Details for: F2RL1

Gene ID: 2150

Symbol: F2RL1

Ensembl ID: ENSG00000164251

Description: F2R like trypsin receptor 1

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Blood coagulation
    (GO:0007596)
  • Cell-cell junction maintenance
    (GO:0045217)
  • Defense response to virus
    (GO:0051607)
  • Early endosome
    (GO:0005769)
  • Establishment of endothelial barrier
    (GO:0061028)
  • G-protein alpha-subunit binding
    (GO:0001965)
  • G-protein beta-subunit binding
    (GO:0031681)
  • Golgi apparatus
    (GO:0005794)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Leukocyte migration
    (GO:0050900)
  • Leukocyte proliferation
    (GO:0070661)
  • Mature conventional dendritic cell differentiation
    (GO:0097029)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of insulin secretion
    (GO:0046676)
  • Negative regulation of jnk cascade
    (GO:0046329)
  • Negative regulation of toll-like receptor 3 signaling pathway
    (GO:0034140)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Neutrophil activation
    (GO:0042119)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of actin filament depolymerization
    (GO:0030836)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of chemotaxis
    (GO:0050921)
  • Positive regulation of cytokine production involved in immune response
    (GO:0002720)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of eosinophil degranulation
    (GO:0043311)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of glomerular filtration
    (GO:0003104)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of leukocyte chemotaxis
    (GO:0002690)
  • Positive regulation of neutrophil mediated killing of gram-negative bacterium
    (GO:0070963)
  • Positive regulation of phagocytosis, engulfment
    (GO:0060100)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of positive chemotaxis
    (GO:0050927)
  • Positive regulation of pseudopodium assembly
    (GO:0031274)
  • Positive regulation of renin secretion into blood stream
    (GO:1900135)
  • Positive regulation of rho protein signal transduction
    (GO:0035025)
  • Positive regulation of superoxide anion generation
    (GO:0032930)
  • Positive regulation of toll-like receptor 2 signaling pathway
    (GO:0034137)
  • Positive regulation of toll-like receptor 3 signaling pathway
    (GO:0034141)
  • Positive regulation of toll-like receptor 4 signaling pathway
    (GO:0034145)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Potassium channel activating, g protein-coupled receptor signaling pathway
    (GO:0099109)
  • Protease binding
    (GO:0002020)
  • Protein binding
    (GO:0005515)
  • Pseudopodium
    (GO:0031143)
  • Regulation of blood coagulation
    (GO:0030193)
  • Regulation of canonical nf-kappab signal transduction
    (GO:0043122)
  • Regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000341)
  • Regulation of jnk cascade
    (GO:0046328)
  • Signaling receptor activity
    (GO:0038023)
  • Signaling receptor binding
    (GO:0005102)
  • T cell activation involved in immune response
    (GO:0002286)
  • Thrombin-activated receptor activity
    (GO:0015057)
  • Thrombin-activated receptor signaling pathway
    (GO:0070493)
  • Vasodilation
    (GO:0042311)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.89
    Marker Score: 12080
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.69
    Marker Score: 2487
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.58
    Marker Score: 4947
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.5
    Marker Score: 1184
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.41
    Marker Score: 3456
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.36
    Marker Score: 6528
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.34
    Marker Score: 1405
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.27
    Marker Score: 1323
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.21
    Marker Score: 299
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.14
    Marker Score: 2583
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.05
    Marker Score: 357
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1014
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.96
    Marker Score: 953
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.95
    Marker Score: 2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1522
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 550
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1771
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.86
    Marker Score: 1633.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.85
    Marker Score: 2026
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.83
    Marker Score: 800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 782
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.77
    Marker Score: 2722
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.71
    Marker Score: 446
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.7
    Marker Score: 986
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.68
    Marker Score: 570
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1582
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.66
    Marker Score: 3996
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2778.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.65
    Marker Score: 22508
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.6
    Marker Score: 664
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.59
    Marker Score: 395
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.56
    Marker Score: 211
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.55
    Marker Score: 130
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.55
    Marker Score: 853
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.55
    Marker Score: 188
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.53
    Marker Score: 533
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.52
    Marker Score: 127
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.52
    Marker Score: 8148
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.52
    Marker Score: 902
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.51
    Marker Score: 1373
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 240
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.5
    Marker Score: 622
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.48
    Marker Score: 253
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.48
    Marker Score: 438
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.47
    Marker Score: 317
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.47
    Marker Score: 865
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.47
    Marker Score: 136
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.47
    Marker Score: 322
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.46
    Marker Score: 270
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.45
    Marker Score: 1104
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.45
    Marker Score: 349
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.44
    Marker Score: 86
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.43
    Marker Score: 435
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.42
    Marker Score: 168
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.41
    Marker Score: 658
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.41
    Marker Score: 680
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.4
    Marker Score: 428
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4
    Marker Score: 1523
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.38
    Marker Score: 403
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.38
    Marker Score: 176
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.37
    Marker Score: 400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.37
    Marker Score: 319
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 366
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.37
    Marker Score: 202
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.36
    Marker Score: 107
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.36
    Marker Score: 810
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 233
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.35
    Marker Score: 166
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.34
    Marker Score: 208
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 138
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.31
    Marker Score: 144
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.31
    Marker Score: 2663
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.3
    Marker Score: 1047
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 193
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3
    Marker Score: 172
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.3
    Marker Score: 2594
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 132
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.3
    Marker Score: 1459
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.29
    Marker Score: 559
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.29
    Marker Score: 66

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Other Information

**Key characteristics:** - F2RL1 is a transmembrane protein that is expressed in the plasma membrane. - It is a single-pass transmembrane protein with a molecular weight of approximately 140 kDa. - It is a member of the GPCR superfamily, which is characterized by a seven-transmembrane domain structure. - It is a ligand-gated ion channel that is expressed in a variety of cell types. **Pathways and functions:** - F2RL1 is a key regulator of immune responses. - It is involved in the regulation of inflammation and the production of cytokines. - It is expressed in high levels in cells that are activated during inflammation, such as macrophages and neutrophils. - F2RL1 is also expressed in cells that are involved in the regulation of renal function, such as podocytes and renal epithelial cells. - It is a positive regulator of cytokine production, promoting the production of pro-inflammatory cytokines such as TNF-alpha and IL-1 beta. - It is also a positive regulator of glomerular filtration, promoting the filtration of blood from the glomerular capillaries into the Bowman's capsule. - It is a positive regulator of leukocyte chemotaxis, promoting the migration of immune cells to sites of inflammation. **Clinical significance:** - Mutations in F2RL1 have been linked to a number of human diseases, including inflammatory bowel disease, rheumatoid arthritis, and asthma. - F2RL1 is a potential target for the treatment of inflammatory diseases. - Inhibition of F2RL1 has been shown to inhibit inflammation and improve disease symptoms in animal models of inflammatory diseases.

Genular Protein ID: 3833560313

Symbol: PAR2_HUMAN

Name: Proteinase-activated receptor 2

UniProtKB Accession Codes:

P55085 Q13317 Q13346 Q53XJ8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 65 Gene3D 1 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7556175

Title: Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2.

PubMed ID: 7556175

DOI: 10.1111/j.1432-1033.1995.tb20784.x

PubMed ID: 8615752

Title: Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2.

PubMed ID: 8615752

DOI: 10.1042/bj3141009

PubMed ID: 16410250

Title: Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1.

PubMed ID: 16410250

DOI: 10.1074/jbc.m510784200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8784787

Title: Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster.

PubMed ID: 8784787

DOI: 10.1007/bf03401632

PubMed ID: 9020112

Title: Interactions of mast cell tryptase with thrombin receptors and PAR-2.

PubMed ID: 9020112

DOI: 10.1074/jbc.272.7.4043

PubMed ID: 10086357

Title: A protective role for protease-activated receptors in the airways.

PubMed ID: 10086357

DOI: 10.1038/18223

PubMed ID: 10788464

Title: Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

PubMed ID: 10788464

DOI: 10.1074/jbc.275.18.13502

PubMed ID: 10725339

Title: beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.

PubMed ID: 10725339

DOI: 10.1083/jcb.148.6.1267

PubMed ID: 10831593

Title: Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates.

PubMed ID: 10831593

DOI: 10.1074/jbc.m002941200

PubMed ID: 10805786

Title: Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa.

PubMed ID: 10805786

DOI: 10.1073/pnas.97.10.5255

PubMed ID: 11447194

Title: Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion.

PubMed ID: 11447194

DOI: 10.1128/iai.69.8.5121-5130.2001

PubMed ID: 11413129

Title: Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes.

PubMed ID: 11413129

DOI: 10.1074/jbc.m100377200

PubMed ID: 11441110

Title: Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells.

PubMed ID: 11441110

DOI: 10.4049/jimmunol.167.2.1014

PubMed ID: 11714832

Title: Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.

PubMed ID: 11714832

DOI: 10.4049/jimmunol.167.11.6615

PubMed ID: 12171601

Title: Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling.

PubMed ID: 12171601

DOI: 10.1042/bj20020706

PubMed ID: 11859856

Title: Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear.

PubMed ID: 11859856

DOI: 10.1254/jjp.88.77

PubMed ID: 12594060

Title: Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.

PubMed ID: 12594060

DOI: 10.1165/rcmb.4908

PubMed ID: 14519665

Title: Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo.

PubMed ID: 14519665

DOI: 10.1096/fj.02-1112com

PubMed ID: 12832443

Title: Expression of and functional responses to protease-activated receptors on human eosinophils.

PubMed ID: 12832443

DOI: 10.1189/jlb.0702351

PubMed ID: 14607272

Title: The role of the C-terminal tail in protease-activated receptor-2-mediated Ca2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity.

PubMed ID: 14607272

DOI: 10.1016/s0898-6568(03)00095-0

PubMed ID: 15155775

Title: Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices.

PubMed ID: 15155775

DOI: 10.1189/jlb.0503221

PubMed ID: 15708858

Title: c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2.

PubMed ID: 15708858

DOI: 10.1074/jbc.m500109200

PubMed ID: 16359518

Title: Protease-activated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling.

PubMed ID: 16359518

DOI: 10.1111/j.1538-7836.2005.01610.x

PubMed ID: 15919826

Title: A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.

PubMed ID: 15919826

DOI: 10.1073/pnas.0409535102

PubMed ID: 15879675

Title: Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice.

PubMed ID: 15879675

DOI: 10.1254/jphs.scz050138

PubMed ID: 16714334

Title: PAR2 activation interrupts E-cadherin adhesion and compromises the airway epithelial barrier: protective effect of beta-agonists.

PubMed ID: 16714334

DOI: 10.1152/ajplung.00046.2006

PubMed ID: 16478888

Title: Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway.

PubMed ID: 16478888

DOI: 10.1182/blood-2005-05-1875

PubMed ID: 16476770

Title: Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.

PubMed ID: 16476770

DOI: 10.1084/jem.20052148

PubMed ID: 17500066

Title: Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2.

PubMed ID: 17500066

DOI: 10.1074/jbc.m701391200

PubMed ID: 17693410

Title: p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking.

PubMed ID: 17693410

DOI: 10.1074/jbc.m703205200

PubMed ID: 17404307

Title: Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2.

PubMed ID: 17404307

DOI: 10.4049/jimmunol.178.8.5237

PubMed ID: 18474671

Title: Chitinase activates protease-activated receptor-2 in human airway epithelial cells.

PubMed ID: 18474671

DOI: 10.1165/rcmb.2007-0410oc

PubMed ID: 18424071

Title: G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes.

PubMed ID: 18424071

DOI: 10.1016/j.cellsig.2008.02.015

PubMed ID: 18622013

Title: Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity.

PubMed ID: 18622013

DOI: 10.1074/jbc.m804800200

PubMed ID: 18453611

Title: Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection.

PubMed ID: 18453611

DOI: 10.4049/jimmunol.180.10.6903

PubMed ID: 18434511

Title: Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors.

PubMed ID: 18434511

DOI: 10.1523/jneurosci.0716-08.2008

PubMed ID: 19684015

Title: Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.

PubMed ID: 19684015

DOI: 10.1074/jbc.m109.025692

PubMed ID: 19815543

Title: Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization.

PubMed ID: 19815543

DOI: 10.1074/jbc.m109.048942

PubMed ID: 19494303

Title: Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway.

PubMed ID: 19494303

DOI: 10.4049/jimmunol.0803743

PubMed ID: 19864598

Title: Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils.

PubMed ID: 19864598

DOI: 10.4049/jimmunol.0901220

PubMed ID: 20584806

Title: Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis.

PubMed ID: 20584806

DOI: 10.1136/ard.2010.130336

PubMed ID: 19781631

Title: Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - a novel paradigm for G(q/11) linked GPCRs.

PubMed ID: 19781631

DOI: 10.1016/j.cellsig.2009.09.028

PubMed ID: 20826780

Title: Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1.

PubMed ID: 20826780

DOI: 10.1074/jbc.m110.163642

PubMed ID: 20530726

Title: Protease-activated receptor-2 (PAR(2)) in human periodontitis.

PubMed ID: 20530726

DOI: 10.1177/0022034510373765

PubMed ID: 19865078

Title: Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo.

PubMed ID: 19865078

DOI: 10.1038/mi.2009.120

PubMed ID: 21501162

Title: Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-gamma on human neutrophils and monocytes.

PubMed ID: 21501162

DOI: 10.1111/j.1365-2567.2011.03443.x

PubMed ID: 21627585

Title: Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor triggered ERK1/2 activation, calcium signalling, and endocytosis.

PubMed ID: 21627585

DOI: 10.1042/bj20101958

PubMed ID: 23202369

Title: Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function.

PubMed ID: 23202369

DOI: 10.1161/atvbaha.112.300474

PubMed ID: 28445455

Title: Structural insight into allosteric modulation of protease-activated receptor 2.

PubMed ID: 28445455

DOI: 10.1038/nature22309

Sequence Information:

  • Length: 397
  • Mass: 44126
  • Checksum: F1A4E1D5AB9B362B
  • Sequence:
    • MRSPSAAWLL GAAILLAASL SCSGTIQGTN RSSKGRSLIG KVDGTSHVTG KGVTVETVFS 
VDEFSASVLT GKLTTVFLPI VYTIVFVVGL PSNGMALWVF LFRTKKKHPA VIYMANLALA 
DLLSVIWFPL KIAYHIHGNN WIYGEALCNV LIGFFYGNMY CSILFMTCLS VQRYWVIVNP 
MGHSRKKANI AIGISLAIWL LILLVTIPLY VVKQTIFIPA LNITTCHDVL PEQLLVGDMF 
NYFLSLAIGV FLFPAFLTAS AYVLMIRMLR SSAMDENSEK KRKRAIKLIV TVLAMYLICF 
TPSNLLLVVH YFLIKSQGQS HVYALYIVAL CLSTLNSCID PFVYYFVSHD FRDHAKNALL 
CRSVRTVKQM QVSLTSKKHS RKSSSYSSSS TTVKTSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.