERK1/2 activation, calcium signalling, and endocytosis.

PubMed ID: 21627585

DOI: 10.1042/bj20101958

PubMed ID: 23202369

Title: Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function.

PubMed ID: 23202369

DOI: 10.1161/atvbaha.112.300474

PubMed ID: 28445455

Title: Structural insight into allosteric modulation of protease-activated receptor 2.

PubMed ID: 28445455

DOI: 10.1038/nature22309

Sequence Information:

  • Length: 397
  • Mass: 44126
  • Checksum: F1A4E1D5AB9B362B
  • Sequence:
    • MRSPSAAWLL GAAILLAASL SCSGTIQGTN RSSKGRSLIG KVDGTSHVTG KGVTVETVFS 
VDEFSASVLT GKLTTVFLPI VYTIVFVVGL PSNGMALWVF LFRTKKKHPA VIYMANLALA 
DLLSVIWFPL KIAYHIHGNN WIYGEALCNV LIGFFYGNMY CSILFMTCLS VQRYWVIVNP 
MGHSRKKANI AIGISLAIWL LILLVTIPLY VVKQTIFIPA LNITTCHDVL PEQLLVGDMF 
NYFLSLAIGV FLFPAFLTAS AYVLMIRMLR SSAMDENSEK KRKRAIKLIV TVLAMYLICF 
TPSNLLLVVH YFLIKSQGQS HVYALYIVAL CLSTLNSCID PFVYYFVSHD FRDHAKNALL 
CRSVRTVKQM QVSLTSKKHS RKSSSYSSSS TTVKTSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.